Association between weight-adjusted-waist index and long-term prognostic outcomes in cardiovascular disease patients: results from the NHANES 1999–2018 study

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 17, 2025

As cardiovascular disease (CVD) morbidity and mortality increase yearly, this study aimed to explore the potential of weight-adjusted-waist index (WWI) its relation long-term in patients with CVD. The diagnosis CVD was based on standardized medical condition questionnaires that incorporated participants' self-reported physician diagnoses. WWI (cm/√kg) is a continuous variable calculated as waist circumference (WC, cm) divided by square root body weight (kg). For analysis purposes, participants were into four groups quartiles (Q1 - Q4) WWI. study's primary outcome all-cause CVD, secondary outcome, sample weights complex survey designs used ensure reliable, accurate results. final included 4,445 participants. In fully adjusted model, highest quartile (WWI > 12.05 cm/√ kg) showed higher rate compared lowest < 11.03 (HR = 1.37, 95% CI: 1.03, 1.82, P 0.05). risk increased linear association congestive heart failure, attack (P-overall 0.05, nonlinear 0.05); nonlinearly associated coronary angina Survival curve further all cause high group (Q4) (P 0.001). time-dependent receiver operating characteristic (ROC) WWI's area under curves (AUC) for 5- 10-year survival rates 0.76 0.792 0.734 0.757 mortality. AUC than those mass (BMI) WC (all 0.01). Our findings indicate positively an Additionally, values strengthen meaningful prognostic marker, underscoring utility clinical practice assessing

Language: Английский

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Association between weight-adjusted-waist index and depression: a cross-sectional study

Endocrine Connections, Journal Year: 2024, Volume and Issue: 13(6)

Published: April 23, 2024

Background Depression has become a multifaceted global health issue, with complex connections to obesity. Weight-adjusted-waist index (WWI) can effectively evaluate central obesity, but the relationship between WWI and depression not been well studied. The study aims investigate potential correlation these two parameters. Methods According data from National Health Nutrition Examination Survey, this cross-sectional used multiple regression analysis, subgroup smooth curve fitting explore depression. assessment ability of was evaluated compared other obesity indicators using receiver operating characteristic (ROC) curve. Results This analyzed 38,154 participants. Higher is associated higher scores ( β = 0.41; 95% CI, 0.36–0.47). After adjusting for various confounding factors, positive remained significant P trend < 0.0001). Nonlinear detected breakpoint 11.14. ROC analysis shows that (ROC 0.593; BMI 0.584; WC 0.581), better discrimination accuracy. DII mediated 4.93%, SII 5.08%, sedentary 0.35% total association Conclusion levels were related an increased likelihood showed stronger than waist circumference. Our findings indicated may serve as simple anthropometric

Language: Английский

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The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 17, 2025

This study aimed to investigate the potential relationship between newly defined adiposity metric, Body Roundness Index (BRI), which assesses central obesity, and development of new-onset hyperuricemia. In Kailuan cohort from 2006 2019, 91,804 eligible participants were included. A multivariate Cox regression model was used test correlation BRI At same time, restricted cubic spline applied solve dose-response risk hyperuricemia.Then, stratified analysis carried out using according age, sex, hs-CRP level, TG education smoking status hypertension status. The results showed that hyperuricemia significantly increased in highest quartile compared with lowest quartile. After adjusting for confounders, Q1, HR (95% CI) 1.24 (1.18–1.30), 1.32 (1.25–1.40), 1.40 (1.29–1.52) Q2, Q3, Q4, respectively. Restricted a J-curve baseline levels hyperuricaemia. Age, income smoking, each had multiplicative interaction at baseline. We found elevated developing addition, association dependency on

Language: Английский

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Relationship between Body Roundness Index and cognitive impairment in middle-aged and older adults: a population-based cross-sectional study

