Impact of SARS‐CoV‐2 infection on risk of prematurity, birthweight and obstetric complications: A multivariate analysis from a nationwide, population‐based retrospective cohort study

BJOG An International Journal of Obstetrics & Gynaecology, Journal Year: 2022, Volume and Issue: 129(7), P. 1084 - 1094

Published: March 7, 2022

To determine the impact of maternal coronavirus disease 2019 (COVID-19) on prematurity, birthweight and obstetric complications.

Language: Английский

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Time to onset of cardiovascular and cerebrovascular outcomes after hypertensive disorders of pregnancy: a nationwide, population-based retrospective cohort study

American Journal of Obstetrics and Gynecology, Journal Year: 2023, Volume and Issue: 229(3), P. 296.e1 - 296.e22

Published: March 17, 2023

BackgroundThe increased maternal cardiocerebrovascular risk after a pregnancy complicated by hypertensive disorders of pregnancy, is well documented in the literature. Recent evidence has suggested shorter timeframe for development these postnatal outcomes, which could have major clinical implications.ObjectiveThis study aimed to determine and time onset cardiovascular cerebrovascular outcomes pregnancy.Study DesignThis included 2,227,711 women, without preexisting chronic hypertension, who delivered during period 2008 2010: 37,043 (1.66%) were diagnosed with preeclampsia, 34,220 (1.54%) gestational 2,156,448 had normotensive pregnancies. Hospitalizations heart failure, coronary disease, peripheral arterial disease studied. A classical Cox regression was performed estimate average effect over 10 years compared pregnancy; moreover, an extended step function model exposure variable different intervals: <1, 1 3, 3 5, 5 follow-up.ResultsThe hypertension preeclampsia 18 times higher first year (adjusted hazard ratio, 18.531; 95% confidence interval, 16.520–20.787) only at birth 4.921; 4.640–5.218). The corresponding risks women 12 11.727; 10.257–13.409]) 6 5.854; 5.550–6.176), respectively. For other there also significant (heart failure: adjusted 6.662 [95% 4.547–9.762]; disease: 3.083 1.626–5.844]; 3.567 2.600–4.893]; 4.802 2.072–11.132]) follow-up. dose-response evident severity averaged 10-year ratios developing early, preterm, late being 10, 7, higher, respectively.ConclusionThe highest pregnancy. We found relationship both age suggesting possible outcomes. These findings call urgent focus on research into effective screening prevention implications. This

Language: Английский

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Review of organ damage from COVID and Long COVID: a disease with a spectrum of pathology

Medical Review, Journal Year: 2024, Volume and Issue: 5(1), P. 66 - 75

Published: July 1, 2024

Long COVID, as currently defined by the World Health Organization (WHO) and other authorities, is a symptomatic condition that has been shown to affect an estimated 10 %-30 % of non-hospitalized patients after one infection. However, COVID-19 can also cause organ damage in individuals without symptoms, who would not fall under current definition COVID. This damage, whether or not, lead various health impacts such heart attacks strokes. Given these observations, it necessary either expand COVID include recognize COVID-19-induced distinct affecting many asymptomatic infections. It important consider known adverse outcomes, including conditions cancers, be until harm thresholds are reached. Many more medical identified testing than those recognized through reported symptoms. therefore similarly while symptoms associated with there have displaying this characterization monitoring

Language: Английский

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The Urinary Metabolome of Newborns with Perinatal Complications

Metabolites, Journal Year: 2024, Volume and Issue: 14(1), P. 41 - 41

Published: Jan. 10, 2024

Maternal pathological conditions such as infections and chronic diseases, along with unexpected events during labor, can lead to life-threatening perinatal outcomes. These outcomes have irreversible consequences throughout an individual’s entire life. Urinary metabolomics provide valuable insights into early physiological adaptations in healthy newborns, well metabolic disturbances premature infants or birth complications. In the present study, we measured 180 metabolites metabolite ratios urine of 13 (hospital-discharged) 38 critically ill newborns (admitted neonatal intensive care unit (NICU)). We used in-house-developed targeted tandem mass spectrometry (MS/MS)-based metabolomic assay (TMIC Mega) combining liquid chromatography (LC-MS/MS) flow injection analysis (FIA-MS/MS) quantitatively analyze up 26 classes compounds. Average urinary concentrations (and ranges) for 167 different from NICU their first 24 h life were determined. Similar sets values determined newborns. reference data been uploaded Human Metabolome Database. ranges 37 are reported time Significant differences found levels 44 between those admitted at NICU. Metabolites acylcarnitines, amino acids derivatives, biogenic amines, sugars, organic dysregulated bronchopulmonary dysplasia (BPD), asphyxia, exposed SARS-CoV-2 intrauterine period. Urine serve a source information understanding alterations associated

