Association between triglyceride-glucose index and in-hospital mortality in critically ill patients with sepsis: analysis of the MIMIC-IV database

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Nov. 8, 2023

Abstract Background This study aimed to explore the association between triglyceride-glucose (TyG) index and risk of in-hospital mortality in critically ill patients with sepsis. Methods was a retrospective observational cohort data were obtained from Medical Information Mart for Intensive Care-IV (MIMIC IV2.2) database. The participants grouped into three groups according TyG tertiles. primary outcome all-cause mortality. Multivariable logistics proportional regression analysis restricted cubic spline used evaluate In sensitivity analysis, feature importance initially determined using machine learning algorithms subgroup based on different subgroups also performed. Results 1,257 (56.88% men) included study. in-hospital, 28-day intensive care unit (ICU) 21.40%, 26.17%, 15.43% respectively. Multivariate showed that independently associated an elevated (OR 1.440 [95% CI 1.106–1.875]; P = 0.00673), 1.391; 1.52–1.678]; 0.01414) ICU 1.597; 1.188–2.147]; 0.00266). model revealed risks 28-day, increased linearly increasing index. Sensitivity indicate effect size direction are consistent, results is stability. Additionally, suggest important outcomes Conclusion Our indicates high sepsis patients. Larger prospective studies required confirm these findings.

Language: Английский

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Association between triglyceride-glucose related indices with the all-cause and cause-specific mortality among the population with metabolic syndrome

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 24, 2024

Abstract Background Triglyceride-glucose (TyG) index has been determined to play a role in the onset of metabolic syndrome (MetS). Whether TyG and with combination obesity indicators are associated clinical outcomes MetS population remains unknown. Method Participants were extracted from multiple cycles National Health Nutrition Examination Survey (NHANES) between 1999 2018 years. Three constructed including index, combining waist circumference (TyG-WC), waist-to-height ratio (TyG-WHtR). The was defined according Cholesterol Education Program (NCPE) Adult Treatment Panel III. Kaplan-Meier (KM) curves, restricted cubic splines (RCS), Cox proportional hazard model used evaluate associations TyG-related indices mortality population. sensitive analyses performed check robustness main findings. Results There 10,734 participants included this study, 5,570 females 5,164 males. median age study 59 years old. multivariate regression showed high levels significantly all-cause [TyG index: adjusted (aHR): 1.36, 95%confidence interval (CI): 1.18–1.56, p < 0.001; TyG-WHtR aHR = 1.29, 95%CI: 1.13–1.47, 0.001]. Meanwhile, TyG-WC cardiovascular (TyG-WC: 1.45, 1.13–1.85, 0.004; TyG-WHtR: 1.50 1.17–1.92, 0.002). consistent significant correlations diabetes (TyG: 4.06, 2.81–5.87, TyG-WC: 2.55, 1.82–3.58, 2.53 1.81–3.54, 0.001). RCS curves non-linear trend (p for nonlinearity 0.004 0.001, respectively). supported positive Conclusion Our highlights value predicting survival would be surrogate biomarkers follow-up

Language: Английский

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Investigation of the connection between triglyceride-glucose (TyG) index and the risk of acute kidney injury in septic patients - a retrospective analysis utilizing the MIMIC-IV database

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: Jan. 6, 2025

The TyG index serves as a valuable tool for evaluating insulin resistance. An elevated has shown strong association with the occurrence of acute kidney injury (AKI). Nevertheless, existing literature does not address relationship between and in patients sepsis. Sepsis were identified from MIMIC-IV database categorized into four groups according to quadrilles their values. primary outcome this study was incidence AKI. risk AKI septic evaluated using Cox proportional hazards restricted cubic spline models. Subgroup analyses conducted investigate prognostic value different subgroups. A total 2,616 sepsis (57% whom male) included study. found be 78%. analysis revealed significant correlation patients. Furthermore, model an approximately linear higher trend hazard ratio (HR) remained consistent across various These findings emphasize reliability independent predictor unfavorable renal outcomes establishing causal two requires demonstration through larger prospective studies.