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: Feb. 19, 2025

Cognitive impairment is a growing public health concern, particularly in aging populations. Obesity, as measured by various indices, has been linked to cognitive decline, but the relationship between Body Roundness Index (BRI) and remains unclear. This study aims evaluate association BRI rural, low-income, low-education population China determine if can be used an independent predictor of decline. cross-sectional included participants aged 35-95 years from rural Tianjin, China. The mean age was 64.35 ± 7.58 years. Data were collected through face-to-face interviews, physical examinations, laboratory tests. function assessed using Mini-Mental State Examination (MMSE), calculated grouped into quartiles. Univariate multivariate logistic regression analyses performed examine impairment. Subgroup conducted explore interactions BRI, age, gender, hypertension. dose-response analyzed restricted cubic spline models. Of participants, 36.5% had Multivariate analysis showed that women, individuals 65 over, those with hypertension higher risk Participants second quartile 31% lower compared first (OR: 0.69, 95% CI: 0.51-0.94, p = 0.017). revealed significantly associated under 65, not older participants. MMSE score inverted U-shaped curve, weakest observed around 4.49. Index, conjunction hypertension, serve useful impairment, younger Early identification at may facilitate timely interventions, reducing burden decline on patients healthcare systems.

Language: Английский

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Inflammatory markers mediate the association between weight-adjusted waist circumference and mortality in patients with cardiometabolic syndrome

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 12, 2025

Cardiometabolic Syndrome (CMS) is associated with increased risks of cardiovascular disease, type 2 diabetes mellitus, and all-cause mortality. The Weight-Adjusted Waist Circumference Index (WWI) has emerged as a novel metric for assessing obesity its health implications. To investigate the relationship between WWI mortality in CMS patients, considering mediating role inflammatory markers. study analyzed National Health Nutrition Examination Survey (NHANES) data from 2003 to 2018 identified 6506 patients CMS. was calculated square root waist circumference (cm) divided by weight (kg). Mortality were correlated Death (NDI). Cox regression models, adjusted demographic clinical covariates, assessed effect on cause-specific Finally, markers explored using mediation analysis. observed positive linear association all-cause, cardiovascular, diabetes-related mortalities among patients. After adjusting confounders, remained significant predictor Mediation analysis revealed that markers, particularly neutrophil systemic immune-inflammation index (SII), significantly mediated an independent inflammation potentially linking risk. These findings may inform risk assessment management strategies

Language: Английский

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Interaction and overall effects of underweight, low muscle mass, malnutrition, and inflammation on early-onset mild cognitive impairment in type 2 diabetes

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 27, 2025

Introduction This study systematically explores the overall impact and interactions of body composition nutritional inflammatory indices on early-onset mild cognitive impairment (EOMCI) in type 2 diabetes mellitus (T2DM). Methods A cross-sectional included 816 T2DM patients. Body mass index (BMI), waist circumference (WC), a shape (ABSI), roundness (BRI), visceral fat area (VFA), percentage (BF%), skeletal muscle (SMMI). Nutritional geriatric risk (GNRI), prognostic (PNI), C-reactive protein-albumin-lymphocyte (CALLY), fibrinogen-to-albumin ratio (FAR). K-means clustering quantile g-computation (QGC) assessed combined impact, with evaluated by simple slope analysis. Results revealed two distinct patterns: Low-pattern High-pattern. The group exhibited significantly lower (BMI 24.6 vs. 27.7 kg/m ; WC 88 99 cm; ABSI 0.081 0.084; BRI 3.89 5.02; VFA 91 112; BF% 29% 31%; SMMI 9.38 10.48 all P &lt; 0.001) poorer status higher inflammation (GNRI 97.9 104.6; PNI 47.9 53.1; CALLY 4 5; FAR 0.082 0.072; 0.05). had prevalence EOMCI (32% 23%, = 0.006). After adjusting for confounders, 1.45-fold increased (OR 1.45, 95% CI 1.01–2.08). QGC analysis demonstrated that effect was negatively associated risk. one-quintile increase linked to significant 31.3% reduction (95% −44.4%, −15.0%). Interaction abdominal obesity (ABSI &gt; 0.08), malnutrition (low GNRI), ( interaction 0.018). Similarly, low (SMMI 11.33 ), when high index), further exacerbated 0.028). Discussion findings suggest patients, effects underweight, reduced mass, obesity, malnutrition, elevated are an EOMCI. Integrated management these factors is essential mitigate

Language: Английский

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Association Between Cognitive impairment and Comprehensive Weight Phenotypes Among Older Adults In China: A Nationwide Survey

