Electrochemical
aptasensors
have
emerged
as
promising
platforms
for
effective
and
efficient
detection
of
a
variety
target
analytes.
In
this
work,
we
reported
the
development
sensitive
selective
electrochemical
aptasensor
zearalenone
(ZEN)
determination
based
on
bimetallic
organic
framework
(CuBi-BPDC),
possessing
mixed
nodes
Cu(II)
Bi(III)
multilayered
nanosheets
bearing
nanoparticles.
Due
to
its
improved
activity
strong
affinity
aptamers,
CuBi-BPDC-based
obtains
low
limit
0.19
fg
mL-1
(IUPAC
S/N
=
3)
in
wide
range
1
-
10
ng
via
EIS
0.73
from
0
1×109
DPV
ZEN
detection,
respectively.
Moreover,
excellent
selectivity
allows
specifically
identify
other
interfering
substances
raw
milk
rice,
indicating
potential
applicability
ZEN.
Science and Technology of Advanced Materials,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: April 22, 2024
Exosomes,
a
type
of
extracellular
vesicles,
have
attracted
considerable
attention
due
to
their
ability
provide
valuable
insights
into
the
pathophysiological
microenvironment
cells
from
which
they
originate.
This
characteristic
implicates
potential
use
as
diagnostic
disease
biomarkers
clinically,
including
cancer,
infectious
diseases,
neurodegenerative
disorders,
and
cardiovascular
diseases.
Aptasensors,
are
electrochemical
aptamers
based
biosensing
devices,
emerged
new
class
powerful
detection
technology
conventional
methods
like
ELISA
Western
analysis,
primarily
because
capability
for
high-performance
bioanalysis.
review
covers
current
research
landscape
on
exosomes
utilizing
nanoarchitectonics
strategy
development
aptasensors.
Strategies
involving
signal
amplification
biofouling
prevention
discussed,
with
an
emphasis
nanoarchitectonics-based
bio-interfaces,
showcasing
enhance
sensitivity
selectivity
through
optimal
conduction
mass
transport
properties.
The
ongoing
challenges
broaden
clinical
applications
these
biosensors
also
highlighted.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 8, 2024
Liquid
biopsy
is
a
minimally
invasive
method
that
uses
biofluid
samples
instead
of
tissue
for
cancer
diagnosis.
Exosomes
are
small
extracellular
vesicles
secreted
by
donor
cells
and
act
as
mediators
intercellular
communication
in
human
health
disease.
Due
to
their
important
roles,
exosomes
have
been
considered
promising
biomarkers
liquid
biopsy.
However,
traditional
methods
exosome
isolation
cargo
detection
time-consuming
inefficient,
limiting
practical
application.
In
the
past
decades,
many
new
strategies,
such
microfluidic
chips,
nanowire
arrays
electrochemical
biosensors,
proposed
achieve
rapid,
accurate
high-throughput
analysis
exosomes.
this
review,
we
discussed
about
advance
exosome-based
technology,
including
isolation,
enrichment,
approaches.
The
comparison
currently
available
also
included.
Finally,
summarized
advantages
limitations
present
strategies
further
gave
perspective
future
translational
use.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 1, 2024
Exosomes
play
a
crucial
role
in
various
biological
processes,
such
as
human
development,
immune
responses,
and
disease
occurrence.
The
membrane
proteins
on
exosomes
are
pivotal
factors
for
their
functionality.
Currently,
numerous
have
been
identified
exosome
membranes,
participating
intercellular
communication,
mediating
target
cell
recognition,
regulating
processes.
Furthermore,
from
derived
cancer
cells
can
serve
relevant
biomarkers
early
diagnosis.
This
article
provides
comprehensive
review
of
the
composition
diverse
functions
organism's
Through
in-depth
exploration
proteins,
it
is
expected
to
offer
essential
foundations
future
development
novel
biomedical
diagnostics
therapies.
Chemosensors,
Journal Year:
2023,
Volume and Issue:
11(9), P. 488 - 488
Published: Sept. 4, 2023
Electrochemical
aptasensors
have
gained
significant
attention
due
to
their
exceptional
sensitivity,
selectivity,
stability,
and
rapid
response,
combining
the
advantages
of
electrochemical
techniques
with
specific
recognition
ability
aptamers.
This
review
aims
provide
a
comprehensive
summary
recent
advances
in
aptasensors.
Firstly,
construction
method
are
introduced.
Subsequently,
highlights
application
progress
detecting
various
chemical
biological
molecules,
including
metal
ions,
small
drugs,
proteins,
exosomes,
tumor
cells,
bacteria,
viruses.
Lastly,
prospects
challenges
associated
discussed.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(9), P. 3855 - 3875
Published: June 20, 2024
Lung
cancer,
highly
prevalent
and
the
leading
cause
of
cancer-related
death
globally,
persists
as
a
significant
challenge
due
to
lack
definitive
tumor
markers
for
early
diagnosis
personalized
therapeutic
interventions.
Recently,
extracellular
vesicles
(EVs),
functioning
natural
carriers
intercellular
communication,
have
received
increasing
attention
their
ability
traverse
biological
barriers
deliver
diverse
cargoes,
including
cytosolic
proteins,
cell
surface
microRNA,
lncRNA,
circRNA,
DNA,
lipids.
EVs
are
increasingly
recognized
valuable
resource
non-invasive
liquid
biopsy,
well
drug
delivery
platforms,
anticancer
vaccines
precision
medicine
in
lung
cancer.
Herein,
given
diagnostic
potential
tumor-associated
we
discuss
this
topic
from
translational
standpoint.
We
delve
into
specific
roles
that
play
cancer
carcinogenesis
offer
particular
perspective
on
how
advanced
engineering
technologies
can
overcome
current
challenges
expedite
and/or
enhance
translation
laboratory
research
clinical
settings.
