Identification and validation of pyroptosis patterns with a novel quantification system for the prediction of prognosis in lung squamous cell carcinoma DOI Open Access
Xianyu Qin, Jiayan Wu, Fei Qin

et al.

Translational Lung Cancer Research, Journal Year: 2024, Volume and Issue: 13(12), P. 3657 - 3674

Published: Dec. 1, 2024

The role of pyroptosis in lung squamous cell carcinoma (LUSC) remains unclear. This study aimed to screen pyroptosis-related genes (PRGs) and construct a model investigate the immune infiltration, gene mutations, response patients LUSC. We conducted comprehensive evaluation patterns with LUSC 51 PRGs. Pyroptosis-related clusters were identified using consistency clustering algorithm. Differences biologic clinical characteristics between analyzed. Cox regression analysis was performed for differentially expressed (DEGs) related prognosis, principal component (PCA) algorithm used based on these genes. score calculated each tumor sample, samples classified into high- low-score groups score. disparities survival, single-nucleotide variation (SNV), copy number (CNV), immunotherapy high-score A total PRGs classify three significant differences survival (P=0.005). Based 390 DEGs clusters, two distinct by secondary clustering, prognosis scoring established evaluate regulatory PRGs, stratified high low scores, median as cutoff. analyses indicated that scores had worse prognoses Cancer Genome Atlas (TCGA)-LUSC cohort (P=0.002), which further supported GSE37745 (P=0.006) GSE135222 datasets (P=0.02). quantification found be important predicting devising personalized treatment strategies

Language: Английский

The interaction of inflammasomes and gut microbiota: novel therapeutic insights DOI Creative Commons
Shirin Manshouri, Farhad Seif, Monireh Kamali

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 2, 2024

Abstract Inflammasomes are complex platforms for the cleavage and release of inactivated IL-1β IL-18 cytokines that trigger inflammatory responses against damage-associated molecular patterns (DAMPs) or pathogen-associated (PAMPs). Gut microbiota plays a pivotal role in maintaining gut homeostasis. Inflammasome activation needs to be tightly regulated limit aberrant bystander damage host cells. Several types inflammasomes, including Node-like receptor protein family (e.g., NLRP1, NLRP3, NLRP6, NLRP12, NLRC4), PYHIN family, pyrin interact with maintain This review discusses current understanding how inflammasomes interact, this interaction impacts human health. Additionally, we introduce novel biologics antagonists, such as inhibitors therapeutic strategies treating gastrointestinal disorders when dysregulated composition changes.

Language: Английский

Citations

4
STK11 genetic alterations in metastatic EGFR mutant lung cancer DOI Creative Commons
Dandan Yin, Xiyi Lu, Liang Xiao

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 17, 2025

This study was conducted to investigate the relationship between STK11 genetic alterations and outcomes of patients with metastatic EGFR mutant lung cancer. Clinical characteristics genomic data were downloaded from cBioPortal database. The information case mutation collected Jiangyin People's Hospital. Univariate multivariate analyses performed distinguish prognostic differences. Outcomes analyzed before after propensity score matching (PSM). A patient insensitive osimertinib had an extremely poor prognosis. Further analysis showed that mutations a strong mutual exclusion mutations. total 960 adenocarcinoma enrolled in analysis. alternation significant predictor worse univariate or analyses. After PSM, alternations still exhibited prognoses. Cell culture experiments also loss could contribute resistance osimertinib. Functionally, positively associated metabolic signaling pathways immune infiltrates negatively. Through drug screening, trametinib identified sensitize STK11-deficient cell. found portend prognosis for cancer led potentially. MEK inhibitors

Language: Английский

Citations

0
Bibliometric analysis of pyroptosis in pathogenesis and treatment of acute lung injury DOI Creative Commons
Chun Wang, Na Liu

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 22, 2025

Objective This study aims to conduct a bibliometric analysis assess the present state, thematic focus, and emerging developments in research literature on involvement of pyroptosis pathogenesis treatment acute lung injury (PFALI), as well other pertinent areas. Methods examined PFALI published from 1 January 2004 24 May 2024, utilizing Web Science database. The was conducted using CiteSpace, VOSviewer, R, GraphPad Prism 8.0, encompassed metadata countries, institutions, authors, journals, keywords represented literature. Results analyzed 1,495 publications, comprising 1,194 articles 301 reviews, publication output PFALI. China exhibited highest with 964 (64.48%) articles. Central South University most prolific institution, contributing 54 (3.61%) publications. Zhou, Yong had greatest individual record, 15 (3.59%) journal International Immunopharmacology PFALI-related at 76 (5.09%). identified frontiers for upcoming years include “iron,” “sirt1,” “repair,” “alveolar macrophage pyroptosis.” Conclusion comprehensively trends advancements related PFALI, including contributions key countries.

