CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects DOI Creative Commons
Lei Tang, Xin Chen, Jianquan Hou

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 4, 2025

CXCL14 is a highly conserved chemokine expressed in various cell types, playing crucial roles both physiological and pathological processes, including immune regulation tumorigenesis. Recently, the role of tumors has attracted considerable attention. However, previous pan-cancer studies have reported inconsistencies regarding effects on tumors, particularly concerning its expression levels tumor tissues influence phenotypes cancer cells. This variability believed to stem from context-dependent nature CXCL14, as different sources secretion within distinct microenvironments may mediate diverse biological effects. Such phenomena also been observed prostate research. Despite foundational understanding cancer, there remains lack comprehensive reviews summarizing specific this systematically analyzing reasons behind complex Therefore, article aims discuss microenvironment explore future research directions potential applications.

Language: Английский

Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy DOI
Yan Zong, Yi Lin, Tuo Wei

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(51)

Published: May 17, 2023

Abstract Messenger RNA (mRNA) has received great attention in the prevention and treatment of various diseases due to success coronavirus disease 2019 (COVID‐19) mRNA vaccines (Comirnaty Spikevax). To meet therapeutic purpose, it is required that must enter target cells express sufficient proteins. Therefore, development effective delivery systems necessary crucial. Lipid nanoparticle (LNP) represents a remarkable vehicle indeed accelerated applications humans, as several mRNA‐based therapies have already been approved or are clinical trials. In this review, focus on mRNA‐LNP‐mediated anticancer therapy. It summarizes main strategies mRNA‐LNP formulations, discusses representative approaches cancer, points out current challenges possible future directions research field. hoped these delivered messages can help further improve application technology cancer

Language: Английский

Citations

180
Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy DOI Creative Commons
Mohammad Chehelgerdi, Matin Chehelgerdi, Milad Khorramian‐Ghahfarokhi

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Jan. 9, 2024

Abstract The CRISPR system is a revolutionary genome editing tool that has the potential to revolutionize field of cancer research and therapy. ability precisely target edit specific genetic mutations drive growth spread tumors opened up new possibilities for development more effective personalized treatments. In this review, we will discuss different CRISPR-based strategies have been proposed therapy, including inactivating genes tumor growth, enhancing immune response cells, repairing cause cancer, delivering cancer-killing molecules directly cells. We also summarize current state preclinical studies clinical trials highlighting most promising results challenges still need be overcome. Safety delivery are important therapy become viable option. limitations overcome, such as off-target effects, safety, site. Finally, provide an overview opportunities in future directions development. change landscape research, review aims overcome realize potential.

Language: Английский

Citations

69
Cell–cell communication: new insights and clinical implications DOI Creative Commons

Jimeng Su,

Ying Song,

Zhipeng Zhu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 7, 2024

Multicellular organisms are composed of diverse cell types that must coordinate their behaviors through communication. Cell-cell communication (CCC) is essential for growth, development, differentiation, tissue and organ formation, maintenance, physiological regulation. Cells communicate direct contact or at a distance using ligand-receptor interactions. So cellular encompasses two processes: signal conduction generation intercellular transmission signals, transduction reception procession signals. Deciphering networks critical understanding metabolism. First, we comprehensively review the historical milestones in CCC studies, followed by detailed description mechanisms molecule importance main signaling pathways they mediate maintaining biological functions. Then systematically introduce series human diseases caused abnormalities progress clinical applications. Finally, summarize various methods monitoring interactions, including imaging, proximity-based chemical labeling, mechanical force analysis, downstream analysis strategies, single-cell technologies. These aim to illustrate how functions depend on these interactions complexity regulatory regulate crucial processes, homeostasis, immune responses diseases. In addition, this enhances our processes occur after cell-cell binding, highlighting its application discovering new therapeutic targets biomarkers related precision medicine. This collective provides foundation developing targeted drugs personalized treatments.

Language: Английский

Citations

40
Principles of CRISPR-Cas9 technology: Advancements in genome editing and emerging trends in drug delivery DOI Creative Commons
Alaa A. A. Aljabali, Mohamed El‐Tanani, Murtaza M. Tambuwala

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 92, P. 105338 - 105338

Published: Jan. 6, 2024

The rapid advancement of CRISPR-Cas9 technology has instigated a profound transformation in genome editing with significant implications for fields like health, agriculture, and biotechnology. This abstract provides an overview the historical significance fundamental components CRISPR-Cas9, notably Cas9 protein guide RNA, underscoring its pivotal role genetic manipulation. It emphasizes CRISPR-Cas9's preeminence domain precise editing, driving breakthroughs personalized medicine, gene therapy, agriculture. Of paramount importance is integration nanomaterials, encompassing lipid-based polymeric nanoparticles, alongside viral vectors, serving as potent vehicles augmenting delivery efficiency precision. We explore strategies aimed at enhancing through while also addressing ethical regulatory considerations. In expert opinion section, we offer nuanced perspective on present state field, highlighting potential transformative progress research therapy. stands brink unlocking new possibilities providing innovative solutions to address pressing global challenges.

Language: Английский

Citations

39
Advances and applications of nanoparticles in cancer therapy DOI Creative Commons

Xianzhou Huang,

Tao He, Xiuqi Liang

et al.

