Phytochemical screening, antioxidant activity of selected methanolic plant extracts and their detoxification capabilities against AFB1 toxicity

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24435 - e24435

Published: Jan. 1, 2024

Aflatoxin B

Language: Английский

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Process optimization of the extraction of reducing sugars and total phenolic compounds from the invasive alga Rugulopteryx okamurae by response surface methodology (RSM)

Algal Research, Journal Year: 2024, Volume and Issue: 80, P. 103500 - 103500

Published: April 8, 2024

The brown marine alga Rugulopteryx okamurae (R. okamurae) has quickly spread through the Mediterranean coasts since it was firstly spotted in area 2015. This alien species already colonized a great part of western and displaced local biota, disrupting natural autochthonous ecosystem. Moreover, related 'green' tides also provoke environmental problems ashore that need to be addressed. Comprehending potential this unwanted biomass could vital importance lessen its ecological impact. In study, R. assessed for as raw material extraction reducing sugars polyphenolic compounds with antioxidant capacities. process evaluated optimized using response surface methodology (RSM) combined modified Box-Behnken design. Initially, 2 key operational factors were identified most influential parameters (i.e. drying temperature milling time). However, type solvent use zeolite included design potentially have significant impact on process. analyzed responses yields total phenolic (TPC) (RS). For TPC based ethanol solvent, 60 °C zeolite-assisted time s, reaching maximum yield 15.33 ggallic acid kg−1. RS water 100 zeolite-absence 50s, 10.42 gglucose

Language: Английский

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Application of Box-Behnken design for optimization of Vernonia amygdalina stem bark extract in relation to its antioxidant and anti-colon cancer activity

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(4), P. 105702 - 105702

Published: March 7, 2024

Vernonia amygdalina is a popular plant used both in traditional medicine and as culinary herb, one of which anticancer. Microwave-assisted extraction (MAE) reported to have the advantage producing extracts with better phenol flavonoid content so that anticancer potential extract increases. This study was conducted produce polyphenol-rich V. stem bark an Responses Surface Methodology (RSM) determine optimum conditions for extracting phenolics flavonoids from bark. The total phenolic contents were carried out using colorimetry assay. antioxidant activity optimal (VABEEo) non-optimum (VABEE) determined DPPH method support its activity. Meanwhile, VABEEo established through several tests cytotoxic test MTT assay, cell cycle arrest apoptosis flow cytometer, protein expression immunocytochemical analysis. research informs highest yield, (TPC), (TFC) obtained respectively at 7.402 g, 73.634 mg GAE/g, 64.466 QE/g microwave power 450 W 3 min solvent concentration 76.19 %. In addition, 25.413 ± 0.525 µg/mL, higher than VABEE 41.254 0.614 µg/mL. vitro studies show inhibits colon cancer growth by inducing G1 stages, increasing apoptosis, decreasing Cyclin D1/p53 levels. showed application RSM successful preparation MAE. Moreover, indicates promising further treatment via tests.

Language: Английский

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Evaluation of antioxidant and antibacterial properties of dehydrocostus lactone isolated from Echinops kebericho root

Health Science Reports, Journal Year: 2024, Volume and Issue: 7(3)

Published: March 1, 2024

, an endemic plant to Ethiopia, traditionally used treat infectious as well noninfectious diseases. The primary objective of this study was isolating dehydrocostus lactone (DHCL) from

Language: Английский

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Enhancement of skin localization of β-carotene from red fruit (Pandanus conoideus Lam.) using solid dispersion-thermoresponsive gel delivered via polymeric solid microneedles

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 660, P. 124307 - 124307

Published: June 12, 2024

Language: Английский

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Phytocompounds Profiling and Assessment of the Antioxidant and Anti-inflammatory Efficacies of Spondias mombin (Linn) Leaf Extracts

Published: Jan. 1, 2025

The medicinal properties of Spondias mombin Linn leaves have been recognized historically, particularly in cancer treatment, diarrhea, and diabetes management.The purpose this study is to investigate the chemical constituents using GC-MS HPLC, assess antioxidant antiinflammatory S. n-hexane methanol leaf extracts animal models.Antioxidant activity was assessed DPPH, hydrogen peroxide ABTS scavenging assays while anti-inflammatory potential acetic acid-induced vascular permeability carrageenan-induced paw edema rats.GC-MS analysis detected 10octadecenoic acid methyl ester, 11,14-octadecadienoic ester phytol, as main compounds extract; tricyclo[8.6.0.0(2,9)]hexadeca-3,15-diene, Original Research Articlehexadecanoic are present key extract.The HPLC extract profile identified quercetin, kaempferol, naringenin, luteolin (flavonoids) along with cholesterol, saponin maleic major bioactive compounds.Both demonstrated a concentration-dependent increase radical activities indicating noteworthy property.The significantly higher levels total phenolics (185.194± 0.271 mg/g gallic acid), flavonoids (130.568± 0.744 rutin) overall capacity (58.389 ± 0.292 ascorbic acid) than extract.Furthermore, promising effects, at 400 mg/kg dose, substantially inhibiting models.Presence various suggest that could be valuable natural sources antioxidants agents, potentially useful managing oxidative stress inflammatory conditions.

Language: Английский

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Phytochemical Screening and Pharmacological Evaluation of Bruguiera gymnorhiza Methanolic Leaf Extract

Journal of Herbs Spices & Medicinal Plants, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Jan. 18, 2025

Language: Английский

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A review on the microbiology of Ethiopian traditional fermented beverage products

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

Traditional fermented beverages are drinks produced locally on the basis of ethnic knowledge and consumed nearby locality production. Ethiopia is a country where wide variety traditional prepared consumed. Tella , borde shamita korefe cheka tej booka grawa areki keribo among in Ethiopia. This review paper highlights fermentation process nutritional value beverages, microorganisms involved traditionally ferreted shelf-life as well bioavailability safety by collecting recent research articles. These significantly enhance health due to presence bioactive compounds their relatively greater than those nonfermented beverages. The byproducts yeast Lactic Acid Bacteria (LAB) increase acidity crucial for maintaining quality characteristics It also helps reduce amount toxins pathogens food. Similarly, foods contain probiotics, which beneficial bacteria that help body digest food absorb nutrients. important preventing non-communicable diseases such cardiovascular diseases, gastrointestinal tissues, immune disorders, cancer. Overall, provides comprehensive overview current tradition Ethiopian

Language: Английский

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Recovery of high-value components from Bauhinia variegata leaves using ultrasound-microwave-assisted extraction technique

Biomass and Bioenergy, Journal Year: 2025, Volume and Issue: 195, P. 107709 - 107709

Published: Feb. 13, 2025

Language: Английский

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Production and Functional Evaluation of Recombinant Active Peptide RH in Pichia Pastoris: Protection Against Escherichia Coli Induced Cell Death

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Language: Английский

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