Signaling pathways and therapeutic interventions in gastric cancer

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Oct. 8, 2022

Abstract Gastric cancer (GC) ranks fifth in global diagnosis and fourth cancer-related death. Despite tremendous progress therapeutic strategies significant improvements patient survival, the low malignancy stage is relatively asymptomatic many GC cases are diagnosed at advanced stages, which leads to unsatisfactory prognosis high recurrence rates. With recent advances genome analysis, biomarkers have been identified that clinical importance for diagnosis, treatment, prognosis. Modern molecular classifications uncovered vital roles signaling pathways, including EGFR/HER2, p53, PI3K, immune checkpoint cell adhesion molecules, play tumorigenesis, progression, metastasis, responsiveness. These open way more precise diagnoses treatments patients. Nevertheless, relative significance, temporal activation, interaction with risk factors, crosstalk between these pathways not well understood. Here, we review regulatory of potential biomarkers, targets an emphasis on discoveries. Current therapies, signaling-based immunotherapies exploited past decade, development treatment GC, particularly challenges developing precision medications, discussed. provide a direction integration clinical, molecular, genomic profiles improve treatments.

Language: Английский

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Wnt/β-catenin signaling pathway-a versatile player in apoptosis and autophagy

Biochimie, Journal Year: 2023, Volume and Issue: 211, P. 57 - 67

Published: March 11, 2023

The Wnt/β-catenin signaling pathway is a highly conserved that involved in cell development, proliferation, differentiation, apoptosis and autophagy. Among these processes, autophagy occur physiologically during host defense the maintenance of intracellular homeostasis. Mounting evidence suggests crosstalk between Wnt/β-catenin-regulated has broad functional significance various diseases. Herein, we summarize recent studies understanding role autophagy, draw following conclusions: a) For apoptosis, regulation generally positive. However, small amount indicates presence negatively regulated relationship apoptosis; b) influences occurrence development by regulating autophagy-related factors, factors turn affect pathway; c) always balances molecular damage caused compensatory manner. Understanding specific different stages may provide new insights into progression related diseases pathway.

Language: Английский

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MicroRNAs in vascular smooth muscle cells: Mechanisms, therapeutic potential, and advances in delivery systems

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123424 - 123424

Published: Jan. 1, 2025

Language: Английский

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Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics

Pharmacology & Therapeutics, Journal Year: 2018, Volume and Issue: 196, P. 15 - 43

Published: Nov. 13, 2018

Language: Английский

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Long noncoding RNA/circular noncoding RNA–miRNA–mRNA axes in cardiovascular diseases

Life Sciences, Journal Year: 2019, Volume and Issue: 233, P. 116440 - 116440

Published: April 30, 2019

Language: Английский

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Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature

BioMed Research International, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 11

Published: July 1, 2019

Cardiac remodeling is a self-regulatory response of the myocardium and vasculature under stressful condition. Cardiomyocytes (CMs), vascular smooth muscle cells (VSMCs), endothelial (ECs), cardiac fibroblasts (CFs) are all involved in this process, characterized by change morphological structures mechanical/chemical activities as well metabolic patterns. Despite current development consciousness, control remains unsatisfactory, to further explore underlying mechanism seek optimal therapeutic targets still urgent need clinical practice. It now emerging that long noncoding RNAs (lncRNAs) play key regulatory roles these adverse responses: lncRNA TUG1, AK098656, TRPV1, GAS5, Giver, Lnc-Ang362 have been indicated hypertension-related remodeling, H19, UCA1, MEG3, APPAT, lincRNA-p21 atherosclerosis (AS), HIF1A-AS1 Lnc-HLTF-5 aortic aneurysm (AA). In addition, Neat1, AK139328, APF, CAIF, AK088388, CARL, MALAT1, HOTAIR, XIST, NRF postischemia myocardial while Mhrt, Chast, CHRF, ROR, Plscr4, MIAT hypertrophy, wisper, H19 extracellular matrix (ECM) reconstitution. Signaling specific miRNAs acting endogenous sponge (ceRNA) was main form regulates target gene expression during remodeling. This review will underline updates lncRNAs lncRNA-miRNA interactions maladaptive also cast light on their potential targets, hoping provide supportive background for following research.

Language: Английский

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LncRNA TUG1 regulates proliferation and apoptosis by regulating miR-148b/IGF2 axis in ox-LDL-stimulated VSMC and HUVEC

Life Sciences, Journal Year: 2020, Volume and Issue: 243, P. 117287 - 117287

Published: Jan. 8, 2020

Language: Английский

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The lncRNA TUG1/miR-145-5p/FGF10 regulates proliferation and migration in VSMCs of hypertension

Biochemical and Biophysical Research Communications, Journal Year: 2018, Volume and Issue: 501(3), P. 688 - 695

Published: May 24, 2018

Language: Английский

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Captopril attenuates TAC-induced heart failure via inhibiting Wnt3a/β-catenin and Jak2/Stat3 pathways

Biomedicine & Pharmacotherapy, Journal Year: 2019, Volume and Issue: 113, P. 108780 - 108780

Published: March 16, 2019

Captopril (Cap) as angiotensin-converting enzyme inhibitor (ACEi) is commonly used to treat hypertension and some types of congestive heart failure. However, few studies reported on whether Cap exerts a protective effect myocardial apoptosis induced by transverse aortic constriction (TAC). This study aimed at investigating the possible mechanism pressure overload. Results showed that significantly decreased heart-to-body weight ratios (HBWR). markedly improved cardiac function, reduced inner diameter ascending aorta (Asc Ao) in TAC mice shown echocardiography. Enzyme-linked immunosorbent assay (ELISA) results demonstrated treatment also level N-terminal pro-B-type natriuretic peptide (NT-proBNP), atrial (ANP), tumor necrosis factor-α (TNF-α) interleukin-6 (IL-6). Cardiac pathological changes fibrosis have been after hematoxylin-eosin (H&E) staining Masson's trichrome staining. Moreover, Terminal deoxynucleotidyl transferase-mediated dexoxyuridine triphosphate nick-end labeling (TUNEL) result indicated inhibited apoptosis. Western Blot obviously expression cleaved capase-3, Bax, phosphorylated Jak2 (p-Jak2), Stat3 (p-Stat3), Wnt3a β-catenin proteins, well increased Bcl-2 expression. In conclusion, TAC-induced apoptosis, which could be attributed inhibition Wnt3a/β-catenin signaling pathway. attenuated hypertrophy via suppression Jak2/Stat3

Language: Английский

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The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases

Clinical Science, Journal Year: 2022, Volume and Issue: 136(15), P. 1157 - 1178

Published: Aug. 1, 2022

Abstract Cardiovascular diseases are the leading cause of death and debility worldwide. Various molecular mechanisms have been studied to better understand development progression cardiovascular pathologies with hope eradicate these diseases. With advancement sequencing technology, it is revealed that majority our genome non-coding. A growing body literature demonstrates critical role long non-coding RNAs (lncRNAs) as epigenetic regulators gene expression. LncRNAs can regulate cellular biological processes through various distinct mechanisms. The abundance lncRNAs in system indicates their significance physiology pathology. LncRNA H19, particular, a highly evolutionarily conserved lncRNA enriched cardiac vascular tissue, underlining its importance maintaining homeostasis system. In this review, we discuss versatile function H19 types We highlight current on demonstrate how dysregulation induces pathophysiology.

Language: Английский

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