Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Bereavement following suicide and fatal overdose is associated with posttraumatic stress disorder (PTSD) prolonged grief (PG). However, information about plausible explanations for these symptoms scarce. Leveraging data from two assessment points, we examine the prospective roles of stigmatization, guilt, shame, avoidant coping on PTSD PG symptom severity whether relations are similar across groups. We analyzed (N = 212) suicide- overdose-bereaved adults who completed waves collection (T1 T2; six months apart) as part a larger study traumatic loss. Multigroup path analysis serial mediation was used to estimate models symptomatology. Stigmatization (T1) guilt were modeled predictors, while shame (T2) mediators explaining (T2). Prospective between T1 stigma, T2 mediated by serially coping. analyses indicated adults, but stronger effect outcomes bereaved adults. Online self-report use convenience sample limitations. Our results suggest avoidance may help explain elevated in context bereavement. Accordingly, transdiagnostic interventions that concurrently target shame-related cognitions behavioral be promising warrant further attention.
Language: Английский
Citations
0Integration of metabolomic and brain-imaging data highlights pleiotropy among posttraumatic stress disorder, glycoprotein acetyls, and pallidum structure
Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: unknown, P. 100482 - 100482
Published: March 1, 2025
The development of posttraumatic stress disorder (PTSD) is attributable to the interplay between exposure severe traumatic events, environmental factors, and biological characteristics. Blood brain imaging markers have been associated with PTSD. However, our knowledge, no study has systematically investigated genetic relationship PTSD, metabolic biomarkers, brainwide imaging. We integrated genome-wide data informative 233 3935 imaging-derived phenotypes (IDPs). Pleiotropy was assessed by applying global local correlation, colocalization, genetically inferred causality. observed significant overlap PTSD glycoprotein acetyls (GlycA) (a stable inflammatory biomarker) in 2 independent cohorts (discovery r g = 0.26, p 1.00 × 10-4; replication 0.23, 5.99 10-19). Interestingly, there correlation anxiety GlycA (p .33). were both correlated median T2∗ left pallidum (IDP-1444: 0.14, 1.39 10-5; -0.38, 2.50 10-3, respectively). Local 7 regions < 2.0 10-5), mapping genes related immune response, inflammation, processes. Furthermore, we identified 1 variant, rs12048743, evidence horizontal pleiotropy linking IDP-1444 (z 17.14, z -6.07, theta 2.06 10-8). Regional colocalization among GlycA, IDP-1444, tissue-specific transcriptomic regulation for frontal cortex testis (rs12048743-chr1q32.1; posterior probability > 0.8). While also tested causality metabolomic IDPs, these not consistent across different informed causal inference methods. Our findings highlight a new putative pleiotropic mechanism that links systemic inflammation structure
Language: Английский
Citations
0Diagnostic accuracy and psychometric performance of two self‐report measures of posttraumatic stress disorder in older veterans
Journal of Traumatic Stress, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Abstract The Primary Care PTSD Screen for DSM‐5 (PC‐PTSD‐5) and Checklist (PCL‐5) have demonstrated high levels of diagnostic accuracy strong psychometric properties across various samples settings. However, the impact age on these measures has been underinvestigated. This is problematic, as without accurate measurement, older adults with posttraumatic stress disorder (PTSD) may be vulnerable to misdiagnosis inappropriate treatment planning. study examined in (≥ 65 years; n = 192) versus younger (< 188) veterans determine whether precision identifying was equally between groups a sample receiving primary care services U.S. Department Veterans Affairs setting. Results indicated that, despite lower prevalence among (9.3% vs. 25.5%), PC‐PTSD‐5 performed better veterans, AUC .960, 95% CI [.928, .992], than .897, [.846, .949], z 2.04, p .042. A cutoff score 4 optimal both groups. PCL‐5 performance excellent older, .925, [.880, .970], .894, [.847, .942], 0.92, .358. Although different scores were found (36) (34) cutoffs not significantly from each other or standard (33), McNemar tests s .125–1.00. Both maintain their robust lifespan.