Language: Английский

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Characteristics and Medication Use Patterns of Pregnancies With COVID‐19 Ending in Live‐Birth in the Sentinel System

Pharmacoepidemiology and Drug Safety, Journal Year: 2025, Volume and Issue: 34(4)

Published: March 26, 2025

Pregnant women are at high risk for developing severe illness related to COVID-19. We adapted the "COVID-19 infectiOn aNd medicineS In pregnancy" (CONSIGN) study protocol as part of an international collaboration examine medication use patterns among pregnancies in US. identified eligible aged 12-55 years with documented live-birth deliveries Sentinel Distributed Database who had least one qualifying diagnosis COVID-19 or a positive-confirmed test SARS-CoV-2, by trimester infection. conducted two sets analyses comparing groups and treatment utilization 30 days prior after to: (1) without during 6 months pregnancy; (2) non-pregnancy episodes From 2020 2022, we 52 355 matched (assigned same date), 40 518 Outpatient date (or date) was quite low (< 15%) Non-pregnancy higher all However, post-COVID-19, anti-bacterials, anti-inflammatories such NSAIDs, analgesics were more common, COVID-19-specific medications less frequently used 1%) Assessing severity, non-severe than (87.2% vs. 79.9%). this retrospective evaluation, selected post-COVID-19 COVID-19, compared those underscores need safety evaluation therapies management pregnant population.

Language: Английский

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COVID-19 vaccination rates among pregnant women in France: A nationwide cohort study

Vaccine, Journal Year: 2025, Volume and Issue: 53, P. 127070 - 127070

Published: April 1, 2025

Pregnant women are at an elevated risk for severe COVID-19, but nationwide rates of vaccination and its timing during pregnancy not well documented in France. To assess COVID-19 among pregnant France, compare them to those the general population, analyse factors associated with status timing. A study using EPI-MERES register, which includes all 1,203,454 who delivered between April 2021 December 2022 Standardization by age social index was used female population. Associations sociodemographic factors, monitoring indicators, pre-existing comorbidities were measured multivariable logistic regression. Overall, 52 % received least one vaccine dose, 62.1 vaccinated before conception 8.2 %, 20.9 8.8 1st, 2nd, 3rd trimester, respectively. Vaccination initially lagged behind population converged June 2022, a six-month lag. Younger more socially deprived less highly vaccinated. Unvaccinated likely be their third (aOR, 1.21 [1.19-1.22]), had fewer ultrasound scans 0.71 [0; 70-0.73]), often took folic acid 0.73 [0.72-0.74]). Women comorbidities, such as obesity, diabetes, hypertension, antidepressant use, or chronic respiratory disease, unvaccinated (aORs ranged from 0.69 0.89). France than crucial pandemic periods eventually reached similar rates. Socioeconomic level prenatal care strongly low uptake. This should focus future interventions policy adjustments across segments this

Language: Английский

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The impact of maternal SARS-CoV-2 infection and COVID-19 vaccination on maternal-fetal outcomes

Reproductive Toxicology, Journal Year: 2022, Volume and Issue: 114, P. 33 - 43

Published: Oct. 22, 2022

The rapidly evolving COVID-19 pandemic has resulted in an upsurge of scientific productivity to help address the global health crisis. One area active research is impact on pregnancy. Here, we provide epidemiological overview about what known effects maternal SARS-CoV-2 infection and vaccination maternal-fetal outcomes, identify gaps knowledge. Pregnant people are at increased risk for severe COVID-19, increases negative outcomes. Despite this elevated risk, there have been high rates vaccine hesitancy, heightened by initial lack safety efficacy data In response, retrospective cohort studies were performed examine during report vaccine's pregnancy its as well booster shots We found that pregnant more associated with worse birth hesitancy remains prevalent population, boosters promote better results should reduce alleviating concerns administering Overall, review provides introduction It expected consolidate current knowledge, accelerate inform clinical, policy, decisions regarding people.

