Psychological factors associated with Long COVID: a systematic review and meta-analysis

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 74, P. 102756 - 102756

Published: July 27, 2024

Language: Английский

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Prevalence and Determinants of Long-term Post-COVID Conditions in the United States: 2022 Behavioral Risk Factor Surveillance System

The American Journal of Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

Language: Английский

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Blood Markers Show Neural Consequences of LongCOVID-19

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 478 - 478

Published: March 8, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persists throughout the world with over 65 million registered cases of survivors post-COVID-19 sequelae, also known as LongCOVID-19 (LongC). LongC exhibit various symptoms that span multiple organ systems, including nervous system. To search for neurological markers LongC, we investigated soluble biomolecules present in plasma and proteins associated neuronal-enriched extracellular vesicles (nEVs) 33 patients impairment (nLongC), 12 COVID-19 without any (Cov), 28 pre-COVID-19 healthy controls (HC). positive participants were infected between 2020 2022, not hospitalized, vaccinated or unvaccinated before infection. IL-1β was significantly increased both nLongC Cov IL-8 elevated only nLongC. Both brain-derived neurotrophic factor cortisol compared to HC. nEVs from people had protein neuronal dysfunction, amyloid beta 42, pTau181 TDP-43. This study shows chronic peripheral inflammation stress after Additionally, differentially expressed nEV neurodegenerative identified recovering regardless persistent symptoms.

Language: Английский

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Adult Long Coronavirus Disease 2019

Infectious Disease Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Vaccination and the risk of post-acute sequelae after COVID-19 in the Omicron-predominant period

Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: 30(5), P. 666 - 673

Published: Feb. 6, 2024

Language: Английский

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Blood Biomarkers Show Neural Consequences of LongCOVID-19

Published: Feb. 16, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persists throughout the world with over 65 million registered cases of survivors post-COVID-19 sequelae, also known as LongCOVID-19 (LongC). LongC exhibit various symptoms that span multiple organ systems, including nervous system. To search for neurological biomarkers LongC, we investigated soluble proteins present in plasma and associated neuronal-enriched extracellular vesicles (nEVs) 33 patients impairment (nLongC), 12 COVID-19 without any (Cov), 28 pre-COVID-19 healthy controls (HC). positive participants were infected from 2020-2022, not hospitalized, vaccinated or unvaccinated before infection. IL-1b was significantly increased both nLongC Cov IL-8 elevated only nLongC. Both brain-derived neurotropic factor cortisol compared to HC. nEVs people had protein markers neuronal dysfunction, amyloid beta 42, pTau181 TDP-43. This study shows chronic peripheral inflammation stress after Additionally, differentially expressed nEV neurodegenerative identified recovering regardless persistent symptoms.

Language: Английский

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Long COVID or Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) and the Urgent Need to Identify Diagnostic Biomarkers and Risk Factors

Medical Science Monitor, Journal Year: 2024, Volume and Issue: 30

Published: Sept. 18, 2024

Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), also known as post-COVID-19 condition post-COVID syndrome, can affect anyone infected with SARS-CoV-2, regardless age the severity initial symptoms COVID-19. COVID/PASC is continuation development new after three months from infection, which lasts for at least two and has no other identifiable cause. occurs in 10-20% patients SARS-CoV-2. The most common include fatigue, cognitive impairment (brain fog), shortness breath. However, more than 200 have been reported. No phenotypic diagnostic biomarkers identified developing long COVID/PASC, a multisystem disorder that present isolated combined respiratory, hematological, immunological, cardiovascular, neuropsychiatric symptoms. There cure. Therefore, individualized patient management requires multidisciplinary clinical approach. Because millions people had continue to COVID-19, even era vaccination antiviral therapies, now will increasingly become health economic burden world must prepare for. Almost five years beginning COVID-19 pandemic, this article aims review what currently about anticipated increasing global burden, why there still an urgent need identify risk factors improve prevention treatment.

Language: Английский

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Overview of COVID-19 Infection, Treatment, and Prevention in Children

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(2), P. 424 - 424

Published: Jan. 12, 2024

Coronavirus disease 2019 (COVID-19), caused by the novel respiratory virus-severe acute syndrome coronavirus 2 (SARS-CoV-2)-was declared a global pandemic World Health Organization on 11 March 2020. Since then, substantial gains have been made in our understanding of COVID-19 epidemiology, presentation, and management. While children tend to less severe courses compared adults, can still develop infections, particularly those with underlying medical conditions such as obesity, chronic lung disease, or prematurity. In addition, are at risk complications infection, multisystem inflammatory (MIS-C) long COVID. The case definitions MIS-C COVID continued evolve increased these new entities; however, improved methods diagnosis determination optimal management needed. Furthermore, circulation SARS-CoV-2 variants, there remains need for clinicians remain up-to-date latest treatment prevention options. purpose this review is provide an evidence-based what we learned about since start how best counsel their families prevention.

Language: Английский

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Serum Spike Protein Persistence Post COVID Is Not Associated with ME/CFS

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1086 - 1086

Published: Feb. 8, 2025

Background/Objectives: According to the World Health Organization (WHO) and Centers for Disease Control Prevention (CDC), an estimated 3–6% of people suffer from post-COVID condition or syndrome (PCS). A subset meets diagnostic criteria myalgic encephalomyelitis/chronic fatigue (ME/CFS). Studies have reported that SARS-CoV-2 proteins RNA can persist after acute infection in serum tissues, but their role PCS is unclear. Methods: Here, spike protein was analyzed 121 patients with predominant exertional intolerance, whom 72 met ME/CFS, 37 recovered healthy controls, 32 pre-pandemic controls. Results: Spike detected 11% 2% patients, 14% ME/CFS between 4 31 months infection, not samples. The occurrence concentration did correlate vaccination timepoints. In presence associated severity symptoms functional disability. 5 out 22 who under-went immunoglobulin depletion, levels were reduced undetectable treatment, indicating binding immunoglobulins. Conclusions: summary, this study identified a found no association ME/CFS.

Language: Английский

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Post-acute sequelae of COVID-19 in people of Black ethnicities living with HIV in the United Kingdom

International Journal of STD & AIDS, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Background The COVID-19 pandemic disproportionately affected people of Black ethnicities, however, there are limited data on the post-acute sequelae infection in these populations, and none those with HIV. Methods We conducted a cross-sectional study ethnicities HIV UK. Participants were assessed for functional impairment, frailty, respiratory symptoms, anxiety depression; they also asked to rate aspects their physical mental health scale from 1 (poor) 10 (excellent), both at enrolment prior pandemic. report associations history recovery status. Results enrolled 183 participants between June 2021 October 2022, 131 (72%) whom reported COVID-19. A was associated reduced ability carry out usual activities (OR 2.54 [1.03–6.21], p = 0.04), an increase pain, tiredness breathlessness, overall decline health. Of COVID-19, 111 (85%) have fully recovered. Those who had not recovered poorer status ( < 0.001) higher generalised scores 0.02). Objective measures function similar no full recovery, incomplete recovery. Conclusions In this cohort HIV, daily living various other issues. Although most self-reported limitations common sequelae.

Language: Английский

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