Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Oct. 2, 2023

Abstract Despite centuries since the discovery and study of cancer, cancer is still a lethal intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much attention as pivotal component tumor microenvironment. The versatility sophisticated mechanisms CAFs in facilitating progression been elucidated extensively, including promoting angiogenesis metastasis, inducing drug resistance, reshaping extracellular matrix, developing an immunosuppressive Owing to their robust tumor-promoting function, are considered promising target for oncotherapy. However, highly heterogeneous group cells. Some subpopulations exert inhibitory role growth, which implies that CAF-targeting approaches must be more precise individualized. This review comprehensively summarize origin, phenotypical, functional heterogeneity CAFs. More importantly, we underscore advances strategies clinical trials CAF various cancers, also progressions immunotherapy.

Language: Английский

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Understanding tumour endothelial cell heterogeneity and function from single-cell omics

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(8), P. 544 - 564

Published: June 22, 2023

Language: Английский

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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Language: Английский

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CXCL12-CXCR4/CXCR7 Axis in Cancer: from Mechanisms to Clinical Applications

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(11), P. 3341 - 3359

Published: Jan. 1, 2023

Cancer is a multi-step disease caused by the accumulation of genetic mutations and/or epigenetic changes, and biggest challenge around world.Cytokines, including chemokines, exhibit expression changes disorders in all human cancers.These cytokine abnormalities can disrupt homeostasis immune function, make outstanding contributions to various stages cancer development such as invasion, metastasis, angiogenesis.Chemokines are superfamily small molecule chemoattractive cytokines that mediate variety cellular functions.Importantly, interactions chemokine members CXCL12 its receptors CXCR4 CXCR7 have broad impact on tumor cell proliferation, survival, angiogenesis, microenvironment, thus participate onset many cancers leukemia, breast cancer, lung prostate multiple myeloma.Therefore, this review aims summarize latest research progress future challenges regarding role CXCL12-CXCR4/CXCR7 signaling axis highlights potential biomarker or therapeutic target for providing essential strategies novel targeted therapies.

Language: Английский

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The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy

Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)

Published: April 11, 2024

Abstract In recent years, advancements in single-cell and spatial transcriptomics, which are highly regarded developments the current era, particularly emerging integration of spatiotemporal have enabled a detailed molecular comprehension complex regulation cell fate. The insights obtained from these methodologies anticipated to significantly contribute development personalized medicine. Currently, technology is less frequently utilized for prostate cancer compared with other types tumors. Starting perspective RNA sequencing technology, this review outlined significance (scRNA-seq) research, encompassing preclinical medicine clinical applications. We summarize differences between mouse human as revealed by scRNA-seq studies, well combination multi-omics methods involving highlight key targets diagnosis, treatment, drug resistance characteristics cancer. These studies expected provide novel immunotherapy innovative treatment strategies castration-resistant Furthermore, we explore potential applications stemming technologies review, paving way future research precision

Language: Английский

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Single-cell analysis of multiple cancer types reveals differences in endothelial cells between tumors and normal tissues

Computational and Structural Biotechnology Journal, Journal Year: 2022, Volume and Issue: 21, P. 665 - 676

Published: Dec. 30, 2022

Endothelial cells (ECs) play an important role in tumor progression. Currently, the main target of anti-angiogenic therapy is vascular endothelial growth factor (VEGF) pathway. Some patients do benefit from anti-VEGF/VEGFR therapy; however, a large number not have response or acquire drug resistance after treatment. Moreover, may lead to nephrotoxicity and cardiovascular-related side effects due its action on normal ECs. Therefore, it necessary identify targets that are specific ECs could be applied various cancer types. We integrated single-cell RNA sequencing data six types constructed multi-cancer EC atlas decode characteristic found tip-like mainly exist tissues but barely tissues. Tip-like involved promotion angiogenesis inhibition anti-tumor immune responses. cells, myeloid pericytes sources pro-angiogenic factors. High proportion associated with poor prognosis multiple also identified prostate-specific membrane antigen (PSMA) marker for all we studied. In summary, demonstrate differential subcluster between tumors promote progression through promoting while inhibiting PSMA was ECs, which used as potential diagnosis treatment non-prostate cancers.

Language: Английский

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Comparative analysis of 10X Chromium vs. BD Rhapsody whole transcriptome single-cell sequencing technologies in complex human tissues

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28358 - e28358

Published: March 19, 2024

The development of single-cell omics tools has enabled scientists to study the tumor microenvironment (TME) in unprecedented detail. However, each different techniques may have its unique strengths and limitations. Here we directly compared two commercially available high-throughput RNA sequencing (scRNA-seq) technologies - droplet-based 10X Chromium

Language: Английский

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Targeting the tumor microenvironment, a new therapeutic approach for prostate cancer

Prostate Cancer and Prostatic Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: April 2, 2024

Language: Английский

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The role of proinflammatory cytokines and CXC chemokines (CXCL1–CXCL16) in the progression of prostate cancer: insights on their therapeutic management

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: May 14, 2024

Abstract Reproductive cancers are malignancies that develop in the reproductive organs. One of leading affecting male system on a global scale is prostate cancer (PCa). The negative consequences PCa metastases endure and severe, significantly mortality life quality for those who affected. association between inflammation has captured interest while. Inflammatory cells, cytokines, CXC chemokines, signaling pathways, other elements make up tumor microenvironment (TME), which characterized by inflammation. cytokines chemokines especially crucial development prognosis. Cytokines (interleukins) such as IL-1, IL-6, IL-7, IL-17, TGF-β, TNF-α, CXCL1–CXCL6, CXCL8–CXCL16 thought to be responsible pleiotropic effects PCa, include inflammation, progression, angiogenesis, leukocyte infiltration advanced therapeutic resistance. inflammatory cytokine systems also promising candidates suppression immunotherapy. Therefore, purpose this work provide insight how spectra evolve develops spreads. We discussed recent developments our awareness diverse molecular pathways these circulating well their associated receptors, may one day serve PCa-targeted therapies. Moreover, current status potential theranostic therapies based receptors (CXCRs) examined.

Language: Английский

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Survival strategies: How tumor hypoxia microenvironment orchestrates angiogenesis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116783 - 116783

Published: May 25, 2024

During tumor development, the itself must continuously generate new blood vessels to meet their growth needs while also allowing for invasion and metastasis. One of most common features tumors is hypoxia, which drives process angiogenesis by regulating microenvironment, thus adversely affecting prognosis patients. In addition, overcome unsuitable environments growth, such as nutrient deficiency, hyperacidity, immunosuppression, microenvironment (TME) coordinates in several ways restore supply oxygen nutrients remove metabolic wastes. A growing body research suggests that hypoxia interact through a complex interplay crosstalk, inextricably linked TME. Here, we review TME's positive contribution from an angiogenesis-centric perspective considering objective impact hypoxic phenotypes status limitations current angiogenic therapies.

Language: Английский

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