A Mini-Review of Flavone Isomers Apigenin and Genistein in Prostate Cancer Treatment DOI Creative Commons

Xiaozhen Ji,

Kai Liu,

Qingyue Li

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: March 11, 2022

The initial responses to standard chemotherapies among prostate cancer (PCa) patients are usually significant, while most of them will finally develop drug resistance, rendering with limited therapies. To discover new regimens for the treatment PCa including resistant PCa, natural products, richest source bioactive compounds, can serve as a library screening and identifying promising candidates, flavones such apigenin genistein have been used in lab clinical trials treating over decades. In this mini-review, we take look into progress genistein, which isomers, past decade. While possessing very similar structure, these two isomers both target same signaling pathways; they also found work differently cells. Given that more combinations being developed tested, appears be option approved. anticancer efficacies confirmed by in-vitro in-vivo studies, their applications remain validated trials. Information gained may provide important information development potential application PCa.

Language: Английский

A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer DOI Creative Commons
Sudharshan Reddy Dachani, Mohammed Kaleem, Md Ali Mujtaba

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(9), P. 10030 - 10048

Published: Feb. 22, 2024

Skin cancer (SC) poses a global threat to the healthcare system and is expected increase significantly over next two decades if not diagnosed at an early stage. Early diagnosis crucial for successful treatment, as disease becomes more challenging cure it progresses. However, identifying new drugs, achieving clinical success, overcoming drug resistance remain significant challenges. To overcome these obstacles provide effective understand causes of skin cancer, how cells grow divide, factors that affect cell growth, occurs. In this review, we have explained various therapeutic approaches SC treatment via ligands, targeted photosensitizers, natural synthetic drugs SC, epigenetic approach management melanoma, photodynamic therapy, therapy BRAF-mutated melanoma. This article also provides detailed summary are in managing melanoma reducing occurrence stages focuses on current status future prospects therapies available cancer.

Language: Английский

Citations

17
Bee Pollen Phytochemicals and Nutrients as Unequaled Pool of Epigenetic Regulators: Implications for Age-Related Diseases DOI Creative Commons

Rachid Kacemi,

María G. Campos

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 347 - 347

Published: Jan. 21, 2025

Bee pollen is characterized by an exceptional diversity and abundance of micronutrients bioactive phytochemicals. This richness remains very sparsely investigated, but accumulating evidence strongly supports a promising future for bee in human nutrition medicine. Epigenetic regulation among the most compelling biomedical topics that remain completely untapped derivative research. In our current research, we identified numerous ubiquitous compounds are consistently present this matrix, regardless its botanical geographical origins, have been well studied documented as epigenetic regulators recent years. Given relative newness both research studies within nutritional, pharmaceutical, medical sciences, review aims to bridge these valuable fields advance related experimental investigations. To best knowledge, first work has aimed comprehensively investigate modulatory potential compounds. Our findings also unveiled several intriguing phenomena, such dual effect same compound depending on cellular context or some cross-generational heritability traits. Although whole extract still lacking, study clearly indicates avenue worth further We hope constitutes foundational cornerstone investigations

Language: Английский

Citations

2
Modulating NLRP3 Inflammasomes in Idiopathic Pulmonary Fibrosis: A Comprehensive Review on Flavonoid-Based Interventions DOI Creative Commons
Megh Pravin Vithalkar, Shaili Pradhan, K. Sandra

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Idiopathic Pulmonary Fibrosis (IPF) is a severe, rapidly advancing disease that drastically diminishes life expectancy. Without treatment, it can progress to lung cancer. The precise etiology of IPF remains unknown, but inflammation and damage the alveolar epithelium are widely thought be pivotal in its development. Research has indicated activating NLRP3 inflammasome crucial mechanism pathogenesis, as triggers release pro-inflammatory cytokines such IL-1β, IL-18, TGF-β. These contribute myofibroblast differentiation extracellular matrix (ECM) accumulation. Currently, treatment options for limited. Only two FDA-approved medications, pirfenidone nintedanib, available. While these drugs decelerate progression, they come with range side effects do not cure disease. Additional strategies primarily involve supportive care therapy. Emerging research highlighted numerous flavonoids derived from traditional medicines inhibit critical regulators responsible inflammasome. show promise potential therapeutic agents managing IPF, offering new avenue targets core inflammatory processes this debilitating condition. Graphical

