Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
206, P. 107308 - 107308
Published: July 15, 2024
Glioma
is
the
most
common
intracranial
malignant
tumor,
with
severe
difficulty
in
treatment
and
a
low
patient
survival
rate.
Due
to
heterogeneity
invasiveness
of
tumors,
lack
personalized
clinical
design,
physiological
barriers,
it
often
difficult
accurately
distinguish
gliomas,
which
dramatically
affects
subsequent
diagnosis,
imaging
treatment,
prognosis.
Fortunately,
nano-delivery
systems
have
demonstrated
unprecedented
capabilities
diagnosing
treating
gliomas
recent
years.
They
been
modified
surface
efficiently
traverse
BBB/BBTB,
target
lesion
sites,
intelligently
release
therapeutic
or
contrast
agents,
thereby
achieving
precise
treatment.
In
this
review,
we
focus
on
systems.
Firstly,
provide
an
overview
standard
emerging
diagnostic
technologies
for
glioma
practice.
After
induction
analysis,
summarizing
delivery
methods
drug
systems,
design
nanoparticles,
their
new
advances
Finally,
discussed
prospects
potential
challenges
drug-delivery
glioma.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(20)
Published: April 23, 2024
Gliomas,
the
most
prevalent
primary
brain
tumors,
pose
considerable
challenges
due
to
their
heterogeneity,
intricate
tumor
microenvironment
(TME),
and
blood-brain
barrier
(BBB),
which
restrict
effectiveness
of
traditional
treatments
like
surgery
chemotherapy.
This
review
provides
an
overview
engineered
cell
membrane
technologies
in
glioma
therapy,
with
a
specific
emphasis
on
targeted
drug
delivery
modulation
immune
microenvironment.
study
investigates
progress
membranes,
encompassing
physical,
chemical,
genetic
alterations,
improve
across
BBB
effectively
target
gliomas.
The
examination
focuses
interaction
membrane-coated
nanoparticles
(ECM-NPs)
TME
gliomas,
emphasizing
potential
modulate
behavior
enhance
therapeutic
efficacy.
further
explores
involvement
ECM-NPs
immunomodulation
techniques,
highlighting
impact
reactions.
While
facing
obstacles
related
stability
manufacturing
scalability,
outlines
forthcoming
research
directions
focused
enhancing
performance.
underscores
promise
surpassing
conventional
constraints,
proposing
novel
approaches
for
efficacious
treatment.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 4533 - 4568
Published: May 1, 2024
Until
now,
there
has
been
a
lack
of
effective
strategies
for
cancer
treatment.
Immunotherapy
high
potential
in
treating
several
cancers
but
its
efficacy
is
limited
as
monotherapy.
Chemoimmunotherapy
(CIT)
holds
promise
to
be
widely
used
Therefore,
identifying
their
involvement
and
synergy
CIT
approaches
decisive.
Nano-based
drug
delivery
systems
(NDDSs)
are
ideal
because
they
can
simultaneously
target
immune
cells
cells,
promoting
accumulation,
reducing
the
toxicity
drug.
In
this
review,
we
first
introduce
five
current
immunotherapies,
including
checkpoint
blocking
(ICB),
adoptive
cell
transfer
therapy
(ACT),
vaccines,
oncolytic
virus
(OVT)
cytokine
therapy.
Subsequently,
immunomodulatory
effects
chemotherapy
by
inducing
immunogenic
death
(ICD),
tumor
killer
infiltration,
down-regulating
immunosuppressive
inhibiting
checkpoints
have
described.
Finally,
NDDSs-mediated
collaborative
introduced
detail,
development
nanoparticles
prospected.
Biomaterials Science,
Journal Year:
2022,
Volume and Issue:
10(14), P. 3911 - 3923
Published: Jan. 1, 2022
Ferroptosis
is
an
emerging
form
of
programmed
cell
death,
and
its
combination
with
sonodynamic
therapy
(SDT)
for
anti-tumor
activity
gradually
attracting
attention.
However,
their
application
against
gliomas
has
not
been
studied.
Herein,
multifunctional
cancer
homologous
targeting
biomimetic
nanoparticles
(PIOC@CM
NPs)
encapsulating
both
Fe3O4
Ce6
were
constructed
as
a
nanosonosensitizer.
Based
on
focused
ultrasound
(US)
combined
circulating
microbubbles
(MBs)
to
open
the
blood-brain
barrier
(BBB)
in
safe
transient
manner,
development
therapeutic
strategy
integrate
nanosonosensitizer-mediated
SDT
ferroptosis
could
achieve
synergistic
effects
gliomas.
We
demonstrated
that
glioma
C6
membrane
(CM)
surface
NPs
allowed
nanosonosensitizer
accumulate
selectively
tumors
through
vitro.
After
efficient
internalization
cells,
PIOC@CM
significantly
increase
level
reactive
oxygen
species
(ROS)
deplete
glutathione
(GSH)
upon
ultrasonic
irradiation,
resulting
loss
peroxidase-4
(GPX4)
activity,
which
facilitated
kill
cells.
Furthermore,
intravenously
injected
after
noninvasively
opening
BBB
via
US-MBs,
enhanced
accumulation
tumor
tissues.
Crucially,
attractive
phenomenon
significant
reduction
orthotopic
second
US
pulse-triggered
was
observed.
Taken
together,
this
study
presents
novel
combinatorial
based
noninvasive
sonotheranostic
system-mediated
ferroptosis.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(24), P. 24593 - 24618
Published: Dec. 6, 2023
Tumor
immunotherapy
is
a
safe
and
effective
strategy
for
precision
medicine.
However,
most
cancer
cases
still
ends
in
failure,
with
the
root
causes
of
immunosuppressive
extraordinary
heterogeneity
solid
tumors
microenvironment.
The
emerging
biomimetic
nanodelivery
system
provides
promising
tactic
to
improve
effect
while
reducing
adverse
reactions
on
nontarget
cells.
Herein,
we
summarize
relationship
between
tumor
occurrence
immune
microenvironment,
mechanism
escape,
classification
(including
adoptive
cellular
therapy,
cytokines,
vaccines,
checkpoint
inhibitors)
recommend
target
cells
first,
then
emphatically
introduce
recent
advances
applications
latest
systems
(e.g.,
cells,
erythrocytes,
platelets,
bacteria)
immunotherapy.
Meanwhile,
separately
application
vaccines.
Finally,
predictable
challenges
perspectives
forward
exploration
are
also
discussed.