Language: Английский

Citations

0
Cell death in acute lung injury: caspase-regulated apoptosis, pyroptosis, necroptosis, and PANoptosis DOI Creative Commons
Jun Xiao,

Lichuan Wang,

Bohan Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

There has been abundant research on the variety of programmed cell death pathways. Apoptosis, pyroptosis, and necroptosis under action caspase family are essential for innate immune response. Caspases classified into inflammatory caspase-1/4/5/11, apoptotic caspase-3/6/7, caspase-2/8/9/10. Although is not caspase-dependent to transmit signals, it can cross-link with pyroptosis apoptosis signals regulation caspase-8. An increasing number studies have reiterated involvement in acute lung injuries caused by bacterial viral infections, blood transfusion, ventilation, which influenced noxious stimuli that activate or inhibit engagement pathways, leading subsequent injury. This article reviews role caspases implicated diverse mechanisms injury status relevant inhibitors against target proteins described mechanisms. The findings this review may help delineating novel therapeutic targets

Language: Английский

Citations

0
The characterization and validation of regulated cell death-related genes in chronic rhinosinusitis with nasal polyps DOI
Hongxia Li, Fei Jing, Wei Xu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114509 - 114509

Published: March 31, 2025

Language: Английский

Citations

0
Can pyridoxine function as an anti-pyroptosis agent? A narrative review DOI
Astari Pranindya Sari, Reviono Reviono, Agus Dwi Susanto

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Pyroptosis, gasdermins and allergic diseases DOI
Ronald Allan M. Panganiban, Kari C. Nadeau, Quan Lu

et al.

Allergy, Journal Year: 2024, Volume and Issue: 79(9), P. 2380 - 2395

Published: July 14, 2024

Pyroptosis is an inflammatory form of programmed cell death that distinct from necrosis and apoptosis. primarily mediated by the gasdermin family proteins (GSDMA-E PVJK), which, when activated proteolytic cleavage, pores in plasma membrane, leading to death. While much past research on pyroptosis has focused its role cancer, metabolic disorders, infectious diseases, recent experimental observational studies have begun implicate allergic diseases. These suggest gasdermin-mediated contributes development conditions could offer novel targets for therapy. Here, we review our current understanding with emphasis gasdermins as executioners potential mediators disease. We highlight new discoveries establish a mechanistic link between biochemical actions onset Additionally, discuss how might contribute dysfunction epithelial barrier, key factor believed initiate progression various

Language: Английский

Citations

2
A new perspective on targeting pulmonary arterial hypertension: Programmed cell death pathways (Autophagy, Pyroptosis, Ferroptosis) DOI Open Access

Qingliang Ge,

Tianqing Zhang, Jinpu Yu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117706 - 117706

Published: Nov. 23, 2024

Language: Английский

Citations

2
Pyroptosis in asthma: inflammatory phenotypes, immune and non-immune cells, and novel treatment approaches DOI Creative Commons

Yuqiu Hao,

Wenrui Wang,

Lin Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

Pyroptosis is a form of inflammatory programmed cell death, and activated by pathogen infections or endogenous danger signals. The canonical pyroptosis process characterized the inflammasome (typically NLRP3)-mediated activation caspase-1, which in turn cleaves activates IL-1β IL-18, as well gasdermin D, pore-forming executor protein, leading to membrane rupture, release proinflammatory cytokines damage-associated molecular pattern molecules. considered part innate immune response. A certain level can help eliminate pathogenic microorganisms, but excessive lead persistent responses, cause tissue damage. In recent years, has emerged crucial contributor development chronic respiratory diseases, such asthma. present study reviews involvement asthma, terms its role different phenotypes disease, influence on various non-immune cells airway. addition, potential therapeutic value targeting for treatment specific asthma discussed.

Language: Английский

Citations

1
Research progress on the effect of pyroptosis on the occurrence, development, invasion and metastasis of colorectal cancer DOI Open Access

Xu Wang,

Qi-Hang Yin,

Lin-Lu Wan

et al.

World Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 16(8), P. 3410 - 3427

Published: Aug. 7, 2024

Pyroptosis is a type of programmed cell death mediated by gasdermines (GSDMs). The N-terminal domain GSDMs forms pores in the plasma membrane, causing membrane rupture and release contents, leading to an inflammatory response mediating pyrodeath. plays important role diseases malignant tumors. With further study pyroptosis, increasing number studies have shown that pyroptosis pathway can regulate tumor microenvironment antitumor immunity colorectal cancer closely related occurrence, development, treatment prognosis cancer. This review aimed explore molecular mechanism (CRC) provide ideas for clinical diagnosis CRC.

Language: Английский

Citations

0