Language: Английский

Citations

2
Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy DOI Open Access
Yu Chong, Bo Yang, Masoud Najafi

et al.

Basic & Clinical Pharmacology & Toxicology, Journal Year: 2021, Volume and Issue: 129(6), P. 397 - 415

Published: Sept. 2, 2021

Cancer is known as a second major cause of death globally. Nowadays, several modalities have been developed for the treatment cancer. Radiotherapy and chemotherapy are most common in countries. However, newer such immunotherapy targeted therapy drugs can kill cancer cells with minimal side effects. All anticancer agents work based on killing cells. Numerous studies ongoing to more effectively without increasing effects normal tissues. The combination low toxic interesting this aim. Curcumin one herbal that has shown properties. It regulate immune system responses against Furthermore, curcumin potentiate cell signalling pathways attenuate survival knowledge how induces cancers improve therapeutic efficiency. In review, regulatory different mechanisms their will be discussed. we explain may other or radiotherapy through modulation apoptosis, mitotic catastrophe, senescence, autophagy ferroptosis.

Language: Английский

Citations

59
Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models DOI
Deepti Singh, Meenakshi Gupta, Maryam Sarwat

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2022, Volume and Issue: 176, P. 103751 - 103751

Published: June 22, 2022

Language: Английский

Citations

55
Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways DOI Creative Commons
Rameesha Abid, Shakira Ghazanfar, Arshad Farid

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(13), P. 4304 - 4304

Published: July 4, 2022

Plant bioactive compounds, particularly apigenin, have therapeutic potential and functional activities that aid in the prevention of infectious diseases many mammalian bodies promote tumor growth inhibition. Apigenin is a flavonoid with low toxicities numerous properties due to which it has been considered as traditional medicine for decades. shows synergistic effects combined treatment sorafenib HepG2 human cell line (HCC) less time statistically reduces viability cells, migration, gene expression apoptosis. The combination anti-cancerous drugs apigenin shown health promoting against various cancers. It can prevent mobility, maintain cycle stimulate immune system. also suppresses mTOR activity raises UVB-induced phagocytosis cancerous proliferation growth. high safety threshold, active (anti-cancer) doses be gained by consuming vegetable rich diet. boosted autophagosome formation, decreased activated autophagy preventing PI3K pathway, specifically cells. This paper provides an updated overview apigenin's beneficial anti-inflammatory, antibacterial, antiviral, anticancer effects, making step right direction therapeutics. study critically analyzed effect on cancer signaling pathways including PI3K/AKT/MTOR, JAK/STAT, NF-κB ERK/MAPK pathways.

Language: Английский

Citations

49
Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer Treatment DOI Creative Commons
Juan Zhang, Hong‐Xi Xu,

Jiaqian Zhu

et al.

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(10), P. 3029 - 3041

Published: Jan. 1, 2023

Nuclear factor erythroid 2-related 2 (Nrf2), a transcription that regulates redox homeostasis, plays pivotal role in several cellular processes such as cell proliferation and survival, has been found to be aberrantly activated many cancers.As one of the key oncogenes, Nrf2 represents an important therapeutic target for cancer treatment.Research unraveled main mechanisms underlying pathway regulation promoting tumorigenesis.Many efforts have made develop potent inhibitors, clinical trials are being conducted on some these inhibitors.Natural products well-recognized valuable source development novel therapeutics cancer.So far, number natural compounds identified apigenin, luteolin, quassinoids including brusatol brucein D. These inhibitors mediate oxidant response display effects different types human cancers.In this article, we reviewed structure function Nrf2/Keap1 system with emphasis their biological cancer.The current status regarding potential treatment was also summarized.It is hoped review will stimulate research naturally occurring candidates treatment.