Language: Английский
Citations
0Systemic inflammation and metabolic syndrome components in threshold/subthreshold posttraumatic stress disorder and food addiction in a Polish community sample
European journal of psychotraumatology, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 26, 2025
Background: Posttraumatic stress disorder (PTSD) is associated with metabolic syndrome and various addictive behaviours. Food addiction (FA) obesity, individuals PTSD have higher rates of FA than those without. It unclear whether addictive-like eating patterns contribute to the dysfunction in PTSD.Objective: We examined relative contributions PTSD, FA, sex - as well their interactive effects systemic inflammation (CRP) components (MetS: waist circumference, glucose, triglycerides, HDL cholesterol, insulin) a general population Upper Silesia region Poland.Method: N = 187 participants (52.7% women) completed Yale Addiction Scale 2.0 (FA symptoms count), Clinician-Administered for DSM-5 (CAPS-5) semi-structured interview (PTSD or other trauma stressor-related (OTSR) diagnosis presence), anthropometric assessment, phlebotomy fasted state.Results: A series hierarchical linear regressions indicated that greater number had significant effect on while PTSD/OTSR insulin levels. Sex did not moderate these relationships.Conclusions: appears dysregulated are abdominal but dysfunction. PTSD/OTSR, contributes The average indices were within normal limits reflecting non-clinical nature sample. Future longitudinal studies should examine detection intervention may be strategy preventing progression
Language: Английский
Citations
0Пос ттравматичний стресовий розлад, метаболічний синдром і вег етативна нервова система
Endokrynologia, Journal Year: 2023, Volume and Issue: 28(4), P. 377 - 392
Published: Dec. 28, 2023
Патофізіологічні особливості взаємозв’язків між посттравматичним стресовим розладом (ПТСР) і метаболічнимсиндромом (МС) залишаються активною галуззю досліджень. Вплив травматичних життєвих подій має серйозні нега-тивні наслідки для функціонування фізіологічних систем, зокрема, ендокринної та вегетативної нервової системи (ВНС).Дисрегуляція ВНС може пов’язувати патофізіологічні психологічні ПТСР. Зокрема, порушення функціону-вання спостерігаються при різних психологічних розладах, зокрема Останнім часом значна увага приділяєть-ся пошуку з’ясуванню особливостей метаболічними дисфункціями психічними розладами, зокре-ма ПТСР, який становити групу ризику МС. ПТСР МС можуть мати схожі біологічні механізми, що лежать в їх основі.Ймовірно, зміни запальної нейроендокринної систем пов’язані з Однак, незрозуміло, чи є ці зв’язки причин-но-наслідковими. Крім того, поведінкові основі цих асоціацій, недостатньо вивчені.Правдоподібною гіпотеза, дисфункціональна індивідуальна адаптація до стресу підвищувати вразливість дометаболічних дисфункцій, які, своєю чергою, здатні сприяти виникненню психопатологічних змін у посттравматичнийперіод. Підхід як системних станів, включають дисфункцію гіпоталамо-гіпофізарно-адреналової вісі(ГГАВ), хронічного запалення низької інтенсивності (ХЗНІ), інсулінової резистентності (ІР), симпато-адреналової системи,інших метаболічних порушень ВНС, а також значний психологічний тягар, важливі точки зору ме-дичних проблем прогнозу захворювання. Необхідні подальші дослідження тестування нових методів діагностики,спрямованих на нейроендокринну імуно-метаболічну системи. Цей огляд меті обговорити значення й осо-бливості Особлива приділена опису наявних доказів епідеміологічних, експериментальних клінічнихвипробувань щодо взаємозв’язків. Розглянуті питання спільних патогенетичних ланок МС, значенняпорушень ГГАВ, ХЗНІ, ІР, ВНС.
