Nanotechnology in the life sciences, Journal Year: 2024, Volume and Issue: unknown, P. 303 - 368
Published: Jan. 1, 2024
Language: Английский
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 18, 2025
Clinically, multimodal therapies are adopted worldwide for the management of cancer, which continues to be a leading cause death. In recent years, immunotherapy has firmly established itself as new paradigm in cancer care that activates body's immune defense cope with cancer. Immunotherapy resulted significant breakthroughs treatment stubborn tumors, dramatically improving clinical outcome patients. Multiple forms immunotherapy, including checkpoint inhibitors (ICIs), adoptive cell therapy and vaccines, have become widely available. However, effectiveness these immunotherapies is not much satisfying. Many patients do respond disease recurrence appears unavoidable because rapidly evolving resistance. Moreover, can give rise severe off-target immune-related adverse events. Strategies remove hindrances mainly focus on development combinatorial or exploitation novel immunotherapeutic mediations. Nanomaterials carrying anticancer agents target site considered practical approaches treatment. Nanomedicine combined offers possibility potentiate systemic antitumor immunity facilitate selective cytotoxicity against cells an effective safe manner. A myriad nano-enabled currently under investigation. Owing gaps between preclinical studies, nano-immunotherapy faces multiple challenges, biosafety nanomaterials trial design. this review, we provide overview summarize evidence indicating how nanomedicine-based increase efficacy immunotherapies. We also discuss key challenges emerged era nanotechnology-based immunotherapy. Taken together, combination drawing increasing attention, it anticipated will achieve desired success therapy.
Language: Английский
Citations
5
Nature Cell and Science, Journal Year: 2024, Volume and Issue: 000(000), P. 000 - 000
Published: June 20, 2024
The use of cancer immunotherapy has considerably revolutionized treatment by leveraging the immune system's capacity to specifically target and eliminate malignant cells.However, field still faces several ongoing challenges, including poor tumor invasion, resistance, off-target effects.The targeted administration immunotherapeutics using polymeric nanoparticles (PNPs) been shown increase both efficacy specificity.In this review, we discuss cutting-edge technology PNPs improve effectiveness immunotherapy.This paper summarizes steps in designing developing for delivery modulators, antigens, other bioactive compounds.It also discusses current challenges explores mechanisms which enhance therapeutic outcomes.Tumor microenvironment modifications, immunological activation, prolonged release agents are described, highlighting successes highlighted.
Language: Английский
Citations
10
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117897 - 117897
Published: Feb. 7, 2025
Language: Английский
Citations
1
Cancer Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 3, 2025
Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need explore alternative approaches such as vaccines. Leveraging immune system's natural ability target and kill cells holds great therapeutic potential. However, development of vaccines is hindered by several challenges, including low stability, inadequate response activation, immunosuppressive tumor microenvironment, which limit their efficacy. Recent progress various fields, click chemistry, nanotechnology, exosome engineering, neoantigen design, offer innovative solutions these challenges. These achievements have led emergence smart vaccine platforms (SVPs), integrate protective carriers for messenger ribonucleic acid (mRNA) with functionalization strategies optimize targeted delivery. Click chemistry further enhances SVP performance improving encapsulation mRNA antigens facilitating precise delivery review highlights latest developments technologies therapy, exploring both opportunities challenges advancing transformative approaches.
Language: Английский
Citations
0
RSC Advances, Journal Year: 2025, Volume and Issue: 15(7), P. 5558 - 5570
Published: Jan. 1, 2025
Background: H. pylori is recognized as one of the main causes gastric cancer, and this type cancer considered leading diseases causing deaths all over world.
Language: Английский
Citations
0
Biofilm, Journal Year: 2024, Volume and Issue: 8, P. 100220 - 100220
Published: Sept. 13, 2024
Language: Английский
Citations
4
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1880(1), P. 189249 - 189249
Published: Dec. 17, 2024
Language: Английский
Citations
4
Vaccines, Journal Year: 2025, Volume and Issue: 13(2), P. 126 - 126
Published: Jan. 27, 2025
Infectious diseases continue to pose a significant global health threat. To combat these challenges, innovative vaccine technologies are urgently needed. Nanoparticles (NPs) have unique properties and emerged as promising platform for developing next-generation vaccines. revolutionizing the field of development, offering new era immunization. They allow creation more effective, stable, easily deliverable Various types NPs, including lipid, polymeric, metal, virus-like particles, can be employed encapsulate deliver components, such mRNA or protein antigens. These NPs protect antigens from degradation, target them specific immune cells, enhance antigen presentation, leading robust durable responses. Additionally, simultaneously multiple antigens, adjuvants, in single formulation, simplifying production administration. Nanovaccines offer approach food- water-borne bacterial diseases, surpassing traditional formulations. Further research is needed address burden infections. This review highlights potential revolutionize platforms. We explore their mechanisms action, current applications, emerging trends. The discusses limitations nanovaccines, solutions role artificial intelligence effective accessible nanovaccines infectious diseases.
Language: Английский
Citations
0
Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13
Published: April 5, 2025
Nanotechnology has revolutionized cancer treatment by providing innovative solutions through nanocancer therapies, nanovaccines, and nanoparticles. This review focuses on the application of these technologies in colorectal (CRC), highlighting their progression from preclinical studies to clinical trials. Nanoparticles, including liposomes, silica, gold, lipid nanoparticles, possess unique properties that enhance drug delivery, improve therapeutic efficacy, minimize systemic toxicity. Additionally, nanovaccines are being developed elicit robust immune responses against CRC cells. paper offers a comprehensive overview current state nanotechnology-based treatments for CRC, emphasizing key trials demonstrate potential. Furthermore, discusses challenges faced this field. It outlines future directions research, underscoring need ongoing efforts translate promising into practical applications.
Language: Английский
Citations
0
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 15, 2025
Cancer immunotherapy aims to harness the body's own immune system for effective and long-lasting elimination of malignant neoplastic tissues. Owing advance in understanding cancer pathology immunology, many novel strategies enhancing immunological responses against various cancers have been successfully developed, some translated into excellent clinical outcomes. As one promising strategy next generation immunotherapies, activating multi-cellular network (MCN) within tumor microenvironment (TME) deploy multiple mechanisms action (MOAs) has attracted significant attention. To achieve this effectively safely, delivering or pleiotropic therapeutic cargoes targeted sites cancerous tissues, cells, intracellular organelles is critical, which numerous nanocarriers developed leveraged. In review, we first introduce payloads categorized according their predicted functions physicochemical structures forms. Then, nanocarriers, along with unique characteristics, properties, advantages, limitations, are introduced notable recent applications immunotherapy. Following discussions on targeting strategies, a summary each nanocarrier matching suitable provided comprehensive background information designing regimens.
Language: Английский
Citations
0