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Objective To investigate the relationship between obesity and cognitive impairment among older adults using body mass index (BMI) weight-adjusted waist circumference (WWI). Methods Drawing on data from Chinese Longitudinal Healthy Longevity Survey database spanning 2011 to 2018, study employed Cox regression analysis restricted cubic spline method examine BMI, WWI, impairment. Results A total of 2546 subjects were included in this study. According lean was a risk factor for (HR = 1.347, 95%CI:1.011 ~ 1.795), overweight 0.446, 95%CI:0.35 0.568) 0.225, 95%CI:0.161 0.314) protective adults. classification high WWI 2.064, 95%CI:1.731 2.461). The showed that when > 11cm/, increased with increase WWI. comprehensive weight phenotype constructed by BMI combined found have highest 1.542, 95%CI:1.087–2.187), low had largest effect function by(HR 0.108, 95%CI: 0.062 0.186). Conclusion Maintaining an appropriate level or even state can contribute preservation health This holds significant importance as it is preventive measure against onset

Language: Английский

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Obesity-induced chronic low-grade inflammation in adipose tissue: A pathway to Alzheimer’s disease

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102402 - 102402

Published: July 6, 2024

Alzheimer's disease (AD) is a leading cause of cognitive impairment worldwide. Overweight and obesity are strongly associated with comorbidities, such as hypertension, diabetes, insulin resistance (IR), which contribute substantially to the development AD subsequent morbidity mortality. Adipose tissue (AT) highly dynamic organ composed diverse array cell types, can be classified based on their anatomic localization or cellular composition. The expansion remodeling AT in context involves immunometabolic functional shifts steered by intertwined actions multiple immune cells cytokine signaling within AT, metabolic disorders, IR, systemic markers chronic low-grade inflammation. Chronic inflammation, prolonged, low-dose stimulation specific immunogens that progress from localized sites affect organs throughout body, leads neurodystrophy, increased apoptosis, disruption homeostasis, manifesting brain atrophy AD-related pathology. In this review, we sought elucidate mechanisms contributes onset progression through mediation particularly focusing roles adipokines AT-resident cells.

Language: Английский

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Cardiometabolic multimorbidity, peripheral biomarkers, and dementia in rural older adults: The MIND‐China study

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(9), P. 6133 - 6145

Published: July 9, 2024

Abstract INTRODUCTION Evidence has emerged that cardiometabolic multimorbidity (CMM) is associated with dementia, but the underlying mechanisms are poorly understood. METHODS This population‐based study included 5704 older adults. Of these, data were available in 1439 persons for plasma amyloid‐β (Aβ), total tau, and neurofilament light chain (NfL) 1809 serum cytokines. We defined CMM following two common definitions used previous studies. Data analyzed using general linear, logistic, mediation models. RESULTS The presence of was significantly an increased likelihood Alzheimer's disease (AD), vascular dementia (VaD) ( p < 0.05). Aβ40, Aβ42, NfL, whereas visceral obesity analysis suggested NfL mediated association AD. DISCUSSION AD, VaD neurodegenerative pathway involved Highlights likelihoods AD‐related biomarkers inflammatory Neurodegenerative partly

Language: Английский

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Estimating global prevalence of mild cognitive impairment and dementia in elderly with overweight, obesity, and central obesity: A systematic review and meta‐analysis

Obesity Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Summary Background and Aim Previous studies have demonstrated that adiposity, particularly obesity during midlife, may a detrimental effect on cognitive function. This study aims to estimate the global prevalence of mild impairment (MCI) dementia in elderly aged 60 years or above with overweight, obesity, central obesity. Methods We searched PubMed, Embase, Web Science, Cochrane Library from inception November 2023. DerSimonian‐Laird random‐effects model Logit transformation was used. Sensitivity analysis, meta‐regression, subgroup analysis were employed investigate determinants MCI dementia. Results A total 72 involving 2,980,947 distinct adiposity status included. Pooled overweight 32.54% 9.47%, respectively. Univariate meta‐regression indicated heterogeneity attributable variations size ( R 2 = 0.01, p < 0.05), while multivariable underscored income country area had most significant predictive importance (60.3% 90.3%) for both prevalence. Subgroup revealed regional disparities diagnostic technique contributing heterogeneity. Based currently available but inadequate epidemiological data, pooled calculated as 10.18% 9.75%, Conclusion Strategies address adiposity‐associated should consider multifaceted interventions beyond simple weight reduction. Macro‐level initiatives such improvement levels micro‐level including adoption accurate techniques also represent equally pivotal components.

Language: Английский

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