The Role of Extracellular Vesicles in Liver Fibrosis: Friends or Foes? DOI Creative Commons
Xiang Tao, Can Chen, Mei Liu

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2665 - 2665

Published: Nov. 22, 2024

Liver fibrosis represents a common pathway in the progression of various chronic liver diseases towards cirrhosis and failure. Extracellular vesicles (EVs) are membrane-enclosed particles secreted by diverse cell types, including exosomes, microvesicles, apoptotic vesicles, recently identified migrasomes. These can be taken up recipient cells, thereby modulating their function through transport cargo molecules. EVs facilitate intercellular communication play significant role development fibrosis. Moreover, detection body fluids offers sensitive diagnostic tools for assessing Additionally, may serve as therapeutic targets, potential agents, drug delivery vehicles. This article reviews recent advances field concerning related diseases, with particular focus on newly discovered migrasomes intracellular crosstalk within liver.

Language: Английский

Zinc oxide nanoparticles promote migrasomes formation DOI
Ang Li, Cheng‐Xiong Yang, Leiliang Zhang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 490, P. 137792 - 137792

Published: Feb. 28, 2025

Language: Английский

Citations

1
Migrasomes, critical players in intercellular communication DOI Creative Commons
Zhiyong Tan,

Chadanfeng Yang,

Shihui Fu

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 25, 2025

Migrasomes are a newly discovered type of extracellular vesicle (EV) formed during cell migration, playing pivotal role in intercellular communication. These vesicles generated by retracting fibers migrating cells and encapsulate various molecules, such as proteins, lipids, RNA, allowing the transfer biochemical signals to neighboring cells. Current evidence suggests that migrasomes involved wide range physiological processes embryogenesis, angiogenesis, immune modulation, mitochondrial quality control. Moreover, implicated pathological conditions, including cancer metastasis, cardiovascular diseases, viral infections. To fully understand their significance, it is critical first explore molecular mechanisms underlying formation function. Recent studies have shed light on biogenesis, release, biological properties migrasomes, all which key understanding cell-to-cell In this review, we provide an up-to-date summary migrasome characterization, activities communication, while also proposing potential new functions for these vesicles.

Language: Английский

Citations

0
Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases DOI Creative Commons
Qingfu Zhang,

Jianyao Su,

Zhichao Li

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 20, 2025

Migrasomes are newly identified organelles that were first discovered in 2015. Since then, their biological structure, formation process, and physiological functions have been gradually elucidated. Research recent years has expanded our understanding of these aspects, highlighting significance various pathological processes. found to play crucial roles normal functions, including embryonic development, vascular homeostasis, material transport, mitochondrial quality control. Additionally, emerging evidence suggests involvement diseases; however, clinical research on remains limited. Current studies indicate migrasomes may contribute disease pathogenesis hold potential for diagnostic therapeutic applications. This review consolidates existing migrasomes, focusing role mechanisms use medical By examining structure function, this aims generate insights encourage further research, ultimately contributing advancements prevention treatment.

Language: Английский

Citations

0
Migrasomes: key players in immune regulation and promising medical applications DOI Creative Commons

Shuping Li,

Yanjie Zhou, Tingting Hu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 15, 2025

Migrasomes are newly discovered extracellular organelles released by migrating cells, such as immune tumor and other special functional cells like podocytes embryonic cells. They contain a diverse array of constituents, including proteins, lipids, RNA which can be to the designated location activate surrounding thereby facilitating intercellular communication signal transduction. Since then, our understanding mechanism function migrasomes has expanded exponentially, with recent evidence indicating they involved in various physiological pathological processes, particularly regulation. Furthermore, methods techniques for extracting, detecting, characterizing constantly advancing. Herein, we summarize current their key roles modulating responses, well prospective challenges clinical application, aiming provide novel insights into emerging organelles.

