Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 192, P. 106722 - 106722
Published: May 28, 2024
Language: Английский
Applied Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 108(1)
Published: Jan. 19, 2024
Language: Английский
Citations
13
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 9, 2025
A significant global health crisis is predicted to emerge due antimicrobial resistance by 2050, with an estimated 10 million deaths annually. Increasing antibiotic necessitates continuous therapeutic innovation as conventional treatments become increasingly ineffective. The naturally occurring antibacterial, antifungal, and antiviral compounds offer a viable alternative synthetic antibiotics. This review presents bacterial mechanisms, nanocarriers for drug delivery, plant-based nanoformulations, particularly nanoantibiotics (nAbts). Green synthesis of nanoparticles has emerged revolutionary approach, it enhances the effectiveness, specificity, transport encapsulated antimicrobials. In addition minimizing systemic side effects, these can maximize impact delivering antimicrobials directly infection site. Furthermore, combining two or more antibiotics within often exhibits synergistic enhancing effectiveness against drug-resistant bacteria. Antimicrobial agents are routinely obtained from secondary metabolites plants, including essential oils, phenols, polyphenols, alkaloids, others. Integrating antibacterial antibiotics, assisted suitable codelivery, potential solution addressing resistance. increasing their boosting immune system, this approach provides safer effective method tackling future infections.
Language: Английский
Citations
1
Infection and Drug Resistance, Journal Year: 2025, Volume and Issue: Volume 18, P. 1007 - 1033
Published: Feb. 1, 2025
The increasing incidence of antibiotic resistance in Staphylococcus aureus (S. aureus) poses a substantial threat to global public health. In recent decades, the evolution bacteria and misuse antibiotics have led progressive development drug S. aureus, resulting worldwide rise methicillin-resistant (MRSA) infection rates. Understanding molecular mechanisms underlying staphylococcal resistance, treatments for infections, efficacy nanomaterials addressing multi-drug is crucial. This review explores mechanisms, which include limiting uptake, target modification, inactivation through production degrading enzymes, active efflux drugs. It also examines current therapeutic strategies, such as combination therapy, phage monoclonal antibody nanoparticle with particular emphasis on role silver-based nanomaterials. Nanoparticles possess ability overcome offering novel avenue management drug-resistant bacteria. demonstrated potent antibacterial activity against various including cell membrane disruption, generation reactive oxygen species (ROS), inhibition essential cellular processes. highlights need further research optimize design, enhance their potency, ensure biocompatibility biodegradability. ultimately concludes by emphasizing importance multifaceted approach treatment, new antibiotics, investment stewardship programs prevent misuse, exploration natural compounds bacteriocins potential antimicrobial agents.
Language: Английский
Citations
1
ECS Journal of Solid State Science and Technology, Journal Year: 2024, Volume and Issue: 13(4), P. 047002 - 047002
Published: April 1, 2024
Multidrug resistance (MDR) is a significant global challenge requiring strategic solutions to address bacterial infections. Recent advancements in nanotechnology, particularly the synthesis of zinc oxide nanoparticles (ZnO NPs) using natural agents as stabilizers and reducing agents, have shown promising results combating MDR. These possess strong antimicrobial properties against different strains Gram-positive Gram-negative, making them suitable for various industries, including food, pharmaceuticals, coatings, medical devices. ZnO-NPs work by generating reactive oxygen species, releasing ions (Zn2+), disrupting cell membrane, interfering with metabolic processes genetic material, inducing oxidative stress apoptosis. However, more research needed refine techniques, control size morphology, increase antibacterial efficacy. To fully understand their potential, interactions proteins, DNA, walls must also be examined. Investigating synergistic potential biogenic ZnO NPs conventional treatments could enhance therapeutic effectiveness while minimizing risk emergence. Here we provide insight into bio extracts applications well factors affecting process characterization techniques NPs. studies on activity pathogens mechanisms action are discussed. Furthermore, highlighted.
Language: Английский
Citations
8
Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 192, P. 106722 - 106722
Published: May 28, 2024
Language: Английский
Citations
8