Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120217 - 120217
Published: Feb. 1, 2025
Language: Английский
Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)
Published: May 17, 2024
Lipid accumulation product (LAP) is an accessible and relatively comprehensive assessment of obesity that represents both anatomical physiological lipid accumulation. Obesity psoriasis are potentially related, according to previous research. Investigating the relationship between adult LAP index was goal this study.
Language: Английский
Citations
5
Diseases, Journal Year: 2024, Volume and Issue: 12(6), P. 119 - 119
Published: June 4, 2024
Background: Individuals with hyperinsulinemia may initially not meet any diagnostic criteria for metabolic syndrome, though displaying a higher risk of cardiovascular complications combined obesity, diabetes, and hypertension. Aim: The main objective our study was to assess the accuracy various indices in hyperinsulinemic children adolescents; secondary estimate optimal cut-offs these indices. Patients methods: This retrospective single-center conducted on 139 patients aged 12.1 ± 2.9 years, managed hyperinsulinism. Results: We found statistically significant differences homeostasis model assessment insulin resistance index (HOMA-IR), triglyceride glucose (TyG), TyG-body mass index, visceral adiposity lipid accumulation product fatty liver hepatic steatosis index. At linear logistic regression assessment, we that growth factor-1 (IGF-1), HOMA-IR, ALT/AST ratio were independently associated confirmed multivariate analysis, IGF-1 levels over 203 ng/mL HOMA-IR than 6.2 respectively 9- 18-times odds other investigated parameters significantly related hyperinsulinism, could predict either presence or subsequent patients. Conclusion: Commonly used adults cannot be considered accurate confirming hyperinsulinism children, exception HOMA-IR. Further studies are needed verify usefulness specific adolescents.
Language: Английский
Citations
5
Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)
Published: July 2, 2024
Abstract Background Nonalcoholic fatty liver disease (NAFLD) has become an important health issue in adolescents. Although several parameters and indices have been investigated for the evaluation of NAFLD adults, these are limited In this study, body mass index, waist circumference, triponderal HbA1c, homeostatic model assessment insulin resistance (HOMA-IR), triglyceride/high-density lipoprotein (Tg/HDL), lipid accumulation product (LAP) triglyceride-glucose (TyG) index aminotransferase (AT) were examined together, their diagnostic values clinical treatment compared. Materials methods Seventynine adolescents (10–19 years old) with obesity who admitted to a pediatric clinic between January August 2022 diagnosed exogenous without any comorbidities included study. The presence was evaluated by magnetic resonance imaging. laboratory findings obtained retrospectively from system records. Parameters compared (+) (-) groups. Logistic regression analysis used determine most effective factors treatment. Receiver operating characteristic (ROC) performed significant indices. Sex, HOMA-IR, TyG AT together multivariate design scale. Results greater group ( P = 0.012; 0.001; 0.002, respectively). There positive correlation fat percentage Tg/HDL. According analysis, male sex elevated HOMA-IR determined be risk NAFLD. A probability scale 4 [sex, alanine (ALT)] designed 82.5% specificity 80% sensitivity. Conclusion Evaluation indices, especially high-risk patients, will support diagnosis via ultrasonography. ALT, TyG, data accuracy may aid obesity.
Language: Английский
Citations
5
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: Oct. 3, 2024
This study aims to investigate the relationship between lipid accumulation product (LAP) index and total femur bone mineral density (BMD), while also examining mediating role of poverty-income ratio (PIR).
