Systemic inflammation index, disease severity, and mortality in patients with COVID-19: a systematic review and meta-analysis

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 21, 2023

Introduction An excessive systemic pro-inflammatory state increases the risk of severe disease and mortality in patients with coronavirus 2019 (COVID-19). However, there is uncertainty regarding whether specific biomarkers inflammation can enhance stratification this group. We conducted a systematic review meta-analysis to investigate an emerging biomarker derived from routine hematological parameters, index (SII), COVID-19 different severity survival status. Methods A literature search was PubMed, Web Science, Scopus, between 1 st December 15 th March 2023. Risk bias certainty evidence were assessed using Joanna Briggs Institute Critical Appraisal Checklist Grades Recommendation, Assessment, Development Evaluation, respectively (PROSPERO registration number: CRD42023420517). Results In 39 studies, or non-survivor status had significantly higher SII values on admission compared non-severe survivor (standard mean difference (SMD)=0.91, 95% CI 0.75 1.06, p<0.001; moderate evidence). The also associated death 10 studies reporting odds ratios (1.007, 1.001 1.014, p=0.032; very low evidence) six hazard (1.99, 1.01 3.92, p=0.047; Pooled sensitivity, specificity, area under curve for 0.71 (95% 0.67 0.75), 0.64 0.77), 0.77 0.73 0.80), respectively. meta-regression, significant correlations observed SMD albumin, lactate dehydrogenase, creatinine, D-dimer. Discussion Our has shown that COVID-19. Therefore, inflammatory haematological parameters be helpful early Systematic https://www.crd.york.ac.uk/PROSPERO , identifier CRD42023420517.

Language: Английский

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Is Systemic Immune-Inflammation Index a Real Non-Invasive Biomarker to Predict Oncological Outcomes in Patients Eligible for Radical Cystectomy?

Medicina, Journal Year: 2023, Volume and Issue: 59(12), P. 2063 - 2063

Published: Nov. 22, 2023

Background and Objectives: To assess the potential prognostic role of systemic immune-inflammation index (SII) in predicting oncological outcomes a cohort patients treated with radical cystectomy (RC). Materials Methods: From 2016 to 2022, retrospective monocentric study enrolled 193 who were divided into two groups based on their SII levels using optimal cutoff determined by Youden index. The was obtained from preoperative blood test approximately one month before RC. Univariable multivariable logistic regression analyses conducted investigate capacity predict lymph node invasion (N), advanced pT stage (pT3/pT4), locally condition at time Multivariable Cox models adjusted for postoperative features used analyze effect recurrence-free survival (RFS), cancer-specific (CSS), overall (OS). Results: value 640.27. An elevated seen 113 (58.5%) patients. Using models, an correlated nodal (N; p = 0.03), (p 0.04), disease 0.005), enhancement AUCs 0.04). In that considered clinicopathologic factors, linked poorer RFS 0.005) OS 0.01). Moreover, high 0.004) Conclusions: this study, higher values predicted worse bladder cancer (BCa) underwent

Language: Английский

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Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index as Predictors of Mortality in ST-Elevation Myocardial Infarction

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(5), P. 1256 - 1256

Published: Feb. 22, 2024

(1) Background: The systemic inflammatory response index (SIRI; neutrophil count × monocyte/lymphocyte count), and the immune-inflammation (SII; platelet count/lymphocyte count) are recently proposed biomarkers to assess immune status. However, data on SIRI SII still relatively lacking do not definitively exhaustively define their role as predictors of an adverse prognosis in acute myocardial infarction (AMI). aim present study was evaluate determinants well prognostic power ST-elevation (STEMI). (2) Methods: A total 105 STEMI patients (74 males, 70 ± 11 years) were studied (median follow-up 54 25 months, 24 deaths). (3) Results: main creatinine brain natriuretic peptide (BNP) (multivariate regression). Patients with higher (>75th percentile, 4.9) 1257.5) had lower survival rates than those low SIRI/SII group (Kaplan–Meier analysis). Univariate Cox regression revealed that high associated mortality (HR: 2.6, 95% CI: 1.1–5.8, p < 0.05; 2.2, 1–4.9, ≤ 0.05, respectively); however, these associations lost significance after multivariate adjustment. (4) Conclusions: association significantly affected by confounding factors our population, especially BNP, which both indices outcome.