Language: Английский

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The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 7, 2025

Abstract Background The triglyceride-glucose (TyG) index is recognized as an alternative measure of insulin resistance (IR) and has been linked to the risks cardiovascular disease (CVD) mortality. This study aimed evaluate whether association between TyG CVD mortality influenced by use antidiabetic hypolipidemic agents, given their potential modifying effects on index. Methods Participants from National Health Nutrition Examination Survey (1999–2018) were included in study. Mortality outcomes tracked through linkage with Death Index records until December 31, 2019. Data medications (including prescribed insulin, diabetic pills, cholesterol-lowering agents) self-reported participants. Results A total 5,046 adults (representing 42,753,806 individuals, weighted mean age 61.08 years [SE: 0.24]; 49.35% female) analyzed. was significantly associated all-cause mortality, these associations modified agents ( p < 0.01). Significant interactions observed for after full adjustments (p-value interaction 0.05). Exposure-effect analysis revealed a U-shaped relationship levels participants using while linear positive not agents. Conclusions modify These findings suggest that future studies its should account Graphical abstract

Language: Английский

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Joint association of TyG index and LDL-C with all-cause and cardiovascular mortality among patients with cardio-renal-metabolic disease

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 18, 2025

Both triglyceride-glucose (TyG) index, as a surrogate marker of insulin resistance, and low-density lipoprotein cholesterol (LDL-C) are independent risk factors for long-term prognosis among patients with cardio-renal-metabolic (CRM) disease. However, the co-exposures TyG index LDL-C to mortality is unclear. The aim this study investigate joint effects stratification on all-cause cardiovascular in CRM patients. We analyzed from National Health Nutrition Examination Survey (NHANES) database (1999–2018), calculating Ln[fasting triglyceride (mg/dL)×fasting glucose (mg/dL)/2] using multivariable Cox regression models assess mortality. interaction between was also evaluated. During median follow-up 7.6 years, 22.8% 8.4% died causes, respectively. Among < 2.6 mmol/L, no significant differences were observed when comparing higher lowest tertile (T1). Specifically, hazard ratio (HR) second (T2) third tertiles (T3) 0.81 (95% confidence interval(CI): 0.59–1.09) 0.87 (95%CI: 0.62–1.22), respectively, P trend 0.468. For mortality, HR T2 T3 compared T1 0.80 0.48–1.32) 0.72 0.45–1.15), 0.173. elevated related markedly increased ≥ mmol/L. 1.01 0.79–1.28) 1.38 1.07–1.79), 0.009. 1.09 CI: 0.72–1.65) 1.80 1.18–2.75) T3, 0.005. Interactive analysis demonstrated that association (P = 0.011) 0.050) observed. findings highlight can significantly increase only but not

Language: Английский

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Triglyceride–glucose index and the risk of in-hospital and ICU all-cause mortality: a systematic review and meta-analysis of observational studies

Nutrition and Diabetes, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 22, 2025

Several studies have illustrated the association of triglyceride glucose (TyG) index with in-hospital and intensive care unit (ICU) mortality. However, no compiled this evidence reached a conclusion. This study aimed to quantify TYG risk ICU An extensive search databases including PubMed, Scopus, Web Science, was performed up 21 Jan 2024. Nineteen were included in meta-analysis. The outcomes mortality 18 8 studies. Among 42,525 participants, 5233 1754 cases reported. pooled analysis revealed that each increase associated 33% 45% (RR = 1.33; 95% CI: 1.23, 1.43; I squared 90.3%) (RR: 1.45; 1.25, 1.67; 44.8%) mortality, respectively. Subgroup stronger between patients cardiovascular diseases than those cerebrovascular (Pheterogeneity Groups 0.014). findings showed positive TyG (PROSPERO registration ID: CRD420245414390).

Language: Английский

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Triglyceride-glucose index correlates with the occurrence and prognosis of acute myocardial infarction complicated by cardiogenic shock: data from two large cohorts

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 11, 2024

Language: Английский

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Diagnostic efficacy of the triglyceride–glucose index in the prediction of contrast-induced nephropathy following percutaneous coronary intervention

