Biomaterials, Journal Year: 2023, Volume and Issue: 301, P. 122233 - 122233
Published: June 28, 2023
Language: Английский
ACS Sensors, Journal Year: 2024, Volume and Issue: 9(6), P. 3009 - 3016
Published: June 5, 2024
Immune checkpoint inhibitors (ICIs) targeting programmed cell death ligand 1 (PD-L1), or its receptor, PD-1 have improved survival in patients with non-small-cell lung cancer (NSCLC). Assessment of PD-L1 expression requires tissue biopsy fine needle aspiration that are currently used to identify most likely respond single agent anti-PD-1/PD-L1 therapy. However, obtaining sufficient generate a proportion score (TPS) ≥ 50% using immunohistochemistry remains challenge potentially may be overcome by liquid biopsies. This study utilized mesoporous gold sensor (MGS) assay examine the phosphorylation status plasma extracellular vesicles (EV pPD-L1) and levels from NSCLC patient samples their association tumor TPS. The 3-dimensional network electrodes provides large surface area, high signal-to-noise ratio, superior electro-conductive framework, thereby significantly improving detection sensitivity nanosensing. Test (
Language: Английский
Citations
3
Vaccines, Journal Year: 2022, Volume and Issue: 10(10), P. 1691 - 1691
Published: Oct. 10, 2022
Extracellular vesicles (EVs) produced by various immune cells, including B and T macrophages, dendritic cells (DCs), natural killer (NK) mast mediate intercellular communication have attracted much attention owing to the novel delivery system of molecules in vivo. DCs are among most active exosome-secreting system. EVs cancer contain antigens; therefore, development vaccine therapy that does not require identification antigens using cancer-cell-derived may significant clinical implications. In this review, we summarise molecular mechanisms underlying EV-based responses their therapeutic effects on tumour vaccination.
Language: Английский
Citations
14
Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(11), P. 2365 - 2381
Published: Nov. 11, 2024
Immune checkpoint proteins (ICPs) serve as critical regulators of the immune system, ensuring protection against damage due to overly activated responses. However, within tumor environment, excessive ICP activation weakens antitumor immunity. Despite development numerous blockade (ICB) drugs in recent years, their broad application has been inhibited by uncertainties about clinical efficacy. A thorough understanding regulation microenvironment is essential for advancing more effective and safer ICB therapies. Extracellular vesicles (EVs), which are pivotal mediators cell-cell communication, have extensively studied found play key roles functionality ICPs. Nonetheless, a comprehensive review summarizing current knowledge crosstalk between EVs ICPs environment lacking. In this review, we summarize interactions several widely well potential implications, providing theoretical basis further investigation EV-related therapeutic approaches.
Language: Английский
Citations
2
Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12
Published: May 12, 2022
Colorectal cancer (CRC) is the second leading cause of death and third most prevalent malignancy. tumors exchange information with surrounding environment influence each other, which collectively constitutes tumor microenvironment (TME) CRC. Many studies have shown that exosome-derived non-coding RNAs (ncRNAs) play important roles in various pathophysiological processes by regulating TME This review summarizes recent findings on fundamental exosomal ncRNAs angiogenesis, vascular permeability, immunity, metabolism drug resistance. Certainly, in-depth understanding will provide comprehensive insights into clinical application these molecules against
Language: Английский
Citations
10
Biomaterials, Journal Year: 2023, Volume and Issue: 301, P. 122233 - 122233
Published: June 28, 2023
Language: Английский
Citations
5