Systemic inflammation and cancer-related frailty: shifting the paradigm toward precision survivorship medicine DOI Creative Commons
Antonio Di Meglio, Inês Vaz-Luís

ESMO Open, Journal Year: 2024, Volume and Issue: 9(1), P. 102205 - 102205

Published: Jan. 1, 2024

Over the past few decades, multiple studies have tried to stratify cancer survivors according their individual risk of treatment-related toxicities, particularly persistent 'sequelae' and deterioration health-related quality life.1Hertz D.L. Lustberg M.B. Sonis S. Evolution predictive factor analysis for chemotherapy-related toxicity.Support Care Cancer. 2023; 31: 601Crossref Scopus (0) Google Scholar Nevertheless, a substantial part contributors this inter-individual variability remains elusive. Seemingly similar patients may follow very different long-term patterns in terms subjective toxicity same—or closely related—classes drugs or treatment protocols.2Di Meglio A. Havas J. Gbenou A.S. et al.Dynamics patient-reported life health behaviors after adjuvant breast chemotherapy.J Clin Oncol. 2022; 40: 3190-3204Crossref PubMed (15) Scholar, 3Vaz-Luis I. Di al.Long-term longitudinal fatigue cancer: group-based trajectory analysis.J 2148-2162Crossref (14) 4Charles C. Bardet Larive al.Characterization depressive symptoms trajectories diagnosis women France.JAMA Netw Open. 5: E225118Crossref (8) This observation has catalyzed need improve ability accurately define predictors cancer-related frailty at level, personalize care pathways accordingly, from moment is made. Such model would allow implementation early, tailored management interventions as well preventive proactive supportive strategies that could reduce morbidity optimize utilization resources. Particularly, identification clinically actionable biomarkers symptom burden crucial intercept optimized patient stratification with delivery adapted interventions, thus successfully move forward field 'precision survivorship medicine'.5Hertz McShane L.M. Hayes D.F. Defining clinical utility germline indicators risk: perspective.J 1721-1731Crossref (6) Scholar,6Hayes tumor biomarker tests: clinician's viewpoint.J 2021; 39: 238-248Crossref (36) Refined knowledge physiological biology allowed unravel several mechanistic underlie enhanced certain individuals along trajectory,7Carroll J.E. Bower Ganz P.A. Cancer-related accelerated ageing biobehavioural modifiers: framework research care.Nat Rev 19: 173-187Crossref (20) identify some its factors, leveraging holistic connection between biology, psychology, behaviors, other socio-environmental mediators.8Sleight A.G. Crowder S.L. Skarbinski al.A new approach understanding fatigue: 3P facilitate prediction care.Cancers (Basel). 14: 1982Crossref Among biological factors been consistently proposed linked increased susceptibility long-lasting particular empirical attention given cancer-induced systemic inflammation, and, larger extent, related mechanisms aging, cellular damage, stress.7Carroll The accumulating evidence such act physiopathological heterogeneity among set out rationale study key pathway components delve deeper into molecular underpinnings, order discover potential drive personalized care. Basic focused on neural-immune signaling suggested stimulation central nervous system through release pool circulating cytokines activation proinflammatory axis herald appearance physical, emotional, cognitive manifestations, more broadly, number inflammation-related 'sickness behaviors'.9Bower role neuro-immune interactions biobehavioral mechanisms.Cancer. 2019; 125: 353-364Crossref (104) 10Dantzer R. O'Connor J.C. Freund G.G. al.From inflammation sickness depression: when immune subjugates brain.Nat Neurosci. 2008; 9: 46-56Crossref (5179) 11Collado-Hidalgo al.Inflammatory survivors.Clin Cancer Res. 2006; 12: 2759-2766Crossref (320) 12Bower fatigue--mechanisms, treatments.Nat 2014; 11: 597-609Crossref (900) Several studies, mostly cancer, described wide range stem common inflammatory substrate. For example, fatigue, decline, sleep disturbance, emotional distress, chronic pain are constellation usually concurrent 'behavioral' highly prevalent distressful survivors, which mutual etiology proposed, although lot granularity still needs be elucidated.10Dantzer Scholar,13Palesh O.G. Roscoe J.A. Mustian K.M. al.Prevalence, demographics, psychological associations disruption University Rochester Center-Community Clinical Oncology Program.J 2010; 28: 292-298Crossref (374) 14Lee B.N. Dantzer Langley K.E. cytokine-based neuroimmunologic mechanism symptoms.Neuroimmunomodulation. 2004; 279-292Crossref (235) 15Miller A.H. Ancoli-Israel al.Neuroendocrine-immune behavioral comorbidities cancer.J 26: 971Crossref (459) Along same lines, data available showing administration induction leads symptomatology also healthy humans16Reichenberg Yirmiya Schuld al.Cytokine-associated disturbances humans.Arch Gen Psychiatry. 