International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125169 - 125169
Published: Jan. 1, 2025
Language: Английский
Pharmacological Research, Journal Year: 2024, Volume and Issue: 201, P. 107086 - 107086
Published: Jan. 29, 2024
The progress in human disease treatment can be greatly advanced through the implementation of nanomedicine. This approach involves targeted and cell-specific therapy, controlled drug release, personalized dosage forms, wearable delivery, companion diagnostics. By integrating cutting-edge technologies with delivery systems, greater precision achieved at tissue cellular levels use stimuli-responsive nanoparticles, development electrochemical sensor systems. targeting – by virtue nanotechnology allows for therapy to directed specifically affected tissues while reducing side effects on healthy tissues. As such, nanomedicine has potential transform conditions such as cancer, genetic diseases, chronic illnesses facilitating precise delivery. Additionally, forms devices offer ability tailor unique needs each patient, thereby increasing therapeutic effectiveness compliance. Companion diagnostics further enable efficient monitoring response, enabling customized adjustments plan. question whether all approaches outlined here are viable alternatives current treatments is also discussed. In general, application field biomedicine may provide a strong alternative existing several reasons. this review, we aim present evidence that, although early stages, fully merging technology innovative shows promise successful across various areas, including cancer or diseases.
Language: Английский
Citations
79
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Feb. 14, 2024
Abstract Despite recent advancements in cancer treatment, this disease still poses a serious threat to public health. Vaccines play an important role preventing illness by preparing the body's adaptive and innate immune responses combat diseases. As our understanding of malignancies their connection system improves, there has been growing interest priming fight more effectively comprehensively. One promising approach involves utilizing nanoparticle systems for antigen delivery, which shown potentiate as vaccines and/or adjuvants. In review, we comprehensively summarized immunological mechanisms while focusing specifically on applications various types nanoparticles field immunotherapy. By exploring these breakthroughs, hope identify significant challenges obstacles making nanoparticle-based adjuvants feasible clinical application. This review serves assess breakthroughs vaccinations shed light prospects potential barriers. doing so, aim inspire future immunotherapies that harness nanotechnology deliver effective targeted treatments. Graphical abstract
Language: Английский
Citations
29
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5842 - 5842
Published: May 27, 2024
This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.
Language: Английский
Citations
27
Cancer Nanotechnology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Jan. 31, 2024
Abstract Owing to unique facets, such as large surface area, tunable synthesis parameters, and ease of functionalization, mesoporous silica nanoparticles (MSNs) have transpired a worthwhile platform for cancer theranostics over the last decade. The full potential MSNs in theranostics, however, is yet be realized. While can employed targeted drug delivery imaging, their effectiveness frequently hindered by factors, biological barriers, complex tumor microenvironment, target non-specificity ineffectiveness individual functionalized moieties. primary purpose this review highlight technological advances tumor-specific, stimuli-responsive “smart” multimodal MSN-based hybrid nanoplatforms that overcome these limitations improve MSN theranostics. This article offers an extensive overview technology outlining key directions future research well challenges are involved aspect. We aim underline vitality relevance current advancements field potentially enhance clinical outcomes through provision more precise focused theranostic approaches.
Language: Английский
Citations
25
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.
Language: Английский
Citations
6
Critical Reviews in Oncology/Hematology, Journal Year: 2023, Volume and Issue: 185, P. 103980 - 103980
Published: March 29, 2023
Language: Английский
Citations
29
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115049 - 115049
Published: June 25, 2023
The management and treatment of disease are achieved via the use pharmacologically active substances or drugs. Drugs do not, however, have an intrinsic ability to be effective; rather, how well they work depends on administered supplied. Treatment a variety biological illnesses, such as autoimmune disorders, cancer, bacterial infections, requires effective drug delivery. Drug absorption, distribution, metabolism, duration therapeutic impact, pharmacokinetics, excretion, toxicity can all impacted by administration. Improved chemistry materials required for delivery concentration novel treatments specified targets within body, necessary time. This requirement is accompanied development new therapeutics. Formulating medication DDS promising strategy directly addressing numerous typical barriers adherence, frequent dosage, side effects, delayed beginning action. In current review, we give compendium controlled release subsequently highlight some newest developments in realm, with particular emphasis cutting-edge methods targeted therapy. each instance, outline obstacles efficient administration chemical material that allowing sector overcome these positive clinical impact.
Language: Английский
Citations
27
Molecular Therapy — Nucleic Acids, Journal Year: 2023, Volume and Issue: 33, P. 774 - 793
Published: July 16, 2023
Long non-coding RNAs (lncRNAs) are a class of RNA transcripts more than 200 nucleotides in length that play crucial roles cancer development and progression. With the rapid high-throughput sequencing technology, considerable number lncRNAs have been identified as novel biomarkers for predicting prognosis patients and/or therapeutic targets therapy. In recent years, increasing evidence has shown biological functions regulatory mechanisms closely associated with their subcellular localization. More importantly, based on important regulating progression (e.g., growth, resistance, metastasis) specific ability nucleic acids siRNA, mRNA, DNA) to regulate expression any target genes, much effort exerted recently develop nanoparticle (NP)-based acid delivery systems
Language: Английский
Citations
25
Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216151 - 216151
Published: March 29, 2023
Language: Английский
Citations
24
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1076 - 1076
Published: Aug. 16, 2024
Preclinical and clinical studies have demonstrated that precision therapy has a broad variety of treatment applications, making it an interesting research topic with exciting potential in numerous sectors. However, major obstacles, such as inefficient unsafe delivery systems severe side effects, impeded the widespread use medicine. The purpose drug (DDSs) is to regulate time place release action. They aid enhancing equilibrium between medicinal efficacy on target hazardous effects off target. One promising approach biomaterial-assisted biotherapy, which takes advantage biomaterials’ special capabilities, high biocompatibility bioactive characteristics. When administered via different routes, molecules deal biological barriers; DDSs help them overcome these hurdles. With their adaptable features ample packing capacity, biomaterial-based allow for targeted, localised, prolonged medications. Additionally, they are being investigated more controlling interface host tissue implanted biomedical materials. This review discusses innovative nanoparticle designs non-personalised applications improve therapies. We prioritised design trends address heterogeneous barriers, because we believe intelligent can patient outcomes by enabling improving general efficacy. additionally reviewed most recent literature biomaterials used biotherapy vaccine development, covering delivery, stem cell therapy, gene other similar fields; also addressed difficulties future biotherapies.
Language: Английский
Citations
18