The Role of Innate Priming in Modifying Tumor-associated Macrophage Phenotype DOI Creative Commons

Ben Topham,

Barry D. Hock, Elisabeth Phillips

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(12)

Published: Dec. 17, 2024

Tumor-associated macrophages (TAMs) are innate immune cells that exert far reaching influence over the tumor microenvironment (TME). Depending on cues within local environment, TAMs may promote angiogenesis, cancer cell invasion and immunosuppression, or, alternatively, inhibit progression via neoantigen presentation, tumoricidal reactive oxygen species generation pro-inflammatory cytokine secretion. Therefore, have a pivotal role in determining response to therapy. TAM phenotypes driven by cytokines physical produced cells, adipocytes, fibroblasts, pericytes, other TME. Research has shown can be primed environmental stimuli, adding another layer of complexity context determines phenotype. Innate priming is functional consequence metabolic epigenetic reprogramming primary stimulant, resulting altered cellular future secondary stimulation. offers novel target for development immunotherapy improved prognosis disease, but also raises risk exacerbating existing inflammatory pathologies. This review will discuss mechanisms underlying including modification, its relevance progression, possible clinical implications treatment.

Language: Английский

Mesenchymal stem cells derived exosomes: a new era in cardiac regeneration DOI Creative Commons
Hossein Rayat Pisheh, Mahsa Sani

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 23, 2025

Language: Английский

Citations

2
Roles of lncRNAs in NF-κB-Mediated Macrophage Inflammation and Their Implications in the Pathogenesis of Human Diseases DOI Open Access

Jae-Joon Shin,

Jeongkwang Park,

Hyeung‐Seob Shin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2670 - 2670

Published: Feb. 25, 2024

Over the past century, molecular biology’s focus has transitioned from proteins to DNA, and now RNA. Once considered merely a genetic information carrier, RNA is recognized as both vital element in early cellular life regulator complex organisms. Long noncoding RNAs (lncRNAs), which are over 200 bases long but do not code for proteins, play roles gene expression regulation signal transduction by inducing epigenetic changes or interacting with various RNAs. These interactions exhibit range of functions cell types, including macrophages. Notably, some macrophage lncRNAs influence activation NF-κB, crucial transcription factor governing immune inflammatory responses. Macrophage NF-κB instrumental progression pathological conditions sepsis, atherosclerosis, cancer, autoimmune disorders, hypersensitivity. It orchestrates related responses, inflammation, survival, proliferation. Consequently, its malfunction key contributor onset development these diseases. This review aims summarize function regulating activity particular emphasis on their relevance human diseases potential therapeutic targets. The insights gained studies lncRNAs, discussed this review, could provide valuable knowledge treatments involving

Language: Английский

Citations

10
Digging Through the Complexities of Immunological Approaches in Emerging Osteosarcoma Therapeutics: A Comprehensive Narrative Review with Updated Clinical Trials DOI Creative Commons
Consolato Sergi,

Mervin Burnett,

Eugeniu Jantuan

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 664 - 664

Published: March 8, 2025

Osteosarcoma (OS) is the predominant mesenchymal primary malignant bone tumor in oncology and pathology, impacting a wide age range from adolescents to older adults. It frequently advances lung metastasis, ultimately resulting mortality of OS patients. The precise pathological pathways responsible for progression dissemination are not fully understood due its heterogeneity. integration surgery with neoadjuvant postoperative chemotherapy has significantly increased 5-year survival rate more than 70% patients localized tumors. However, about 30% experience local recurrence and/or metastasis. Hence, there requirement innovative therapeutic approaches address limitations traditional treatments. Immunotherapy garnered increasing attention as promising avenue tumors resistant standard therapies, including OS, despite underlying mechanisms disease remaining well elucidated. may have been suitable use because tumor’s immunosuppressive microenvironment limited immunogenicity. Nevertheless, immune-based treatments now being developed clinical use, such bispecific antibodies, chimeric antigen receptor T cells, immune checkpoint inhibitors. Also, additional immunotherapy techniques cytokines, vaccines, modified-Natural Killer (NK) cells/macrophages early phases research but will certainly be popular subjects nearest future. Our goal writing this review was spark new lines inquiry into by summarizing findings both preclinical current studies examining different approaches.

Language: Английский

Citations

1
New Strategies for Macrophage Re-Education in Cancer: An Update DOI Open Access
Nadia Lampiasi

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3414 - 3414

Published: March 18, 2024

The association between cancer and inflammation is well established. Chronic represents a fundamental step in the development progression of some types cancer. Tumors are composed heterogeneous population infiltrating cells including macrophages, fibroblasts, lymphocytes, granulocytes, mast cells, which respond to signals from microenvironment and, turn, produce cytokines, chemokines, transcription factors, receptors, miRNAs. Recent data demonstrate that, addition classical (M1) alternative (M2) macrophage subtypes, there many intermediate subtypes that potentially play different roles response environmental stimuli. infiltrated by macrophages called TAMs mainly display an M2-like phenotype tumor growth-permissive activities. There bidirectional interaction tumor-infiltrating determines polarization ultimately or regression. These complex interactions still unclear but understanding them for new therapeutic strategies. Re-educating tumor-permissive into anti-tumor focus research. This review aims analyze most recent articles investigating interplay tumors, TAMs, strategies re-educating macrophages.