Language: Английский

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Implication of viruses in the etiology of preeclampsia

American Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 91(4)

Published: April 1, 2024

Abstract Preeclampsia is one of the most common disorders that poses threat to both mothers and neonates a major contributor perinatal morbidity mortality worldwide. Viral infection during pregnancy not typically considered cause preeclampsia; however, syndromic nature preeclampsia etiology immunomodulatory effects viral infections suggest microbes could trigger subset preeclampsia. Notably, SARS‐CoV‐2 associated with an increased risk Herein, we review potential role in this great obstetrical syndrome. According vitro vivo experimental studies, can by introducing poor placentation, syncytiotrophoblast stress, and/or maternal systemic inflammation, which are all known play critical development Moreover, clinical investigations have suggested link between several viruses onset via multiple pathways. However, results research always consistent. Therefore, future studies should investigate causal elucidate mechanism behind relationship itself.

Language: Английский

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Fetal brain vulnerability to SARS-CoV-2 infection

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 112, P. 188 - 205

Published: June 16, 2023

Whether or not SARS-CoV-2 can cross from mother to fetus during a prenatal infection has been controversial; however, recent evidence such as viral RNA detection in umbilical cord blood and amniotic fluid, well the discovery of additional entry receptors fetal tissues suggests potential for transmission fetus. Furthermore, neonates exposed maternal COVID-19 later development have displayed neurodevelopmental motor skill deficiencies, suggesting consequential neurological inflammation utero. Thus, we investigated consequences on developing brain using human ACE2 knock-in mice. In this model, found that tissues, including brain, occurred at developmental stages, primarily targeted male fetuses. largely within vasculature, but also other cells neurons, glia, choroid plexus cells; replication increased cell death were observed tissues. Interestingly, early gross differences between infected mock-infected offspring, high levels gliosis seen brains 7 days post initial despite clearance time point. pregnant mice, more severe infections, with greater weight loss dissemination compared non-pregnant Surprisingly, did observe an increase antiviral IFN response these showing clinical signs disease. Overall, findings concerning implications regarding neurodevelopment pregnancy complications following exposure.

Language: Английский

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Utility of Newborn Dried Blood Spots to Ascertain Seroprevalence of SARS-CoV-2 Antibodies Among Individuals Giving Birth in New York State, November 2019 to November 2021

JAMA Network Open, Journal Year: 2022, Volume and Issue: 5(8), P. e2227995 - e2227995

Published: Aug. 22, 2022

Importance

Serosurveys can be used to monitor population-level dynamics of COVID-19 and vaccination. Dried blood spots (DBSs) collected from infants contain maternal IgG antibodies are useful for serosurveys individuals recently giving birth.

Objectives

To examine SARS-CoV-2 antibody prevalence in pregnant New York State, identify associations between status infant characteristics, detect vaccination among this population.

Design, Setting, Participants

A population-based, repeated cross-sectional study was conducted nucleocapsid (N) spike (S) antibodies. Deidentified DBS samples data submitted the State Newborn Screening Program November 1, 2019, 30, 2021, were analyzed.

Exposures

Prenatal exposure

Main Outcomes Measures

The presence N S antigens measured using a microsphere immunoassay. Data analyzed by geographic region compared with reported cases vaccinations reproductive-aged females (15-44 years age). stratified birth weight, gestational age, multiple status.

Results

spot 415 293 (median [IQR] 1.04 [1.00-1.20] days; 210 805 [51.1%] male) first known antibody-positive born on March 29, 2020. seroprevalence reflected statewide regional prevaccine period. From February through strongly correlated cumulative each state overall (r_s = 0.92-1.00,P ≤ .001). seroprevalences significantly lower newborns very low weight (720 [14.8%] 138 [2.8%] N,P < .001) (5160 [19.3%] 1233 [4.6%] .009) normal (77 116 [20.1%] 19 872 [5.2%] N). Lower higher observed births (odds ratio [OR], 0.84; 95% CI, 0.75-0.94;P .002 OR, 1.24; 1.18-1.31;P .001 S) vs single age older than 30 (OR, 0.87; 0.80-0.94;P 1.17; 1.11-1.23;P younger 20 years.

Conclusions Relevance

In study, newborn case fluctuations women during These results demonstrate utility testing estimate individuals.

Language: Английский

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