Language: Английский
Citations
5
European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)
Published: May 10, 2023
Abstract Purpose Diabetes is the leading cause of kidney disease. Up to 40% population with diabetes experience diabetic disease (DKD). The correlation DKD insulin resistance (IR) indices has been shown in previous studies. In this study, objective was evaluate surrogate IR indices, including Triglyceride-Glucose (TyG) index, Visceral Adiposity Index (VAI), Lipid Accumulation Product (LAP), and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) find most valuable index for between albuminuria type 2 (T2D) population. Albuminuria defined as urine albumin excretion > 30 mg/day. Methods cross-sectional 2934 participants were enrolled evaluated urinary excretion, detected 526 entries. logistic regression models Receiver Operating Characteristic (ROC) curve analysis performed assess relationship TyG VAI, LAP, HOMA-IR's patients T2D. Results had highest association (OR 1.67) presence T2D, followed by HOMA-IR 1.127), VAI 1.028), LAP 1.004). These four remained independent after adjustment multiple confounders. Based on ROC curve, revealed best area under (AUC) revealing sufficient accuracy (AUC: 0.62) comparison other measured indices. calculated cut-off point 9.39. Conclusion Among significant
Language: Английский
Citations
11
International Urology and Nephrology, Journal Year: 2024, Volume and Issue: 56(6), P. 1825 - 1833
Published: Jan. 27, 2024
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 3, 2024
Abstract Metabolic syndrome (MetS) is closely associated with adverse cardiometabolic outcomes. The objective of this study was to identify practical methods that could enable the effective identification MetS based on anthropometric indices. basis our involved retrospective database obtained from routine medical prophylactic examinations. This a cross-sectional health status male workers employed in hazardous working conditions at industrial enterprises Ural region conducted 2019. A total 347 under were investigated. presence established by healthcare professional accordance guidelines International Diabetes Federation (IDF). Simple linear regression used evaluate associations between indices and incidence. Logistic determine odds ratios relation increases ROC curves calculated compare ability each index predict diagnostic thresholds indicators considered. According IDF criteria, 36.3% had MetS. direct relationship found individual components studied. highest OR shown Body Roundness Index (BRI) 2.235 (95% CI 1.796–2.781). For different age quartiles, optimal cut-off values for predicting as follows: BRI, 4.1–4.4 r.u.; body shape (ABSI), 0.080–0.083 m 11/6 kg −2/3 ; lipid accumulation product (LAP), 49.7–70.5 cm mmol/l. most significant observed where greater than these points (Se = 97.4%). results demonstrated rapid use new indicators, which have good predictive are quite easy use.
Language: Английский
Citations
4
BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)
Published: Oct. 15, 2024
The presence of hypertension significantly increases the risk diabetes, particularly type 2 diabetes. Recently, Visceral Adiposity Index (VAI) has been introduced as a straightforward and robust alternative indicator for early detection metabolic syndrome, cardiovascular disease, T2DM. adiposity, more dangerous than subcutaneous fat, is associated with syndrome diseases. VAI Lipid Accumulation Product (LAP) are indices that quantify visceral fat lipid overaccumulation, respectively. This study aims to explore association between VAI, LAP, diabetes mellitus (T2DM) in US adults using NHANES data from 2005 2018.
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Dec. 30, 2024
Language: Английский
Citations
4
Asian Journal of Pharmaceutical and Clinical Research, Journal Year: 2025, Volume and Issue: unknown, P. 22 - 29
Published: Jan. 7, 2025
Objective: This is a systematic review and meta-analysis that aims to evaluate the prevalence of non-alcoholic fatty liver disease (NAFLD) risk factors such as type 2 diabetes mellitus (T2DM), hypertension, obesity, PCOS, sleep apnea associated with it. NAFLD one most prevalent diseases affect approximately 40% diabetic, hypertensive, dyslipidemic obese individuals. Its asymptomatic nature often leads under diagnosis progress severe cirrhosis hepatocellular carcinoma. Methods: A total 1819 studies from database 2019 2024 were identified, finally 10 selected, Statistical Package for Social Sciences software was used data analysis. Results: The analyses across different geographic regions 620,3969 patients NAFLD, T2DM came out be 15% among males, whereas 22.2% in females. 52.55% noted population 26.74% lean individuals, PCOS 43%, metabolic syndrome 75.3%, various also identified. Conclusion: throws light on focusing need increased awareness screening people at risk, strategies could help avert progression.
Language: Английский
Citations
0