Language: Английский

Citations

6
Construction and Osteogenic Capacity Study of Engineered Exosome-based Nanoplatform Targeting Macrophages DOI Creative Commons
Wei Xiang,

Zhoujun Zhu,

Qisong Shang

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106912 - 106912

Published: April 1, 2025

Language: Английский

Citations

0
Influencing immunity: role of extracellular vesicles in tumor immune checkpoint dynamics DOI Creative Commons
Ziyang Ye, Genpeng Li, Jianyong Lei

et al.

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(11), P. 2365 - 2381

Published: Nov. 11, 2024

Immune checkpoint proteins (ICPs) serve as critical regulators of the immune system, ensuring protection against damage due to overly activated responses. However, within tumor environment, excessive ICP activation weakens antitumor immunity. Despite development numerous blockade (ICB) drugs in recent years, their broad application has been inhibited by uncertainties about clinical efficacy. A thorough understanding regulation microenvironment is essential for advancing more effective and safer ICB therapies. Extracellular vesicles (EVs), which are pivotal mediators cell-cell communication, have extensively studied found play key roles functionality ICPs. Nonetheless, a comprehensive review summarizing current knowledge crosstalk between EVs ICPs environment lacking. In this review, we summarize interactions several widely well potential implications, providing theoretical basis further investigation EV-related therapeutic approaches.

Language: Английский

Citations

2
Exosomes in cancer diagnosis based on the Latest Evidence: Where are We? DOI
Ketao Jin,

Huanrong Lan,

Yuejun Han

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113133 - 113133

Published: Sept. 14, 2024

Language: Английский

Citations

1
Efficacy and safety of PD-1 and PD-L1 inhibitors in advanced colorectal cancer: a meta-analysis of randomized controlled trials DOI Creative Commons

Zhen-Zi Wang,

Yuan Liu, Kedi Wang

et al.

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 18, 2024

PD-1 and PD-L1 inhibitors have emerged as promising therapies for advanced colorectal cancer (CRC), but their efficacy safety profiles require further evaluation. This meta-analysis aims to assess the of PD-1/PD-L1 in this patient population. A systematic review were conducted following PRISMA guidelines, with data sourced from PubMed, Embase, CENTRAL, Web Science, CNKI up August 3, 2024. Nine randomized controlled trials (RCTs) involving 1680 patients included. The primary outcomes overall survival (OS), progression-free (PFS) objective response rate (ORR), while was assessed through adverse events (AEs) grade ≥ 3 AEs. Effect sizes calculated using mean differences (MD) risk ratios (RR) 95% confidence intervals (CIs). Overall, showed that did not significantly extend OS (MD = 0.86, CI: -0.55, 2.27), they improved PFS 2.53, 0.92, 4.15). Additionally, increase ORR compared controls (RR 1.19, 0.99, 1.44). In terms safety, incidence Subgroup analysis indicated 1.24, 0.20, 2.29) 6.27, 0.56, 11.97), a significant impact on these outcomes. associated higher AEs 1.29, 1.07, 1.57), observed inhibitors. improve CRC, making them preferable option over inhibitors, which show limited severe These findings support prioritizing clinical practice group, caution is warranted due concerns. PROSPERO (CRD42024611696).

Language: Английский

Citations

1
The Role of Innate Priming in Modifying Tumor-associated Macrophage Phenotype DOI Creative Commons

Ben Topham,

Barry D. Hock, Elisabeth Phillips

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(12)

Published: Dec. 17, 2024

Tumor-associated macrophages (TAMs) are innate immune cells that exert far reaching influence over the tumor microenvironment (TME). Depending on cues within local environment, TAMs may promote angiogenesis, cancer cell invasion and immunosuppression, or, alternatively, inhibit progression via neoantigen presentation, tumoricidal reactive oxygen species generation pro-inflammatory cytokine secretion. Therefore, have a pivotal role in determining response to therapy. TAM phenotypes driven by cytokines physical produced cells, adipocytes, fibroblasts, pericytes, other TME. Research has shown can be primed environmental stimuli, adding another layer of complexity context determines phenotype. Innate priming is functional consequence metabolic epigenetic reprogramming primary stimulant, resulting altered cellular future secondary stimulation. offers novel target for development immunotherapy improved prognosis disease, but also raises risk exacerbating existing inflammatory pathologies. This review will discuss mechanisms underlying including modification, its relevance progression, possible clinical implications treatment.

Language: Английский

Citations

0