The relationship between remnant cholesterol and young-onset myocardial infarction in patients with type 2 diabetes: a retrospective study DOI Creative Commons
Yajie Gao, Lei Tang, Peizhu Dang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Remnant cholesterol (RC) has emerged as a novel therapeutic target beyond low-destiny-lipoproteins (LDL-c). While elevated RC levels are strongly associated with cardiovascular disease risk in the general population, their specific role young-onset acute myocardial infarction (AMI) among patients type 2 diabetes mellitus (T2DM) remains insufficiently explored and warrants further investigation. This retrospective study included AMI T2DM admitted to First Affiliated Hospital of Xi'an Jiaotong University from 2018 2022. Patients were stratified into tertiles according compared using thresholds derived commanded values PREDIMED cohort study. The primary outcome was AMI. Group differences analyzed chi-square test Kruskal-Wallis H test, while Spearman correlation analyses assessed relationships between variables. Univariate multivariate logistic regression employed evaluate association Among 2,514 participants (mean age 61.58 ± 11.15 years), 802 (31.9%) had increase increased significantly rising (27.0% vs 29.7% 39.1%, P < 0.001). showed significant positive total (TC, r = 0.497, 0.001), triglycerides (TG, 0.411, LDL-c (r 0.166, independently higher (OR: 1.579; 95% CI: 1.354-1.842; even after adjusting for other traditional factors 1.415; CI 1.189-1.684; Notably, remained linked regardless whether within desired range. is independent factor patients, irrespective level. These findings underscore importance monitoring managing clinical practice mitigate this population.

Language: Английский

Insulin resistance potentiates the effect of remnant cholesterol on cardiovascular mortality in individuals without diabetes DOI
Arsenio Vargas‐Vázquez, Carlos A. Fermín‐Martínez, Neftalí Eduardo Antonio-Villa

et al.

Atherosclerosis, Journal Year: 2024, Volume and Issue: 395, P. 117508 - 117508

Published: March 13, 2024

Language: Английский

Citations

7
Association of remnant cholesterol with risk of dementia: a nationwide population-based cohort study in South Korea DOI Creative Commons
Ji Hye Heo, Han Na Jung, Eun Roh

et al.

The Lancet Healthy Longevity, Journal Year: 2024, Volume and Issue: 5(8), P. e524 - e533

Published: July 26, 2024

Language: Английский

Citations

6
Remnant cholesterol and low-grade inflammation jointly in atherosclerotic cardiovascular disease: implications for clinical trials DOI
Daniel Elías-López, Takahito Doi, Børge G. Nordestgaard

et al.

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2023, Volume and Issue: 27(2), P. 125 - 135

Published: Nov. 21, 2023

Purpose of review Atherosclerotic cardiovascular disease (ASCVD) is the leading cause death despite development effective treatments. Recently, elevated remnant cholesterol and low-grade inflammation have emerged as factors explaining part residual ASCVD risk. Interestingly, coexistence both high can further increase risk ASCVD. The aim this to describe role inflammation, separately combined, in Recent findings Results from recently published studies, including observational genetic Mendelian randomization support a causal relationship between on primary secondary prevention settings. In addition, current evidence studies suggests that increases Summary suggest combined with may confer particular for Attention dual threat necessary, research field warranted. effect cholesterol-lowering drugs anti-inflammatory alone remains be elucidated. Video abstract http://links.lww.com/COCN/A20

Language: Английский

Citations

15
Remnant cholesterol as a new lipid-lowering target to reduce cardiovascular events DOI
Paolo Raggi, Maria Laura Becciu, Eliano Pio Navarese

et al.

Current Opinion in Lipidology, Journal Year: 2024, Volume and Issue: 35(3), P. 110 - 116

Published: Jan. 23, 2024

Purpose of review Remnant cholesterol has become increasingly recognized as a direct contributor to the development atherosclerosis and an additional marker cardiovascular risk. This aims summarize pathophysiological mechanisms, current evidence base from epidemiological investigations genetic studies that support causal link between remnant atherosclerotic disease. Current novel therapeutic approaches target are discussed. Recent findings A recent Mendelian randomization study over 12 000 single-nucleotide polymorphisms associated with high levels cholesterol, demonstrated association adverse events among 958 434 participants. Summary In this light, emerging role independent lipid risk warrants reevaluation management guidelines underscores potential for targets in disease prevention.

Language: Английский

Citations

5
Circulating PCSK9 as a prognostic biomarker of cardiovascular events in individuals with type 2 diabetes: evidence from a 16.8-year follow-up study DOI Creative Commons
Massimiliano Ruscica, Chiara Macchi, Angelica Giuliani

et al.

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Aug. 24, 2023

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality, being twofold to fourfold more common in patients with type 2 diabetes mellitus (T2DM) than individuals without diabetes. However, despite this decade-old knowledge, identification a specific prognostic risk biomarker remains particularly challenging.Taking advantage large sample Caucasian (n = 529) diagnosis T2DM followed for median 16.8 years, present study was aimed at testing hypothesis that fasting serum proprotein convertase subtilisin/kexin 9 (PCSK9) levels could be major adverse events (MACE) all-cause mortality.Median PCSK9 were 259.8 ng/mL, higher women compared men increasing even presence complication (e.g., diabetic kidney disease). positively correlated markers blood glucose homeostasis HbA1c, insulin HOMA-IR) atherogenic lipid profile non-HDL-C, apoB remnant cholesterol). Serum predicted new-onset MACE, either fatal or non-fatal, only (Odds Ratio: 2.26, 95% CI 1.12-4.58) mortality (Hazard 1.79, 1.13-2.82).Considering up two-thirds develop ASCVD their lifetime, assessment circulating can envisioned within context biomarker-based strategy stratification. sex difference found highlights an urgent need sex-specific strategies.It retrospective study.

