Clinical & Experimental Metastasis,
Journal Year:
2024,
Volume and Issue:
41(5), P. 567 - 587
Published: March 15, 2024
Abstract
As
a
major
energy
source
for
cells,
mitochondria
are
involved
in
cell
growth
and
proliferation,
as
well
migration,
fate
decisions,
many
other
aspects
of
cellular
function.
Once
thought
to
be
irreparably
defective,
mitochondrial
function
cancer
cells
has
found
renewed
interest,
from
suggested
potential
clinical
biomarkers
mitochondria-targeting
therapies.
Here,
we
will
focus
on
the
effect
movement
breast
progression.
Mitochondria
move
both
within
cell,
such
localize
areas
high
energetic
need,
between
where
stroma
have
been
shown
donate
their
via
multiple
methods
including
tunneling
nanotubes.
The
donation
seen
increase
aggressiveness
chemoresistance
which
increased
recent
efforts
uncover
mechanisms
transfer.
metabolism
energetics
gaining
attention
targets,
better
understanding
implications
required
developing
effective,
targeted
therapeutics
patients.
Expert Opinion on Therapeutic Targets,
Journal Year:
2023,
Volume and Issue:
27(9), P. 807 - 816
Published: Sept. 2, 2023
Introduction
Exosomes
are
cell-derived
nanovesicles
involved
in
cell-to-cell
communications.
These
generally
considered
to
contain
important
carriers
of
information
such
as
DNA
and
RNA,
show
specific
tropism.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
25(1), P. 485 - 485
Published: Dec. 29, 2023
Extracellular
vesicles
(EVs)
are
nanoparticles
released
from
various
cell
types
that
have
emerged
as
powerful
new
therapeutic
option
for
a
variety
of
diseases.
EVs
involved
in
the
transmission
biological
signals
between
cells
and
regulation
processes,
highlighting
them
potential
novel
targets/platforms
therapeutics
intervention
and/or
delivery.
Therefore,
it
is
necessary
to
investigate
aspects
EVs'
biogenesis,
biodistribution,
metabolism,
excretion
well
safety/compatibility
both
unmodified
engineered
upon
administration
different
pharmaceutical
dosage
forms
delivery
systems.
In
this
review,
we
summarize
current
knowledge
essential
physiological
pathological
roles
organs
organ
We
provide
an
overview
regarding
application
targets,
therapeutics,
drug
platforms.
also
explore
approaches
implemented
over
years
improve
specific
EV
products
routes.
Clinical & Experimental Metastasis,
Journal Year:
2024,
Volume and Issue:
41(5), P. 567 - 587
Published: March 15, 2024
Abstract
As
a
major
energy
source
for
cells,
mitochondria
are
involved
in
cell
growth
and
proliferation,
as
well
migration,
fate
decisions,
many
other
aspects
of
cellular
function.
Once
thought
to
be
irreparably
defective,
mitochondrial
function
cancer
cells
has
found
renewed
interest,
from
suggested
potential
clinical
biomarkers
mitochondria-targeting
therapies.
Here,
we
will
focus
on
the
effect
movement
breast
progression.
Mitochondria
move
both
within
cell,
such
localize
areas
high
energetic
need,
between
where
stroma
have
been
shown
donate
their
via
multiple
methods
including
tunneling
nanotubes.
The
donation
seen
increase
aggressiveness
chemoresistance
which
increased
recent
efforts
uncover
mechanisms
transfer.
metabolism
energetics
gaining
attention
targets,
better
understanding
implications
required
developing
effective,
targeted
therapeutics
patients.