2001; 58: 445-452Crossref 17Späth-Schwalbe E. Hansen K. Schmidt F. al.Acute effects recombinant human interleukin-6 endocrine functions men.J Endocrinol Metab. 1998; 83: 1573-1579Crossref (362) 18Eisenberger N.I. Inagaki T.K. Mashal N.M. al.Inflammation social experience: an challenge induces feelings disconnection addition depressed mood.Brain Behav Immun. 24: 558-563Crossref (298) elevated detected non-cancer populations distress syndromes.19Howren Lamkin D.M. Suls Associations depression C-reactive protein, IL-1, IL-6: meta-analysis.Psychosom Med. 2009; 71: 171-186Crossref (2210) Scholar,20Irwin M. Effects loss immunity cytokines.Brain 2002; 16: 503-512Crossref (293) However, seems prolonged severe compared without history suggesting precipitating treatments (particularly chemo-, radiation-, hormone-, immunotherapy targeted agents), potentially triggering hyperactivated cross-signaling feedforwarding cascades.12Bower Mounting pointed accelerator aging sustained damage While accumulation impairments interfering day-to-day function, deficit, increasing reduced physical performance, typical normative leading state elderly irrespective many report decline earlier onset greater likelihood becoming chronic, detriment life.21Guida J.L. Ahles T.A. Belsky D. al.Measuring identifying phenotypes survivors.J Natl Inst. 111: 1245-1254Crossref 22Searle S.D. Mitnitski Gahbauer E.A. standard procedure creating index.BMC Geriatr. 8: 1-10Crossref (2046) 23Fried L.P. Tangen C.M. Walston al.Frailty older adults: phenotype.J Gerontol A Biol Sci Med Sci. 56: M146-M156Crossref 24Henderson T.O. Ness K.K. Cohen H.J. Accelerated survivors: pediatrics geriatrics.Am Soc Oncol Educ Book. : e423-e430Crossref (103) Pre-existing, predisposing including age diagnosis, comorbid conditions, baseline psychosocial traits, coupled precipitating, perpetuating unhealthy lifestyles, favor cells enriched inflammation- stress mediators-biased 'secretome'.12Bower Scholar,15Miller Scholar,25Campisi Senescent cells, suppression, organismal aging: good citizens, bad neighbors.Cell. 2005; 120: 513-522Abstract Full Text PDF (1874) Scholar,26Van Waart H. Stuiver M.M. Van Harten W.H. al.Effect low-intensity activity moderate- high-intensity exercise during chemotherapy fitness, completion rates: results PACES randomized trial.J 2015; 33: 1918-1927Crossref (406) brought highlight specific markers inflammation. cytokines,27Bower Irwin M.R. al.Cytokine genetic variations 2013; 1656-1661Crossref (102) 28Collado-Hidalgo gene polymorphisms early findings.Brain 22: 1197-1200Crossref (110) 29Barsevick Frost Zwinderman Hall P. Halyard I'm so tired: fatigue.Qual Life 1419-1427Crossref 30Maurer T. Jaskulski Behrens al.Tired feeling tired – survivors.Breast. 103-109Abstract 31Shi W. Misra Li biomarkers, hematopoietic undergoing radiation therapy.JNCI Spectr. 2020; 4pkaa037Google 32Cohen Levkovich Katz al.Low activity, moderation by levels IL-6 IL-8158.Int J Psychophysiol. 158: 96-102Crossref 33Hiensch A.E. Mijwel Bargiela mediates cancer.Med Sports Exerc. 53: 496-504Crossref (27) 34Henneghan Wright M.L. Bourne G. cross-sectional exploration cytokine-symptom networks using network analysis.Can Nurs 303-315Crossref 35Cohen R.A. Gullett J.M. Woods A.J. prior to, during, post-chemotherapy Neuroimmunol. 334577001Abstract 36Toh Y.L. Tan C.J. Yeo A.H.L. al.Association plasma leptin, pro-inflammatory adipokines early-stage patients: prospective cohort study.J Cell Mol 23: 4281-4289Crossref 37Witek Janusek L. Tell Mathews H.L. Mindfulness based reduction provides benefit restores function newly diagnosed trial active control.Brain 80: 358-373Crossref (65) 38Lengacher C.A. Reich R.R. Paterson C.L. large trial: mindfulness-based (MBSR) (BC) salivary cortisol IL-6.Biol Res Nurs. 21: 39-49Crossref 39Chae J.W. Chua P.S. Ng mitochondrial DNA content peripheral blood impairment study.Breast Treat. 2018; 168: 713-721Crossref 40van Vulpen J.K. M.E. Velthuis M.J. al.Effects chemotherapy.Breast 421-431Crossref (22) 41Serra M.C. Ryan Ortmeyer H.K. al.Resistance training reduces improves survivors.Menopause. 25: 211Crossref 42Zimmer Baumann F.T. Oberste al.Influence recommendations rehabilitation sustainability objectively measured levels, fatigue-related cancer.Integr Ther. 17: 306Crossref (17) 43Xiao Miller Felger al.Depressive independent survivors.Psychol 2017; 47: 1733-1743Crossref (46) 44Zick S.M. Zwickey Wood al.Preliminary differences brain metabolites fatigued non-fatigued pilot study.Brain Imaging Behav. 