Cell Communication and Signaling,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: May 8, 2023
Hematopoietic
stem
cells
(HSCs)
are
known
for
their
significant
capability
to
reconstitute
and
preserve
a
functional
hematopoietic
system
in
long-term
periods
after
transplantation
into
conditioned
hosts.
HSCs
thus
crucial
cellular
targets
the
continual
repair
of
inherited
hematologic,
metabolic,
immunologic
disorders.
In
addition,
can
undergo
various
fates,
such
as
apoptosis,
quiescence,
migration,
differentiation,
self-renewal.
Viruses
continuously
pose
remarkable
health
risk
request
an
appropriate,
balanced
reaction
from
our
immune
system,
which
well
affects
bone
marrow
(BM).
Therefore,
disruption
due
viral
infection
is
essential.
patients
whom
risk-to-benefit
ratio
HSC
(HSCT)
acceptable
have
seen
increase
use
HSCT
recent
years.
suppression,
BM
failure,
exhaustion
all
linked
chronic
infections.
Virus
infections
continue
be
leading
cause
morbidity
mortality
recipients,
despite
advancements
field.
Furthermore,
whereas
COVID-19
manifests
initially
respiratory
tract,
it
now
understood
systemic
illness
that
significantly
impacts
hematological
system.
Patients
with
advanced
often
thrombocytopenia
blood
hypercoagulability.
era
COVID-19,
Hematological
manifestations
(i.e.,
lymphopenia),
response,
may
affected
by
SARS-CoV-2
virus
ways.
important
determine
whether
exposure
affect
used
HSCT,
this,
turn,
engraftment
efficiency.
this
article,
we
reviewed
features
HSCs,
effects
on
SARS-CoV-2,
HIV,
cytomegalovirus,
Epstein-Barr
virus,
etc.
Video
Abstract.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 21, 2024
Abstract
Inflammation-associated
diseases
encompass
a
range
of
infectious
and
non-infectious
inflammatory
diseases,
which
continuously
pose
one
the
most
serious
threats
to
human
health,
attributed
factors
such
as
emergence
new
pathogens,
increasing
drug
resistance,
changes
in
living
environments
lifestyles,
aging
population.
Despite
rapid
advancements
mechanistic
research
development
for
these
current
treatments
often
have
limited
efficacy
notable
side
effects,
necessitating
more
effective
targeted
anti-inflammatory
therapies.
In
recent
years,
nanotechnology
has
provided
crucial
technological
support
prevention,
treatment,
detection
inflammation-associated
diseases.
Various
types
nanoparticles
(NPs)
play
significant
roles,
serving
vaccine
vehicles
enhance
immunogenicity
carriers
improve
targeting
bioavailability.
NPs
can
also
directly
combat
pathogens
inflammation.
addition,
facilitated
biosensors
pathogen
imaging
techniques
This
review
categorizes
characterizes
different
NPs,
summarizes
their
applications
It
discusses
challenges
associated
with
clinical
translation
this
field
explores
latest
developments
prospects.
conclusion,
opens
up
possibilities
comprehensive
management
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Aug. 21, 2023
Abstract
The
gradual
deterioration
of
the
supporting
periodontal
tissues
caused
by
periodontitis,
a
chronic
multifactorial
inflammatory
disease,
is
thought
to
be
triggered
colonization
dysbiotic
plaque
biofilms
in
vulnerable
host.
One
most
prevalent
dental
conditions
world,
periodontitis
now
leading
factor
adult
tooth
loss.
When
does
develop,
it
treated
scraping
mineralized
deposits
and
biofilm
off
surfaces.
Numerous
studies
have
shown
that
non-surgical
treatment
significantly
improves
clinical
microbiological
indices
individuals
with
periodontitis.
Although
parameters
improved,
certain
bacterial
reservoirs
often
persist
on
root
surfaces
even
after
standard
therapy.
Periodontitis
has
been
local
or
systemic
antibiotics
as
well
scaling
planning.