Language: Английский

Citations

11
The Role of Triglyceride-rich Lipoproteins and Their Remnants in Atherosclerotic Cardiovascular Disease DOI Creative Commons
Mohanad Gabani, Michael D. Shapiro, Peter P. Tóth

et al.

European Cardiology Review, Journal Year: 2023, Volume and Issue: 18

Published: Sept. 28, 2023

Atherosclerotic cardiovascular disease (ASCVD) is the world's leading cause of death. ASCVD has multiple mediators that therapeutic interventions target, such as dyslipidaemia, hypertension, diabetes and heightened systemic inflammatory tone, among others. LDL cholesterol one most well-studied established targeted for primary secondary prevention ASCVD. However, despite strength evidence supporting reduction by management strategies, events can still recur, even in patients whose been very aggressively reduced. Hypertriglyceridaemia elevated levels triglyceride-rich lipoproteins (TRLs) may be key contributors to residual risk. Several observational genetic epidemiological studies have highlighted causal role triglycerides within TRLs and/or their remnant development progression consist intestinally derived chylomicrons hepatically synthesised LDL. Lifestyle modification considered first line intervention managing hypertriglyceridaemia. Multiple novel therapies are development, shown efficacy preclinical clinical phases study hypertriglyceridaemia TRLs. This comprehensive review provides an overview biology, pathogenicity, epidemiology, genetics TRLs, how they impact risk In addition, we provide a summary currently available emerging triglyceride-lowering development.

Language: Английский

Citations

11
MX1 and UBE2L6 are potential metaflammation gene targets in both diabetes and atherosclerosis DOI Creative Commons
Guisheng Wang, Rongrong Hua, Xiaoxia Chen

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e16975 - e16975

Published: Feb. 21, 2024

The coexistence of diabetes mellitus (DM) and atherosclerosis (AS) is widespread, although the explicit metabolism metabolism-associated molecular patterns (MAMPs) responsible for correlation are still unclear.

Language: Английский

Citations

4
High remnant-cholesterol levels increase the risk for end-stage renal disease: a nationwide, population-based, cohort study DOI Creative Commons
Han Na Jung,

Ji Hye Huh,

Eun Roh

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 4, 2024

Abstract Background The effect of remnant-cholesterol (remnant-C) on incident end-stage renal disease (ESRD) has not been studied longitudinally. This retrospective cohort study evaluated the association between remnant-C and development ESRD in a nationwide Korean cohort. Methods Participants National Health Insurance Service health examination ( n = 3,856,985) were followed up until onset ESRD. median duration follow-up was 10.3 years. Martin-Hopkins equation used to determine low-density lipoprotein cholesterol (LDL-C) levels from directly measured triglyceride, high-density (HDL-C), total levels. Remnant-C determined by subtracting HDL-C LDL-C cholesterol. risk for calculated each quartile remnant-C, adjusting conventional factors such as baseline function, comorbidities, Results developed 11,073 (0.29%) participants. exhibited gradual increase according higher with 61% increased highest than lowest (hazard ratio [HR] 1.61 [95% confidence interval (CI) 1.50–1.72]). elevated versus more prominent younger older subjects (20–29 years, HR 4.07 CI 2.85–5.83]; 30–39 2.39 1.83–3.13]; ≥ 70 1.32 1.16–1.51]). In addition, related greater females males. Conclusions Independent factors, positively associated ESRD, particularly populations adult females. Reducing may be novel preventive strategy against

Language: Английский

Citations

4
Reduction in Remnant Cholesterol in Obese Individuals After Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy DOI Open Access
Jan Aaseth, Kjetil Retterstøl, Helge Rootwelt

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(1), P. 189 - 189

Published: Jan. 5, 2025

Background: The effectiveness of bariatric surgery in reducing remnant cholesterol (RC) levels, particularly when obesity is accompanied by elevated glycated hemoglobin (HbA1c), insufficiently investigated. In this study, we aimed to examine the impacts two common procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), as regards their effects on RC HbA1c levels. Methods: Adult morbidly obese subjects were included assigned receive either RYGB or SG. levels determined 6 12 months after compared preoperative assess efficacy these surgical methods. statistical evaluation covariations between other biomarkers, previously C-reactive protein (CRP), triglycerides, apolipoprotein B, A1, low- high-density lipoprotein included. A linear mixed regression model for repeated analyses was used. Results: markedly reduced both SG but without significant differences surgery. Furthermore, values strongly associated with CRP HbA1c. Conclusions: lowering appeared paralleled concomitant reductions Together, lead a lower risk cardiovascular disease.

Language: Английский

Citations

0
Understanding cardiovascular risks in type 2 diabetes mellitus DOI Creative Commons
Rajeev Chawla,

Siddhant Trehan

International Journal of Diabetes in Developing Countries, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

Citations

0