The effects of MYC on tumor immunity and immunotherapy DOI Creative Commons
Jiajin Li,

Tingyu Dong,

Zhenhua Wu

et al.

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: March 25, 2023

Abstract The oncogene MYC is dysregulated in a host of human cancers, and as an important point convergence multitudinous oncogenic signaling pathways, it plays crucial role tumor immune regulation the microenvironment (TIME). Specifically, promotes expression immunosuppressive factors inhibits activation regulators. Undoubtedly, therapeutic strategy that targets can initiate new era cancer treatment. In this review, we summarize essential pathway immunity development status MYC-related therapies, including strategies targeting combined MYC-based immunotherapy. These studies have reported extraordinary insights into translational application treatment are conducive to emergence more effective immunotherapies for cancer.

Language: Английский

Universal STING mimic boosts antitumour immunity via preferential activation of tumour control signalling pathways DOI
Ying Wang, Sirui Li, Mengying Hu

et al.

Nature Nanotechnology, Journal Year: 2024, Volume and Issue: 19(6), P. 856 - 866

Published: March 13, 2024

Language: Английский

Citations

27
Natural products targeting the MAPK-signaling pathway in cancer: overview DOI Creative Commons

Aiwen Shi,

Li Liu, Shuang Li

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(1)

Published: Jan. 1, 2024

Abstract Purpose This article summarizes natural products that target the MAPK-signaling pathway in cancer therapy. The classification, chemical structures, and anti-cancer mechanisms of these are elucidated, comprehensive information is provided on their potential use Methods Using PubMed database, we searched for keywords, including “tumor”, “cancer”, “natural product”, “phytochemistry”, “plant components”, “MAPK-signaling pathway”. We also screened compounds with well-defined structures targeting have effects. used Kingdraw software Adobe Photoshop to draw compound structural diagrams. Results A total 131 papers were searched, from which 85 selected. These clear treatment mainly related pathway. Examples include eupatilin, carvacrol, oridonin, sophoridine, diosgenin, juglone. components classified as flavonoids, phenols, terpenoids, alkaloids, steroidal saponins, quinones. Conclusions Certain MAPK inhibitors been clinical treatment. However, feedback has not promising because genomic instability, drug resistance, side Natural few effects, good medicinal efficacy, a wide range sources, individual heterogeneity biological activity, capable treating disease multiple targets. characteristics make drugs

Language: Английский

Citations

20
Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics DOI Creative Commons

Tosin Akinsipe,

Rania Mohamedelhassan,

Ayuba Akinpelu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 12, 2024

The breast cancer tumor microenvironment (TME) is dynamic, with various immune and non-immune cells interacting to regulate progression anti-tumor immunity. It now evident that the within TME significantly contribute resistance conventional newly developed therapies. Both in play critical roles onset, uncontrolled proliferation, metastasis, evasion, Consequently, molecular cellular components of have emerged as promising therapeutic targets for developing novel treatments. primarily comprises cells, stromal vasculature, infiltrating cells. Currently, numerous clinical trials targeting specific are underway. However, complexity its impact on evasion immunity necessitate further research develop improved multifaceted nature arises from their phenotypic functional plasticity, which endows them both pro during progression. In this review, we discuss current understanding recent advances anti-tumoral functions implications safe effective therapies control progress.

Language: Английский

Citations

18
Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in breast cancer lymphatic node, bone, and brain metastases DOI Creative Commons

Longyu Zhu,

Miao Liu,

Yuguang Shang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 17, 2025

Breast cancer is the most common malignant tumor in world, and its metastasis main cause of death breast patients. However, differences between primary tissue lymphatic node, bone, brain metastases at single-cell level are not fully understood. We analyzed microenvironment heterogeneity samples (n = 4), node 3), bone 2) using sequencing data from GEO database. The epithelial cells were characterized by InferCNV algorithm. cell-cell communication was CellChat package. biological function cell subpopulations gene set variation analysis. expression STMN1 immunohistochemical staining. proportion pCAFs explored multispectral identified seven clusters metastatic (Lymphatic brain, metastases) analyzing transcriptomic profiles. T-NK B dominated with metastasis, whereas fibroblasts prevalent cancer. five T (T memory, CD8 + cells, regulatory natural killer CD4 cells), three (naïve memory plasma cancer-associated (CAFs) (Smooth muscle (SMC), pericyte, antigen-presenting CAFs (apCAFs), proliferative (pCAFs), matrix (mCAFs)). Notably. metastasis. Furthermore, we four subpopulations: G0, G1, G2, G3. G2 population exhibited strong invasion ability, it can differentiate into G3 ability proliferation-related G1 after Cell-cell demonstrated an interaction metastasis-associated cells. Finally, discovered that advanced cancer, pCAF increased associated a poor prognosis This study elucidated potential cellular origins drivers to nodes, utilizing prognosis.