Since
there
aren't
many
brand-new
market,
several
researchers
are
currently
concentrating
creating
alternate
methods
combating
germs.
There
delay
study
subject
nanoparticle
(NP)
toxicity,
which
especially
concerned
mechanisms
action,
while
area
nanomedicine
develops.
promising
them
metal
NPs
since
they
potent
antibacterial
action.
Metal
may
employed
efficient
growth
inhibitors
variety
bacteria,
making
useful
for
In
this
way,
new
contributed
development
anti-inflammatory
platforms
current
therapeutic
effects
metallic
summarized
study.
This
data
might
used
develop
NP-based
alternatives
infections.
Graphical
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 5, 2024
Abstract
Periodontitis,
one
of
the
most
prevalent
dental
diseases,
causes
loss
bone
and
gum
tissue
that
hold
teeth
in
place.
Several
bacteria,
commonly
present
clinically
healthy
oral
cavities,
may
induce
perpetuate
periodontitis
when
their
concentration
rises
gingival
sulcus.
Antibacterial
effect
against
various
Gram-negative
Gram-positive
including
pathogenic
drug-resistant
ones,
has
been
shown
for
several
distinct
transient
metal
oxide
NPs.
Therefore,
NPs
be
used
biomedicine
to
treat
periodontal
problems
nanotechnology
inhibit
development
microorganisms.
Instead
using
harmful
chemicals
or
energy-intensive
machinery,
biosynthesis
nanoparticles
(NPs)
suggested.
To
produce
NPs,
ideal
technique
is
“Green”
synthesis
because
its
low
toxicity
safety
human
health
environment.
Gold
(AuNPs)
appear
less
toxic
mammalian
cells
than
other
nanometals
antibacterial
activity
not
dependent
on
reactive
oxygen
species
(ROS).
AgNPs
also
possess
chemical
stability,
catalytic
activity,
superior
electrical
thermal
conductivity,
name
a
few
advantageous
characteristics.
It
was
observed
zinc
(ZnO)
copper
(Cu)
exhibited
discernible
inhibitory
effects
gram-positive
gram-negative
bacterial
strains,
respectively.
ZnO
demonstrated
bactericidal
microorganisms
responsible
periodontitis.
Medications
containing
magnetic
are
highly
effective
multidrug-resistant
fungal
infections.
The
titanium
dioxide
(TiO
2
)
implicated
elevating
salivary
peroxidase
individuals
diagnosed
with
chronic
Furthermore,
specific
metallic
have
potential
enhance
antimicrobial
efficacy
treatments
combined.
these
as
well
only
some
metals
oxides
synthesized
environmentally
friendly
ways
therapeutic
benefits
Graphical
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(3), P. 1739 - 1763
Published: Jan. 23, 2023
The
outbreak
of
COVID-19
provided
a
warning
sign
for
society
worldwide:
that
is,
we
urgently
need
to
explore
effective
strategies
combating
unpredictable
viral
pandemics.
Protective
textiles
such
as
surgery
masks
have
played
an
important
role
in
the
mitigation
pandemic,
while
revealing
serious
challenges
terms
supply,
cross-infection
risk,
and
environmental
pollution.
In
this
context,
with
antivirus
functionality
attracted
increasing
attention,
many
innovative
proposals
exciting
commercial
possibilities
been
reported
over
past
three
years.
review,
illustrate
progress
textile
filtration
pandemics
summarize
recent
development
antiviral
personal
protective
purposes
by
cataloging
them
into
classes:
metal-based,
carbon-based,
polymer-based
materials.
We
focused
on
preparation
routes
emerging
textiles,
providing
forward-looking
perspective
their
opportunities
challenges,
evaluate
efficacy,
scale
up
manufacturing
processes,
expand
high-volume
applications.
Based
conclude
ideal
are
characterized
high
efficiency,
reliable
effect,
long
storage
life,
recyclability.
expected
processes
should
be
economically
feasible,
scalable,
quickly
responsive.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Nucleic
acid
therapeutics
represent
a
highly
promising
treatment
approach
in
modern
medicine,
treating
diseases
at
the
genetic
level.
