Experimental Neurology, Journal Year: 2024, Volume and Issue: 379, P. 114842 - 114842
Published: May 31, 2024
Language: Английский
Nature, Journal Year: 2024, Volume and Issue: 626(8000), P. 727 - 736
Published: Feb. 21, 2024
Language: Английский
Citations
140
Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)
Published: Nov. 27, 2023
Abstract Immunotherapies have revolutionized the treatment paradigms of various types cancers. However, most these immunomodulatory strategies focus on harnessing adaptive immunity, mainly by inhibiting immunosuppressive signaling with immune checkpoint blockade, or enhancing immunostimulatory bispecific T cell engager and chimeric antigen receptor (CAR)-T cell. Although agents already achieved great success, only a tiny percentage patients could benefit from immunotherapies. Actually, immunotherapy efficacy is determined multiple components in tumor microenvironment beyond immunity. Cells innate arm system, such as macrophages, dendritic cells, myeloid-derived suppressor neutrophils, natural killer unconventional also participate cancer evasion surveillance. Considering that cornerstone antitumor response, utilizing immunity provides potential therapeutic options for control. Up to now, exploiting agonists stimulator interferon genes, CAR-macrophage -natural therapies, metabolic regulators, novel exhibited potent activities preclinical clinical studies. Here, we summarize latest insights into roles cells discuss advances arm-targeted strategies.
Language: Английский
Citations
84
Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)
Published: Feb. 7, 2023
Abstract In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-T) therapy are two milestone achievements in clinical immunotherapy. However, both show limited efficacies most solid neoplasms, which necessitates the exploration of new immunotherapeutic modalities. The failure CAR-T several neoplasms is attributed to multiple factors, including low antigenicity tumor cells, infiltration effector diverse mechanisms immunosuppression microenvironment. New adoptive therapies have been attempted for TCR-T, CAR-natural killer cells (CAR-NK), CAR-macrophages (CAR-M). Compared CAR-T, these certain advantages treating neoplasms. this review, we summarized 40-year evolution therapies, then focused on advances CAR-NK, CAR-M discussed their potential applications.
Language: Английский
Citations
67
Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(4), P. 315 - 331
Published: March 5, 2024
Abstract Natural killer (NK) cell-based immunotherapies are attracting increasing interest in the field of cancer treatment. Early clinical trials have shown promising outcomes, alongside satisfactory product efficacy and safety. Recent developments greatly increased therapeutic potential NK cells by endowing them with enhanced recognition cytotoxic capacities. This review focuses on surface receptor engineering cell therapy discusses its impact, challenges, future directions. Most approaches based chimeric antigen receptors to allow target specific tumor antigens independent human leukocyte restriction. approach has precision potency NK-mediated elimination cells. In addition, T-cell also mediates intracellular epitopes, which broadens range peptides. Indirect peptide been improved optimizing immunoglobulin constant fragment expression signaling. Indeed, engineered an ability recognize destroy coated antibodies, thereby their antibody-dependent cellular cytotoxicity. The promote expansion, persistence, infiltration transferred microenvironment explored. Receptor-based strategies for sustained functionality within environment discussed, these providing perspectives counteract tumor-induced immunosuppression. Overall, led significant advances immunotherapies. As technical challenges addressed, innovative treatments will likely reshape immunotherapy.