506Crossref (23) 45Pertl Hevey Boyle N.T. al.C-reactive protein predicts independently chemotherapy.Brain 34: 108-119Crossref (68) 46Liu Mills P.J. Rissling al.Fatigue associated changes 2012; 706Crossref (163) 47Bower treatment: do depression, disturbance share underlying mechanism?.J 2011; 29: 3517Crossref (385) 48Bower Tao therapy prostate cancer.Clin 15: 5534-5540Crossref (251) 49Von Ah Kang D.H. Carpenter J.S. Predictors before, therapy.Cancer 134-144Crossref (52) 50Bower Aziz N. responses relationship glucocorticoids.Brain 2007; 251-258Crossref (129) 51Mills Parker B. Dimsdale al.The anthracycline-based cancer.Biol Psychol. 69: 85-96Crossref (93) 52Geinitz Zimmermann F.B. Stoll al.Fatigue, serum cytokine cell counts radiotherapy cancer.Int Radiat Phys. 51: 691-698Abstract (149) 53Rogers L.Q. Vicari Trammell al.Biobehavioral mediate survivors.Med 46: 1077-1088Crossref (51) interleukin (IL)-1b, IL-6, necrosis factor-alpha (TNF-a), seem implications orchestrating local spectrum host-defense energy mood.11Collado-Hidalgo Scholar,44Zick Scholar,53Rogers 54Bower patients.JNCI 6pkac052Google 55Raudonis B.M. Kelley I.H. Rowe chemotherapy.Cancer 323-331Crossref 56Minton O. Coulton G.R. Stone Multi-analyte profiling proteins syndrome disease-free primary treatment.BMJ Support Palliat Care. 4: 349-356Crossref these mediators higher across disease continuum, before surgery throughout treatments.11Collado-Hidalgo Scholar,57Bower survivors.Psychosom 64: 604-611Crossref Scholar,58Bower Asher Garet al.Testing cancer.Cancer. 633-641Crossref Downstream products play relevant response can contribute frailty. these, (CRP) acute-phase synthesized hepatocytes infectious processes marker diseases cardiovascular risk.59Furman Campisi Verdin al.Chronic span.Nature 1822-1832Crossref 60Carroll Nakamura Z.M. Small B.J. al.Elevated subsequent problems thinking living 41: 295-306Crossref (10) 61Pradhan A.D. Manson Rifai 6, developing type 2 diabetes mellitus.J Am Assoc. 286: 327-334Crossref Higher CRP meaning, (>3 mg/l) survivors.60Carroll Furthermore, variants toxicities shed optimism possibility acquired models characteristics.5Hertz instance, setting often take form single-nucleotide promoter region genes implicated oxidative behavioral-like symptoms.19Howren Scholar,27Bower Scholar,28Collado-Hidalgo Scholar,62Miaskowski Dodd Lee association functional IL6 polymorphism oncology family caregivers.J Pain Symptom Manage. 531Abstract 63Jim H.S.L. Park J.Y. Permuth-Wey al.Genetic treated androgen deprivation therapy: preliminary 1030-1036Crossref (32) 64Doong S.H. Dhruva Dunn L.B. al.Associations cluster pain, surgery.Biol 237-247Crossref (117) 65Bull S.J. Huezo-Diaz Binder E.B. al.Functional serotonin transporter genes, induced interferon-alpha ribavirin treatment.Mol 1095-1104Crossref (196) 66Musselman Porter al.Higher than normal concentrations findings.Am 1252-1257Crossref (387) 67Elderkin-Thompson V. Hellemann al.Interleukin-6 memory encoding recall adults.Am Geriatr 20: 753-763Abstract Additional polymorphisms, them stress, predisposition contributing cardiomyopathy following chemotherapy,68Kim Y. Seidman J.G. C.E. Genetics therapy-associated cardiotoxicity.J Cardiol. 167: 85-91Abstract Scholar,69Wang X. Sun Quiñones-Lombraña al.CELF4 variant anthracycline-related cardiomyopathy: children's group genome-wide 2016; 863-870Crossref oxaliplatin-associated neurotoxicity.70Sereno Gutiérrez-Gutiérrez Rubio SCN9A oxaliplatin-induced neuropathy.BMC 63Crossref How it then possible leverage link inform practice burden? Some aforementioned easily detectable if adequately incorporated screening tools build factors.71Di Soldato al.Development validation diagnosis: toward care.J 1111-1123Crossref (19) Novel technologies continuous monitoring 'dynamic biomarker', aiming anticipating symptoms.72Jagannath Lin K.C. Pali Sankhala Muthukumar Prasad sweat-based wearable enabling technology real-time IL-1β bowel disease.Inflamm Bowel Dis. 1533-1542Crossref (13) Scholar,73Laliberte Scott Khan Mahmud M.S. Song graphene transistor-based biosensor biomarker.Microelectron Eng. 262111835Crossref (7) cascade complex, was proxy low-grade status, therefore useful detection, monitoring, cancer- conditions.74Liu Zhang Q. all types: study.Int 151: 297-307Crossref Scholar,75Orsolini Pompili Tempia Valenta Salvi Volpe U. major disorder?.Int 1616Crossref (29) Understanding behind pave way development novel therapeutic target prevent symptomatic deterioration. With improved players cross-talk modifiers modulators identified. In setting, strong consistent traits. adiposity lower those who smokers, markers.12Bower Scholar,76Goodwin Stambolic Impact obesity epidemic cancer.Annu 66: 281-296Crossref (140) Similarly, bidirectional sarcopenia (i.e. skeletal muscle) neutrophil-to-lymphocyte ratio types.77Feliciano E.M.C. Kroenke C.H. Meyerhardt survival nonmetastatic colorectal

