The Artificial-Liver Blood-Purification System Can Effectively Improve Hypercytokinemia for COVID-19

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: Dec. 23, 2020

Since the December 2019 outbreak of coronavirus disease (COVID-19) in Wuhan, infection has spread locally and globally resulting a pandemic. As numbers confirmed diagnoses deaths continue to rise, COVID-19 become focus international public health. is highly contagious, there no effective treatment yet. New strategies are urgently needed improve success rate severe critically ill patients. Increasing evidence shown that cytokine storm plays an important role progression COVID-19. The artificial-liver blood-purification system (ALS) expected outcome storm. In present study, levels cytokines were detected 12 patients pre- post-ALS with promising results. study shows ALS can block storm, rapidly remove inflammatory mediators, hopefully, suppress disease, thereby providing new strategy for clinical

Language: Английский

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Application of extracorporeal therapies in critically ill COVID-19 patients

Journal of Zhejiang University SCIENCE B, Journal Year: 2021, Volume and Issue: 22(9), P. 701 - 717

Published: Sept. 1, 2021

The coronavirus disease 2019 (COVID-19) pandemic is a major public health event caused by severe acute respiratory syndrome 2 (SARS-CoV-2). COVID-19 has spread widely all over the world. A high proportion of patients become severely or critically ill, and suffer mortality due to failure multiple organ dysfunction. Therefore, providing timely effective treatment for ill essential reduce overall mortality. Convalescent plasma therapy pharmacological treatments, such as aerosol inhalation interferon-α (IFN-α), corticosteroids, tocilizumab, have been applied in clinical practice; however, their effects remain controversial. Recent studies shown that extracorporeal therapies might potential role treating patients. In this review, we examine application continuous renal replacement (CRRT), therapeutic exchange (TPE), hemoadsorption (HA), membrane oxygenation (ECMO), carbon dioxide removal (ECCO2R) provide support further diagnosis COVID-19.

Language: Английский

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Blood Purification Studies in the ICU: What Endpoints Should We Use?

Blood Purification, Journal Year: 2022, Volume and Issue: 51(12), P. 990 - 996

Published: Jan. 1, 2022

The potential for treatment of the critically ill using blood purification techniques has been discussed several decades. However, since first attempts at applying extracorporeal to patients with sepsis were described, there considerable hesitancy towards widespread adoption such methods, given lack mortality benefit observed and indeed paucity randomized controlled studies. this is not unique so far as studies on are concerned where a dearth providing positive finding influence clinical practice. Consequently, well targeted patient selection, it perhaps time consider endpoints other than in ill, particularly where, to-date, heterogeneous groups have studied.

Language: Английский

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Adsorption Properties and Hemolytic Activity of Porous Aluminosilicates in a Simulated Body Fluid

ChemEngineering, Journal Year: 2022, Volume and Issue: 6(5), P. 78 - 78

Published: Oct. 6, 2022

A study of the adsorption features bovine serum albumin (BSA), sodium and potassium cations, vitamin B1 by porous aluminosilicates with different structures in a medium simulating blood plasma was conducted. The objects this were synthetic silicates montmorillonite structure Na2x(Al2(1-x),Mg2x)Si4O10(OH)2·nH2O (x = 0.5, 0.9, 1), kaolinite subgroup Al2Si2O5(OH)4 particle morphologies (spherical, nanosponge, nanotubular, platy), as well framed (Beta zeolite). An assessment possibility using hemosorbents for extracorporeal purification carried out. For purpose, sorption capacity samples both respect to model molecular weight toxicants (BSA) natural components—vitamins alkaline cations—was investigated. also studied X-ray diffraction, electron microscopy, low-temperature nitrogen adsorption. zeta potential sample’s surfaces distribution active centers on their method acid-base indicators determined. hemolytic test used determine ability damage membranes eukaryotic cells. Langmuir, Freundlich, Temkin models describe experimental BSA isotherms. To process kinetic data, pseudo-first-order pseudo-second-order used. It found that have high pathogens (up 12 times activated charcoal some samples) low toxicity Based obtained results, conclusions made about prospects development new selective non-toxic based given set properties.

