Unravelling the potential of mitochondria-targeted liposomes for enhanced cancer treatment

Drug Discovery Today, Journal Year: 2023, Volume and Issue: 29(1), P. 103819 - 103819

Published: Nov. 7, 2023

Language: Английский

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Understanding the theranostic potential of quantum dots in cancer management

Materials Today Communications, Journal Year: 2023, Volume and Issue: 36, P. 106424 - 106424

Published: June 12, 2023

Language: Английский

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Aptamer-grafted, cell membrane-coated dendrimer loaded with doxorubicin as a targeted nanosystem against epithelial cellular adhesion molecule (EpCAM) for triple negative breast cancer therapy

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 86, P. 104745 - 104745

Published: July 7, 2023

Language: Английский

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Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 2, 2024

As a new form of regulated cell death, ferroptosis has unraveled the unsolicited theory intrinsic apoptosis resistance by cancer cells. The molecular mechanism depends on induction oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage structural integrity Due their high loading tunability, nanocarriers can escort delivery ferro-therapeutics desired site enhanced permeation or retention effect active targeting. This review shed light necessity iron in growth fascinating features regulating cycle metastasis. Additionally, we discussed ferroptosis-mediated therapy using nanoplatforms chemical basis overcoming barriers therapy.

Language: Английский

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Designing Multivalent Aptamers: Recent Advancements in Diagnostic and Therapeutic Approaches for Cancer Treatment

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106614 - 106614

Published: Jan. 1, 2025

Language: Английский

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Energy Metabolism and Stemness and the Role of Lauric Acid in Reversing 5-Fluorouracil Resistance in Colorectal Cancer Cells

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 664 - 664

Published: Jan. 14, 2025

While 5-fluorouracil (5FU) plays a central role in chemotherapy for colorectal cancer (CRC), resistance to 5FU remains major challenge CRC treatment, and its underlying mechanisms remain unclear. In this study, we investigated the relationship between acquisition, stemness, energy metabolism. Among two cell lines, HT29 cells exhibited glycolytic quiescent properties, while CT26 relied on oxidative phosphorylation (OXPHOS) energy. contrast, 5FU-resistant sublines (HT29R CT26R), developed through continuous exposure low concentrations of 5FU, demonstrated enhanced stemness. This was associated with dominance, proliferation, reduced reactive oxygen species (ROS) production. However, treatment medium-chain fatty acid lauric shifted OXPHOS, reducing increasing ROS levels, inducing death, therefore reversing resistance. These findings suggest that an enhancement stemness reprogramming metabolism play key roles acquiring CRC. reversed resistance, further clinical studies are required.

Language: Английский

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PLGA nanomedical consignation: A novel approach for the management of prostate cancer

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 652, P. 123808 - 123808

Published: Jan. 14, 2024

Language: Английский

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Cellular and molecular mechanisms of gastrointestinal cancer liver metastases and drug resistance

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 77, P. 101125 - 101125

Published: Aug. 6, 2024

Language: Английский

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Remodeling the tumor immune microenvironment via siRNA therapy for precision cancer treatment

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(5), P. 100852 - 100852

Published: Sept. 1, 2023

How to effectively transform the pro-oncogenic tumor microenvironments (TME) surrounding a into an anti-tumoral never fails attract people study. Small interfering RNA (siRNA) is considered one of most noteworthy research directions that can regulate gene expression following process known as interference (RNAi). The about siRNA delivery targeting cells and TME has been on rise in recent years. Using drugs silence critical proteins was efficient solutions. However, manufacture system faces three major obstacles, i.e., appropriate cargo protection, accurately targeted delivery, site-specific release. In review, we summarized pharmacological actions remolding TME. addition, strategies combination therapy with remodel are thoroughly discussed. meanwhile, advancements development all clinically investigated commercialized technologies also presented. Ultimately, propose nanoparticle drug may be future focus oncogene therapy. This summary offers thorough analysis roadmap for general readers working field.

Language: Английский

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Dasatinib: a potential tyrosine kinase inhibitor to fight against multiple cancer malignancies

Medical Oncology, Journal Year: 2023, Volume and Issue: 40(6)

Published: May 10, 2023

Language: Английский

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