Language: Английский

TTD: Therapeutic Target Database describing target druggability information DOI Creative Commons
Ying Zhou, Yintao Zhang,

Donghai Zhao

et al.

Nucleic Acids Research, Journal Year: 2023, Volume and Issue: 52(D1), P. D1465 - D1477

Published: Sept. 15, 2023

Target discovery is one of the essential steps in modern drug development, and identification promising targets fundamental for developing first-in-class drug. A variety methods have emerged target assessment based on druggability analysis, which refers to likelihood a being effectively modulated by drug-like agents. In therapeutic database (TTD), nine categories established characteristics were thus collected 426 successful, 1014 clinical trial, 212 preclinical/patented, 1479 literature-reported via systematic review. These characteristic classified into three distinct perspectives: molecular interaction/regulation, human system profile cell-based expression variation. With rapid progression technology concerted effort discovery, TTD other databases highly expected facilitate explorations validation innovative target. now freely accessible at: https://idrblab.org/ttd/.

Language: Английский

Citations

229

Hydrogel systems for targeted cancer therapy DOI Creative Commons
Xinlin Li, Xinyi Xu,

Mengfei Xu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 16, 2023

When hydrogel materials with excellent biocompatibility and biodegradability are used as new drug carriers in the treatment of cancer, they confer following three advantages. First, can be a precise controlled release systems, which continuously sequentially chemotherapeutic drugs, radionuclides, immunosuppressants, hyperthermia agents, phototherapy agents other substances widely cancer through radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy photothermal therapy. Second, have multiple sizes delivery routes, targeted to different locations types cancer. This greatly improves targeting thereby reducing dose drugs improving effectiveness. Finally, intelligently respond environmental changes according internal external stimuli so that anti-cancer active remotely released on demand. Combining abovementioned advantages, transformed into hit field treatment, bringing hope further increase survival rate quality life patients

Language: Английский

Citations

51

Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target DOI Creative Commons

Mengwei Zhang,

Jinkai Liu,

Qiang Xia

et al.

