Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)
Published: July 11, 2023
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12378 - 12378
Published: Aug. 3, 2023
Diabetes mellitus (DM) belongs to the category of socially significant diseases with epidemic rates increases in prevalence. Diabetic nephropathy (DN) is a specific kind kidney damage that occurs 40% patients DM and considered serious complication DM. Most modern methods for treatments aimed at slowing down progression DN have side effects do not produce unambiguous positive results long term. This fact has encouraged researchers search additional or alternative treatment methods. Hyperglycemia negative effect on renal structures due number factors, including activation polyol hexosamine glucose metabolism pathways, renin-angiotensin-aldosterone sympathetic nervous systems, accumulation advanced glycation end products insulin resistance endothelial dysfunction tissues. The above mechanisms cause development oxidative stress (OS) reactions mitochondrial dysfunction, which turn contribute DN. Modern antioxidant therapies involve various phytochemicals (food antioxidants, resveratrol, curcumin, alpha-lipoic acid preparations, etc.), are widely used only diabetes but also other systemic diseases. It been suggested therapeutic approaches target source reactive oxygen species may certain advantages terms nephroprotection from OS. review describes significance studies OS biomarkers pathogenesis analyzes reducing intensity prevention
Language: Английский
Citations
47
Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(1), P. 66 - 85
Published: Jan. 4, 2024
Abstract Mitochondria have been primarily considered intracellular organelles that are responsible for generating energy cell survival. However, accumulating evidence suggests mitochondria secreted into the extracellular space under physiological and pathological conditions, these play diverse roles by regulating metabolism, immune response, or differentiation/maturation in target cells. Furthermore, increasing amount of research shows therapeutic effects local systemic administration various disease models. These findings led to growing interest exploring as potential agents. Here, we discuss emerging extracellularly shed light on their functions beyond production. Additionally, provide information outcomes mitochondrial transplantation animal models diseases an update ongoing clinical trials, underscoring using a novel intervention.
Language: Английский
Citations
25
Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 325 - 325
Published: Jan. 17, 2025
Background/Objectives: A fucoidan oligosaccharide (FOS), a potent compound derived from algae, is known for its diverse biological activities, including prebiotic activity, anticancer and antioxidative properties, has demonstrated supportive therapeutic effects in treating kidney ailments. This study was conducted to explore the protective influence of FOS on damage due aging induced by D-galactose Sprague Dawley (SD) rats. Methods: The low-dose group administered (100 mg/kg) gavage, high-FOS received (200 gavage. Results: findings showed that could effectively mitigate improve pathological condition tissues caused D-gal enhance function. Intervention with significantly reduced serum creatinine, uric acid, urea nitrogen levels, compared model group. mechanism D-gal-induced injury may be inhibit oxidative stress impaired mitochondrial function downregulating AMPK/ULK1 signaling pathway. also modulate expression autophagy-related proteins (Beclin-1, P62, LC3II/LC3I), thereby excessive mitophagy kidney. Furthermore, protect against preserving intestinal homeostasis. decreased lipopolysaccharide levels enhanced mucosal barrier upregulated abundances Bacteroidota, Muribaculaceae, Lactobacillus, while it Firmicutes, NK4A136_group, Lachnospiraceae_NK4A136_group. supplementation modulated gut microbiota composition, increasing beneficial bacteria reducing detrimental ones, potentially contributing improved Conclusions: safeguard renal D-gal-exposed rats inhibiting mitophagy, function, regulating
Language: Английский
Citations
1
Clinical and Translational Medicine, Journal Year: 2025, Volume and Issue: 15(5)
Published: May 1, 2025
Abstract Mitochondria‐derived vesicles (MDVs) participate in early cellular defence mechanisms initiated response to mitochondrial damage. They maintain quality control (MQC) by clearing damaged components, thereby ensuring the normal functioning of processes. This process is crucial for cell survival and health, as mitochondria are energy factories cells, their damage can cause dysfunction even death. Recent studies have shown that MDVs not only health but also a significant impact on tumour progression. selectively encapsulate transport proteins under oxidative stress reduce adverse effects which may promote proliferation cells. Furthermore, it has been indicated after cells experience mild stress, number significantly increases within 2–6 h, whereas mitophagy, mitochondria, occurs 12–24 h later. suggests play critical role Moreover, intercellular communication, specifically microenvironment. carry transmit various bioactive molecules, such proteins, nucleic acids, lipids, regulate cell's growth, invasion, metastasis. communication facilitate spread metastasis, making potential therapeutic target. Advances MDV research identified novel biomarkers, clarified regulatory mechanisms, provided evidence clinical use. These breakthroughs pave way MDV‐targeted therapies, offering improved treatment alternatives cancer patients. Further identify MDVs' development elucidate future horizons.
Language: Английский
Citations
1
Life Sciences, Journal Year: 2024, Volume and Issue: 342, P. 122510 - 122510
Published: Feb. 20, 2024
Rac1 is a member of the Rho GTPase family which plays major roles in cell mobility, polarity and migration, as fundamental regulator actin cytoskeleton. Signal transduction by occurs through interaction with multiple effector proteins, its activity regulated guanine nucleotide exchange factors (GEFs) GTPase-activating proteins (GAPs). The small protein mainly anchored to inner side plasma membrane but it can be found endocellular compartments, notably endosomes nuclei. localizes also into mitochondria where contributes regulation mitochondrial dynamics, including both mitobiogenesis mitophagy, addition signaling processes via different partners, such proapoptotic Bcl-2 chaperone sigma-1 receptor (σ-1R). form (mtRac1) has been understudied thus far, essential nuclear or forms, implication oxidative stress DNA damages. subject diverse post-translational modifications, geranylgeranylation importantly import anchorage membranes. In addition, translocation other p53. localization functions are discussed here, context human diseases cancers. Inhibitors have identified (NSC-23766, EHT-1864) some being developed for treatment cancer (MBQ-167) central nervous system (JK-50561). Their effects on mtRac1 warrant further investigations. An overview provided here.