Language: Английский

Citations

3
Signaling pathways governing breast cancer stem cells behavior DOI Creative Commons
Kai Song,

Maryam Farzaneh

Stem Cell Research & Therapy, Journal Year: 2021, Volume and Issue: 12(1)

Published: April 16, 2021

Abstract Breast cancer is the second common and leading cause of malignancy among females overall. stem cells (BCSCs) are a small population breast that play critical role in metastasis to other organs body. BCSCs have both self-renewal differentiation capacities, which thought contribute aggressiveness metastatic lesions. Therefore, targeting can be suitable approach for treatment cancer. Growing evidence has indicated Wnt, NFκB, Notch, BMP2, STAT3, hedgehog (Hh) signaling pathways govern epithelial-to-mesenchymal transition (EMT) activation, growth, tumorigenesis primary regions. miRNAs as central regulatory molecules also roles BCSC self-renewal, metastasis, drug resistance. Hence, these might novel therapeutic diagnosis therapy. This review discusses known mechanisms involved stimulation or prevention tumorigenesis.

Language: Английский

Citations

92
Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer DOI Open Access
Reyhaneh Farghadani, Rakesh Naidu

Cancers, Journal Year: 2021, Volume and Issue: 13(14), P. 3427 - 3427

Published: July 8, 2021

Breast cancer is the most frequently diagnosed and leading cause of death among women worldwide. Despite overall successes in breast therapy, hormone-independent HER2 negative cancer, also known as triple (TNBC), lacking estrogens progesterone receptors with an excessive expression human epidermal growth factor receptor 2 (HER2), along positive subtype, still remain major challenges treatment. Due to their poor prognoses, aggressive phenotype, highly metastasis features, new alternative therapies have become urgent clinical need. One noteworthy phytochemicals, curcumin, has attracted enormous attention a promising drug candidate prevention treatment due its multi-targeting effect. Curcumin interrupts stages tumorigenesis including cell proliferation, survival, angiogenesis, through modulation multiple signaling pathways. The current review highlighted anticancer activity curcumin via focusing on impact key pathways PI3K/Akt/mTOR pathway, JAK/STAT MAPK NF-ĸB p53 Wnt/β-catenin, well apoptotic cycle Besides, therapeutic implications trials are here presented.

Language: Английский

Citations

91
Triple-negative breast cancer: understanding Wnt signaling in drug resistance DOI Creative Commons
Parnaz Merikhian,

Mohammad Reza Eisavand,

Leila Farahmand

et al.

Cancer Cell International, Journal Year: 2021, Volume and Issue: 21(1)

Published: Aug. 10, 2021

Abstract Triple-negative breast cancer (TNBC) is not as prevalent hormone receptor or HER2-positive cancers and all tests come back negative. More importantly, the heterogeneity complexity of TNBC on molecular clinical levels have limited successful development novel therapeutic strategies led to intrinsic developed resistance chemotherapies new agents. Studies demonstrated deregulation Wnt/β-catenin signaling in tumorigenesis which plays decisive roles at low survival rate patients facilitates currently existing therapies. This review summarizes mechanisms for TNBC, complex interaction between signaling, transactivated tyrosine kinase (RTK) pathways, lymphocytic infiltration, epithelial-mesenchymal transition (EMT), induction metastasis. Such associations how these pathways interact progression careful analysis effective combination therapies without generating significant toxicity resistance.

Language: Английский

Citations

73
Epithelial-to-Mesenchymal Transition Signaling Pathways Responsible for Breast Cancer Metastasis DOI

Busra Buyuk,

Sha Jin, Kaiming Ye

et al.

Cellular and Molecular Bioengineering, Journal Year: 2021, Volume and Issue: 15(1), P. 1 - 13

Published: Sept. 2, 2021

Language: Английский

Citations

68
CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt/β-catenin signalling pathway DOI
Yun Li, Chenying Liu, Xin Zhang

et al.

British Journal of Cancer, Journal Year: 2022, Volume and Issue: 126(12), P. 1684 - 1694

Published: Feb. 22, 2022

Language: Английский

Citations

54
Graph attention network for link prediction of gene regulations from single-cell RNA-sequencing data DOI Open Access
Guangyi Chen, Zhi–Ping Liu

Bioinformatics, Journal Year: 2022, Volume and Issue: 38(19), P. 4522 - 4529

Published: Aug. 12, 2022

Single-cell RNA sequencing (scRNA-seq) data provides unprecedented opportunities to reconstruct gene regulatory networks (GRNs) at fine-grained resolution. Numerous unsupervised or self-supervised models have been proposed infer GRN from bulk RNA-seq data, but few of them are appropriate for scRNA-seq under the circumstance low signal-to-noise ratio and dropout. Fortunately, surging TF-DNA binding (e.g. ChIP-seq) makes supervised inference possible. We regard as a graph-based link prediction problem that expects learn low-dimensional vectorized representations predict potential interactions.In this paper, we present GENELink latent interactions between transcription factors (TFs) target genes in using graph attention network. projects single-cell expression with observed TF-gene pairs space. Then, specific learned serve downstream similarity measurement causal pairwise by optimizing embedding Compared eight existing reconstruction methods, achieves comparable better performance on seven datasets four types ground-truth networks. further apply human breast cancer metastasis reveal heterogeneity Notch Wnt signalling pathways primary tumour lung metastasis. Moreover, ontology enrichment results unique indicate mitochondrial oxidative phosphorylation (OXPHOS) is functionally important during seeding step metastatic cascade, which validated pharmacological assays.The code available https://github.com/zpliulab/GENELink.Supplementary Bioinformatics online.

Language: Английский

Citations

49