Clinical and Preclinical Outcomes of Combining Targeted Therapy With Radiotherapy DOI Creative Commons
May Elbanna,

Nayela N. Chowdhury,

Ryan Rhome

et al.

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: Oct. 18, 2021

In the era of precision medicine, radiation medicine is currently focused on precise delivery highly conformal treatments. However, tremendous developments in targeted therapy are yet to fulfill their full promise and arguably have potential dramatically enhance therapeutic ratio. The increased ability molecularly profile tumors both at diagnosis relapse co-incident progress field radiogenomics could potentially pave way for a more personalized approach treatment contrast current ‘‘one size fits all’’ paradigm. Few clinical trials date shown an improved outcome when combining agents with therapy, however, most failed show benefit, which due limited preclinical data. Several key molecular pathways theoretically effect rationally either by directly enhancing tumor cell kill or indirectly through abscopal combined novel immunotherapies. timing also important determine greatly affect depending pathway being inhibited.

Language: Английский

The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy DOI Open Access

E. Pavitra,

Jyothsna Kancharla, Vivek Kumar Gupta

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114822 - 114822

Published: May 3, 2023

Breast cancer (BC) is the second most fatal disease and prime cause of allied female deaths. BC caused by aberrant tumor suppressor genes oncogenes regulated transcription factors (TFs) like NF-κB. NF-κB a pro-inflammatory TF that crucially alters expressions various associated with inflammation, cell progression, metastasis, apoptosis modulates network underlie tumorigenesis. Herein, we focus on signaling pathways, its regulators, rationale for targeting This review also includes TFs maintain crosstalk their roles in promoting angiogenesis metastasis. In addition, discuss importance combination therapies, resistance to treatment, potential novel therapeutic strategies including nanomedicine targets

Language: Английский

Citations

84
Current Understanding of Flavonoids in Cancer Therapy and Prevention DOI Creative Commons
Mohd Farhan, Asim Rizvi, Mohammad Aatif

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(4), P. 481 - 481

Published: March 27, 2023

Cancer is a major cause of death worldwide, with multiple pathophysiological manifestations. In particular, genetic abnormalities, inflammation, bad eating habits, radiation exposure, work stress, and toxin consumption have been linked to cancer disease development progression. Recently, natural bioactive chemicals known as polyphenols found in plants were shown anticancer capabilities, destroying altered or malignant cells without harming normal cells. Flavonoids demonstrated antioxidant, antiviral, anticancer, anti-inflammatory effects. Flavonoid type, bioavailability, possible method action determine these biological actions. These low-cost pharmaceutical components significant activities are beneficial for several chronic disorders, including cancer. Recent research has focused primarily on isolating, synthesizing, studying the effects flavonoids human health. Here we attempted summarize our current knowledge flavonoids, focusing their mode better understand

Language: Английский

Citations

43
Unraveling the intricacies of glioblastoma progression and recurrence: insights into the role of NFYB and oxidative phosphorylation at the single-cell level DOI Creative Commons
Pulin Liu,

Naifei Xing,

Zhikai Xiahou

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 6, 2024

Background Glioblastoma (GBM), with its high recurrence and mortality rates, makes it the deadliest neurological malignancy. Oxidative phosphorylation is a highly active cellular pathway in GBM, NFYB tumor-associated transcription factor. Both are related to mitochondrial function, but studies on their relationship GBM at single-cell level still scarce. Methods We re-analyzed profiles of from patients different subtypes by transcriptomic analysis further subdivided large population Glioma cells into subpopulations, explored interrelationships pathways among cell stages clinical populations, investigated between factor key subpopulations searching for prognostic genes NFYB, verified experiments. Results C5 subpopulation had highest percentage G2M staging rGBM, which we hypothesized might be higher dividing proliferating ability both subpopulations. activity elevated subgroup, suggesting possible involvement proliferation recurrence, close association function. also identified 13 associated MEM60 may cause have poor prognosis promoting drug resistance. Knockdown was found contribute inhibition proliferation, invasion, migration cells. Conclusion These findings help elucidate mechanisms function progression establish new model therapeutic target based NFYB.

Language: Английский

Citations

30
Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review) DOI Creative Commons
Rui Liu,

Yan Bian,

Lin Liu

et al.

International Journal of Molecular Medicine, Journal Year: 2022, Volume and Issue: 49(5)

Published: March 15, 2022

Radiotherapy is an essential and effective treatment modality for cancer. Excessive levels of reactive oxygen species (ROS) induced by ionizing radiation disrupt the redox homeostasis lead to oxidative stress that may result in cell death. However, tumor microenvironment dynamic responds radiotherapy activating numerous cellular signaling pathways. By scavenging excess ROS, activity endogenous antioxidant enzymes radioresistance worsen clinical outcomes. To assess full potential radiotherapy, it explore underlying mechanisms target identification. The present review article summarized recent data demonstrating nuclear factor‑erythroid factor 2‑related 2 (Nrf2) as a powerful transcription one major defense protect against response radiotherapy; glutathione (GSH) thioredoxin (Trx) systems complement each other are associated with protection cancer cells from damage. In addition, suggested dual targeting inhibit GSH Trx be strategy development radiosensitive radioprotective drugs.

