Systemic autoinflammatory diseases

Journal of Autoimmunity, Journal Year: 2020, Volume and Issue: 109, P. 102421 - 102421

Published: Feb. 1, 2020

Systemic autoinflammatory diseases (SAIDs) are a growing group of disorders caused by dysregulation the innate immune system leading to episodes systemic inflammation. In 1997, MEFV was first gene identified as disease causing for Familial Mediterranean Fever, most common hereditary SAID. cases, have strong genetic background with mutations in single genes. Since 1997 more than 30 new genes associated been identified, affecting different parts system. Nevertheless, at least 40–60% patients phenotypes typical SAIDs, distinct diagnosis cannot be met, undefined SAIDs (uSAIDs). However, can also polygenic or multifactorial origin, environmental influence modulating phenotype. The implementation continuum model combining adaptive and autoimmune shows complexity importance methods elucidate molecular changes causative factors SAIDs. Diagnosis is often based on clinical presentation testing. timeline from onset takes up 7.3 years, highlighting indisputable need identify treatment diagnostic targets. Recently, other under investigation additional contributors pathogenesis This review gives an overview etiology summarizes recent options.

Language: Английский

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Comparative Proteomic Analysis of Polarized Human THP-1 and Mouse RAW264.7 Macrophages

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: June 29, 2021

Macrophages can be polarized into classically activated macrophages (M1) and alternatively (M2) in the immune system, performing pro-inflammatory anti-inflammatory functions, respectively. Human THP-1 mouse RAW264.7 cell line models have been widely used various macrophage-associated studies, while similarities differences protein expression profiles between two macrophage are still largely unclear. In this study, of M1 M2 phenotypes from both were systematically investigated using mass spectrometry-based proteomics. By quantitatively analyzing more than 5,000 proteins among different types (M0, M2) lines, we identified a list that uniquely up-regulated each type further confirmed 43 commonly lines. These results revealed considerable divergences polarization macrophages. Moreover, mRNA CMPK2, RSAD2, DDX58, DHX58 strongly for models. data serve as important resources studies diseases experimental pathology human

Language: Английский

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Neutrophils in cancer: dual roles through intercellular interactions

Oncogene, Journal Year: 2024, Volume and Issue: unknown

Published: March 12, 2024

Language: Английский

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Resveratrol Role in Autoimmune Disease—A Mini-Review

Nutrients, Journal Year: 2017, Volume and Issue: 9(12), P. 1306 - 1306

Published: Dec. 1, 2017

Autoimmune diseases are still considered to be pressing concerns due the fact that they leaders in death and disability causes worldwide. Resveratrol is a polyphenol derived from variety of foods beverages, including red grapes wine. Anti-inflammatory, antioxidant, antiaging properties resveratrol have been reported, some animal human studies this compound reduced ameliorated progression autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, psoriasis, inflammatory bowel disease, type 1 diabetes mellitus. Thus, review aims summarize critically analyze role modulation several organ-specific or diseases.

Language: Английский

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Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation

Nature Metabolism, Journal Year: 2019, Volume and Issue: 1(7), P. 731 - 742

Published: July 12, 2019

Language: Английский

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Macrophages with regulatory functions, a possible new therapeutic perspective in autoimmune diseases

Autoimmunity Reviews, Journal Year: 2019, Volume and Issue: 18(10), P. 102369 - 102369

Published: Aug. 9, 2019

Language: Английский

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Barbaloin protects against lipopolysaccharide (LPS)-induced acute lung injury by inhibiting the ROS-mediated PI3K/AKT/NF-κB pathway

International Immunopharmacology, Journal Year: 2018, Volume and Issue: 64, P. 140 - 150

Published: Aug. 31, 2018

Language: Английский

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<p>Role of Chemokines and Chemokine Receptors in Rheumatoid Arthritis</p>

ImmunoTargets and Therapy, Journal Year: 2020, Volume and Issue: Volume 9, P. 43 - 56

Published: March 1, 2020

Abstract: Rheumatoid arthritis (RA) is one of the most prevalent autoimmune diseases and a prototypic inflammatory disease, affecting small joints hands feet. Chemokines chemokine receptors play critical role in RA pathogenesis via immune cells recruitment. Several chemokines are abundant peripheral blood local inflamed RA. Furthermore, synthetic biologics disease modifying anti rheumatic drugs have been reported to affect expression. Thus, many studies focused on targeting receptors, where some shown positive promising results. However, blockers human trials treatment displayed failures that can be attributed several reasons their structures binding affinities. Nevertheless, will continue under development, order improve therapeutic potentials other diseases. In this review we provide an up-to-date knowledge regarding with emphasis activities cells. We also discussed effects those molecules This might impetus for developing new modalities treat chronic disease. Keywords: rheumatoid arthritis, chemokines, immunotherapy, immunotargets,

Language: Английский

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Oridonin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-induced RAW264.7 cells and acute lung injury

Oncotarget, Journal Year: 2017, Volume and Issue: 8(40), P. 68153 - 68164

Published: July 12, 2017

Acute lung injury (ALI) is a life-threatening inflammatory disease owing to the lack of specific and effective therapies. Oridonin (Ori) an active diterpenoid isolated from Rabdosiarubescens (R.rubescens) that has been shown possess broadspectrum pharmacological properties including anti-inflammatory, antitumour, antioxidative neuroregulatory effects. However, its potential protective mechanism in ALI not well characterized. In this study, we demonstrated Ori reduces mortality mice with induced by high dose lipopolysaccharide (LPS), which suggests effect on LPS ALI. Next, our results confirmed improves LPS-induced localized pulmonary pathology decreased concentration pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) serum. Nuclear factor-kappa B (NF-κB) capable regulating transcription factors. Interestingly, showed inhibits expression TLR4/MyD88 phosphorylation NF-κB p65 tissues. To confirm this, further validated possible regulatory anti-inflammatory mechanisms vitro. RAW264.7 cells, are widely used as inflammation model evaluate drugs vitro, were chosen for study. Similar observed, is, pre-treatment Ori, markedly inhibited nuclear translocation subsequently release increased LPS. Overall, these exerts therapeutic inhibiting cytokines, such IL-1β, TNF-α, through TLR4/MyD88/NF-κB axis.

Language: Английский

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Modulation of innate immunity by cyclosporine A

Biochemical Pharmacology, Journal Year: 2019, Volume and Issue: 163, P. 472 - 480

Published: March 15, 2019

Language: Английский

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