Experimental Hematology and Oncology, Journal Year: 2023, Volume and Issue: 12(1)

Published: Sept. 28, 2023

Immunotherapy has emerged as an effective treatment for various types of cancers. Recent studies have highlighted a significant correlation between the gut microbiome and patients' response to immunotherapy. Several characteristics microbiome, such community structures, taxonomic compositions, molecular functions, been identified crucial biomarkers predicting immunotherapy immune-related adverse events (irAEs). Unlike other -omics, can serve not only but also potential targets enhancing efficacy Approaches modulating include probiotics/prebiotics supplementation, dietary interventions, fecal microbiota transplantation (FMT), antibiotic administration. This review primarily focuses on elucidating role in cancer improving its efficacy. Notably, we explore reasons behind inconsistent findings observed different studies, highlight underlying benefits antibiotics liver

Language: Английский

Citations

50

Toxicity of immunotherapy combinations with chemotherapy across tumor indications: Current knowledge and practical recommendations DOI Creative Commons
Layal Rached, Ariane Laparra, Madona Sakkal

et al.

Cancer Treatment Reviews, Journal Year: 2024, Volume and Issue: 127, P. 102751 - 102751

Published: May 4, 2024

Chemotherapy associated with Immune Checkpoint Inhibitors is currently the standard of care in several tumor indications. This combination approach improves progression free survival (PFS), overall (OS) and complete pathological response (pCR) cancer types both early metastatic approaches. However, distinct spectrum toxicities between cytotoxic side effects immune related adverse events (irAEs) similar clinical presentations different management strategies remains a challenge daily practice for healthcare professionals. review summarizes most common reported randomized trials that led to subsequent FDA approval these combinations, across We cite particular: non-small cell lung cancer, small triple negative breast squamous carcinoma head neck, gastric carcinoma, esophageal cervical biliary tract carcinoma. found chemotherapy immunotherapy was an increased incidence all grade (RR 1.11 [1.09; 1.12]) without excess treatment mortality when compared alone. report also increase serious (grade ≥ 3) 1.16 [1.10;1.24]); high diarrhea, dyspnea, fatigue, rash elevated liver enzymes. Together collaboration our institutional network organ specialists expertise irAEs, we propose practical recommendations physicians enhance patients undergoing combined ICI chemotherapy.

Language: Английский

Citations

22

Roles of microbiota in pancreatic cancer development and treatment DOI Creative Commons
Mariana Santos Cruz, Joseph Tintelnot, Nicola Gagliani

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 27, 2024

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis. This due to the fact that most cases are only diagnosed at advanced and palliative stage, there a high incidence of therapy resistance. Despite ongoing efforts, date, mechanisms underlying PDAC oncogenesis its responses treatment still largely unclear. As study microbiome in cancer progresses, growing evidence suggests bacteria or fungi might be key players both as well resistance chemo- immunotherapy, for instance through modulation tumor microenvironment reshaping host immune response. Here, we review how microbiota exerts these effects directly indirectly via microbial-derived metabolites. Finally, further discuss potential modulating composition PDAC.

Language: Английский

Citations

21

Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications DOI

Sravan Baddi,

Auphedeous Y. Dang-i,

Fengli Gao

et al.

Progress in Materials Science, Journal Year: 2025, Volume and Issue: 151, P. 101428 - 101428

Published: Jan. 9, 2025

Language: Английский

Citations

2

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches DOI Open Access
Md. Shimul Bhuia, Raihan Chowdhury, Fatema Akter Sonia

et al.

