Unraveling the Complex Web of Fibromyalgia: A Narrative Review

Medicina, Journal Year: 2024, Volume and Issue: 60(2), P. 272 - 272

Published: Feb. 4, 2024

Fibromyalgia is a complex and often misunderstood chronic pain disorder. It characterized by widespread musculoskeletal pain, fatigue, heightened sensitivity, has evolved in diagnostic criteria understanding over the years. Initially met with skepticism, fibromyalgia now recognized as global health concern affecting millions of people, prevalence transcending demographic boundaries. The clinical features diagnosis encompass range symptoms beyond including sleep disturbances cognitive difficulties. This study emphasizes importance comprehensive evaluation for accurate diagnosis, considering shift from tender point reliance to more holistic approach. Etiology pathophysiology involve genetic predisposition, neurotransmitter dysregulation, central sensitization, immune system involvement. Risk factors such gender, age, family history, comorbid conditions contribute susceptibility. impact on quality life profound, physical social aspects, accompanied mood disorders. Management approaches include pharmacological interventions, non-pharmacological therapies, lifestyle modifications, alternative treatments. also delves into emerging research, exploring advances neurobiological understanding, brain imaging, markers, glutamate modulation, cannabinoids, gut microbiome, digital tools management. Overall, this provides nuanced up-to-date overview complexities surrounding fibromyalgia, aiming enhance support individuals grappling challenging condition.

Language: Английский

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Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(2), P. 403 - 403

Published: Jan. 11, 2024

Limitations of pharmaceutical drugs and biologics for chronic diseases (e.g., medication non-adherence, adverse effects, toxicity, or inadequate efficacy) can be mitigated by mobile medical apps, known as digital therapeutics (DTx). Authorization adjunct DTx the US Food Drug Administration draft guidelines on “prescription drug use-related software” illustrate opportunities to create + combination therapies, ultimately leading towards drug–device products (DTx has a status devices). Digital interventions (mobile, web-based, virtual reality, video game applications) demonstrate clinically meaningful benefits people living with Alzheimer’s disease, dementia, rheumatoid arthritis, cancer, pain, epilepsy, depression, anxiety. In respective animal disease models, preclinical studies environmental enrichment other non-pharmacological modalities (physical activity, social interactions, learning, music) surrogates “active ingredients” also show improved outcomes. this narrative review, we discuss how therapies impact translational research, discovery development, generic repurposing, gene therapies. Market-driven incentives are illustrated Humira® (adalimumab) facing “patent-cliff” competition cheaper more effective biosimilars seamlessly integrated DTx. conclusion, pharma biotech companies, patients, healthcare professionals will benefit from accelerating integration pharmacotherapies.

Language: Английский

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Advances in transcranial focused ultrasound neuromodulation for mental disorders

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111244 - 111244

Published: Jan. 1, 2025

Language: Английский

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Psychotherapy in patients with long/post-COVID – A systematic review on the feasibility, acceptability, safety, and efficacy of available and emerging interventions

Journal of Psychosomatic Research, Journal Year: 2025, Volume and Issue: 190, P. 112048 - 112048

Published: Feb. 8, 2025

Language: Английский

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Mechanisms for Orofacial Pain: Roles of Immunomodulation, Metabolic Reprogramming, Oxidative Stress and Epigenetic Regulation

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 434 - 434

Published: Feb. 11, 2025

Background and Objectives: Orofacial pain corresponds to sensitization originating from the facial oral regions, often accompanied by diagnostic complexity due a multitude of contributory factors, leading significant patient distress impairment. Here, we have reviewed current mechanistic pathways biochemical aspects complex orofacial pathology, highlighting recent advancements in understanding its multifactorial regulation signaling thus providing holistic approach challenging it. Materials Methods: Studies were identified an online search PubMed database without any time range. Results: We discussed neuron–glia interactions glial cell activation terms immunomodulatory effects, metabolism reprogramming effects epigenetic modulatory response comprising different factors. highlighted fundamental role oxidative stress affecting cellular as well machinery, which renders pathology intricate multidimensional. Emerging research on modulation regulatory genes molecular environmental factors is also discussed, alongside updates novel treatment approaches. Conclusions: This review deliberates integrative perspectives implications immune system, glucose metabolism, lipid redox homeostasis mitochondrial dysfunction accommodating effect dysregulated non-coding RNAs for interdisciplinary at level, aiming improve outcomes with precise diagnosis offering improved management treatment.

Language: Английский

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Evaluating Feasibility and Acceptability of a Telehealth Integrative Pain Management Program Among Primary Care Safety-Net Patients

Global Advances in Integrative Medicine and Health, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 1, 2025

Background The COVID-19 pandemic exacerbated pain care inequities for low-income people. Telehealth Integrative Pain Management Program (t-IPMP) was developed to provide management services patients in public health clinics of the San Francisco Health Network (SFHN). Adapted from an existing program, t-IPMP delivered multimodal treatment via telehealth groups when in-person healthcare restricted. Objective This mixed-methods study evaluates feasibility and acceptability t-IPMP. Methods We conducted a single-arm evaluation three cohorts t-IPMP, comprising 12 two-hour weekly online sessions on education, mindfulness, therapeutic movement, self-acupressure. Participants were adults with chronic referred by SFHN primary providers. baseline surveys, three-month qualitative interviews (n = 15); participant observation per cohort; 3 focus 20). Mixed-methods analysis included descriptive statistics, pre/post comparisons using t-tests, codebook thematic analysis. Results received 107 referrals 52 providers at 11 clinics, 35% enrolled. 37) attended average 6 sessions. who completed surveys 15) majority cisgender women (67%) below-average wealth (87%) diverse racial ethnic identities. Qualitative data highlighted that created supportive environment which fostered social connection reduced isolation. Social support encouraged use new mind-body practices pain. well received, though some participants preferred interaction. From follow up, scores increased measures physical function (mean 1.9, 95% CI 0.2-3.6); global quality life 3.8, 1.6-6.0); self-efficacy 5.3, 0.9-9.7). Conclusion Integrative, through is feasible among safety net patients, however, may not be optimal all. Findings indicate offering options participating either or best address patient needs preferences.

