The Crustacean Hyperglycemic Hormone Superfamily: Progress Made in the Past Decade

Frontiers in Endocrinology, Journal Year: 2020, Volume and Issue: 11

Published: Oct. 1, 2020

Earlier studies recognizing the importance of decapod eyestalk in terms endocrine regulation crustacean physiology − molting, metabolism, reproduction, osmotic balance etc. helped found field endocrinology. Characterization putative factors using distinct functional bioassay ultimately led to discovery a group structurally related and functionally diverse neuropeptides, hyperglycemic hormone (CHH), molt-inhibiting (MIH), gonad-inhibiting (GIH) or vitellogenesis-inhibiting (VIH), mandibular organ-inhibiting (MOIH). These peptides, along with first insect member (ion transport peptide, ITP), constitute original arthropod members (CHH) superfamily. Presence genes encoding CHH-superfamily peptides across representative ecdysozoan taxa has been established. The objective this review is to, aside from providing general framework, highlight progresses obtained during past decade so. include, at least, continuous identification particular non-crustaceans, which reshaped phylogenetic profile Some new were characterized novel function, exceptional opportunities for understanding structure-function relationship superfamily peptides. Functional are challenging, especially those species, where widely expressed various tissues usually pleiotropic. Progresses have made regarding CHH, ITP, their alternatively spliced counterparts (CHH-L, ITP-L) metabolism ionic/osmotic hemostasis under (eco)physiological, developmental, pathological contexts, MIH stimulation ovarian maturation, that implicates as regulator coordinating growth (molt) reproduction. In addition, experimental elucidation steric structure gave better understandings structural basis diversification overlapping among Finally, an important progress was first-ever receptors any specifically ITPs silkworm, would undoubtedly give great impetus study years come. Studies these presented synthesized, prospective developments remarked.

Language: Английский

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Signaling Pathways That Regulate the Crustacean Molting Gland

Frontiers in Endocrinology, Journal Year: 2021, Volume and Issue: 12

Published: June 21, 2021

A pair of Y-organs (YOs) are the molting glands decapod crustaceans. They synthesize and secrete steroid hormones (ecdysteroids) their activity is controlled by external internal signals. The YO transitions through four physiological states over molt cycle, which mediated molt-inhibiting hormone (MIH; basal state), mechanistic Target Rapamycin Complex 1 (mTORC1; activated Transforming Growth Factor-β (TGFβ)/Activin (committed ecdysteroid (repressed state) signaling pathways. MIH, produced in eyestalk X-organ/sinus gland complex, inhibits synthesis ecdysteroids. model for MIH organized into a cAMP/Ca

Language: Английский

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Hormonal control of the crustacean molting gland: Insights from transcriptomics and proteomics

General and Comparative Endocrinology, Journal Year: 2020, Volume and Issue: 294, P. 113493 - 113493

Published: April 24, 2020

Language: Английский

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The moulting arthropod: a complete genetic toolkit review

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Journal Year: 2024, Volume and Issue: 99(6), P. 2338 - 2375

Published: July 22, 2024

ABSTRACT Exoskeletons are a defining character of all arthropods that provide physical support for their segmented bodies and appendages as well protection from the environment predation. This ubiquitous yet evolutionarily variable feature has been instrumental in facilitating adoption variety lifestyles exploitation ecological niches across environments. Throughout radiation produced more than one million described modern species, adaptability afforded by segmentation exoskeletons led to diversity is unrivalled amongst animals. However, because limited extensibility exoskeleton chitin cuticle components, they must be periodically shed replaced with new larger ones, notably accommodate growing individuals encased within. Therefore, grow discontinuously undergoing periodic moulting events, which follow series steps preparatory pre‐moult phase ecdysis itself post‐moult maturation exoskeletons. Each event represents particularly vulnerable period an arthropod's life cycle, so processes tightly regulated meticulously executed ensure successful transitions normal growth development. Decades research representative foundation understanding mechanisms involved. Building on this, studies continue develop test hypotheses presence function molecular including neuropeptides, hormones, receptors, so‐called early, late, fate genes, arthropod diversity. Here, we review literature comprehensive overview status accumulated knowledge genetic toolkit governing moulting. From biosynthesis regulation ecdysteroid sesquiterpenoid factors involved hormonal stimulation responses remodelling, identify commonalities differences, highlighting major gaps, groups. We examine available evidence supporting current models how components operate together prepare for, execute, recover ecdysis, comparing reports Chelicerata, Myriapoda, Crustacea, Hexapoda. Evidence generally highly taxonomically imbalanced, most based insect study systems. Biases also evident different phases processes, early triggers late effectors being least explored. Our synthesis contrasts reported observations reasonably plausible assumptions given taxonomic sampling, exposes weak or gaps need addressing. Encouragingly, advances genomics driving diversification tractable systems cataloguing putative toolkits previously under‐explored taxa. Analysis genome transcriptome data supported experimental investigations have validated “ultra‐conserved” core genes processes. The machinery likely evolved elaborations this conserved pathway backbone, but exploration needed characterise lineage‐specific changes novelties. Furthermore, linking these transformative innovations Arthropoda remains hampered untested assumptions. Promisingly however, emerging framework highlights avenues underlying genetics dynamic biology through complex physiology

Language: Английский

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Sex Determination and Differentiation in Decapod and Cladoceran Crustaceans: An Overview of Endocrine Regulation