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 20(9)

Published: Aug. 7, 2023

With the increasing prevalence of cancer and toxic side effects synthetic drugs, natural products are being developed as promising therapeutic approaches. Gracillin is a naturally occurring triterpenoid steroidal saponin with several activities. It obtained major compound from different Dioscorea species. This review was designated to summarize research progress on anti-cancer activities gracillin focusing underlying cellular molecular mechanisms, well its pharmacokinetic features. The data were collected (up date May 1, 2023) various reliable authentic literatures comprising PubMed, Springer Link, Scopus, Wiley Online, Web Science, ScienceDirect, Google Scholar. findings demonstrated that displays anticancer through including anti-inflammatory effects, apoptotic cell death, induction oxidative stress, cytotoxicity, genotoxicity, cycle arrest, anti-proliferative effect, autophagy, inhibition glycolysis, blocking migration. Additionally, this highlighted features gracillin, indicating lower oral bioavailability. As conclusion, it can be proposed could serve hopeful chemotherapeutic agent. However, further extensive clinical recommended establish safety, efficacy, potential in treatment.

Language: Английский

Citations

34

Nano-enabled colorectal cancer therapy DOI
Qingqing Pan, Fan Xi, Li Xie

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 548 - 564

Published: Sept. 9, 2023

Language: Английский

Citations

33

Association of Antibiotic Receipt With Survival Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma Receiving Chemotherapy DOI Creative Commons

Daniel Jeremy Fulop,

Haley M. Zylberberg, Yakun Wu

et al.

JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(3), P. e234254 - e234254

Published: March 23, 2023

Importance The prognosis for patients with metastatic pancreatic ductal adenocarcinoma (PDAC) is dismal, due in part to chemoresistance. Bacteria-mediated mechanisms of chemoresistance suggest a potential role antibiotics modulating response chemotherapy. Objective To evaluate whether use peritreatment associated survival among PDAC treated first-line gemcitabine or fluorouracil Design, Setting, and Participants Using the population-based Surveillance, Epidemiology, End Results–Medicare linked database, this retrospective cohort study analyzed data diagnosed between January 1, 2007, December 31, 2017. Data analysis was conducted September 2021, 15, 2023. sample included 3850 primary Patients who received were matched based on propensity scores did not receive antibiotics. Exposures Receipt 5 more days oral 1 injectable antibiotic month before after beginning Main Outcomes Measures Overall cancer-specific survival. end follow-up 2019, overall 2018, Results Of (3150 [81.8%]) (700 [18.2%]), 2178 (56.6%) mean (SD) age at diagnosis 74.2 (5.8) years predominantly women (2102 [54.6%]), White (3396 [88.2%]), from metropolitan areas (3393 [88.1%]) northeastern western US (2952 [76.7%]). In total, 1672 propensity-matched pairs analyzed. Antibiotic receipt an 11% improvement (hazard ratio [HR], 0.89; 95% CI, 0.83-0.96; P = .003) 16% (HR, 0.84; 0.77-0.92; < .001) gemcitabine. contrast, there no association 1.08; 0.90-1.29; .41) 1.12; 0.90-1.36; .29) fluorouracil. subgroup gemcitabine-treated antibiotics, nonpenicillin β-lactams benefit 0.81-0.97; .01). Conclusions Relevance study, perichemotherapy improved gemcitabine, but fluorouracil, suggesting that may modulate bacteria-mediated resistance have improve outcomes.

Language: Английский

Citations

28

A Rodent Model of Human-Dose-Equivalent 5-Fluorouracil: Toxicity in the Liver, Kidneys, and Lungs DOI Creative Commons
Mariana Conceição da Silva, Lilian Catarim Fabiano,

Karile Cristina da Costa Salomão

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1005 - 1005

Published: April 26, 2023

5-Fluorouracil (5-FU) is a chemotherapy drug widely used to treat range of cancer types, despite the recurrence adverse reactions. Therefore, information on its side effects when administered at clinically recommended dose relevant. On this basis, we examined 5-FU clinical treatment integrity liver, kidneys, and lungs rats. For purpose, 14 male Wistar rats were divided into treated control groups was 15 mg/kg (4 consecutive days), 6 alternate 14th day. 15th day, blood, kidney, lung samples collected for histological, oxidative stress, inflammatory evaluations. We observed reduction in antioxidant markers an increase lipid hydroperoxides (LOOH) liver animals. also detected elevated levels markers, histological lesions, apoptotic cells, aspartate aminotransferase. Clinical with did not promote or alterations kidney samples; however, biochemical changes observed, including increased serum urea uric acid. reduces endogenous defenses increases LOOH lungs, suggesting stress. Inflammation histopathological detected. The protocol promotes toxicity healthy rats, resulting different alterations. These results will be useful search new adjuvants attenuate such organs.

Language: Английский

Citations

27