Preterm birth among women with and without severe acute respiratory syndrome coronavirus 2 infection

Acta Obstetricia Et Gynecologica Scandinavica, Journal Year: 2021, Volume and Issue: 100(12), P. 2253 - 2259

Published: Sept. 21, 2021

Studies directly comparing preterm birth rates in women with and without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited. Our objective was to determine whether affected by SARS-CoV-2 within a large integrated health system New York universal testing protocol.This retrospective cohort study evaluated data from seven hospitals City Long Island between March 2020 June 2021, incorporating both the first second waves of disease 2019 (COVID-19) pandemic USA. All patients live singleton gestations who had polymerase chain reaction (PCR) at delivery were included. Deliveries before 20 weeks gestation excluded. The rate (before 37 weeks) compared positive negative test results. This analysis performed separately for resolved prenatal infections delivery, latter group subdivided symptom status. Multiple logistic regression used examine association birth, adjusting maternal age, race-ethnicity, parity, history body mass index, marital status, insurance type, medical co-morbidities, month wave pandemic.A total 31 550 included 2473 (7.8%) laboratory-confirmed infection. Patients symptomatic COVID-19 more likely deliver (19.0%; adjusted odds ratio 2.76, 95% CI 1.92-3.88) asymptomatic (8.8%) or (7.1%). Among births associated infection, 72.5% medically indicated 44.1% among (p < 0.001). Risk unchanged when occurred frequently during (13.6% vs. 8.7%, respectively; p 0.006). However, this not significant on multiple after other explanatory variables.Pregnant than twice as have Asymptomatic increased risk.

Language: Английский

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COVID‐19 disease and vaccination in pregnant and lactating women

American Journal of Reproductive Immunology, Journal Year: 2022, Volume and Issue: 88(1)

Published: April 22, 2022

Abstract Background More than 325,000 cases of coronavirus disease 2019 (COVID‐19) have been reported among pregnant women in the Americas. Aims This review examines impact COVID‐19 and describes available evidence on safety, effectiveness, immune response(s) to vaccination lactating women. Content Multiple studies indicate that are more susceptible adverse outcomes, including hospitalization, intensive care unit admission, invasive ventilation non‐pregnant with COVID‐19. Furthermore, pregnancy is associated maternal neonatal outcomes. Adverse outcomes appear disproportionately affect from low‐ middle‐income countries, likely reflecting inequities access quality healthcare. Despite absence safety efficacy data randomized clinical trials this subpopulation, observational registries thus far demonstrated or against safe, effective, results robust responses transfer antibodies newborn via placenta breast milk, respectively. Implications These support recommendations intending help protect these vulnerable individuals its sequelae. Randomized will further evaluate immunogenicity vaccines populations.

Language: Английский

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Impact of SARS‐CoV‐2 infection on risk of prematurity, birthweight and obstetric complications: A multivariate analysis from a nationwide, population‐based retrospective cohort study

BJOG An International Journal of Obstetrics & Gynaecology, Journal Year: 2022, Volume and Issue: 129(7), P. 1084 - 1094

Published: March 7, 2022

To determine the impact of maternal coronavirus disease 2019 (COVID-19) on prematurity, birthweight and obstetric complications.

Language: Английский

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SARS-CoV-2 Infection in Pregnancy: Placental Histomorphological Patterns, Disease Severity and Perinatal Outcomes

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(15), P. 9517 - 9517

Published: Aug. 3, 2022

The association between maternal COVID-19 infection, placental histomorphology and perinatal outcomes is uncertain. published studies on how structure affected after SARS-CoV-2 virus in COVID-19-infected pregnant women are lacking. We investigated the effects of infection pregnancy outcomes. A retrospective cohort study 47 with confirmed matched non-infected controls, was conducted. Relevant clinicopathological data primary birth were recorded. Histomorphology immunohistochemistry analyses tissues performed. Only 1 cases showed immunoreactivity syncytiotrophoblasts. Histologically, decidual vasculopathy (n = 22/47, p 0.004), vascular thrombosis 9/47, 0.015) chronic histiocytic intervillositis 10/47, 0.027) significantly higher placentas when compared to control group. Maternal a significant feature active lower gestational age (p < 0.001)) at delivery caesarean section rate 0.007) observed SARS-CoV-2-infected cases, resulting fetal-placental weight ratio 0.022) poorer Apgar score 0.001). Notably, 0.027), symptomatic 0.039), severe-critical 0.002) inflammation 0.011) associated an increased risk preterm delivery. Altered villous maturation elevated poor scores 0.018) mortality 0.023), respectively.

