Adipose tissue may not be a major player in the inflammatory pathogenesis of Autism Spectrum Disorder DOI Creative Commons
Baojiang Wang, Yongqiang Qin, Bin He

et al.

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 43, P. 100929 - 100929

Published: Dec. 24, 2024

Autism spectrum disorder (ASD) is a complex neurodevelopmental increasingly recognized for its strong association with chronic inflammation. Adipose tissue functions as an endocrine organ and can secrete inflammatory cytokines to mediate However, involvement in ASD-related inflammation remains unclear. The present study aimed clarify the role of adipose inducing responses associated ASD. A total 36 children ASD 18 unrelated healthy controls, aged 2-14.5 years, were enrolled study. up-regulated differentially expressed genes from GSE18123 dataset subjected gene ontology (GO) enrichment analysis explore ASD-associated pathways. Plasma adipokines levels quantified using Milliplex MAP immunoaffinity technology. BTBR T + Itprtf/J (BTBR) mice that are known their core behavioral traits phenotypes employed animal model verify key clinical findings. GO analyses revealed immune dysfunction Symptom showed recruited individuals had typical autistic symptoms. no significant difference levels, including adiponectin, leptin, resistin, adipsin, lipocalin-2, between control groups. markedly elevated IL-6, IL-8, tumor necrosis factor (TNF-α) detected ASD, suggesting state independent adipokines. Similar results also observed mice. Notably, insulin, which closely related exertion function, changes. Our findings suggest likely originates non-adipocyte sources, implying may not play major pathogenesis Consequently, targeting adipose-related be effective treatment approach, providing new directions development targeted interventions.

Language: Английский

The role of exosomes derived from stem cells in nerve regeneration: A contribution to neurological repair DOI
Qiankun Zhang, Jiale Liu, Wei Wang

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 380, P. 114882 - 114882

Published: July 14, 2024

Language: Английский

Citations

4
Mesenchymal stem cell exosomes enhance the development of hair follicle to ameliorate androgenetic alopecia DOI
Yu Fu,

Yao-ting Han,

Junling Xie

et al.

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(3)

Published: March 19, 2025

Mesenchymal stem cells (MSCs) and their secretome have significant potential in promoting hair follicle development. However, the effects of MSC therapy been reported to vary due heterogeneous characteristics. Different sources MSCs or culture systems may cause heterogeneity exosomes. To define human adipose-derived exosomes (hADSC-Exos) umbilical cord-derived (hUCMSC-Exos) for improving dermal papillary cell proliferation androgenetic alopecia. We conducted liquid chromatography-mass spectrometry proteomic analysis hADSC-Exos hUCMSC-Exos. Liquid suggested that were related metabolism immunity. Additionally, hADSC-Exo proteins regulated cycle other 9 functional groups. verified inhibited glycogen synthase kinase-3β expression by activating Wnt/β-catenin signaling pathway via division protein 42, enhanced migration. Excess dihydrotestosterone caused alopecia shortening growth phase, but reversed these effects. This study indicated development is influenced hADSC-Exo-mediated cell-to-cell communication pathway.

Language: Английский

Citations

0
Exosomes in acute pancreatitis: Pathways to cellular death regulation and clinical application potential DOI

Kaiyi Ruan,

Jinglei Zhang, Zhaowei Chu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114491 - 114491

Published: March 21, 2025

Language: Английский

Citations

0
The roles of extracellular vesicles in mental disorders: information carriers, biomarkers, therapeutic agents DOI Creative Commons

Longkun Wang,

Ruixue Liu, Ying Wang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 9, 2025

Mental disorders are complex conditions that encompass various symptoms and types, affecting approximately 1 in 8 people globally. They place a significant burden on both families society as whole. So far, the etiology of mental remains poorly understood, making diagnosis treatment particularly challenging. Extracellular vesicles (EVs) nanoscale particles produced by cells released into extracellular space. contain bioactive molecules including nucleotides, proteins, lipids, metabolites, which can mediate intercellular communication involved physiological pathological processes. Recent studies have shown EVs closely linked to like schizophrenia, major depressive disorder, bipolar playing key role their development, diagnosis, prognosis, treatment. Therefore, based recent research findings, this paper aims describe roles summarize potential applications treatment, providing new ideas for future clinical transformation application EVs.