Language: Английский

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Effects of cytokine hemadsorption as salvage therapy on common laboratory parameters in patients with life-threatening COVID-19

Transfusion and Apheresis Science, Journal Year: 2023, Volume and Issue: 62(3), P. 103701 - 103701

Published: March 11, 2023

Language: Английский

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Hemoperfusion techniques using Jafron HA330 cartridge combined with BBraun Dialog+ dialysis machine in patient with coronavirus disease 2019 pneumonia and septic shock: a case report

Journal of Medical Case Reports, Journal Year: 2023, Volume and Issue: 17(1)

Published: April 8, 2023

Abstract Background The use of hemoperfusion for cytokine removal and inflammatory mediators is increasingly intense, especially in coronavirus disease 2019 patients who are already known to the general public having storms. However, we have about these storms a long time critical care world. One modalities remove cytokines filtration adsorption techniques with continuous renal replacement therapy. therapy usually constrained by its very high cost compared standard care, Indonesia, where health costs covered national insurance. In this case, hemodialysis hemoperfusion, using dialysis machine, which more cost-effective easy use. Case presentation We used Jafron HA330 cartridge, modified BBraun Dialog+ machine. This case report presents an 84-year-old Asian man septic shock due pneumonia, congestive heart failure, acute chronic kidney accompanied fluid overload. After undergoing separately, there was gradual significant clinical improvement. Clinical indicators, including vasopressor inotropic score infection markers, should all be considered when deciding whether begin hemoperfusion. Conclusion general, treat can reduce length stay intensive unit, morbidity mortality.

Language: Английский

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Efficacy of the Cytokine Adsorption Therapy in Patients with Severe COVID-19-Associated Pneumonia: Lesson Learned from a Prospective Observational Study

Blood Purification, Journal Year: 2023, Volume and Issue: 53(1), P. 10 - 22

Published: Nov. 2, 2023

Severe COVID-19 pneumonia can activate a cytokine storm. Hemoperfusion reduce pro-inflammatory cytokines in sepsis but is still debated the setting. Thus, we sought to investigate benefits of HA-330 adsorption through clinical and laboratory outcomes.

Language: Английский

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Efficacy of additional hemoperfusion in hospitalized patients with severe to critical COVID-19 disease

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 31, 2024

The evidence supporting additional hemoperfusion (HP) with cytokine adsorbents for improving clinical outcomes in severe to critical coronavirus disease 2019 (COVID-19) patients remains limited. We compared COVID-19 who received HP a adsorbent matched cases receiving standard medical treatment (SMT). primary outcome was hospital mortality. In our study, we 45 1:1 the SMT group based on key parameters. mortality rates did not differ between groups (33% vs 38%, p = 0.83). had significantly shorter ICU stay (22 32 days; 0.017) and reduced mechanical ventilation duration (15 35 < 0.001). Additionally, incidence of pulmonary complications (20% 42%; 0.04), sepsis (38% 64%; 0.02), disseminated intravascular coagulopathy (DIC) (13% 33%; 0.046) were lower group. conclusion, among patients, improve However, it length stay, ventilator days, incidences lung complications, sepsis, DIC. Trial registration: TCTR20231002006. Registered 02 October 2023 (retrospectively registered).

Language: Английский

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Evaluation of clinical features and laboratory findings in critical intensive care unit patients with severe coronavirus disease‐19 who underwent extracorporeal cytokine adsorption

Therapeutic Apheresis and Dialysis, Journal Year: 2023, Volume and Issue: 27(5), P. 890 - 897

Published: May 12, 2023

Abstract Aim To evaluate the inflammatory parameters and oxygenation in severe coronavirus disease‐19 patients who underwent extracorporeal cytokine adsorption (CA). Methods Patients CA for storm were included study. The changes oxygenation, laboratory parameters, mortality rates investigated. Results Thirty‐six hemoglobin, thrombocyte, C‐reactive protein (CRP) decreased, PaO 2 /FiO ratio increased ( p < 0.001; 0.01; = 0.04, respectively). Twelve (33.3%) received a single session, 24 (66.6%) or more sessions. CRP fibrinogen levels /FIO session group 0.04; 0.01, In multi‐session group, platelet, procalcitonin, 0.02; Day 15, 30, 90 61.1%, 83.3%, 88.9%. Conclusion with hemoperfusion reduced improved oxygenation; however, high.

Language: Английский

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The Supporting Role of Combined and Sequential Extracorporeal Blood Purification Therapies in COVID-19 Patients in Intensive Care Unit

Biomedicines, Journal Year: 2022, Volume and Issue: 10(8), P. 2017 - 2017

Published: Aug. 19, 2022

Critical clinical forms of COVID-19 infection often include Acute Kidney Injury (AKI), requiring kidney replacement therapy (KRT) in up to 20% patients, further worsening the outcome disease. No specific medical therapies are available for treatment COVID-19, while supportive care remains standard with control systemic inflammation playing a pivotal role, avoiding disease progression and improving organ function. Extracorporeal blood purification (EBP) has been proposed cytokines removal sepsis could be beneficial preventing release syndrome (CRS) providing Extra-corporeal support (ECOS) critical patients. Different EBP procedures patients have including hemoperfusion (HP) on sorbent, continuous (CRRT) adsorbing capacity, or use high cut-off (HCO) membranes. Depending local experience, multidisciplinary capabilities, hardware, devices, can combined sequentially parallel. The purpose this paper is illustrate how perform EBPs, practical extracorporeal AKI.

Language: Английский

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