Language: Английский
Citations
7
Redox Biology, Journal Year: 2023, Volume and Issue: 69, P. 102972 - 102972
Published: Nov. 24, 2023
Oxidative stress (OS) is regarded as the dominant theory for aging. While compelling correlative data have been generated to support OS theory, a direct cause-and-effect relationship between accumulation of oxidation-mediated damage and aging has not firmly established. Superoxide dismutase 1 (SOD1) primary antioxidant in all cells. It is, however, susceptible oxidation due gains toxic properties This study investigates role oxidized SOD1 derived from amyotrophic lateral sclerosis (ALS) linked mutations cell senescence Herein, we shown that line NSC34 expressing G93A mutation human (hSOD1G93A) entered premature evidenced by decreased number 5-ethynyl-2′-deoxyuridine (EdU)-positive There was an upregulation cellular markers compared cells wild-type (hSOD1WT). Transgenic mice carrying hSOD1G93A gene showed phenotypes at early age (135 days) with high levels P53 P16 but low SIRT1 SIRT6 age-matched hSOD1WT transgenic mice. Notably, were significantly elevated both senescent 135-day Selective removal our CT4-directed autophagy decelerated aging, indicating causal factor Intriguingly, mitochondria malfunctioned middle-aged hSODG93A They exhibited increased production mitochondrial-derived vesicles (MDVs) response mild mutant hSOD1 younger age; mitochondrial gradually declined In conclusion, show ALS-linked mutants Compromised responsiveness may serve indicator
Language: Английский
Citations
14
BJU International, Journal Year: 2024, Volume and Issue: 134(5), P. 696 - 713
Published: July 5, 2024
The mitochondrion serves as a critical intracellular organelle, engaging in essential roles the regulation of energy production, oxidative stress management, calcium homeostasis, and apoptosis. One such disease that has been particularly associated with these functions is kidney stone (KSD), specifically oxalate (CaOx). It underpinned by tissue inflammation. Recent studies have shed light on vital involvement mitochondrial dysfunction, nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) inflammasome, endoplasmic reticulum subsequent cell death CaOx crystal retention aggregation. These processes are pivotal pathogenesis formation. This review focuses mitochondria renal provides an overview intricate interconnectedness between dysfunction NLRP3 inflammasome activation context KSD. to recognise utmost significance gaining comprehensive understanding mechanisms safeguard function regulate inflammasome. Such knowledge carries significant scientific implications opens up promising avenues for development innovative strategies prevent formation stones.
Language: Английский
Citations
5
Clinical & Experimental Metastasis, Journal Year: 2024, Volume and Issue: 41(5), P. 567 - 587
Published: March 15, 2024
Abstract As a major energy source for cells, mitochondria are involved in cell growth and proliferation, as well migration, fate decisions, many other aspects of cellular function. Once thought to be irreparably defective, mitochondrial function cancer cells has found renewed interest, from suggested potential clinical biomarkers mitochondria-targeting therapies. Here, we will focus on the effect movement breast progression. Mitochondria move both within cell, such localize areas high energetic need, between where stroma have been shown donate their via multiple methods including tunneling nanotubes. The donation seen increase aggressiveness chemoresistance which increased recent efforts uncover mechanisms transfer. metabolism energetics gaining attention targets, better understanding implications required developing effective, targeted therapeutics patients.
Language: Английский
Citations
4
Advanced NanoBiomed Research, Journal Year: 2025, Volume and Issue: unknown
Published: May 20, 2025
Kidney stone ranks as one of the most prevalent disorders in urology department, causing substantial personal suffering and healthcare costs globally. However, prediction, early diagnosis, treatment kidney disease are still limited. Extracellular vesicles (EVs), loaded with nucleic acids, proteins, metabolites, lipids, released by a wide variety cell types have potential biomarkers for disease. Meanwhile, some natural EVs derived from plants animals been evidenced to effects on elimination calcium oxalate crystals. More importantly, recent explorations elucidated multifaceted role therapeutic applications. These engineered can be RNAs, oligonucleotides, peptides, small molecules; this approach has shown great promise targeted drug delivery presents solution challenges prevention treatment. This review focuses blood, urine, kidney, gut microbiota, urine bacteria, which contribute crystal elimination. The is significant, offering personalized options. it crucial assess moving EV‐based therapies laboratory settings clinical
Language: Английский
Citations
0
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(11), P. 3678 - 3678
Published: May 23, 2025
Managing nephrolithiasis in chronic kidney disease (CKD) poses a therapeutic challenge: preventing stone recurrence while preserving function. Standard urological interventions and preventive strategies, such as high fluid intake, thiazides, potassium citrate, cut by 50–60% healthy kidneys but risk overload, hyperkalemia, diminished efficacy CKD glomerular filtration rate (GFR) declines. Often, prevention care are addressed separately, leaving clinicians without unified guidance for this rising patient group. This review explores the bidirectional relationship between CKD, integrating pathophysiology strategies into practical, decision-oriented framework. It offers tailored based on GFR category, type, comorbid conditions, emphasizing potential dual-purpose therapies. Going beyond previous reviews, it connects clinical practice with existing research gaps, offering tools to balance outcomes guide future studies.
Language: Английский
Citations
0