Language: Английский

Citations

49
Epithelial Mesenchymal Transition (EMT) and Associated Invasive Adhesions in Solid and Haematological Tumours DOI Creative Commons
David Greaves, Yolanda Calle

Cells, Journal Year: 2022, Volume and Issue: 11(4), P. 649 - 649

Published: Feb. 13, 2022

In solid tumours, cancer cells that undergo epithelial mesenchymal transition (EMT) express characteristic gene expression signatures promote invasive migration as well the development of stemness, immunosuppression and drug/radiotherapy resistance, contributing to formation currently untreatable metastatic tumours. The traits associated with EMT can be controlled by signalling nodes at adhesion sites (focal contacts, invadopodia microtentacles) where regulation cell migration, cycle progression pro-survival converge. haematological ample evidence accumulated during last decade indicates an EMT-like phenotype is indicative poor disease prognosis. However, this has not been directly linked assembly specific forms adhesions. current review we discuss role in malignancies examine its possible link towards more aggressive these We also known types adhesions formed speculate on their connection phenotype. postulate understanding architecture EMT-related will lead discovery new therapeutic interventions overcome resistance therapies.

Language: Английский

Citations

46
Application of Ultrasound Combined with Microbubbles for Cancer Therapy DOI Open Access
Deepa Sharma, Kai Xuan Leong, Gregory J. Czarnota

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(8), P. 4393 - 4393

Published: April 15, 2022

At present, cancer is one of the leading causes death worldwide. Treatment failure remains prime hurdles in treatment due to metastatic nature cancer. Techniques have been developed hinder growth tumours or at least stop metastasis process. In recent years, ultrasound therapy combined with microbubbles has gained immense success treatment. Ultrasound-stimulated (USMB) other treatments including radiation therapy, chemotherapy immunotherapy demonstrated potential improved outcomes various vitro and vivo studies. Studies shown that low dose administered USMB can similar effects as high therapy. addition, use conjunction radiotherapy minimize toxicity chemotherapeutic drugs, respectively. this review, we discuss biophysical properties its applicability particular, highlight important preclinical early clinical findings demonstrate antitumour effect combining modalities (radiotherapy chemotherapy). Our review mainly focuses on tumour vascular mediated by these therapies. We also several current limitations, addition ongoing future efforts for applying

Language: Английский

Citations

44
The Promise of Nanoparticles-Based Radiotherapy in Cancer Treatment DOI Open Access
Munima Haque, Md Salman Shakil, Kazi Mustafa Mahmud

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(6), P. 1892 - 1892

Published: March 22, 2023

Radiation has been utilized for a long time the treatment of cancer patients. However, radiotherapy (RT) many constraints, among which non-selectivity is primary one. The implementation nanoparticles (NPs) with RT not only localizes radiation in targeted tissue but also provides significant tumoricidal effect(s) compared to alone. NPs can be functionalized both biomolecules and therapeutic agents, their combination significantly reduces side effects RT. NP-based destroys cells through multiple mechanisms, including ROS generation, turn damages DNA other cellular organelles, inhibiting double-strand damage-repair system, obstructing cell cycle, regulating tumor microenvironment, killing stem cells. Furthermore, such combined treatments overcome radioresistance drug resistance chemotherapy. Additionally, have shown synergistic benefit(s) enhanced window. phototherapy, i.e., photodynamic therapy photothermal RT, phototoxicity offers excellent benefits. Moreover, using promise outcomes clinical trials. Therefore, extensive research this field will pave way toward improved treatment.

Language: Английский

Citations

36
Cancer stem cell in prostate cancer progression, metastasis and therapy resistance DOI
Poornima Verma, Neha Shukla, Shivani Kumari

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(3), P. 188887 - 188887

Published: March 29, 2023

Language: Английский

Citations

36
Tumor microenvironment remodeling in oral cancer: Application of plant derived-natural products and nanomaterials DOI
Hendrik Setia Budi, Bagher Farhood

Environmental Research, Journal Year: 2023, Volume and Issue: 233, P. 116432 - 116432

Published: June 16, 2023

Language: Английский

Citations

25
Long noncoding RNA MALAT-1: A versatile regulator in cancer progression, metastasis, immunity, and therapeutic resistance DOI Creative Commons

Dexin Xu,

Wenhai Wang, Duo Wang

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(2), P. 388 - 406

Published: Feb. 1, 2024

Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that do not code for proteins but have been linked to cancer development and metastasis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) influences crucial hallmarks through intricate molecular mechanisms, including proliferation, invasion, angiogenesis, apoptosis, the epithelial-mesenchymal transition (EMT). The current article highlights involvement of MALAT-1 in drug resistance, making it a potential target overcome chemotherapy refractoriness. It discusses impact on immunomodulatory molecules, such as major histocompatibility complex (MHC) PD-L1, leading immune evasion hindering anti-tumor responses. also plays significant role immunology by regulating diverse cell populations. In summary, is versatile regulator, influencing tumorigenesis, chemoresistance, immunotherapy Understanding its precise mechanisms developing targeted therapies, therapeutic strategies targeting show promise improving treatment outcomes. However, further research needed fully uncover biology translate these findings into clinical applications.

Language: Английский

Citations

12