Language: Английский

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Phthalate exposure and markers of biological aging: The mediating role of inflammation and moderating role of dietary nutrient intake

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116649 - 116649

Published: July 1, 2024

Language: Английский

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Comparison of PIV and Other Immune Inflammation Markers of Oncological and Survival Outcomes in Patients Undergoing Radical Cystectomy

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 651 - 651

Published: Feb. 3, 2024

Inflammation is widely acknowledged as a significant characteristic of cancer, playing substantial function in both the initiation and advancement cancers. In this research, we planned to compare pan-immune inflammation markers other well-known (systemic immune index neutrophil lymphocyte ratio) predict prognosis individuals treated with radical cystectomy for bladder cancer. Methods: retrospective analysis, focused on preoperative PIV, systemic (SII), neutrophil–lymphocyte ratio (NLR) 193 managed cancer between January 2016 November 2022. Multivariable logistic regression assessments were performed assess predictive capabilities SII, NLR infiltration lymph nodes (N), aggressive tumor stage (pT3/pT4), any non-organ limited disease at time RC. Cox analyses conducted impact PIV Relapse-free survival (RFS), Cancer-specific (CSS), Overall (OS). Results: Our divided into high low cohorts using optimal cut-off value (340.96 × 109/L) based receiver operating curve analysis relapse-free survival. multivariable models, only SII correlated nodes, disease, confined disease. models considering presurgical clinicopathological variables, higher was associated diminished RFS (p = 0.017) OS 0.029). addition, postoperative outcomes, 0.034) 0.048). Conclusions: study suggests that are two very similar may serve independent predictors worse impacts undergoing neoplasm.

Language: Английский

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The diagnostic role of the systemic inflammation index in patients with immunological diseases: a systematic review and meta-analysis

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 29, 2024

Abstract The identification of novel, easily measurable biomarkers inflammation might enhance the diagnosis and management immunological diseases (IDs). We conducted a systematic review meta-analysis to investigate an emerging biomarker derived from full blood count, systemic index (SII), in patients with IDs healthy controls. searched Scopus, PubMed, Web Science inception 12 December 2023 for relevant articles evaluated risk bias certainty evidence using Joanna Briggs Checklist Grades Recommendation, Assessment, Development, Evaluation Working Group system, respectively. In 16 eligible studies, had significantly higher SII when compared controls (standard mean difference, SMD = 1.08, 95% CI 0.75 1.41, p < 0.001; I 2 96.2%, moderate evidence). pooled area under curve (AUC) diagnostic accuracy was 0.85 (95% 0.82–0.88). subgroup analysis, effect size significant across different types ID, barring lupus erythematosus ( 0.20). further analyses, ID active disease vs. those remission (SMD 0.81, 0.34–1.27, 93.6%, AUC 0.74 0.70–0.78). Our study suggests that can effectively discriminate between subjects without disease. Prospective studies are warranted determine whether routine practice. (PROSPERO registration number: CRD42023493142).

Language: Английский

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Association of the systemic immune-inflammation index with all-cause and cardiovascular mortality in individuals with rheumatoid arthritis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 2, 2024

Abstract The systemic immune-inflammation index (SII), a metric reflecting inflammatory response and immune activation, remains underexplored concerning its correlation with mortality among rheumatoid arthritis (RA) patients. This study aimed to delineate the association between SII both all-cause cardiovascular within cohort of American adults diagnosed RA, utilizing data from National Health Nutrition Examination Survey (NHANES) spanning 1999 2018. investigation extracted NHANES cycles 2018, identifying RA patients through questionnaire responses. was computed based on complete blood counts, employing formula: (platelets × neutrophils) / lymphocytes. optimal cutoff value for significant survival outcomes determined using maximally selected rank statistics. Multivariable Cox proportional hazards models assessed relationship levels (all-cause cardiovascular) patients, subgroup analyses examining potential modifications by clinical confounders. Additionally, restricted cubic spline (RCS) were conducted explore linearity SII-mortality association. encompassed 2070 whom 287 exhibited higher (≥ 919.75) 1783 lower (< 919.75). Over median follow-up duration 108 months, 602 participants died. After adjustments demographic, socioeconomic, lifestyle variables, associated 1.48-fold increased risk (hazard ratio [HR] = 1.48, 95% confidence interval [CI] 1.21–1.81, P < 0.001) 1.51-fold (HR 1.51, CI 1.04–2.18, 0.030) compared SII. Kaplan–Meier corroborated significantly reduced rates ( 0.0001 0.0004). RCS confirmed positive nonlinear rates. In conclusion, offers straightforward indicator equilibrium detrimental innate inflammation beneficial adaptive immunity. Our investigation, comprehensive nationally representative sample, reveals that elevated independently forecast greater all causes, as well cardiovascular-specific mortality, in individuals suffering RA. These insights underscore relevance an affordable readily accessible biomarker. Its incorporation into regular practice could enhance precision assessment forecasting facilitating more tailored effective management strategies. Specifically, high be identified stringent management, including closer monitoring, interventions, aggressive pharmacological treatments mitigate their mortality.

