Th17 cell function in cancers: immunosuppressive agents or anti-tumor allies?

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 27, 2024

T helper (Th) 17 cells, a distinct subset of Th lymphocytes, are known for their prominent interleukin (IL)-17 production and other pro-inflammatory cytokines. These cells exhibit remarkable plasticity, allowing them to different phenotypes in the cancer microenvironment. This adaptability enables Th17 promote tumor progression by immunosuppressive activities angiogenesis, but also mediate anti-tumor immune responses through employing setting or even directly converting toward Th1 phenotype producing interferon-gamma (IFN-γ). dual role makes it double-edged sword encountering cancer. In this review, we aim elucidate complexities cell function summarizing recent studies and, ultimately, design novel therapeutic strategies, especially targeting milieu, which could pave way more effective treatments.

Language: Английский

---

Contemporary Perspectives on the Role of Vitamin D in Enhancing Gut Health and Its Implications for Preventing and Managing Intestinal Diseases

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2352 - 2352

Published: July 20, 2024

Vitamin D, a crucial fat-soluble vitamin, is primarily synthesized in the skin upon exposure to ultraviolet radiation and widely recognized as bone-associated hormone. However, recent scientific advancements have unveiled its intricate association with gut health. The intestinal barrier serves vital component, safeguarding milieu maintaining overall homeostasis. Deficiencies vitamin D been implicated altering microbiome composition, compromising integrity of mucosal barrier, predisposing individuals various pathologies. exerts regulatory function by binding receptors (VDR) present immune cells, thereby modulating production pro-inflammatory cytokines influencing function. Notably, numerous studies reported lower serum levels among patients suffering from diseases, including inflammatory bowel disease, irritable syndrome, celiac highlighting growing significance health maintenance. This comprehensive review delves into latest understanding mechanistic role function, emphasizing pivotal regulation. Furthermore, we consolidate relevant findings pertaining therapeutic potential management diseases.

Language: Английский

---

Bacteroidetes promotes esophageal squamous carcinoma invasion and metastasis through LPS-mediated TLR4/Myd88/NF-κB pathway and inflammatory changes

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 4, 2024

Abstract Gut microbiota plays a crucial role in gastrointestinal tumors. Additionally, gut microbes influence the progression of esophageal cancer. However, major bacterial genera that affect invasion and metastasis cancer remain unknown, underlying mechanisms unclear. Here, we investigated flora metabolites patients with squamous cell carcinoma found abundant Bacteroides increased secretion entry surface antigen lipopolysaccharide (LPS) into blood, causing inflammatory changes body. We confirmed these results mouse model 4NQO-induced situ further identified epithelial–mesenchymal transition (EMT) occurrence TLR4/Myd88/NF-κB pathway activation vitro experiments revealed LPS from fragile promoted proliferation, migration, invasion, induced EMT by activating pathway. These reveal are closely associated through higher response level signaling both common to inflammation tumors LPS, providing new biological target for prevention or treatment.

Language: Английский

---

Elevated IL-17A-Secreting Regulatory T Cells in Sinonasal Tissues of Chronic Rhinosinusitis with Nasal Polyps

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Language: Английский

---

New Insights in Natural Bioactive Compounds for Periodontal Disease: Advanced Molecular Mechanisms and Therapeutic Potential

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 807 - 807

Published: Feb. 10, 2025

Periodontal disease is a chronic inflammatory condition that destroys the tooth-supporting structures due to host's immune response microbial biofilms. Traditional periodontal treatments, such as scaling and root planing, pharmacological interventions, surgical procedures, have significant limitations, including difficulty accessing deep pockets, biofilm recolonization, development of antibiotic resistance. In light these challenges, natural bioactive compounds derived from plants, herbs, other sources offer promising alternative their anti-inflammatory, antioxidant, antimicrobial, tissue-regenerative properties. This review focuses on molecular mechanisms through which compounds, curcumin, resveratrol, epigallocatechin gallate (EGCG), baicalin, carvacrol, berberine, essential oils, Gum Arabic, exert therapeutic effects in disease. Bioactive inhibit critical pathways like NF-κB, JAK/STAT, MAPK while activating protective Nrf2/ARE, reducing cytokine production oxidative stress. They also activity matrix metalloproteinases (MMPs), preventing tissue degradation promoting healing. addition, demonstrated potential disrupt bacterial biofilms by interfering with quorum sensing, targeting cell membranes, enhancing efficacy.Bioactive modulate system shifting balance pro-inflammatory anti-inflammatory responses efferocytosis, helps resolve inflammation supports regeneration. However, despite challenges related poor bioavailability, stability oral cavity, absence large-scale clinical trials need be addressed. Future strategies should prioritize advanced delivery systems nanoparticles hydrogels enhance bioavailability sustain release, alongside long-term studies assess human populations. Furthermore, combining traditional treatments could provide synergistic benefits managing aims explore disease, emphasizing action offering insights into integration conventional therapies for more comprehensive approach health.

Language: Английский

---

Associations between traditional Chinese medicine constitution and depression/anxiety/sleep disturbances in patients with chronic pain: A cross-sectional study

Journal of Traditional Chinese Medical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

---

The Major Role of T Regulatory Cells in the Efficiency of Vaccination in General and Immunocompromised Populations: A Review

Vaccines, Journal Year: 2024, Volume and Issue: 12(9), P. 992 - 992

Published: Aug. 30, 2024

Since their conception with the smallpox vaccine, vaccines used worldwide have mitigated multiple pandemics, including recent COVID-19 outbreak. Insightful studies uncovered complexities of different functional networks CD4 T cells (T helper 1 (Th1); Th2, Th17) and CD8 cytotoxic; Tc), as well B cell (B

Language: Английский

---

The Role of Inflammation in the Pathogenesis of Viral Respiratory Infections

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2526 - 2526

Published: Dec. 7, 2024

Viral respiratory infections (VRIs) are a leading cause of morbidity and mortality worldwide, making them significant public health concern. During infection, viruses, including Influenza virus, SARS-CoV-2, syncytial virus (RSV), trigger an antiviral immune response, specifically boosting the inflammatory response that plays critical role in their pathogenesis. The induced by viruses can be double-edged sword since it initially to protective/reparative from virus-induced injuries. Still, also detrimental host cells tissues. However, mechanisms differentiate complex crosstalk between favorable responses harmful poorly understood. This review explores interplay viral pathogens mainly focusing on inflammation pathogenesis VRIs. We discuss how both contain exacerbate progression infections, highlighting potential therapeutic targets emerging drugs for modulating aberrant during

Language: Английский

---

Plasticity deficits of Tregs remodeling toward Th1-like and Th17-like Tregs in individuals with type 1 diabetes

Journal of Endocrinological Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

---

Treatment of the atrial premature contraction by Traditional Chinese Medicine: The Yin-Yang theory

Asian Journal of Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

---