Language: Английский

Citations

0
Hydrophilic Components as Key Active Ingredients in Adipose‐Derived Matrix Bioscaffolds for Inducing Fat Regeneration DOI Creative Commons

Xiaomu Ma,

Yue Qiang,

Qian Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(31)

Published: Aug. 27, 2024

Decellularized adipose-derived matrix (DAM) has emerged as a promising biomaterial for soft tissue reconstruction. However, due to lack of research on its complex composition, the understanding key components in DAM remains limited, leading inconsistent adipogenic properties and challenges optimizing preparation methods purposefully. In this study, it is proposed first time that comprises two distinct components: hydrophilic (H-DAM) lipophilic (L-DAM), each with markedly different effects fat regeneration. It confirmed H-DAM component inducing regeneration enhanced cell-cell cell-scaffold interactions, primarily mediated by Hedgehog signaling pathway. contrast, L-DAM exhibits poor cell adhesion contains more antigenic components, higher immunoinflammatory response reduced adipogenesis. addition, found intracellular proteins, which are abundant H-DAM, can be retained beneficial their hydrophilicity, contrary conventional view they shall removed. Accordingly, purified bioscaffold unprecedented efficacy immunogenicity. This finding provides insights developing scaffolds promotes realization xenotransplantation.

Language: Английский

Citations

3
Decellularized adipose-derived matrix from Superficial layers of abdominal adipose tissue exhibits superior capacity of adipogenesis compared to deep layers DOI Creative Commons

Xiaomu Ma,

Yue Qiang,

Su Fu

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101235 - 101235

Published: Sept. 12, 2024

Language: Английский

Citations

2
Migrasomes: Emerging organelles for unveiling physiopathology and advancing clinical implications DOI

Janet Mei,

Xiaoli Cao, Bo Zhou

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123152 - 123152

Published: Oct. 1, 2024

Language: Английский

Citations

1
CXCL13 promote angiogenesis by recruiting M2 macrophages and endothelial progenitor cells in beige adipose grafts DOI
Zhang Xining, Xinyao Chen, Jiapeng Li

et al.

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(22)

Published: Nov. 18, 2024

Fat grafting is an emerging clinical technique to address soft tissue deficiencies. This study investigates whether the secretory function of beige adipose tissue(BeigeAT) grafts involved in promoting regeneration fat grafting. In this study, mice were randomly divided into white (WAT) and BeigeAT groups. Each type (0.3 mL) was transplanted respective groups, samples harvested at 2, 4, 12 week. Subsequently, further three group, with CXCL13 treatment TAK-779 investigate role transplants. Graft retention rate, vascularization, fibrosis levels compared among Compared WAT transplants, transplants exhibited moderate inflammation, enhanced revascularization, reduced fibrosis, increased infiltration M2 macrophages endothelial progenitor cells early stages following expression significantly higher week post-grafting. Additionally, modulation affected cells. However, superior rates groups after weeks achieve improved through CXCL13-induced

Language: Английский

Citations

1
Localized Hydrogel Microspheres for Osteoarthritis Treatment: Recruitment and Differentiation of Stem Cells DOI

Qi-Ming Pang,

Zhuolin Chen,

Jingdi Zhan

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Osteoarthritis (OA) represents a common degenerative joint disorder marked by progressive cartilage degradation, necessitating innovative therapeutic approaches beyond symptom management. Here, this study introduces novel strategy leveraging the regenerative capabilities of mesenchymal stem cells (MSCs) utilizing bioactive extracellular matrix (ECM) derived from IFN-γ-stimulated MSCs, encapsulated within aldehyde- and methacrylic anhydride-modified hyaluronic acid hydrogel microspheres (AH). This engineered scaffold effectively mimics native microenvironment, promoting targeted adhesion retention at damaged sites via spontaneous Schiff base reactions. Notably, IFN-γ-ECM@AH facilitate localized release key chemokines, such as CXCL12, enhancing endogenous cell recruitment, factors (e.g., TGF-βI TGF-β3) to drive chondrogenic differentiation. Additionally, possesses binding for cellular integrins, further augmenting potential cells. Collectively, approach presents dual-action mechanism that supports efficient repair regeneration, positioning microenvironment promising avenue OA potentially other conditions.

Language: Английский

Citations

1
The roles of migrasomes in immunity, barriers, and diseases DOI

Changsheng Cai,

Jun Shen

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

0