However,
these
face
numerous
challenges
practical
applications,
particularly
regarding
their
stability,
effectiveness,
cellular
uptake
efficiency,
and
limitations
delivering
them
specifically
to
target
tissues.
To
overcome
obstacles,
researchers
have
developed
various
innovative
delivery
systems,
including
viral
vectors,
lipid
nanoparticles,
polymer
inorganic
protein
carriers,
exosomes,
antibody
oligonucleotide
conjugates,
DNA
nanostructure-based
systems.
These
systems
enhance
therapeutic
efficacy
of
nucleic
drugs
by
improving
targeting
specificity,
half-life
vivo.
In
this
review,
we
systematically
discuss
different
types
drugs,
analyze
major
barriers
encountered
delivery,
summarize
current
research
progress
emerging
We
also
highlight
latest
advancements
application
for
diseases,
infectious
cancer,
brain
wound
healing.
This
review
aims
provide
comprehensive
overview
drug
systems'
status
future
directions
integrating
nanotechnology,
biomaterials
science,
gene
editing
technologies,
emphasizing
transformative
potential
precision
medicine.
Vaccines,
Journal Year:
2023,
Volume and Issue:
11(7), P. 1172 - 1172
Published: June 29, 2023
Ever
since
the
development
of
first
vaccine,
vaccination
has
had
great
impact
on
global
health,
leading
to
decrease
in
burden
numerous
infectious
diseases.
However,
there
is
a
constant
need
improve
existing
vaccines
and
develop
new
strategies
vaccine
platforms
that
induce
broader
immune
response
compared
traditional
vaccines.
Modern
tend
rely
certain
nanotechnology
but
are
still
expected
be
readily
available
easy
for
large-scale
manufacturing
durable
response.
In
this
review,
we
present
an
overview
most
promising
nanoadjuvants
nanoparticulate
delivery
systems
discuss
their
benefits
from
tehchnological
immunological
standpoints
as
well
objective
drawbacks
possible
side
effects.
The
presented
nano
alums,
silica
clay
nanoparticles,
nanoemulsions,
adenoviral-vectored
systems,
adeno-associated
viral
vectors,
vesicular
stomatitis
lentiviral
virus-like
particles
(including
bacteriophage-based
ones)
virosomes
indicate
developers
can
now
choose
different
adjuvants
and/or
per
requirement,
specific
combatting
Virology Journal,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: May 31, 2024
Abstract
Cervical
cancer
(CC)
and
other
malignant
malignancies
are
acknowledged
to
be
primarily
caused
by
persistent
human
papillomavirus
(HPV)
infection.
Historically,
vaccinations
against
viruses
that
produce
neutralizing
antibodies
unique
the
virus
have
been
an
affordable
way
manage
viral
diseases.
CC
risk
is
decreased,
but
not
eliminated,
HPV
vaccinations.
Since
made
available
globally,
almost
90%
of
infections
successfully
avoided.
On
lesions
diseases
already
present,
however,
no
discernible
treatment
benefit
has
shown.
As
a
result,
therapeutic
vaccines
elicit
immune
responses
mediated
cells
necessary
for
established
cancers.
mRNA
possess
remarkable
potential
in
combating
malignancy
as
result
their
superior
industrial
production,
safety,
efficacy.
Furthermore,
considering
expeditiousness
vaccine
exhibits
promise
approach
targeting
HPV.
Given
HPV-encoded
early
proteins,
including
oncoproteins
E6
E7,
consistently
present
HPV-related
cancers
pre-cancerous
crucial
functions
progression
persistence
diseases,
they
serve
ideal
targets
vaccines.
The
action
mechanism
vaccines,
recent
advancements
clinical
trials,
applications
highlighted
this
study,
which
also
offers
quick
summary
state
Lastly,
we
highlight
few
difficulties
with
vaccination
practice
provide
our
thoughts
on
further
quickly
changing
sector.
It
expected
will
soon
produced
prevention
treatment.
Graphical
