Altered metabolism in cancer: insights into energy pathways and therapeutic targets

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 18, 2024

Language: Английский

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Targeting lipid metabolism in regulatory T cells for enhancing cancer immunotherapy

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189259 - 189259

Published: Jan. 1, 2025

As immunosuppressive cells, Regulatory T cells (Tregs) exert their influence on tumor immune escape within the microenvironment (TME) by effectively suppressing activity of other thereby significantly impeding anti-tumor response. In recent years, metabolic characteristics Tregs have become a focus research, especially important role lipid metabolism in maintaining function Tregs. Consequently, targeted interventions aimed at modulating been recognized as an innovative and promising approach to enhance effectiveness immunotherapy. This review presents comprehensive overview pivotal regulating Tregs, with specific targeting augment responses. Furthermore, we discuss potential opportunities challenges associated this strategy, aiming provide novel insights for enhancing efficacy cancer

Language: Английский

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Unraveling the intricate relationship between lipid metabolism and oncogenic signaling pathways

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: June 12, 2024

Lipids, the primary constituents of cell membrane, play essential roles in nearly all cellular functions, such as cell-cell recognition, signaling transduction, and energy provision. Lipid metabolism is necessary for maintenance life since it regulates balance between processes synthesis breakdown. Increasing evidence suggests that cancer cells exhibit abnormal lipid metabolism, significantly affecting their malignant characteristics, including self-renewal, differentiation, invasion, metastasis, drug sensitivity resistance. Prominent oncogenic pathways modulate metabolic gene expression elevate enzyme activity include phosphoinositide 3-kinase (PI3K)/AKT, MAPK, NF-kB, Wnt, Notch, Hippo pathway. Conversely, when are not regulated, they can lead to malfunctions signal transduction pathways. This, turn, enables uncontrolled growth by providing energy, building blocks, redox potentials. Therefore, targeting metabolism-associated could be an effective therapeutic approach decrease incidence promote survival. This review sheds light on interactions reprogramming cancer. Exploring a target provide promising creating anticancer treatments identifying inhibitors. Additionally, we have also provided overview drugs this review.

Language: Английский

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The Age‐Dependent Anticancer Efficacy of Agaricus blazei Murill Polysaccharide in Colon Cancer

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

ABSTRACT Agaricus blazei Murill polysaccharide (ABMP) has been found to exhibit significant immune regulatory effects, making them a promising candidate for complementary the pharmacological treatment of colorectal cancer immune‐related diseases. As prevalence among younger individuals increases, possible age‐dependent anticancer modulatory effect ABMP not clarified. This study evaluated immunoregulatory efficacy polysaccharides extraction from A. in colon tumor. Hematoxylin‐eosin staining, immunohistochemistry, and vibrational spectroscopic image analysis subcutaneous tumor tissues after preventive intervention 14 weeks were analyzed depth. In vivo data demonstrated that could more effectively inhibit growth mice at 8 compared with 12 months old without toxic side effect. Concurrently, Raman imaging spectroscopy showed significantly reduce lipid content microenvironment (TME) 8‐month‐old tumor‐bearing mice, suggesting changes TME are closely related activity. These results stress importance considering age as factor adjuvant therapy. work highlights first time is key determinant effectiveness by affecting levels thereby exerting

Language: Английский

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The Role of Inflammation in Cancer: Mechanisms of Tumor Initiation, Progression, and Metastasis

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 488 - 488

Published: March 25, 2025

Inflammation is an essential component of the immune response that protects host against pathogens and facilitates tissue repair. Chronic inflammation a critical factor in cancer development progression. It affects every stage tumor development, from initiation promotion to invasion metastasis. Tumors often create inflammatory microenvironment induces angiogenesis, suppression, malignant growth. Immune cells within interact actively with cells, which drives progression through complex molecular mechanisms. triggered by factors such as infections, obesity, environmental toxins strongly linked increased risk. However, acute responses can sometimes boost antitumor immunity; thus, presents both challenges opportunities for therapeutic intervention. This review examines how contributes biology, emphasizing its dual role tumorigenesis potential target.