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 22, 2023

Introduction Contrast-induced nephropathy (CIN) is a common complication of percutaneous coronary intervention (PCI). Identifying patients at high CIN risk remains challenging. The triglyceride-glucose (TyG) index may help predict but evidence limited. We conducted meta-analysis to evaluate the diagnostic value TyG for after PCI. Methods A systematic literature search was performed in MEDLINE, Cochrane, and EMBASE until August 2023 (PROSPERO registration: CRD42023452257). Observational studies examining predicting PCI were included. This aimed accuracy likelihood CIN. Secondary outcomes assess pooled incidence association between an elevated Results Five (Turkey, n=2; China, n=3) with 3518 (age range: 57.6 68.22 years) 15.3% [95% confidence interval (CI) 11-20.8%]. associated increased (odds ratio: 2.25, 95% CI 1.82-2.77). Pooled sensitivity specificity 0.77 (95% 0.59-0.88) 0.55 0.43-0.68) respectively. Analysis summary receiver operating characteristic (sROC) curve revealed area under 0.69 0.65-0.73). There low publication bias (p = 0.81). Conclusion displayed noteworthy correlation subsequent However, its overall found be moderate nature. While promising, should not used isolation screening given heterogeneity studies. In addition, findings cannot considered conclusive scarcity data. Further large-scale are warranted validate cutoffs determine how optimally incorporate it into current prediction models. Systematic Review Registration https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023452257 , identifier CRD42023452257.

Language: Английский

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Combined Use of Pan-Immune-Inflammation Value and Triglyceride-Glucose Index for Risk Prediction of Contrast-Induced Nephropathy After Coronary Angiography in Patients with STEMI

Bratislavské lekárske listy/Bratislava medical journal, Journal Year: 2025, Volume and Issue: 126(2), P. 211 - 218

Published: Feb. 1, 2025

Abstract Aim The pan-immune-inflammation value (PIV) and triglyceride-glucose (TyG) index are very important parameters that predict contrast-induced nephropathy (CIN) well in patients with ST-elevation myocardial infarction (STEMI) underwent percutaneous coronary intervention (PCI). There limited data on the predictive of CIN derived from combination PIV TyG compared to use alone STEMI who PCI. We aimed evaluate ability index, routinely obtained admission, identify at risk CIN. Method Between 2018 2024, 2367 PCI were included. was defined as a 25% or 0.5 mg/dL increase creatinine baseline within 48–72 h after Receiver operating curve (ROC) analysis performed development Results In ROC analysis, cut-off values for best predicting 548, 8.97 respectively. two markers most powerful predictor when included single variable such high index. Furthermore, co-presence exhibited highest specificity CIN(82%) PIV(77%) index(71%) alone. Conclusion simple cost-effective assessment, may be more reliable prognostic indicator undergoing than

Language: Английский

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Triglyceride-glucose index correlates with the incidences and prognoses of cardiac arrest following acute myocardial infarction: data from two large-scale cohorts

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 8, 2025

The triglyceride-glucose (TyG) index, renowned for its efficacy and convenience in assessing insulin resistance, has been validated as a reliable indicator various cardiovascular conditions. current study aims clarifying the link of TyG with incidences prognoses cardiac arrest (CA) following acute myocardial infarction (AMI). Our analysis is multicenter, retrospective utilizing data from Medical Information Mart Intensive Care IV eICU Collaborative Research Database. Patients AMI whom could be calculated within first 24 h after admission were included. main endpoints in-hospital ICU mortalities. Correlations between outcomes evaluated using logistic regression models, restricted cubic splines (RCS), well correlation linear analyses. Overlap weighting (OW), inverse probability treatment (IPTW), propensity score matching (PSM) methodologies utilized to balance cohorts, thereby minimizing potential biases. Subgroup analyses performed accordance identified modifiers. In total, 5208 individuals diagnosed AMI, among 371 developed CA, ultimately Higher levels observed populations CA compared those without [9.2 (8.7–9.7) vs. 9.0 (8.5–9.4)], demonstrated moderate discriminatory capacity identifying occurrences entire populations. Multivariate regressions revealed serves significant risk both (OR 1.711) mortalities 1.520) AMI-CA patients, it also associated prolonged LOSs. RCS confirmed relationships ascending increased mortality risks (P nonlinearity: 0.592 0.816, respectively), which persisted PSM, OW, IPTW adjustments. further strong rates elders, females, BMI < 28 kg/m2, hypertension. Elevated found apparently correlate higher prevalence adverse regarding patients AMI. findings point fresh insight into significance critically ill coronary

Language: Английский

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