Language: Английский

Citations

0
From aberrant neurodevelopment to neurodegeneration: Insights into the hub gene associated with autism and alzheimer's disease DOI
Yu Fu,

Guangming Xie,

Rong-qi Liu

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1838, P. 148992 - 148992

Published: May 8, 2024

Language: Английский

Citations

2
Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases DOI Creative Commons
Bohua Wei, Mengting Wei,

Haonan Huang

et al.

Cell Proliferation, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

The global increase in the aging population has led to a concurrent rise incidence of age-related diseases, posing substantial challenges healthcare systems and affecting well-being elderly. Identifying securing effective treatments become an urgent priority. In this context, mesenchymal stem cell-derived exosomes (MSC-Exos) have emerged as promising innovative modality field anti-aging medicine, offering multifaceted therapeutic approach. MSC-Exos demonstrate significant potential due their immunomodulatory anti-inflammatory properties, ability inhibit oxidative stress, reparative effects on senescent tissues. These attributes make them valuable combating range conditions associated with aging, such cardiovascular neurodegeneration, skin osteoarthritis. integration membrane-penetrating peptides introduces novel strategy for delivery biomolecules, surmounting traditional cellular barriers enhancing efficacy. This review provides comprehensive synthesis current understanding MSC-Exos, underscoring role potent against intricate diseases.

Language: Английский

Citations

2
The function of long non-coding RNA IFNG-AS1 in autoimmune diseases DOI

Jiale Zhao,

Yibei Gui,

Wei Wu

et al.

Human Cell, Journal Year: 2024, Volume and Issue: 37(5), P. 1325 - 1335

Published: July 14, 2024

Language: Английский

Citations

1
Synergistic delivery of hADSC-Exos and antioxidants has inhibitory effects on UVB-induced skin photoaging DOI Creative Commons

Yu Fu,

Junling Xie,

Wanting Zhang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e34321 - e34321

Published: July 9, 2024

Ultraviolet B (UVB) light exposure accelerates skin photoaging. Human adipose-derived stem cell exosomes (hADSC-Exos) and some antioxidants may have anti-photoaging effects. However, it is unknown whether the combination of hADSC-Exos plays a synergistic role in anti-photoaging. In cellular 3D models, we showed that vitamin E (VE) were optimal combinations. vivo, VE increased tightening elasticity UVB-induced photoaging mice Combined treatment with inhibited SIRT1/NF-κB pathway. These findings contribute to understanding conjunction other antioxidants, thereby providing valuable insights for future pharmaceutical cosmetic industries.

Language: Английский

Citations

0
The role of lncRNA in the differentiation of adipose-derived stem cells: from functions to mechanism DOI
Yujing Wang,

Yuxi Zhou,

Kun Li

et al.

Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

Language: Английский

Citations

0
Adipose tissue may not be a major player in the inflammatory pathogenesis of Autism Spectrum Disorder DOI Creative Commons
Baojiang Wang, Yongqiang Qin, Bin He

et al.

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 43, P. 100929 - 100929

Published: Dec. 24, 2024

Autism spectrum disorder (ASD) is a complex neurodevelopmental increasingly recognized for its strong association with chronic inflammation. Adipose tissue functions as an endocrine organ and can secrete inflammatory cytokines to mediate However, involvement in ASD-related inflammation remains unclear. The present study aimed clarify the role of adipose inducing responses associated ASD. A total 36 children ASD 18 unrelated healthy controls, aged 2-14.5 years, were enrolled study. up-regulated differentially expressed genes from GSE18123 dataset subjected gene ontology (GO) enrichment analysis explore ASD-associated pathways. Plasma adipokines levels quantified using Milliplex MAP immunoaffinity technology. BTBR T + Itprtf/J (BTBR) mice that are known their core behavioral traits phenotypes employed animal model verify key clinical findings. GO analyses revealed immune dysfunction Symptom showed recruited individuals had typical autistic symptoms. no significant difference levels, including adiponectin, leptin, resistin, adipsin, lipocalin-2, between control groups. markedly elevated IL-6, IL-8, tumor necrosis factor (TNF-α) detected ASD, suggesting state independent adipokines. Similar results also observed mice. Notably, insulin, which closely related exertion function, changes. Our findings suggest likely originates non-adipocyte sources, implying may not play major pathogenesis Consequently, targeting adipose-related be effective treatment approach, providing new directions development targeted interventions.

Language: Английский

Citations

0