Language: Английский

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Role of metabolic transformation in cancer immunotherapy resistance: molecular mechanisms and therapeutic implications

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 2, 2025

Immunotherapy in the treatment of cancer, with immune inhibitors helps many cancer types. Many patients still encounter resistance to these treatments, though. This is mediated by metabolic changes tumour microenvironment and cells. The development novel treatments overcome boost immunotherapy's effectiveness depends on changes. review concentrates molecular mechanisms through which transformation contributes immunotherapy resistance. Additionally, research therapeutic approaches that target pathways enhance for We used databases available PubMed, Scopus, Web Science perform a thorough peer-reviewed literature. focusing tumor microenvironment, mechanisms, metabolism. study covers oxidative phosphorylation, glycolysis, lipid metabolism, amino acid An immunosuppressive produced cells, such as dysregulated enhanced glutaminolysis, increased glycolysis (Warburg effect). Myeloid-derived suppressor cells regulatory T are promoted, responses suppressed, cell activity impaired when lactate other metabolites build up. metabolism acids arginine tryptophan, nutrients crucial function. By enhancing their function alterations aid checkpoint inhibitors. Metabolic change plays key role Gaining knowledge processes can help develop efficient improve effectiveness. In order determine best targets intervention, future studies should concentrate patient-specific profiling.

Language: Английский

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Biocompatible lipid nanovehicles for preventive and therapeutic vaccine development

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 538, P. 216718 - 216718

Published: April 22, 2025

Language: Английский

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Comprehensive analysis of plasma cell heterogeneity and immune interactions in multiple myeloma

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

This study focused on the role of plasma cells in multiple myeloma (MM) and associated potential mechanisms. Transcriptomic data MM various gene sets from several public databases were downloaded for subsequent analyses. Through single-cell sequencing, 10 major cell types identified annotated. The differential expression pathway enrichment between different subtypes as well communication analysis, transcriptional regulation analysis conjunction with malignant subpopulation performed. Next, samples clustered into two groups by applying non-negative matrix factorization (NMF). Additional revealed notable disparities survival clusters, correlation genes involved classical metabolic pathways dysregulation, thus confirming stability validity clustering. Subsequently, Weighted Gene Co-expression Network Analysis was performed hub modules most strongly clustering extracted. We then constructed a prognostic prediction model using Least Absolute Shrinkage Selection Operator multiCox regression analysis. predictive accuracy evaluated robustness confirmed separate validation cohort. dysregulation risk analyzed. Ultimately, an investigation conducted association immunological features, terms antitumor immunotherapy, tumor microenvironment, immune checkpoints. provides in-depth mechanisms underlying development offers new directions to improve therapeutic approaches enhance patient outcomes.

Language: Английский

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Obesity-Associated Colorectal Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8836 - 8836

Published: Aug. 14, 2024

Colorectal cancer (CRC) affects approximately 2 million people worldwide. Obesity is the major risk factor for CRC. In addition, obesity contributes to a chronic inflammatory stage that enhances tumor progression through secretion of proinflammatory cytokines. addition an increased response, obesity-associated presents accrued molecular factors related characteristics, such as genome instability, sustained cell proliferation, telomere dysfunctions, angiogenesis, and microbial alteration, among others. Despite evidence accumulated over last few years, treatments CRC do not differ from in normal-weight individuals. this review, we summarize current knowledge on cancer, including its epidemiology, factors, treatments. Finally, enumerate possible new therapeutic targets may improve conditions obese patients. key development CRC, resulting reversal should be considered strategy improving antineoplastic therapies.

Language: Английский

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The shared genetic landscape of polycystic ovary syndrome and breast cancer: convergence on ER + breast cancer but not ER- breast cancer

Breast Cancer Research, Journal Year: 2024, Volume and Issue: 26(1)

Published: Nov. 25, 2024

The clinically high comorbidity between polycystic ovary syndrome (PCOS) and breast cancer (BC) has been extensively reported. However, limited knowledge exists regarding their shared genetic basis underlying mechanisms. Leveraging summary statistics from the largest genome-wide association studies (GWASs) to date, we conducted a comprehensive cross-trait analysis of PCOS BC. A variety statistical methods were employed uncover potential causes. Our revealed overlap three trait pairs. After partitioning genome into 2,495 independent regions, identified two loci, chr8: 75,011,700–76,295,483 chr17: 6,305,079–7,264,458, with significant localized correlations. Pleiotropic under composite null hypothesis 1,183 pleiotropic single nucleotide polymorphisms (SNPs) across FUMA mapped 26 regions 16q12.2 6q25.1 duplicated all pairs, while COLOC detected loci colocalization evidence. Gene-based 23 unique candidate genes, including FTO by as well SER1, RALB, others in Pathway enrichment further highlighted key biological pathways, primarily involving pathways metabolism regulation autophagy, cellular catabolic process, positive process. Latent Heritable Confounder Mendelian randomization (LHC-MR) supported causal relationship both BCALL ERPBC but not ERNBC. In conclusion, our BC, specific identical mechanisms causality various BC subtypes, which could better explains genetics co-morbidity rather than These findings provide new insights these complex diseases, have important implications for clinical disease intervention, treatment, improved prognosis.

Language: Английский

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