Language: Английский

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Inflammation indices in association with periodontitis and cancer

Periodontology 2000, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Abstract Inflammation is a complex physiological process that plays pivotal role in many if not all pathological conditions, including infectious as well inflammatory diseases, like periodontitis and autoimmune disorders. Inflammatory response to periodontal biofilms tissue destruction associated with the release of mediators. Chronic inflammation can promote development cancer. Persistence mediators crucial this process. Quantification monitoring severity relation cancer essential. Periodontitis mainly quantified based on extent attachment loss and/or pocket probing depth, addition bleeding probing. In recent years, studies started investigate indices association diseases. To date, only few reviews have been published focusing relationship between blood cell count, indices, periodontitis. This review presents comprehensive overview different systemic their methods measurement, clinical applications outlines basis underlying cellular molecular mechanisms parameters described. Key are commonly utilized periodontology such neutrophil lymphocyte ratio. platelet ratio, distribution width, plateletcrit, red monocyte delta index, immune index also used hospital settings will be discussed. The roles limitations, diseases treatment

Language: Английский

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J‐shaped association between systemic immune‐inflammation index and periodontitis: Results from NHANES 2009–2014

Journal of Periodontology, Journal Year: 2023, Volume and Issue: 95(4), P. 397 - 406

Published: Sept. 15, 2023

Abstract Background To examine the relationship between systemic immune‐inflammation index (SII) and periodontitis to investigate possible effect modifiers. Methods Data used in present cross‐sectional study are from National Health Nutrition Examination Survey (NHANES) 2009–2014 ( N = 10,301). The SII was calculated using following formula: (neutrophils count × platelet count)/lymphocytes count. category of defined by Centers for Disease Control Prevention American Academy Periodontology (CDC/AAP) classification. We employed natural cubic spline multivariable logistic regression analyses evaluate associations with periodontitis. Results periodontal health followed a J‐shape p < 0.001). risk tended reduce increment log 2 participants ≤ 8.66 (odds radio [OR] 0.83; 95% CI: 0.69–0.999), especially among non‐Hispanic Whites (OR 0.70; 0.52–0.95), increased > 1.19; 1.02–1.38). A similar trend also observed number sites probing pocket depth (PPD) ≥4 mm clinical attachment loss (CAL) ≥ 3 or 5 mm. Furthermore, we found significantly stronger correlation lymphocytes either neutrophils platelets individuals 8.66, as opposed those 8.66. Conclusions There is J‐shaped association US adults, an inflection point at which may provide potential adjunctive treatment strategies different immune response states. Further prospective trials still required confirm our findings.

Language: Английский

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Depressive Symptoms, Systemic Inflammation, and Survival Among Patients With Head and Neck Cancer

JAMA Otolaryngology–Head & Neck Surgery, Journal Year: 2024, Volume and Issue: 150(5), P. 405 - 405

Published: March 28, 2024

Importance Patients with head and neck cancer experience high rates of depression. Depression systemic inflammation have been found to be associated in numerous types, often independently from disease status. Depression-related may elevate the risks for poor tumor response treatment early mortality, comprises a mechanism by which depression is survival cancer. Objective To assess mediation pathways incorporating pretreatment depressive symptoms, inflammation, posttreatment on overall among patients Design, Setting, Participants This was prospective observational cohort study treated single multidisciplinary clinic May 10, 2013, December 30, 2019, followed up 2 years. Data analysis performed June 29, 2022, 23, 2023. Exposures Patient-reported symptoms using Patient Health Questionnaire−9 item (PHQ−9) at planning; hematology workup index (SII) score; clinical data review (complete vs incomplete) survival. Main Outcomes Two-year Results The total included 394 (mean [SD] age, 62.5 [11.5] years; 277 [70.3%] males) Among 285 (72.3%) who scored below cutoff PHQ−9, were significantly (partial r , 0.168; 95% CI, 0.007-0.038). In addition, both mortality (PHQ−9: hazard ratio [HR], 1.04; 1.02-1.07; SII: HR, 1.36; 1.08-1.71). depression-survival association fully mediated (HR, 1.28; 1.00-1.64). Depressive also poorer (odds ratio, 1.05; 1.01-1.08), partially 9.44; 6.23-14.32). Systemic not response. Conclusions this study, emerged as novel candidate mortality. Tumor effects replicating prior work. Thus, stands out highly feasible target renewed attention. Even mild during treatment-planning phase higher addition outcomes; therefore, should clinically addressed.

Language: Английский

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