Extracellular vesicle-loaded hydrogels for tissue repair and regeneration

Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100522 - 100522

Published: Dec. 21, 2022

Extracellular vesicles (EVs) are a collective term for nanoscale or microscale secreted by cells that play important biological roles. Mesenchymal stem class of with the potential self-healing and multidirectional differentiation. In recent years, numerous studies have shown EVs, especially those mesenchymal cells, can promote repair regeneration various tissues and, thus, significant in regenerative medicine. However, due to rapid clearance capacity circulatory system, EVs barely able act persistently at specific sites target tissues. Hydrogels good biocompatibility loose porous structural properties allow them serve as EV carriers, thereby prolonging retention certain areas slowing release EVs. When needed function sites, EV-loaded hydrogels stand an excellent approach. this review, we first introduce sources, roles, extraction characterization methods describe their current application status. We then review different types discuss factors influencing abilities carry summarize several strategies loading into characterizing hydrogels. Furthermore, applications tissue repair. This article concludes summary state research on outlook future directions, which hope will provide promising ideas researchers.

Language: Английский

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All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: March 2, 2023

Abstract Macrophages are highly heterogeneous and exhibit a diversity of functions phenotypes. They can be divided into pro‐inflammatory macrophages (M1) anti‐inflammatory (M2). Diabetic wounds characterized by prolonged inflammatory phase difficulty in healing due to the accumulation wound. Therefore, hydrogel dressings with macrophage heterogeneity regulation function hold great promise promoting diabetic wound clinical applications. However, precise conversion M1 M2 simple biosafe approaches is still challenge. Here, an all‐natural ability regulate developed promote angiogenesis healing. The protocatechuic aldehyde hybridized collagen‐based exhibits good bioadhesive antibacterial properties as well reactive oxygen species scavenging ability. More importantly, able convert without need for any additional ingredients or external intervention. This safe immunomodulatory approach shows application potential shortening repair accelerating

Language: Английский

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Sustained release of magnesium and zinc ions synergistically accelerates wound healing

Bioactive Materials, Journal Year: 2023, Volume and Issue: 26, P. 88 - 101

Published: Feb. 24, 2023

Skin wounds are a major medical challenge that threaten human health. Functional hydrogel dressings demonstrate great potential to promote wound healing. In this study, magnesium (Mg) and zinc (Zn) introduced into methacrylate gelatin (GelMA) via low-temperature magnetic stirring photocuring, their effects on skin the underlying mechanisms investigated. Degradation testing confirmed GelMA/Mg/Zn released ions (Mg2+) (Zn2+) in sustained manner. The Mg2+ Zn2+ not only enhanced migration of fibroblasts (HSFs) immortalized keratinocytes (HaCats), but also promoted transformation HSFs myofibroblasts accelerated production remodeling extracellular matrix. Moreover, healing full-thickness defects rats collagen deposition, angiogenesis re-epithelialization. We identified through which healing: entry increased concentration HSFs, effectively induced differentiate by activating STAT3 signaling pathway. synergistic effect conclusion, our study provides promising strategy for regeneration.

Language: Английский

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Construction of multifunctional wound dressings with their application in chronic wound treatment

Biomaterials Science, Journal Year: 2022, Volume and Issue: 10(15), P. 4058 - 4076

Published: Jan. 1, 2022

Multifunctional wound dressings or smart with pro-angiogenic function, antibacterial properties, anti-inflammatory/antioxidant activity and tissue adhesion for chronic repair.

Language: Английский

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Transdermal drug delivery via microneedles to mediate wound microenvironment

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 195, P. 114753 - 114753

Published: Feb. 23, 2023

Language: Английский

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Intelligent biobased hydrogels for diabetic wound healing: A review

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149493 - 149493

Published: Feb. 10, 2024

Language: Английский

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Human urine-derived stem cell exosomes delivered via injectable GelMA templated hydrogel accelerate bone regeneration

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100569 - 100569

Published: Feb. 1, 2023

The key to critical bone regeneration in tissue engineering relies on an ideal bio-scaffold coated with a controlled release of growth factors. Gelatin methacrylate (GelMA) and Hyaluronic acid (HAMA) have been novel topic interest while introducing appropriate nano-hydroxyapatite (nHAP) improve its mechanical properties. And the exosomes derived from human urine-derived stem cells (human USCEXOs) also reported promote osteogenesis engineering. present study aimed design new GelMA-HAMA/nHAP composite hydrogel as drug delivery system. USCEXOs were encapsulated slow-released for better osteogenesis. characterization GelMA-based showed excellent performance vitro studies that USCEXOs/GelMA-HAMA/nHAP could marrow mesenchymal (BMSCs) angiogenesis endothelial progenitor (EPCs), respectively. Meanwhile, vivo results confirmed this significantly defect repair cranial rat model. In addition, we found can formation H-type vessels area, enhancing therapeutic effect. conclusion, our findings suggested controllable biocompatible may effectively by coupling angiogenesis.

Language: Английский

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Current status and progress in research on dressing management for diabetic foot ulcer

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 17, 2023

Diabetic foot ulcer (DFU) is a major complication of diabetes and associated with high risk lower limb amputation mortality. During their lifetime, 19%–34% patients can develop DFU. It estimated that 61% DFU become infected 15% those require amputation. Furthermore, developing increases the mortality by 50%–68% at 5 years, higher than some cancers. Current standard management includes surgical debridement, use topical dressings wound decompression, vascular assessment, glycemic control. Among these methods, local treatment builds protective physical barrier, maintains moist environment, drains exudate from wounds. This review summarizes development, pathophysiology, healing mechanisms The latest research progress main application in laboratory clinical stage are also summarized. discussed this include traditional (gauze, oil yarn, Chinese medicine, others), basic (hydrogel, hydrocolloid, sponge, foam, film agents, bacteriostatic dressings, composite (collagen, nanomaterials, chitosan bioactive (scaffold stem cells, decellularized matrix, autologous platelet enrichment plasma, modern technology (3D bioprinting, photothermal effects, bioelectric microneedle smart bandages, orthopedic prosthetics regenerative medicine). dressing challenges limitations purpose to help readers understand pathogenesis mechanism DFU, physicians select correctly, provide an updated overview potential biomaterials devices management, ideas for further exploration development dressings. Proper promote healing, reduce cost treating patient pain.

Language: Английский

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Extracellular vesicles and their engineering strategies, delivery systems, and biomedical applications

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 365, P. 1089 - 1123

Published: Jan. 1, 2024

Language: Английский

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Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects

Engineering, Journal Year: 2023, Volume and Issue: unknown

Published: June 1, 2023

Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly deliver therapeutics to site lesions, resulting in increased therapeutic efficacy while having minimum side effects. MNs are different kinds (e.g., small molecules, macromolecules, nanomedicines, living cells, bacteria, and exosomes) treating various disorders, including superficial tumors, wounds, infections, inflammatory diseases, abnormal appearance. The improved by integrating advantages multiple perform combination therapy. Through careful designing, further modified with biomimetic structures responsive drug release from internal external stimuli enhance transdermal delivery efficiency robust outcomes. Some studies have proposed use drug-free a promising mechanotherapeutic strategy promote wound healing, scar removal, hair regeneration via mechanical communication pathway. Although several advantages, practical application suffers problems related industrial manufacture clinical evaluation, making it difficult translation. In this study, we summarized applications, emerging challenges, developmental prospects provide information on ways advance

Language: Английский

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