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Language: Английский

Citations

26
Writers, readers, and erasers RNA modifications and drug resistance in cancer DOI Creative Commons
Di Chen, Xinyu Gu,

Yeltai Nurzat

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 30, 2024

Drug resistance in cancer cells significantly diminishes treatment efficacy, leading to recurrence and metastasis. A critical factor contributing this is the epigenetic alteration of gene expression via RNA modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), pseudouridine (Ψ), adenosine-to-inosine (A-to-I) editing. These modifications are pivotal regulating splicing, translation, transport, degradation, stability. Governed by "writers," "readers," "erasers," impact numerous biological processes progression, including cell proliferation, stemness, autophagy, invasion, apoptosis. Aberrant can lead drug adverse outcomes various cancers. Thus, targeting modification regulators offers a promising strategy for overcoming enhancing efficacy. This review consolidates recent research on role prevalent resistance, with focus m6A, m1A, m5C, m7G, Ψ, A-to-I Additionally, it examines regulatory mechanisms linked underscores existing limitations field.

Language: Английский

Citations

18
Injecting hope: the potential of intratumoral immunotherapy for locally advanced and metastatic cancer DOI Creative Commons
Markéta Skaličková, Katerina Hadrava Vanova, Ondřej Uher

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

Despite enormous progress, advanced cancers are still one of the most serious medical problems in current society. Although various agents and therapeutic strategies with anticancer activity known used, they often fail to achieve satisfactory long-term patient outcomes survival. Recently, immunotherapy has shown success patients by harnessing important interactions between immune system cancer. However, many these therapies lead frequent side effects when administered systemically, prompting treatment modifications or discontinuation or, severe cases, fatalities. New approaches like intratumoral immunotherapy, characterized reduced effects, cost, systemic toxicity, offer promising prospects for future applications clinical oncology. In context locally metastatic cancer, combining diverse immunotherapeutic other targeting multiple cancer hallmarks appears crucial. Such combination hold promise improving survival promoting a sustained response. This review aims provide overview approaches, specifically focusing on administration drugs cancers. It also explores integration modalities maximize Additionally, summarizes recent advances discusses novel outlining directions field.

Language: Английский

Citations

2
Extrachromosomal circular DNA: biogenesis, structure, functions and diseases DOI Creative Commons
Ludi Yang,

Ruobing Jia,

Tongxin Ge

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Oct. 2, 2022

Abstract Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base pairs, is independent conventional chromosomes. Recently, eccDNAs have been considered an unanticipated major source somatic rearrangements, contributing genomic remodeling through chimeric circularization and reintegration into the linear genome. In addition, origin eccDNA be associated with essential chromatin-related events, including formation super-enhancers repair machineries. Moreover, our understanding properties functions has continuously greatly expanded. Emerging investigations demonstrate that serve as multifunctional molecules various organisms during diversified biological processes, such epigenetic remodeling, telomere trimming, regulation canonical signaling pathways. Importantly, its special distribution potentiates a measurable biomarker many diseases, especially cancers. The loss homeostasis facilitates tumor initiation, malignant progression, heterogeneous evolution An in-depth provides novel insights for precision cancer treatment. this review, we summarized discovery history eccDNA, discussed biogenesis, characteristics, eccDNA. emphasized role pathogenesis evolution. Therapeutically, potential clinical applications target aberrant multiple diseases.

Language: Английский

Citations

59
Research Progress of Nanomedicine-Based Mild Photothermal Therapy in Tumor DOI Creative Commons
Xiang He, Shengtao Zhang, Yuhang Tian

et al.

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 1433 - 1468

Published: March 1, 2023

Abstract: With the booming development of nanomedicine, mild photothermal therapy (mPTT, 42– 45°C) has exhibited promising potential in tumor therapy. Compared with traditional PTT (> 50°C), mPTT less side effects and better biological conducive to treatment, such as loosening dense structure tissues, enhancing blood perfusion, improving immunosuppressive microenvironment. However, a relatively low temperature cannot allow completely eradicate tumors, therefore, substantial efforts have been conducted optimize application This review extensively summarizes latest advances mPTT, including two sections: (1) taking leading role maximize its effect by blocking cell defense mechanisms, (2) regarding supporting assist other therapies achieve synergistic antitumor curative effect. Meanwhile, special characteristics imaging capabilities nanoplatforms applied various are discussed. At last, this paper puts forward bottlenecks challenges current research path possible solutions directions future proposed correspondingly. Keywords: nanotechnology, therapy,

Language: Английский

Citations

40
CRISPR/dCas9 Tools: Epigenetic Mechanism and Application in Gene Transcriptional Regulation DOI Open Access

Ruijie Cai,

Runyu Lv, Xin’e Shi

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14865 - 14865

Published: Oct. 3, 2023

CRISPR/Cas9-mediated cleavage of DNA, which depends on the endonuclease activity Cas9, has been widely used for gene editing due to its excellent programmability and specificity. However, changes DNA sequence that are mediated by CRISPR/Cas9 affect structures stability genome, may accuracy results. Mutations in RuvC HNH regions Cas9 protein lead inactivation into dCas9 with no activity. Despite loss activity, can still bind strand using guide RNA. Recently, proteins active/inhibitory effects have linked end form fusion transcriptional effects, named CRISPRa CRISPRi, respectively. These CRISPR tools mediate transcription protein-coding non-coding genes regulating chromosomal modification states target promoters, enhancers, other functional elements. Here, we highlight epigenetic mechanisms applications common CRISPR/dCas9 tools, hope provide a reference future related regulation, function, high-throughput screening, disease treatment.

Language: Английский

Citations

39