Language: Английский

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Modulating neuroplasticity for chronic pain relief: noninvasive neuromodulation as a promising approach

Experimental & Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Chronic neuropathic pain is a debilitating neuroplastic disorder that notably impacts the quality of life millions people worldwide. This complex condition, encompassing various manifestations, such as sciatica, diabetic neuropathy and postherpetic neuralgia, arises from nerve damage or malfunctions in processing pathways involves biological, physiological psychological processes. Maladaptive neuroplasticity, known central sensitization, plays critical role persistence chronic pain. Current treatments for include pharmacological interventions (for example, antidepressants anticonvulsants), invasive procedures deep brain stimulation) physical therapies. However, these approaches often have limitations potential side effects. In light challenges, interest noninvasive neuromodulation techniques alternatives complementary increasing. These methods aim to induce analgesia while reversing maladaptive plastic changes, offering advantages over conventional practices methods. Recent technological advancements spurred exploration therapies, repetitive transcranial magnetic stimulation, direct current stimulation ultrasound well innovative transformations into at both preclinical clinical levels. Here this review aims critically examine mechanisms neuroplasticity evaluate efficacy relief. By focusing on optimizing techniques, we can better assess their short-term long-term effects, refine treatment variables ultimately improve management.

Language: Английский

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Unraveling the Complex Web of Fibromyalgia: A Narrative Review

Published: Jan. 12, 2024

Fibromyalgia is a complex and often misunderstood chronic pain disorder. It characterized by widespread musculoskeletal pain, fatigue, heightened sensitivity, has evolved in diag-nostic criteria understanding over the years. Initially met with skepticism, fibromyalgia now recognized as global health concern affecting millions of people, prevalence trans-cending demographic boundaries. The clinical features diagnosis encompass range symptoms beyond including sleep disturbances cognitive difficulties. study emphasizes importance comprehensive evaluation for accurate diagnosis, considering shift from tender point reliance to more holistic approach. Etiology pathophysiology involve genetic predisposition, neurotransmitter dysregulation, central sensitization, immune system involvement. Risk factors such gender, age, family history, comorbid conditions contribute susceptibility. impact on quality life profound, physical social aspects, accompanied mood disorders. Management approaches include pharmacological interventions, non-pharmacological therapies, lifestyle modifications, alternative treatments. also delves into emerging research, exploring advances neurobiological understanding, brain imaging, markers, glutamate modulation, cannabinoids, gut microbiome, digital tools manage-ment. Overall, this provides nuanced up-to-date overview complexities sur-rounding fibromyalgia, aiming enhance support individuals grappling challenging condition.

Language: Английский

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Psycho-Neuroendocrinology in the Rehabilitation Field: Focus on the Complex Interplay between Stress and Pain

Medicina, Journal Year: 2024, Volume and Issue: 60(2), P. 285 - 285

Published: Feb. 7, 2024

Chronic stress and chronic pain share neuro-anatomical, endocrinological, biological features. However, prepares the body for challenging situations or mitigates tissue damage, while is an unpleasant sensation due to nociceptive receptor stimulation. When chronic, it might lead allostatic overload in brain dysregulation of physiological systems that are normally involved adapting environmental challenges. Managing (CP) neurorehabilitation presents a significant challenge healthcare professionals researchers, as there no definitive effective solution these issues. Patients suffering from neurological disorders often complain CP, which significantly reduces their quality life. The aim this narrative review examine correlation between potential negative impact on rehabilitation process. Moreover, we described most relevant interventions used manage population. In conclusion, sheds light connection pathway. Our results emphasize need tailored protocols effectively pain, improve treatment adherence, ensure comprehensive patient care.

Language: Английский

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Electrochemical Sensors, Biosensors, and Optical Sensors for the Detection of Opioids and Their Analogs: Pharmaceutical, Clinical, and Forensic Applications

Chemosensors, Journal Year: 2024, Volume and Issue: 12(4), P. 58 - 58

Published: April 8, 2024

Pharmaceutical opioids are intravenously or orally administered analgesics. While they effective in relieving chronic and acute pain, their narrow window of therapeutic use contributes to the high occurrence abuse. The associated abuse this family drugs can be correlated increase dependency, overdose, death users. negative effects extend beyond physical psychological experienced by user unregulated synthesis sale, which contribute socioeconomic challenges a biproduct global public health epidemic. From clinical point-of-care applications, detection real-time monitoring drug is critical fight decrease improve settings. Chromatographic separations chromatography–mass spectrometry traditional methods opioid analyses, but cost, long analysis time, absence portability highlight need for development fast, situ, analysis, community services. This review highlights recent electrochemical optical (FTIR, Raman, colorimetric, fluorescent) advances biosensors pharmaceutical illicit analysis. Specifically, an emphasis placed on metabolites biological samples vitro cellular assays diagnosis forensic applications. prospects role sensors, biosensors, sensors promoting diagnosis, study, point-of-care, services reduce harm also provided.

Language: Английский

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