Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 16, 2024
Adipose
tissue
(AT)
serves
as
an
energy-capacitive
organ
and
performs
functions
involving
paracrine-
endocrine-mediated
regulation
via
extracellular
vesicles
(EVs)
secretion.
Exosomes,
a
subtype
of
EVs,
contain
various
bioactive
molecules
with
regulatory
effects,
such
nucleic
acids,
proteins,
lipids.
AT-derived
exosomes
(AT-exos)
include
derived
from
cells
in
AT,
including
adipocytes,
adipose-derived
stem
(ADSCs),
macrophages,
endothelial
cells.
This
review
aimed
to
comprehensively
evaluate
the
impacts
different
AT-exos
on
physiological
pathological
processes.
The
contents
adipocyte-derived
ADSC-derived
are
compared
simultaneously,
highlighting
their
similarities
differences.
have
been
shown
exert
complex
effects
local
inflammation,
tumor
dynamics,
insulin
resistance.
Significantly,
differences
cargoes
observed
among
diabetes
patients,
obese
individuals,
healthy
individuals.
These
could
be
used
predict
development
mellitus
therapeutic
targets
for
improving
sensitivity
glucose
tolerance.
However,
further
research
is
needed
elucidate
underlying
mechanisms
potential
applications
AT-exos.
Life,
Journal Year:
2023,
Volume and Issue:
13(10), P. 2033 - 2033
Published: Oct. 9, 2023
The
development
of
therapy
resistance
still
represents
a
major
hurdle
in
treating
cancers,
leading
to
impaired
treatment
success
and
increased
patient
morbidity.
establishment
minimally
invasive
liquid
biopsies
is
promising
approach
improving
the
early
diagnosis,
as
well
monitoring,
solid
tumors.
Because
their
manifold
functions
tumor
microenvironment,
tumor-associated
small
extracellular
vesicles,
referred
exosomes,
have
become
subject
intense
research.
Besides
important
roles
cancer
progression,
metastasis,
immune
response,
it
has
been
proposed
that
exosomes
also
contribute
acquisition
transfer
resistance,
mainly
by
delivering
functional
proteins
RNAs,
facilitating
export
active
drugs
or
functioning
decoys.
Extensive
research
focused
on
understanding
molecular
mechanisms
underlying
occurrence
translating
these
into
strategies
for
detection.
With
this
review,
we
want
provide
an
overview
current
knowledge
about
(patho-)biology
state-of-the-art
methods
isolation
analysis.
Furthermore,
highlight
role
tumorigenesis
treatment,
where
they
can
function
therapeutic
agents,
biomarkers,
and/or
targets.
By
focusing
will
reveal
new
paths
exploiting
diagnosis
treatment.
Small,
Journal Year:
2024,
Volume and Issue:
20(29)
Published: Feb. 17, 2024
Abstract
Compared
to
conventional
radiotherapy
(RT),
FLASH‐RT
delivers
ultra‐high
dose
radiation,
significantly
reducing
damage
normal
tissue
while
guaranteeing
the
effect
of
cancer
treatment.
However,
recurrence
and
metastasis
frequently
occur
after
all
RT
due
existence
intractable
stem
cells
(CSCs).
To
address
this,
a
biomimetic
nanoplatform
(named
TAFL)
tumor‐derived
exosome
fusion
liposomes
is
designed
by
co‐loading
aggregation‐induced
emission
photothermal
agents,
TPE‐BBT,
anti‐cancer
drugs,
aspirin,
aiming
clear
CSCs
for
inhibiting
therapy
.
Aspirin
released
in
TAFL
system
triggered
laser
irradiation
can
induce
apoptosis
DNA
4T1
CSCs,
comprehensively
downregulate
their
stemness
phenotype,
inhibit
sphericity.
Furthermore,
TPE‐BBT
mediated
mild‐photothermal
alleviate
hypoxic
tumor
microenvironment,
repair
which
further
amplifies
aspirin
against
therefore
reduces
effective
making
more
biologically
safe.
In
vivo
experimental
results
demonstrated
that
decreased
population
treatment
inhibited
therapy.
summary,
this
provides
new
idea
future
clinical
application
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2024,
Volume and Issue:
43(1)
Published: April 23, 2024
Abstract
Background
Triple-negative
breast
cancer
(TNBC)
is
the
most
aggressive
subtype
of
cancer,
and
chemotherapy
still
serves
as
cornerstone
treatment
functioning
by
inducing
cytotoxic
cell
death.
Notably,
emerging
evidence
suggests
that
dying
cell-released
signals
may
induce
progression
metastasis
modulating
surrounding
microenvironment.
However,
underlying
molecular
mechanisms
targeting
strategies
are
yet
to
be
explored.
Methods
Apoptotic
TNBC
cells
induced
paclitaxel
or
adriamycin
were
sorted
their
released
extracellular
vesicles
(EV-dead)
isolated
from
supernatants.
Chemokine
array
analysis
was
conducted
identify
crucial
molecules
in
EV-dead.
Zebrafish
mouse
xenograft
models
used
investigate
effect
EV-dead
on
vivo.
Results
It
demonstrated
phagocytized
macrophages
promoting
infiltration
immunosuppressive
PD-L1
+
TAMs.
identified
CXCL1
a
component
activate
TAM/PD-L1
signaling.
knockdown
macrophage
depletion
significantly
inhibited
EV-dead-induced
growth
metastasis.