Citations
8Severity of posttraumatic stress disorder, type 2 diabetes outcomes and all-cause mortality: A retrospective cohort study
Journal of Psychosomatic Research, Journal Year: 2023, Volume and Issue: 175, P. 111510 - 111510
Published: Sept. 29, 2023
Language: Английский
Citations
4The lipidome of posttraumatic stress disorder
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 28, 2024
ABSTRACT Posttraumatic stress disorder (PTSD) can develop after trauma exposure. Some studies report that women PTSD at twice the rate of men, despite greater exposure in men. Lipids and their metabolites (lipidome) regulate a myriad key biological processes pathways such as membrane integrity, oxidative stress, neuroinflammation brain by maintaining neuronal connectivity homeostasis. In this study, we analyzed lipidome 40 individuals with trauma-exposed non-PTSD individuals. Plasma samples were for lipidomics using Quadrupole Time-of-Flight (QToF) mass spectrometry. Additionally, ∼ 90 measures collected, on sleep, mental physical health indices. Sleep quality worsened severity increased both sexes. The analysis identified total 348 quantifiable known lipid 1951 are yet unknown; part 13 classes lipids. After adjusting sleep quality, PTSD, only one subclass, phosphatidylethanolamine (PE) was altered, whereas, men 9 out subclasses altered compared to respectively. Severe associated 22% 5% women, Of changed metabolites, 0.5% (2 PEs cholesterol) common between PTSD. Several sphingomyelins, PEs, ceramides, triglycerides severe ceramide most highly correlated cholesterol systolic blood pressure but not always Alterations ceramides linked cardiac metabolic function humans. Thus, disturbed higher weight may have contributed changes found
Language: Английский
Citations
1Exploring diet-induced ketosis with exogenous ketone supplementation as a potential intervention in post-traumatic stress disorder: a feasibility study
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: Oct. 31, 2024
Post-Traumatic Stress Disorder (PTSD) is a severe and pervasive mental disorder, patients experience numerous distressing symptoms impairments that significantly impact their lives. In addition to being PTSD strongly associated with wide range of metabolic abnormalities affect the entire body. Existing treatment options psychotherapy medications are often ineffective. Exploring other potential treatments necessitated. The ketogenic diet has shown as therapy in certain neurological disorders promising intervention PTSD.
Language: Английский
Citations
1Transtorno por estrés postraumático en excombatientes de grupos armados organizados
Revista Latinoamericana Estudios de la Paz y el Conflicto, Journal Year: 2023, Volume and Issue: 5(9), P. 72 - 83
Published: Dec. 5, 2023
En los conflictos armados, la salud mental tanto individual como colectiva, tiene alto riesgo de verse afectada no sólo forma inmediata sino también a mediano y largo plazo, es por ello lo que esta investigación se desarrolló con el objetivo identificar trastorno estrés postraumático en excombatientes las FARC – EP. Metodología: Investigación transversal analítica, desarrollada 114 Fuerza Armada Revolucionaria Colombia, ejército del pueblo (FARC-EP), ubicados espacio territorial capacitación reincorporación (ETCR) departamento Cesar, programó un trabajo campo multietápico donde aplicó cuestionario sociodemográfico indagó aspectos sexo, edad, edad ingreso y, ocupación antes durante conflicto. Se Escala Gravedad Síntomas Trastorno Estrés Postraumático (EGS-R). Resultados: De acuerdo análisis datos recogidos evaluaciones (TEPT) participaron investigación, evidenciaron diferencias significativas sintomatología severidad TEPT. encontró asociación (OR 3,84 IC95% 1,73 - 8,51) entre labor desempeñada dentro FARC-EP núcleos sintomáticos Reexperimentación, evitación OR 1,15 (IC95% 1,02 1,28) Alteraciones Cognitivas 2,56 1,11 5,86) e hiper activación psicológica 10,2 2,29 45,6).
Citations
3Rivastigmine for treatment-refractory posttraumatic stress disorder: a systematic review
East Asian Archives of Psychiatry, Journal Year: 2024, Volume and Issue: 34(2), P. 29 - 36
Published: June 19, 2024
We conducted a systematic review evaluating the efficacy of rivastigmine augmentation for treatmentrefractory posttraumatic stress disorder (PTSD).The Preferred Reporting Items Systematic Reviews and Meta-Analyses guidelines were followed.The databases Ovid MEDLINE, PubMed, CINAHL, EMBASE searched using key words: 'rivastigmine' OR 'Exelon' 'rivastigmine augmentation' 'Exelon AND 'posttraumatic disorder*' 'post-traumatic 'PTSD' 'combat symptoms'.The asterisk specified plural forms relevant word.Four papers identified, comprising one double-blind randomised controlled trial, non-controlled open case series (presenting three studies), paper with two studies.The trial found no statistically significant difference in efficacy, PTSD CheckList-Military Version as outcomes measure, between active add-on interventions placebo or treatment usual.The although reporting relatively positive outcomes, had weak study design lacked information, including participant sex age pre-rivastigmine measures.The assessment was based on participants' subjective benefits, clinician-rating Clinical Global Impression, rather than established assessments scales.Although five studies reported improvement symptoms, there confounding factors limitations clinical demographic data, warranting caution regarding attributed benefits.There is lack methodologically robust evidence supporting refractory PTSD.Additional research may help further its possible efficacy.
Language: Английский
Citations
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