Language: Английский
Citations
63
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 109 - 135
Published: Jan. 1, 2024
Abstract: The tumor microenvironment (TME) plays an important role in various stages of generation, metastasis, and evasion immune monitoring treatment. TME targeted therapy is based on components, related pathways or active molecules as therapeutic targets. Therefore, environmental differences between normal cells has been widely studied. Biomimetic nanocarriers with low clearance, immunogenicity, high targeting have enormous potential This review introduces the composition characteristics TME, including cancer‑associated fibroblasts (CAFs), extracellular matrix (ECM), blood vessels, non-tumor cells, latest research progress biomimetic nanoparticles (NPs) TME. It also discusses opportunities challenges clinical transformation nanoparticles. Keywords: nanoparticles, delivery system, therapy, cell membrane-coating
Language: Английский
Citations
30
Nature Biomedical Engineering, Journal Year: 2024, Volume and Issue: 8(5), P. 579 - 592
Published: Feb. 29, 2024
Language: Английский
Citations
29
Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)
Published: Feb. 2, 2024
Abstract Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain can impair this response help escape. Therefore, exploring the factors that influence T-cell infiltration is crucial to understand immunity improve therapeutic effect of cancer immunotherapy. The use single-cell RNA sequencing (scRNA-seq) allows high-resolution analysis precise composition with different phenotypes other microenvironmental factors, including non-immune stromal related molecules microenvironment various types. In review, we summarized research progress on crosstalk cytokines during using scRNA-seq provide insights into mechanisms regulating contribute new perspectives
Language: Английский
Citations
26
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 9, 2024
Natural Killer (NK) cells, intrinsic to the innate immune system, are pivotal in combating cancer due their independent cytotoxic capabilities antitumor response. Unlike predominant treatments that target T cell immunity, limited success of immunotherapy emphasizes urgency for innovative approaches, with a spotlight on harnessing potential NK cells. Despite tumors adapting mechanisms evade cell-induced cytotoxicity, there is optimism surrounding Chimeric Antigen Receptor (CAR) This comprehensive review delves into foundational features and recent breakthroughs comprehending dynamics cells within tumor microenvironment. It critically evaluates applications challenges associated emerging CAR-NK therapeutic strategies, positioning them as promising tools evolving landscape precision medicine. As research progresses, unique attributes offer new avenue interventions, paving way more effective precise approach treatment.
Language: Английский
Citations
24
Science Translational Medicine, Journal Year: 2024, Volume and Issue: 16(747)
Published: May 15, 2024
Apart from their killer identity, natural (NK) cells have integral roles in shaping the tumor microenvironment. Through immune gene deconvolution, present study revealed an interplay between NK and myeloid-derived suppressor (MDSCs) nonresponders of checkpoint therapy. Given that mechanisms governing outcome cell–to–myeloid cell interactions remain largely unknown, we sought to investigate cross-talk suppressive myeloid cells. Upon contact with tumor-experienced cells, monocytes neutrophils displayed increased expression MDSC-related factors along capacities suppress T These changes were accompanied by impaired antigen presentation ER stress response neutrophils. In a cohort patients sarcoma breast cancer, production interleukin-6 (IL-6) tumor-infiltrating correlated S100A8/9 arginase-1 MDSCs. At same time, cell–derived IL-6 was associated tumors higher major histocompatibility complex class I expression, which further validated b2m -knockout (KO) mice models. Similarly syngeneic wild-type KO mouse models, then demonstrated accumulation MDSCs influenced presence such regulatory Inhibition IL-6/signal transducer activator transcription 3 (STAT3) axis alleviated suppression responses, resulting reduced growth metastatic dissemination. Together, these results characterize critical cell–mediated mechanism drives development during escape.
Language: Английский
Citations
18
Clinical and Translational Medicine, Journal Year: 2023, Volume and Issue: 13(2)
Published: Feb. 1, 2023
Abstract Introduction Cancer‐associated fibroblasts (CAFs) are correlated with the immunotherapy response. However, culprits that link CAFs to resistance still rarely investigated in real‐world studies. Objectives This study aims systematically assess landscape of cancer patients by combining single‐cell and bulk profiling data from pan‐cancer cohorts. We further sought decipher expression, survival predictive value association response biglycan (BGN), a proteoglycan extracellular matrix, multiple Methods Pan‐cancer tumor bulks 27 RNA sequencing cohorts were enrolled investigate correlations crosstalk between or immune cells. Specific secreting factors then identified expression at tissue microdissection, isolated primary level. The role BGN was dissected additional three five datasets validated who have received PD‐1 blockade using immunohistochemistry immunofluorescence. Results closely components. Frequent other cells revealed CellChat analysis. Single‐cell regulatory network inference clustering common distinct regulators for across cancers. determined be specific factor CAFs. served as an unfavourable indicator overall In cohort, high levels presented higher proportion poor compared those low (46.7% vs. 11.8%) lower level infiltrating CD8+ T also observed. Conclusions highlighted importance microenvironment BGN, which is mainly derived CAFs, may applicable clinical practice serve therapeutic target resistance.
Language: Английский
Citations
35