Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: May 25, 2025
Engineered
extracellular
vesicles
(EVs),
which
are
EVs
modified
to
enhance
certain
biological
properties,
offer
a
promising
therapeutic
strategy
for
the
treatment
of
skin
defects.
Conventional
nanomaterials
often
encounter
clinical
translation
challenges
due
potential
toxicity
and
limited
targeting.
EVs,
utilizing
inherent
biocompatibility
effective
physiological
barrier
traversal,
can
ameliorate
limitations
conventional
EV
therapies
some
extent,
including
detection,
isolation,
purification,
validation.
Recent
advances
in
engineering,
such
as
genetic
modification
production
cells
control
cargo,
surface
engineering
targeted
delivery,
pre-treatment
parental
optimize
bioactivity,
have
improved
efficacy
laboratory
studies
through
enhanced
targeting,
prolonged
retention
time,
increased
yield.
Many
suggested
ability
engineered
treat
variety
defects,
diabetic
wounds,
burns,
hypertrophic
scars,
providing
avenue
their
this
area.
This
paper
reviews
regeneration,
highlighting
role
promoting
cell
migration
angiogenesis,
modulating
inflammation
reducing
scar
formation
during
wound
healing.
In
addition,
given
investment
rapidly
evolving
field
growing
trial
activity,
review
also
explores
recent
global
provides
an
outlook
on
future
application
opportunities
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
38, P. 1 - 30
Published: April 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
The
rising
prevalence
of
diabetes
has
underscored
concerns
surrounding
diabetic
wounds
and
their
potential
to
induce
disability.
intricate
healing
mechanisms
are
multifaceted,
influenced
by
ambient
microenvironment,
including
prolonged
hyperglycemia,
severe
infection,
inflammation,
elevated
levels
reactive
oxygen
species
(ROS),
ischemia,
impaired
vascularization,
altered
wound
physicochemical
properties.
In
recent
years,
hydrogels
have
emerged
as
promising
candidates
for
treatment
owing
exceptional
biocompatibility
resemblance
the
extracellular
matrix
(ECM)
through
a
three-dimensional
(3D)
porous
network.
This
review
will
first
summarize
microenvironment
alterations
occurring
in
wounds,
aiming
provide
comprehensive
understanding
its
pathogenesis,
then
classification
recently
developed
be
presented,
encompassing
properties
such
hypoglycemic
effects,
anti-inflammatory
capabilities,
antibacterial
attributes,
ROS
scavenging
abilities,
promotion
angiogenesis,
pH
responsiveness,
more.
primary
objective
is
offer
valuable
reference
repairing
based
on
unique
microenvironment.
Moreover,
this
paper
outlines
avenues
future
advancements
hydrogel
dressings
facilitate
expedite
process
wounds.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Dec. 5, 2024
Abstract
Neutrophils,
the
most
abundant
type
of
granulocyte,
are
widely
recognized
as
one
pivotal
contributors
to
acute
inflammatory
response.
Initially,
neutrophils
were
considered
mobile
infantry
innate
immune
system,
tasked
with
immediate
response
invading
pathogens.
However,
recent
studies
have
demonstrated
that
versatile
cells,
capable
regulating
various
biological
processes
and
impacting
both
human
health
disease.
Cytokines
other
active
mediators
regulate
functional
activity
by
activating
multiple
receptors
on
these
thereby
initiating
downstream
signal
transduction
pathways.
Dysfunctions
in
disruptions
neutrophil
homeostasis
been
implicated
pathogenesis
numerous
diseases,
including
cancer
disorders,
often
due
aberrant
intracellular
signaling.
This
review
provides
a
comprehensive
synthesis
functions,
integrating
advancements
this
field.
Moreover,
it
examines
roles
signaling
pathways
involved
regulation
activity.
The
pathophysiology
diseases
emerging
therapeutic
approaches
targeting
them
also
elaborated.
addresses
current
limitations
within
field
research,
highlighting
critical
gaps
knowledge
warrant
further
investigation.
In
summary,
seeks
establish
multidimensional
model
regulation,
providing
new
perspectives
for
potential
clinical
applications
research.
Molecular Therapy,
Journal Year:
2024,
Volume and Issue:
32(3), P. 580 - 608
Published: Jan. 29, 2024
Cardiovascular
disease
(CVD)
continues
to
impose
a
significant
global
health
burden,
necessitating
the
exploration
of
innovative
treatment
strategies.
Ribonucleic
acid
(RNA)-based
therapeutics
have
emerged
as
promising
avenue
address
complex
molecular
mechanisms
underlying
CVD
pathogenesis.
We
present
comprehensive
review
current
state
RNA
in
context
CVD,
focusing
on
diverse
modalities
that
bring
about
transient
or
permanent
modifications
by
targeting
different
stages
biology
central
dogma.
Considering
immense
potential
therapeutics,
we
identified
common
gene
targets
could
serve
interventions
for
prevalent
Mendelian
caused
single
mutations,
well
acquired
CVDs
developed
over
time
due
various
factors.
These
offer
opportunities
develop
RNA-based
treatments
tailored
specific
genetic
and
pathways,
presenting
novel
precise
approach
pathogenesis
both
types
cardiovascular
conditions.
Additionally,
discuss
challenges
associated
with
delivery
strategies
achieve
targeted
system.
This
highlights
combat
paving
way
future
advancements
therapeutics.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(19)
Published: March 1, 2024
Abstract
Exosomes,
nanoparticles
secreted
by
various
cells,
composed
of
a
bilayer
lipid
membrane,
and
containing
bioactive
substances
such
as
proteins,
nucleic
acids,
metabolites,
etc.,
have
been
intensively
investigated
in
tissue
engineering
owing
to
their
high
biocompatibility
versatile
biofunction.
However,
there
is
still
lack
high‐quality
review
on
bone
defect
regeneration
potentiated
exosomes.
In
this
review,
the
biogenesis
isolation
methods
exosomes
are
first
introduced.
More
importantly,
engineered
current
state
knowledge
discussed
review.
Afterward,
biomaterial
carriers
mechanisms
repair
elucidated
compelling
evidence
presented.
Thus,
future
perspectives
concerns
revealed
help
devise
advanced
modalities
based
overcome
challenges
regeneration.
It
totally
believed
will
attract
special
attention
from
clinicians
provide
promising
ideas
for
works.
Burns & Trauma,
Journal Year:
2025,
Volume and Issue:
13
Published: Jan. 1, 2025
Poor
wound
healing
is
a
refractory
process
that
places
an
enormous
medical
and
financial
burden
on
diabetic
patients.
Exosomes
have
recently
been
recognized
as
crucial
players
in
the
of
lesions.
They
excellent
stability,
homing
effects,
biocompatibility,
reduced
immunogenicity
novel
cell-free
therapies.
In
addition
to
transporting
cargos
target
cells
enhance
intercellular
communication,
exosomes
are
beneficial
nearly
every
phase
healing.
participate
modulating
inflammatory
response,
accelerating
proliferation
reepithelization,
increasing
angiogenesis,
regulating
extracellular
matrix
remodeling.
Accumulating
evidence
indicates
hydrogels
or
dressings
conjunction
with
can
prolong
duration
exosome
residency
wounds.
This
review
provides
overview
mechanisms,
delivery,
clinical
application,
engineering,
existing
challenges
use
repair.
We
also
propose
future
directions
for
biomaterials
incorporating
exosomes:
2D
3D
scaffolds,
loaded
healing-promoting
gases,
intelligent
biomaterials,
prospect
systematic
application
exosomes.
These
findings
may
might
shed
light
treatments
enlighten
some
studies
improve
quality
life
among
diabetes
