Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel

Nature Biomedical Engineering, Journal Year: 2021, Volume and Issue: 5(11), P. 1377 - 1388

Published: June 24, 2021

Language: Английский

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Gut microbiota-derived short-chain fatty acids and colorectal cancer: Ready for clinical translation?

Cancer Letters, Journal Year: 2021, Volume and Issue: 526, P. 225 - 235

Published: Nov. 26, 2021

Language: Английский

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Targeting the gut microbiota for cancer therapy

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(12), P. 703 - 722

Published: Oct. 17, 2022

Language: Английский

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Gut Microbiota Modulation of Efficacy and Toxicity of Cancer Chemotherapy and Immunotherapy

Gastroenterology, Journal Year: 2022, Volume and Issue: 164(2), P. 198 - 213

Published: Oct. 27, 2022

Accumulating evidence supports not only the functional role of gut microbiome in cancer development and progression but also its defining efficacy toxicity chemotherapeutic agents (5-fluorouracil, cyclophosphamide, irinotecan, oxaliplatin, gemcitabine, methotrexate) immunotherapeutic compounds (anti–programmed death-ligand 1/anti–programmed cell death protein 1 anti–cytotoxic T-lymphocyte-associated antigen 4). This is supported numerous vitro, animal, clinical studies that highlight importance microbial mechanisms therapeutic responses. The therefore shapes oncologic outcomes now being leveraged for novel personalized approaches treatment. However, if to be successfully translated into next-generation treatments, a new multimodal model oncomicrobiome must conceptualized incorporates cometabolism pharmacologic care. objective this review outline current knowledge pharmacomicrobiomics describe how multiparametric functions influence treatment response across types. secondary propose innovative modulating environments improve therapy diminish toxic effects derived from antineoplastic patient benefit.

Language: Английский

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Immune System, Microbiota, and Microbial Metabolites: The Unresolved Triad in Colorectal Cancer Microenvironment

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: March 26, 2021

Colorectal cancer (CRC) is one of the most common cancers worldwide. As with other cancers, CRC a multifactorial disease due to combined effect genetic and environmental factors. Most cases are sporadic, but small proportion hereditary, estimated at around 5-10%. In both, tumor interacts heterogeneous cell populations, such as endothelial, stromal, immune cells, secreting different signals (cytokines, chemokines or growth factors) generate favorable microenvironment for invasion metastasis. There ample evidence that inflammatory processes have role in carcinogenesis progression CCR. Different profiles activation can promote pro anti-tumor pathways; hence they studied key target control progression. Additionally, intestinal mucosa close contact microorganism community, including bacteria, bacteriophages, viruses, archaea, fungi composing gut microbiota. Aberrant composition this microbiota, together alteration diet‐derived microbial metabolites content (such butyrate polyamines) compounds has been related CRC. Some pks+ Escherichia coli Fusobacterium nucleatum , involved colorectal through pathomechanisms induction mutations epithelial cells modulation microenvironment. Epithelial from Pattern-recognition receptors G-protein coupled (receptor butyrate), suggesting their be regulated by microbiota metabolites. review, we discuss how dynamics metabolites, interplays sporadic hereditary CRC, modulating

Language: Английский

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Intestinal Microbiota-Derived Short Chain Fatty Acids in Host Health and Disease

Nutrients, Journal Year: 2022, Volume and Issue: 14(9), P. 1977 - 1977

Published: May 9, 2022

Intestinal microbiota has its role as an important component of human physiology. It produces metabolites that module key functions to establish a symbiotic crosstalk with their host. Among them, short chain fatty acids (SCFAs), produced by intestinal bacteria during the fermentation partially and non-digestible polysaccharides, play roles in regulating colon physiology changing environment. Recent research found SCFAs not only influence signal transduction pathway gut, but they also reach tissues organs outside through circulation blood. Growing evidence highlights importance level influencing health maintenance disease development. are probably involved management host complicated (positive or negative) way. Here, we review current understanding effects on discuss potential prevention therapeutics variety disorders. provides systematic theoretical basis for study mechanisms precise intake promote health.

Language: Английский

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Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites

Aging, Journal Year: 2021, Volume and Issue: 13(5), P. 6375 - 6405

Published: March 2, 2021

teaching and research institutions in France or abroad, from public private centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement recherche français étrangers, laboratoires publics privés.

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Role of the intestinal microbiome and microbial-derived metabolites in immune checkpoint blockade immunotherapy of cancer

Genome Medicine, Journal Year: 2021, Volume and Issue: 13(1)

Published: June 23, 2021

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block immune inhibitory pathways. Administration of ICIs augments T cell-mediated responses against tumor, resulting in improved overall survival cancer patients. It has emerged the intestinal microbiome can modulate to via host system and use antibiotics lead reduced efficacy ICIs. Recently, reports fecal microbiota transplantation ICI therapy patients previously refractory suggest targeting may be a viable strategy reprogram tumor microenvironment augment therapy. Intestinal microbial metabolites also linked response rates In addition rates, certain toxicities arise during have been found associated with microbiome, including particular colitis. A key mechanistic question is how microbes enhance anti-tumor or, alternatively, predispose ICI-associated Evidence outcomes therapies two major mechanisms, those antigen-specific antigen-independent. Antigen-specific mechanisms occur when epitopes shared between antigens could enhance, reduce cross-reactive adaptive cells. Antigen-independent include modulation by engaging innate and/or To establish microbiome-based biomarkers specifically immunotherapy, further prospective interventional studies will required.

Language: Английский

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To metabolomics and beyond: a technological portfolio to investigate cancer metabolism

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 22, 2023

Abstract Tumour cells have exquisite flexibility in reprogramming their metabolism order to support tumour initiation, progression, metastasis and resistance therapies. These reprogrammed activities include a complete rewiring of the bioenergetic, biosynthetic redox status sustain increased energetic demand cells. Over last decades, cancer field has seen an explosion new biochemical technologies giving more tools than ever before navigate this complexity. Within cell or tissue, metabolites constitute direct signature molecular phenotype thus profiling concrete clinical applications oncology. Metabolomics fluxomics, are key technological approaches that mainly revolutionized enabling researchers both qualitative mechanistic model cancer. Furthermore, upgrade from bulk single-cell analysis provided unprecedented opportunity investigate biology at cellular resolution allowing depth quantitative complex heterogenous diseases. More recently, advent functional genomic screening allowed identification pathways, processes, biomarkers novel therapeutic targets concert with other allow patient stratification treatment regimens. This review is intended be guide for metabolism, highlighting current emerging technologies, emphasizing advantages, disadvantages potential leading development innovative anti-cancer

Language: Английский

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A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(15)

Published: March 23, 2023

Abstract Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer progression, primarily by remodeling tumor microenvironment regulating signaling pathways in cells multiple immune cells. The use of microbial radiotherapy chemotherapy mitigates severe side effects from treatment improves efficacy treatment. Immunotherapy combined with effectively activates system to kill tumors overcomes drug resistance. Consequently, various novel strategies have been developed modulate metabolites. Manipulation genes involved metabolism using synthetic biology approaches directly affects levels metabolites, while fecal transplantation phage affect altering composition microbiome. However, some harbor paradoxical functions depending on context (e.g., type cancer). Furthermore, metabolic microorganisms certain anticancer drugs such as irinotecan gemcitabine, render ineffective or exacerbate their adverse effects. Therefore, a personalized comprehensive consideration patient's condition is required when employing treat cancer. purpose this review summarize correlation between cancer, provide fresh ideas for future scientific research.

Language: Английский

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