Language: Английский

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The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis

Obstetrics & Gynecology Science, Journal Year: 2023, Volume and Issue: 66(4), P. 270 - 289

Published: May 17, 2023

The coronavirus disease 2019 (COVID-19) outbreak which started in December rapidly developed into a global health concern. Pregnant women are susceptible to respiratory infections and can experience adverse outcomes. This systematic review meta-analysis compared pregnancy outcomes according COVID-19 status. MEDLINE, EMBASE, Cochrane Library databases were searched for relevant articles published between 1, 2019, October 19, 2022. Main inclusion criterion was any population-based, cross-sectional, cohort, or case-control study that assessed with without laboratory-confirmed COVID-19. Sixty-nine studies including 1,606,543 pregnant (39,716 [2.4%] diagnosed COVID-19) retrieved. COVID-19-infected had higher risk of preterm birth (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.42-1.78), preeclampsia (OR, 1.41; CI, 1.30-1.53), low weight 1.52; 1.30-1.79), cesarean delivery 1.20; 1.10-1.30), stillbirth 1.71; 1.39-2.10), fetal distress 2.49; 1.54-4.03), neonatal intensive care unit admission 2.33; 1.72-3.16), perinatal mortality 1.96; 1.15-3.34), maternal 6.15; 3.74-10.10). There no significant differences total miscarriage, premature rupture membranes, postpartum hemorrhage, cholestasis, chorioamnionitis infection. demonstrates infection during lead information could aid researchers clinicians preparing another pandemic caused by newly discovered viruses. findings this may assist evidence-based counseling help manage

Language: Английский

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The Urinary Metabolome of Newborns with Perinatal Complications

Metabolites, Journal Year: 2024, Volume and Issue: 14(1), P. 41 - 41

Published: Jan. 10, 2024

Maternal pathological conditions such as infections and chronic diseases, along with unexpected events during labor, can lead to life-threatening perinatal outcomes. These outcomes have irreversible consequences throughout an individual’s entire life. Urinary metabolomics provide valuable insights into early physiological adaptations in healthy newborns, well metabolic disturbances premature infants or birth complications. In the present study, we measured 180 metabolites metabolite ratios urine of 13 (hospital-discharged) 38 critically ill newborns (admitted neonatal intensive care unit (NICU)). We used in-house-developed targeted tandem mass spectrometry (MS/MS)-based metabolomic assay (TMIC Mega) combining liquid chromatography (LC-MS/MS) flow injection analysis (FIA-MS/MS) quantitatively analyze up 26 classes compounds. Average urinary concentrations (and ranges) for 167 different from NICU their first 24 h life were determined. Similar sets values determined newborns. reference data been uploaded Human Metabolome Database. ranges 37 are reported time Significant differences found levels 44 between those admitted at NICU. Metabolites acylcarnitines, amino acids derivatives, biogenic amines, sugars, organic dysregulated bronchopulmonary dysplasia (BPD), asphyxia, exposed SARS-CoV-2 intrauterine period. Urine serve a source information understanding alterations associated

Language: Английский

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Factors Associated with Post-Traumatic Stress Symptoms in Pregnant and Postpartum Women

Journal of Women s Health, Journal Year: 2023, Volume and Issue: 32(5), P. 583 - 591

Published: Feb. 14, 2023

Background: Evidence of post-traumatic stress disorder (PTSD) symptoms related to the COVID-19 pandemic during perinatal period and associated risk factors are still limited. Thus, we aimed investigate PTSD with in a large sample both pregnant postpartum women. Methods: A cross-sectional study was conducted on 3319 up 6-month women from Spain. An online survey completed between June 2020 January 2021. The assessment included measures (evaluated 10 questions checklist for Diagnostic Statistical Manual Mental Disorders, Fifth Edition), pandemic-related concerns health background (assessed by Coronavirus Perinatal Experiences-Impact Survey), demographic characteristics. Results: We found that >40% suffered pandemic. Difficulty concentrating irritability were most common symptoms, showing marked alterations arousal reactivity traumatic event. Being younger, suffering distress, changes due previous mental problems In addition, whereas being an immigrant (non-Spanish) factor women, having other children financial infection did not appear be Conclusions: increased highlights importance early detection treatment postnatal beyond Trial Registration: ClinicalTrials.gov Identifier (NCT04595123).