Genes, Journal Year: 2021, Volume and Issue: 12(2), P. 305 - 305

Published: Feb. 21, 2021

Mechanisms underlying sex determination and differentiation in animals are known to encompass a diverse array of molecular clues. Recent innovations high-throughput sequencing mass spectrometry technologies have been widely applied non-model organisms without reference genomes. Crustaceans no exception. They particularly among the Arthropoda contain wide variety commercially important fishery species such as shrimps, lobsters crabs (Order Decapoda), keystone aquatic ecosystems water fleas Branchiopoda). In terms decapod differentiation, previous approaches attempted elucidate their components, establish mono-sex breeding technology. Here, we overview reports describing physiological functions hormones regulating masculinization feminization, gene discovery by transcriptomics species. Moreover, this review summarizes recent progresses studies on juvenile hormone-driven system branchiopod genus Daphnia, then compares endocrine systems between decapods branchiopods. This provides not only substantial insights for aquaculture research, but also opportunity re-organize current future trends field.

Language: Английский

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Comparative and Evolutionary Physiology of Vasopressin/ Oxytocin-Type Neuropeptide Signaling in Invertebrates

Frontiers in Endocrinology, Journal Year: 2020, Volume and Issue: 11

Published: April 17, 2020

The identification of structurally related hypothalamic hormones that regulate blood pressure and diuresis (vasopressin, VP; CYFQNCPRG-NH2) or lactation uterine contraction (oxytocin, OT; CYIQNCPLG-NH2) was a major advance in neuroendocrinology, recognised the award Nobel Prize for Chemistry 1955. Furthermore, discovery central actions VP OT as regulators reproductive social behaviour humans other mammals has broadened interest these neuropeptides beyond physiology into psychology. VP/OT-type their G-protein coupled receptors originated common ancestor Bilateria (Urbilateria), with invertebrates typically having single neuropeptide cognate receptor. Gene/genome duplications followed by gene loss gave rise to variety number different vertebrate lineages. Recent advances comparative transcriptomics/genomics have enabled an ever-growing diversity invertebrate taxa, providing new opportunities gain insights evolution function Bilateria. Here we review invertebrates, roles regulation reproduction, feeding water/salt homeostasis emerging themes. For example, highlight recent reports oocyte maturation sea-squirt Ciona intestinalis, extraoral starfish Asterias rubens energy status dessication resistance ants. Thus, are pleiotropic physiological processes, evolutionarily conserved can be traced back Urbilateria. To deeper understanding it may necessary not only determine peptides but also characterise transcriptomic/proteomic/metabolomic profiles cells expressing precursors and/or within framework anatomically functionally identified neuronal networks. investigation wider range species is now needed if how when this ancient signalling system recruited diverse behavioural processes branches animal phylogeny contrasting environmental contexts.

Language: Английский

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Ancestral Role of Ecdysis-Related Neuropeptides in Animal Life Cycle Transitions

Current Biology, Journal Year: 2020, Volume and Issue: 31(1), P. 207 - 213.e4

Published: Oct. 30, 2020

Language: Английский

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A Crab Is Not a Fish: Unique Aspects of the Crustacean Endocrine System and Considerations for Endocrine Toxicology

Frontiers in Endocrinology, Journal Year: 2021, Volume and Issue: 12

Published: March 2, 2021

Crustaceans-and arthropods in general-exhibit many unique aspects to their physiology. These include the requirement moult (ecdysis) order grow and reproduce, ability change color, multiple strategies for sexual differentiation. Accordingly, endocrine regulation of these processes involves hormones, receptors, enzymes that differ from those utilized by vertebrates other non-arthropod invertebrates. As a result, environmental chemicals known disrupt are often not disruptors crustaceans; while, crustaceans vertebrates. In this review, we present an overview evolution system crustaceans, highlight endpoints be target disruption chemicals, identify components signaling may prove targets disruption. This review highlights need evaluated with consideration

Language: Английский

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The gonadotropin-releasing hormone (GnRH) superfamily across Pancrustacea/Tetraconata: A role in metabolism?

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 590, P. 112238 - 112238

Published: April 13, 2024

Language: Английский

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Integration of ATAC-seq and RNA-seq reveals signal regulation during post-molt and inter-molt stages in muscle of Eriocheir sinensis

Frontiers in Marine Science, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 21, 2025

Introduction The molting processes are crucial for the survival and development of crustaceans. Eriocheir sinensis demonstrates representative discontinuous growth during molting, while muscle is most obvious tissue exhibiting this property. However, signal regulation mechanisms involved in remain unexplored. Methods In work, a comprehensive analysis gene expressions E. between post-molt inter-molt stages were performed by integrating ATAC-seq RNA-seq techniques. Results integration identified 446 up-regulated 21 down-regulated genes two stages. GO enrichment revealed that largely associated with protein phosphorylation phosphorus metabolism, mainly DNA transcription, cell adhesion, G protein-coupled receptor (GPCR) signaling pathway. all enriched pathways, GPCR pathway includes differentially expressed (8 genes), which underlines its importance transduction from stage to stage. Further structure RT-qPCR validation confirmed five related process, four ( GRM7, FMRFaR, mth2, gpr161 ) active one moody functions Discussion These findings highlight key regulatory proteins pathways also offer foundational data studying

Language: Английский

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