The therapeutic potential of quercetin for cigarette smoking–induced chronic obstructive pulmonary disease: a narrative review

Therapeutic Advances in Respiratory Disease, Journal Year: 2023, Volume and Issue: 17

Published: Jan. 1, 2023

Quercetin is a flavonoid with antioxidant and anti-inflammatory properties. has potentially beneficial therapeutic effects for several diseases, including cigarette smoking–induced chronic obstructive pulmonary disease (CS-COPD). Many studies have shown that quercetin’s properties positive potential CS-COPD. In addition, immunomodulatory, anti-cellular senescence, mitochondrial autophagy–modulating, gut microbiota–modulating may also value However, there appears to be no review of the possible mechanisms quercetin treating Moreover, combination common drugs CS-COPD needs further refinement. Therefore, in this article, after introducing definition metabolism quercetin, its safety, we comprehensively presented pathogenesis related oxidative stress, inflammation, immunity, cellular autophagy, microbiota. We then reviewed anti-CS-COPD effects, performed by influencing these mechanisms. Finally, explored possibility using commonly used CS-COPD, providing basis future screening excellent drug combinations This provided meaningful information on clinical use

Language: Английский

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Molecular mechanism of Jianpiyifei II granules in the treatment of chronic obstructive pulmonary disease: Network pharmacology analysis, molecular docking, and experimental assessment

Phytomedicine, Journal Year: 2024, Volume and Issue: 126, P. 155273 - 155273

Published: Jan. 6, 2024

Language: Английский

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A new perspective on gut-lung axis affected through resident microbiome and their implications on immune response in respiratory diseases

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(3)

Published: Feb. 18, 2024

Language: Английский

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The role of gut-lung axis in COPD: Pathogenesis, immune response, and prospective treatment

Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e30612 - e30612

Published: May 1, 2024

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and healthcare burden worldwide. The progression COPD combination genetic predisposition environmental factors, primarily cigarette smoking, the underlying mechanisms are still unknown. Intestinal microecology impacts host immunity, metabolism, resistance to pathogenic infections, which may be involved in disease. Moreover, substantial interaction occurs between intestinal respiratory immune niches. After reviewing nearly 500 articles, we found gut-lung axis plays an important role development COPD. patients often have dysbiosis microenvironment, can affect immunity through series mechanisms, exacerbating or protecting against progression. This paper summarizes how influences COPD, including alterations microecology, pathological responses. Finally, summarize latest research advances treatment from perspective regulating evaluate potential value improving prognosis.

Language: Английский

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Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 9, 2024

The gut microbiota offers numerous benefits to the human body, including promotion of nutrient absorption, participation in metabolic processes, and enhancement immune function. Recent studies have introduced concept gut-organ axis, which encompasses interactions such as gut-brain gut-liver gut-lung axis. This underscores complex interplay between various organs tissues, brain, heart, lungs, liver, kidneys, muscles, bones. Growing evidence indicates that can influence onset progression multi-organ system diseases through their effects on Traditional Chinese medicine has demonstrated significant efficacy regulating gastrointestinal system, leveraging its unique advantages. Considerable advancements been made understanding role axis within mechanisms action traditional medicine. review aims elucidate roles health, explore potential connections microbiota, examine therapeutic microbiota-gut-organ Furthermore, addresses limitations challenges present current research while proposing directions for future investigations this area.

Language: Английский

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Development and Characterization of a Novel Rat Model for Emulating COPD-Associated Cor Pulmonale

American Journal Of Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Acupuncture improves the symptoms, gut microbiota, metabolomics, and inflammation of patients with chronic obstructive pulmonary disease: a multicenter, randomized, sham-controlled trial protocol

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 3, 2025

Background Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease. The occurrence of COPD associated with gut microbiota, meticulous metabolism and inflammation. Acupuncture may be effective as an adjunctive therapy for COPD, but the available evidence limited. This study aims to confirm whether acupuncture has therapeutic effect on investigate relationship between efficacy metabolomics Methods multicenter randomized controlled trial. A total 72 patients stable eligible will in 1:1 ratio receive either manual (MA) or sham (SA) without puncturing skin. There no changes essential medicines used all patients. intervention 12 weeks, 3 times per week follow-up 52 weeks. primary outcome change Assessment Test (CAT) score before after treatment. Secondary outcomes include modified Medical Research Council (mMRC), St. George’s Respiratory Questionnaire (SGRQ), 6-min walk test (6MWT), number moderate severe acute exacerbations during follow-up. 36 healthy volunteers also recruited normal control. In addition, feces blood collected from each participant characterize metabolomics, immune cells inflammatory cytokines. Differences participants observed, well treatment MA SA groups. Ultimately, correlation among cells, cytokines clinical analyzed. Discussion evaluate provide preliminary possible mechanisms treating COPD. it identify biomarkers metabolites, efficacy. results this published peer-reviewed journal.

Language: Английский

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Fu brick tea supplementation ameliorates non-alcoholic fatty liver disease and associated endotoxemia via maintaining intestinal homeostasis and remodeling hepatic immune microenvironment

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116207 - 116207

Published: March 1, 2025

Language: Английский

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Exosomes from Tregs mitigate lung damage caused by smoking via inhibiting inflammation and altering T lymphocyte subsets in COPD rats

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 14, 2025

Language: Английский

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Bidirectional Mendelian randomization and potential mechanistic insights into the causal relationship between gut microbiota and malignant mesothelioma

Medicine, Journal Year: 2025, Volume and Issue: 104(17), P. e42245 - e42245

Published: April 25, 2025

Malignant mesothelioma (MM) is a rare but aggressive cancer originating from mesothelial cells, which presents significant challenges to patients’ physical and psychological well-being. The gut–lung axis underscores the connection between gut microbiota respiratory diseases, with emerging evidence suggesting strong association development of MM. In this study, we conducted two-sample Mendelian randomization (MR) analysis investigate potential causal relationship MM, while also exploring underlying mechanisms through bioinformatics approaches. Gut summary data were obtained MiBioGen consortium, MM sourced FinnGen R11 dataset. Causality was examined using inverse variance weighted method as primary analysis. Additional methods, including median, simple mode, MR-Egger, employed. robustness findings validated sensitivity analyses, reverse causality considered further strengthen MR results. Moreover, analyses on genetic loci associated both explore mechanisms. Our study suggests that genetically predicted increases in class.Bacilli , family.Rikenellaceae genus.Clostridium innocuum group order.Lactobacillales suggestively higher risk whereas genus.Ruminococcaceae UCG004 genus.Flavonifractor phylum.Firmicutes genus.Anaerofilum sensu stricto 1 genus.Lactobacillus appeared confer protective effects. Bioinformatics indicated differentially expressed genes near might affect by modulating pathways tumor microenvironment. results point predisposition linking Further experimental validation crucial confirm these candidate microbes, establish causality, elucidate

Language: Английский

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