Language: Английский

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Outcomes of Preterm Infants Admitted to Canadian NICUs Before and During the SARS-COV Pandemic

Children, Journal Year: 2025, Volume and Issue: 12(2), P. 193 - 193

Published: Feb. 6, 2025

Background: To better elucidate the impact of SARS-COV pandemic on neonatal outcomes, we compared health outcomes infants born preterm requiring care in a Canadian NICU before and during pandemic. Methods: Using retrospective cohort study, between 23 32 weeks gestation who were admitted to tertiary NICUs included. A total 7280 pre-pandemic (admitted 1 April 2018–31 December 2019), 7088 2020–31 2021). The primary included major morbidity or mortality rates. Care strategies treatments across two periods. relative risk (RR) for period, was calculated using Poisson regression model, adjusted identified factors. Results: There no significant differences infant characteristics cohorts. comparable (37% pre-pandemic, 36% pandemic; RR = 1.01, 95% CI 0.92, 1.01). Individual risks did not differ significantly clinically decline receipt mothers’ own milk exclusively at discharge (45% 37% during; 0.85, 0.68, 1.06). Conclusions: rates cohorts NICUs.

Language: Английский

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Impact of maternal COVID-19 infection on offspring immunity and maternal-fetal outcomes at different pregnancy stages: a cohort study

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 28, 2025

To investigate the impact of COVID-19 infection on maternal and neonatal outcomes immunity in pregnant women China. 283 with were included prospective observational cohort study divided into five groups based stage. Antibody levels measured plasma, umbilical cord blood, breast milk, combined clinical data 6-month follow-up results. We SARS-CoV-2 antibody using a chemiluminescence immunoassay analyzed Kruskal-Wallis test, χ2 or Fisher's exact test. No significant differences found age, BMI, weight change during pregnancy, incidence gestational hypertension, diabetes, hypothyroidism, intrahepatic cholestasis, transaminitis, preterm birth, small for NICU transfers, developmental delays, hearing damage among groups. The infants from mothers infected at different stages pregnancy was significantly lower than uninfected group (P < 0.05). Maternal blood showed higher IgG compared to median transplacental transfer ratio across all 1.15 (0.98–1.30), no between them. reinfection had IgA other adverse observed any stage infection. Antibodies milk may offer passive newborns 1–3 months. Reinfection extend this without raising risk outcomes.

Language: Английский

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The impact of SARS-CoV-2 infection on vaccinated versus unvaccinated pregnant women: a retrospective cohort study

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 30, 2025

Pregnant women were included in the COVID-19 vaccination strategy adopted Spain May 2021. We evaluated obstetric and neonatal symptoms complications presented by these first pregnant infected with SARS-CoV-2, vaccinated unvaccinated. A retrospective observational cohort study of 156 a positive diagnosis SARS-CoV-2 (infection rate 4.2%, 156/3719 births), treated at two public hospitals Valencian Community (Spain) over years (2020-2022). Of those infected, 28.8% (45) had received least one dose vaccine before infection. The data obtained from digital medical record, Nominal Vaccination Registry (RNV), symptom Epidemiological Surveillance Application (AVE) CV, supervised epidemiology units. analyzed disease main variables depending on whether or not they mRNA vaccines. Most diagnosed third trimester pregnancy (p = 0.003) reported associated infection (73%), but all described to lesser extent, headache (R1.38, 95%IC 1.15 1.66) vomiting (R 1.38, statistically significant. All cases pneumonia occurred unvaccinated who required ventilatory assistance referral Intensive Care Unit. against lower rates gestational pathology, milder symptoms, fewer postpartum than women, although small sample size did allow for significant difference be seen. Neonatal outcomes similar both groups. is reduced less vomiting, maternal complications, including pneumonia, which occur cohort. Furthermore, Apgar score five minutes higher 7 children immunized mothers.Public health strategies should promote access vaccines during as an urgent priority, minimize risk COVID-19.

Language: Английский

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