Mechanistic
investigations
revealed
enhanced
signaling
transcriptionally
activating
EED-mediated
promoter
activity.
More
importantly,
TPCA-1
(2-[(aminocarbonyl)
amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide)
screened
promising
inhibitor
EVs
enhance
chemosensitivity
limit
without
noticeable
toxicities.
Conclusions
Our
results
highlight
novel
signal
provide
candidate
improve
prognosis.
Graphical
abstract
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 2, 2025
Radiotherapy
is
crucial
in
local
cancer
management
and
needs
advancements.
Tumor
cells
elevate
intracellular
copper
levels
to
promote
growth
resist
radiation;
thus,
targeted
delivery
mitochondria
could
enhance
radiotherapy
by
inducing
cuproptosis
tumor
cells.
In
this
study,
we
engineered
a
multifunctional
nanoliposome
complex,
termed
Lipo-Ele@CuO2,
which
encapsulates
both
peroxide
(CuO2)
the
chelator
elesclomol,
can
Cu
ions
mitochondria.
The
Lipo-Ele@CuO2
complex
induces
mitochondria-mediated
synergistically
enhances
efficacy
of
radiotherapy.
CuO2
acts
as
donor
exhibits
inherent
sensitivity
acidic
environments.
Additionally,
it
depletes
glutathione,
thereby
sensitizing
cuproptosis.
Leveraging
its
pH-responsive
properties
microenvironment,
facilitate
controlled
release
efficiently
delivering
at
sites.
combined
vitro
vivo
studies
demonstrate
that
Lipo-Ele@CuO2-based
therapy
significantly
improves
antitumor
excellent
safety
profiles,
effectively
boosting
effectiveness
Furthermore,
metabolomic
transcriptomic
analyses
reveal
combination
precipitates
significant
alterations
energy
metabolism,
notably
repressing
genes
related
iron-sulfur
cluster
assembly
glycolysis,
confirming
induction
This
therapeutic
strategy
provides
viable
approach
for
addressing
clinical
resistance
demonstrates
translational
potential.
Macromolecular Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 8, 2025
The
rapid
development
of
nanotechnology
enables
wide
exploration
biomimetic
nanoplatforms,
which
can
combine
traditional
nanoparticles
and
bio-derived
materials
to
have
a
better
performance.
Exosomes
work
as
messenger
between
cells
specific
biomarkers
are
also
involved
in
the
developmental
process
diseases.
Dendrimers
with
high
physical
stability
unique
structure
always
used
carriers
for
drugs
or
genes,
thereby
realizing
enhanced
delivery
precise
theranostics.
Therefore,
it
is
promising
utilize
exosomes
transmitters
packaging
dendrimers,
thus
reducing
cytotoxicity
dendrimers
improving
treatment
efficiency.
Meanwhile,
using
multifunctional
capture
detect
disease
diagnosis
potential
strategy.
Herein,
recent
progresses
combination
summarized,
related
biomedical
applications
reviewed.
Finally,
current
challenges
future
perspectives
regard
this
up-and-coming
briefly
discussed.
Journal of Hematology & Oncology,
Journal Year:
2021,
Volume and Issue:
14(1)
Published: Sept. 8, 2021
Abstract
Pancreatic
cancer
has
the
worst
prognosis
among
common
tumors
which
is
attributed
to
its
aggressive
phenotype,
diagnosis
at
advanced,
inoperable
stages,
and
resistance
systemic
therapy.
Non-coding
RNAs
(ncRNAs)
such
as
microRNAs,
long
non-coding
RNAs,
circular
have
been
established
important
regulators
of
gene
expression
their
deregulation
implicated
in
multiple
diseases
foremost
cancer.
In
tumor
microenvironment,
can
be
distributed
cells,
stromal
immune
cells
via
small
extracellular
vesicles
(sEVs),
thereby
facilitating
intercellular
communication
influencing
major
hallmarks
angiogenesis,
evasion
system,
metastatic
dissemination.
Furthermore,
sEV-ncRNAs
shown
promising
potential
liquid
biopsies
with
diagnostic
prognostic
significance.
this
review,
we
summarize
role
sEVs
carriers
ncRNAs
underlying
molecular
mechanisms
pancreatic
Moreover,
review
biomarkers
highlight
suitability
delivery
vehicles
for
ncRNA-based
Cell Death and Disease,
Journal Year:
2021,
Volume and Issue:
12(11)
Published: Oct. 20, 2021
Abstract
Pancreatic
cancer
(PC)
is
one
of
the
leading
causes
cancer-related
death
worldwide
due
to
delayed
diagnosis
and
limited
treatments.
More
than
90%
all
pancreatic
cancers
are
ductal
adenocarcinoma
(PDAC).
Extensive
communication
between
tumour
cells
other
cell
types
in
microenvironment
have
been
identified
which
regulate
hallmarks
during
tumorigenesis
via
secretory
factors
extracellular
vesicles
(EVs).
The
EV-capsuled
not
only
facilitate
growth
locally,
but
also
enter
circulation
reach
distant
organs
construct
a
pre-metastatic
niche.
In
this
review,
we
delineate
key
derived
EVs
that
mediate
different
processes.
Also,
highlight
related
crosstalk
with
stem
cells/cancer-initiating
(CSC/CIC),
subpopulation
can
efficiently
metastasize
resist
currently
used
chemotherapies.
Lastly,
discuss
potential
early
antitumour
therapeutic
strategies.
