The pharmacology, toxicology, and detoxification of Aconitum kusnezoffii Reichb., traditional and modern views DOI Creative Commons

Kenneth Happy,

Sungyu Yang, Chang-Ho Kang

et al.

Applied Biological Chemistry, Journal Year: 2025, Volume and Issue: 68(1)

Published: Jan. 20, 2025

Language: Английский

Gold nanoparticles and gold nanorods in the landscape of cancer therapy DOI Creative Commons
Prashant Kesharwani,

Ruiyang Ma,

Liang Sang

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: June 21, 2023

Abstract Cancer is a grievous disease whose treatment requires more efficient, non-invasive therapy, associated with minimal side effects. Gold nanoparticles possessing greatly impressive optical properties have been forerunner in bioengineered cancer therapy. This theranostic system has gained immense popularity and finds its application the field of molecular detection, biological imaging, cell targeting, etc. The photothermal property nanoparticles, especially gold nanorods, causes absorption light incident by source, transforms it into heat, resulting tumor destruction. review describes different features summarizes advance research done for precisely nanorods combating various cancers including breast, lung, colon, oral, prostate, pancreatic cancer.

Language: Английский

Citations

164
Engineering siRNA therapeutics: challenges and strategies DOI Creative Commons
Syed Saqib Ali Zaidi, Faria Fatima, Syed Aqib Ali Zaidi

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Oct. 18, 2023

Abstract Small interfering RNA (siRNA) is a potential method of gene silencing to target specific genes. Although the U.S. Food and Drug Administration (FDA) has approved multiple siRNA-based therapeutics, many biological barriers limit their use for treating diseases. Such limitations include challenges concerning systemic or local administration, short half-life, rapid clearance rates, nonspecific binding, cell membrane penetration inability, ineffective endosomal escape, pH sensitivity, endonuclease degradation, immunological responses, intracellular trafficking. To overcome these barriers, various strategies have been developed stabilize siRNA, ensuring delivery site. Chemical modifications implemented with nucleotides phosphate backbone can reduce off-target binding immune stimulation. Encapsulation formulation protect siRNA from degradation enhance cellular uptake while promoting escape. Additionally, techniques such as viral vectors, aptamers, cell-penetrating peptides, liposomes, polymers delivering greatly improving bioavailability therapeutic potential.

Language: Английский

Citations

73
Emerging application of magnetic nanoparticles for breast cancer therapy DOI

Tenzin Tsering Dongsar,

Tenzin Sonam Dongsar,

Mohammed A. S. Abourehab

et al.

European Polymer Journal, Journal Year: 2023, Volume and Issue: 187, P. 111898 - 111898

Published: Feb. 13, 2023

Language: Английский

Citations

65
Advancements in dextran-based nanocarriers for treatment and imaging of breast cancer DOI
Mohammad Sameer Khan, B.H. Jaswanth Gowda, Nazim Nasir

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 643, P. 123276 - 123276

Published: July 27, 2023

Language: Английский

Citations

55
New opportunities for RGD-engineered metal nanoparticles in cancer DOI Creative Commons
Qin Wei,

Jyoti Chandra,

Mohammed A. S. Abourehab

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: May 25, 2023

The advent of nanotechnology has opened new possibilities for bioimaging. Metal nanoparticles (such as gold, silver, iron, copper, etc.) hold tremendous potential and offer enormous opportunities imaging diagnostics due to their broad optical characteristics, ease manufacturing technique, simple surface modification. arginine-glycine-aspartate (RGD) peptide is a three-amino acid sequence that seems have considerably greater ability adhere integrin adhesion molecules exclusively express on tumour cells. RGD peptides act the efficient tailoring ligand with variety benefits including non-toxicity, precision, rapid clearance, etc. This review focuses possibility non-invasive cancer using metal assistance.

Language: Английский

Citations

43
Nanotechnology-empowered strategies in treatment of skin cancer DOI

Jyoti Chandra,

Nazeer Hasan, Nazim Nasir

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 235, P. 116649 - 116649

Published: July 13, 2023

Language: Английский

Citations

42
Targeted delivery systems of siRNA based on ionizable lipid nanoparticles and cationic polymer vectors DOI
Zhao Yao,

Taiqing Liu,

Jingwen Wang

et al.

Biotechnology Advances, Journal Year: 2025, Volume and Issue: 81, P. 108546 - 108546

Published: Feb. 26, 2025

Language: Английский

Citations

2
Advances in siRNA delivery approaches in cancer therapy: challenges and opportunities DOI

Houman Isazadeh,

Farshid Oruji, Shima Shabani

et al.

Molecular Biology Reports, Journal Year: 2023, Volume and Issue: 50(11), P. 9529 - 9543

Published: Sept. 23, 2023

Language: Английский

Citations

33
Self-nanoemulsifying drug delivery system for pancreatic cancer DOI

Neha Parveen,

Afsana Sheikh,

Mohammed A. S. Abourehab

et al.

European Polymer Journal, Journal Year: 2023, Volume and Issue: 190, P. 111993 - 111993

Published: March 15, 2023

Language: Английский

Citations

28
The cubosome-based nanoplatforms in cancer therapy: Seeking new paradigms for cancer theranostics DOI
B.H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Saad Ali Alshehri

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 237, P. 116894 - 116894

Published: Aug. 14, 2023

Language: Английский

Citations

27