Language: Английский

Citations

35
Mechanisms of ferroptosis regulating oxidative stress and energy metabolism in myocardial ischemia-reperfusion injury and a novel perspective of natural plant active ingredients for its treatment DOI Open Access
Tianqing Zhang,

Wenxu Deng,

Ying Deng

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 114706 - 114706

Published: July 1, 2023

Acute myocardial infarction remains the leading cause of death in humans. Timely restoration blood perfusion to ischemic myocardium most effective strategy treatment acute infarction, which can significantly reduce morbidity and mortality. However, after flow reperfusion, injury will aggravate induce apoptosis cardiomyocytes, a process called ischemia-reperfusion injury. Studies have shown that loss cardiomyocytes caused by oxidative stress, iron load, increased lipid peroxidation, inflammation mitochondrial dysfunction, etc., are involved In recent years, with in-depth research on pathology injury, people gradually realized there is new form cell pathological namely ferroptosis. A number studies found tissue patients changes closely related ferroptosis, such as metabolism disorder, reactive oxygen species free radicals. Natural plant products resveratrol, baicalin, cyanidin-3-O-glucoside, naringenin, astragaloside IV also exert therapeutic effects correcting imbalance these ferroptosis-related factors expression levels. Combining our previous studies, this review summarizes regulatory mechanism natural intervening ferroptosis order provide reference information for development targeted inhibitor drugs cardiovascular diseases.

Language: Английский

Citations

35
Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells DOI Creative Commons
Maryam Ghanbari-Movahed, Sahar Shafiee, Jack T. Burcher

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(3), P. 404 - 404

Published: March 9, 2023

It has been demonstrated that cancer stem cells (CSCs) go through metabolic changes differentiate them from non-CSCs. The altered metabolism of CSCs plays a vital role in tumor initiation, progression, immunosuppression, and resistance to conventional therapy. Therefore, defining the CSC carcinogenesis emerged as main focus research. Two natural flavonoids, apigenin isovitexin, have shown act synergistically with chemotherapeutic drugs by sensitizing CSCs, ultimately leading improved therapeutic efficacy. aim this study is present critical broad evaluation anti-CSC capability isovitexin different cancers novel untapped compounds for developing drugs. A thorough review included literature supports strong association between activity treatment or isovitexin. Additionally, it affected reduced various mechanisms, including suppression Wnt/β-catenin signaling pathway, inhibition nuclear factor-κB protein expression, downregulation cell cycle via upregulation p21 cyclin-dependent kinases. findings demonstrate are potent candidates treating due their antagonistic effects on metabolism.

Language: Английский

Citations

25
Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading DOI Open Access
Valeria Naponelli, Maria Teresa Rocchetti, Domenica Mangieri

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5569 - 5569

Published: May 20, 2024

Due to its propensity metastasize, cancer remains one of the leading causes death worldwide. Thanks in part their intrinsic low cytotoxicity, effects flavonoid family prevention and treatment various human cancers, both vitro vivo, have received increasing attention recent years. It is well documented that Apigenin (4′,5,7-trihydroxyflavone), among other flavonoids, able modulate key signaling molecules involved initiation cell proliferation, invasion, metastasis, including JAK/STAT, PI3K/Akt/mTOR, MAPK/ERK, NF-κB, Wnt/β-catenin pathways, as oncogenic non-coding RNA network. Based on these premises, aim this review emphasize some events through which suppresses focusing specifically ability target molecular pathways angiogenesis, epithelial-to-mesenchymal transition (EMT), maintenance stem cells (CSCs), cycle arrest, death.

Language: Английский

Citations

11