The impact of long-acting Gonadotropin-releasing hormone agonist pretreatment on the clinical pregnancy outcomes of hormone replacement therapy-frozen embryo transfer in recurrent implantation failure patients with and without polycystic ovary syndrome: a retrospective clinical study

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 11, 2025

Several studies have demonstrated that pre-treatment with long-acting Gonadotropin-Releasing Hormone agonists (GnRHa) can significantly enhance the clinical pregnancy rate among recurrent implantation failure (RIF) patients. Investigations also suggested GnRHa could ameliorate and live birth rates in polycystic ovary syndrome (PCOS) But there is a dearth of research on whether yields superior outcomes for RIF patients PCOS. The retrospective study enrolled 1602 under age 40 meeting criteria at Reproductive Medicine Center Nanjing Drum Tower Hospital, who underwent frozen-thawed embryo transfer (FET) between January 2017 December 2021. All cycles were categorized into hormone replacement therapy (HRT) Group (n = 1283) GnRHa-HRT 319), contingent usage pretreatment. Primary investigated this was rate, while early miscarriage deemed as secondary outcomes. Univariate analysis multivariate logistic regression model employed to assess impact pretreatment influence re-examined PCOS non-PCOS subgroups. Additionally, an interaction performed evaluate effect relationship rate. Multiple showed had positive (aOR 1.51, 95%CI: 1.15–1.99, P 0.003). We divided population two subgroups, patients, although higher women received compared those did not, it not statistically significant 0.81–2.82, 0.195). Interaction no difference (P 0.818), indicating influenced by Our demonstrates RIF. Among without PCOS, exhibited increase following control group. However, concurrent elevation post-GnRHa Therefore, effective improving suitable requires more cautious discussion.

Language: Английский

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Impact of different endometrial preparation protocols before frozen embryo transfer on pregnancy outcomes: a review

Fertility and Sterility, Journal Year: 2022, Volume and Issue: 118(5), P. 820 - 827

Published: Oct. 20, 2022

Language: Английский

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Gonadotropins as pharmacological agents in assisted reproductive technology and polycystic ovary syndrome

Trends in Endocrinology and Metabolism, Journal Year: 2023, Volume and Issue: 34(4), P. 194 - 215

Published: Feb. 28, 2023

Language: Английский

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Pharmacological and non-pharmacological interventions for improving endometrial receptivity in infertile patients with polycystic ovary syndrome: a comprehensive review of the available evidence

Reproductive BioMedicine Online, Journal Year: 2024, Volume and Issue: 49(6), P. 104381 - 104381

Published: July 20, 2024

Language: Английский

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Association between Pre-Pregnancy Overweightness/Obesity and Pregnancy Outcomes in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(15), P. 9094 - 9094

Published: July 26, 2022

Polycystic ovary syndrome (PCOS) is a common metabolic problem in women of reproductive age. Evidence suggests pregnant with PCOS may have higher risk the development adverse pregnancy outcomes; however, relationship between pre-pregnancy overweight/obesity and outcomes remains uncertain. We try to clarify subsequent outcomes. Therefore, we conducted this systematic review meta-analysis. used databases obtained from PubMed, Embase, Web Science, Cochrane databases, plus hand-searching, examine association overweightness/obesity inception 4 February 2022. A total 16 cohort studies, including 14 retrospective studies (n = 10,496) another two prospective 818), contributed 11,314 for analysis. The meta-analysis showed significantly increased odds miscarriage rate whose body mass index (BMI) above overweight (OR 1.71 [95% CI 1.38-2.11]) or obese 2.00 1.38-2.90]) under random effect model. tests subgroup difference indicated was consistent, regardless which cut-off (24 25 kg/m2) obesity (28 30 used. With same strategies, found that control group live birth compared those as well 0.79 0.71-0.89], OR 0.78 0.67-0.91]). By contrast, did not find any preterm birth. Based on aforementioned findings, main critical factor contributing worse outcome be an early fetal loss these overweight/obesity. Since were associated outcomes, supposed weight reduction before attempting improve

Language: Английский

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Genetic and Epigenetic Landscape for Drug Development in Polycystic Ovary Syndrome

Endocrine Reviews, Journal Year: 2024, Volume and Issue: 45(4), P. 437 - 459

Published: Jan. 31, 2024

Abstract The treatment of polycystic ovary syndrome (PCOS) faces challenges as all known treatments are merely symptomatic. US Food and Drug Administration has not approved any drug specifically for treating PCOS. As the significance genetics epigenetics rises in development, their pivotal insights have greatly enhanced efficacy success target discovery validation, offering promise guiding advancement PCOS treatments. In this context, we outline genetic epigenetic PCOS, which provide novel into pathogenesis complex disease. We also delve prospective method harnessing strategies to identify potential targets ensure safety. Additionally, shed light on preliminary evidence distinctive associated with gene therapies context

Language: Английский

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Long-term health risk of offspring born from assisted reproductive technologies

Journal of Assisted Reproduction and Genetics, Journal Year: 2023, Volume and Issue: 41(3), P. 527 - 550

Published: Dec. 26, 2023

Language: Английский

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IVF Protocols: Past, Present, and Future

Published: Jan. 1, 2025

Language: Английский

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Association of endometrial preparation protocols and embryonic development stages with ectopic pregnancy in freeze–thaw cycles

Journal of Assisted Reproduction and Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

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Impact of endometrial preparation protocols on pregnancy outcomes in patients with unexplained recurrent implantation failure undergoing frozen embryo transfer

Ultrasound in Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

ABSTRACT Objectives To evaluate the impact of different endometrial preparation protocols on pregnancy outcomes in patients with unexplained recurrent implantation failure (uRIF) undergoing frozen embryo transfer (FET). Methods This retrospective cohort study reviewed 110 372 FET cycles from three fertility centers China between January 2014 and July 2021. Among them, 4346 were performed uRIF, including 557 who had natural cycle (NC) protocol, 1310 stimulated (SC) protocol 2479 artificial (AC) protocol. The primary outcome measure was live birth rate. For singleton births, main obstetric (hypertensive disorders pregnancy, gestational diabetes mellitus, abnormal placentation prelabor rupture membranes) neonatal (Cesarean delivery, preterm birth, post‐term low weight, macrosomia, small‐for‐gestational age, large‐for‐gestational age major defect) collected through standardized questionnaire interviews. Potential confounders controlled by 1:1:1 propensity score matching multivariable logistic regression analysis using prematched data. Results There 397 each group after all baseline characteristics balanced no significant differences groups. rate comparable among NC, SC AC groups (29.5% vs 35.3% 33.0%, respectively; P = 0.21), as rates clinical miscarriage. differed significantly Cesarean delivery (65.6% 71.1% 81.1%, 0.04), post‐hoc statistical significance identified NC ( 0.01). No associations observed other outcomes. results good agreement multivariable‐adjusted before matching. Conclusions Our findings do not prioritize one specific over another for improving uRIF; however, increased risk necessitates careful consideration to optimize Nonetheless, given overall high groups, further clarification is required whether medical indication or personal preference influenced decision mode delivery. © 2025 International Society Ultrasound Obstetrics Gynecology.

Language: Английский

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