Effect of Caloric Restriction Combined with Probiotic Supplementation on Parameters Related to Weight Loss, Homeostatic, and Hedonic Systems of Food Intake in Adult Men Living with Obesity: Secondary Data from a Randomized, Parallel, Double-Blind, Placebo-Controlled Clinical Trial
Abstract
We
aimed
to
investigate
the
effect
of
CR
with
probiotic
supplementation
on
weight
loss
and
parameters
related
homeostatic
hedonic
systems.
It
is
a
randomized,
double-blind,
parallel,
placebo-controlled
clinical
trial
(UTN:
U1111-1247-9906).
include
obese
adult
males,
aged
25
44
years.
The
established
was
30%
daily
energy
expenditure.
Probiotic
was:
two
sachets
1
g
each
1×10⁹
CFU
Lactobacillus
acidophilus
NCFM,
rhamnosus
HN001,
paracasei
Lpc-37,
Bifidobacterium
lactis
HN019.
primary
outcomes:
body
composition.
Secondary
leptin,
ghrelin,
GLP-1,
glucose-dependent
insulinotropic
polypeptide
(GIP),
insulin,
peptide
YY
(PYY),
adiponectin.
Additionally,
binge
eating,
emotional
cognitive
restraint
were
assessed
by
Three-Factor
Eating
Questionnaire.
study
includes
per
protocol
analyses
(CR
+
placebo
[CRPLA]
n
=
12
vs.
[CRPRO]
13).
Body
mass
(F
65.9;
p
<
0.001)
decreased
after
4
weeks
(p
0.001).
A
similar
result
found
for
absolute
fat
71.0;
Leptin
levels
13.2;
0.002)
0.001),
without
group
or
interaction
effect.
Moreover,
GLP-1
did
not
change
intervention
2.29;
0.114).
Likewise,
GIP
2.0;
0.148)
adiponectin
3.14;
0.053)
change.
Binge
eating
reduced
16.5;
only
in
CRPRO
0.018).
Emotional
9.44;
0.005),
but
0.047).
Finally,
increased
43.2;
CRPLA
0.003)
groups.
In
summary,
fat,
as
well
leptin
restraint.
reductions
scores
seen
group.
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 9, 2024
Language: Английский
