The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a predictive indicator of CKD risk in NAFLD patients: NHANES 2017–2020 DOI Creative Commons

Yong-Qiang Fan,

Hao Wang, Peipei Wang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 24, 2024

Background Non-alcoholic fatty liver disease (NAFLD) and chronic kidney (CKD) are both closely related to dyslipidemia. However, the relationship between dyslipidemia in patients with NAFLD CKD is not yet clear. The non-high-density lipoprotein cholesterol high-density ratio (NHHR) an innovative comprehensive lipid index. purpose of this study was investigate correlation NHHR risk or without fibrosis. Methods This used data from National Health Nutrition Examination Survey (NHANES) 2017 2020 for analysis, including a total 4,041 subjects diagnosed NAFLD. Among subjects, 3,315 individuals fibrosis 726 Weighted multivariate linear regression, weighted logistic restricted cubic spline (RCS) curves, subgroup analysis were evaluate Results Our findings indicate that fibrosis, highest tertile NHHR, as compared lowest tertile, inversely glomerular filtration rate (eGFR) ( β : −2.14, 95% CI: −3.97, −0.32, p < 0.05) positively (OR: 1.67, 1.12, 2.49, 0.05). No significant associations observed eGFR, urinary albumin creatinine (ACR) RCS revealed ACR, while U-shaped Conclusion In non-fibrotic NAFLD, significantly elevated associated increased shows CKD. fibrotic LD, underscore practical utility biomarker early stratification

Language: Английский

Therapeutic Potential of Quercetin as an Antioxidant for Bone-Muscle-Tendon Regeneration and Aging DOI Creative Commons
Jae Gyu Kim, Ashish Ranjan Sharma, Yeon‐Hee Lee

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Quercetin (QC), a naturally occurring bioflavonoid found in various fruits and vegetables, possesses many potential health benefits, primarily attributed to its robust antioxidant properties. The generation of oxidative stress bone cells is key modulator their physiological behavior. Moreover, status influences the pathophysiology mineralized tissues. Increasing scientific evidence demonstrates that manipulating redox balance might be an effective technique for developing disease therapies. QC abilities skeletal muscle significantly enhance regeneration reduce atrophy. In addition, has been shown have protective effects against stress, inflammation, apoptosis, matrix degradation tendons, helping maintain structural integrity functionality tendons. Thus, properties crucial addressing age-related musculoskeletal disorders like osteoporosis, sarcopenia, tendon-related inflammatory conditions. Understanding how signaling pathways involved disorders, including effect on bone, muscle, tendon differentiation, provide insights into diverse advantages promoting tissue preventing cellular damage. Therefore, this study reviewed intricate relationship among repair, affected by antioxidative QC, tissues improve overall bones, muscles, tendons system. Also, reviewing ongoing clinical trials systems encouraging. Given positive health, further investigations controlled human intervention studies are necessary explore therapeutic optimum strength.

Language: Английский

Citations

7
Targeting of mitochondrial fission through natural flavanones elicits anti-myeloma activity DOI Creative Commons

Roberta Torcasio,

Maria Eugenia Gallo Cantafio,

Claudia Veneziano

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 27, 2024

Abstract Background Mitochondrial alterations, often dependent on unbalanced mitochondrial dynamics, feature in the pathobiology of human cancers, including multiple myeloma (MM). Flavanones are natural flavonoids endowed with targeting activities. Herein, we investigated capability Hesperetin (Hes) and Naringenin (Nar), two aglycones Hesperidin Naringin flavanone glycosides, to selectively target Drp1, a pivotal regulator prompting anti-MM activity. Methods Molecular docking analyses were performed crystallographic structure Dynamin-1-like protein (Drp1), using Hes Nar molecular structures. Cell viability apoptosis assessed MM cell lines, or co-culture systems primary bone marrow stromal cells, Titer Glo Annexin V-7AAD staining, respectively; clonogenicity was determined methylcellulose colony assays. Transcriptomic carried out Ion AmpliSeq™ platform; mRNA expression levels by quantitative RT-PCR western blotting, respectively. architecture transmission electron microscopy. Real time measurement oxygen consumption high resolution respirometry living cells. In vivo anti-tumor activity evaluated NOD-SCID mice subcutaneously engrafted Results found accommodate within GTPase binding site inhibit Drp1 activity, leading hyperfused mitochondria reduced OXPHOS. vitro, viability, even presence patient-derived triggering ER stress apoptosis. Interestingly, rewired metabolism through down-regulation master transcriptional activators (SREBF-1, c-MYC) lipogenesis genes. An extract Tacle, Citrus variety rich Naringin, capable recapitulate phenotypic perturbations each flavanone, vivo. Conclusion proliferation, rewire induce cells via antagonism fission driver Drp1. These results provide framework for development therapeutics aberrant dependencies.

Language: Английский

Citations

6
The Association between Dietary Nutrient Intake and Acceleration of Aging: Evidence from NHANES DOI Open Access

MA Jian-hua,

Ping-An Li, Yue Jiang

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1635 - 1635

Published: May 27, 2024

The acceleration of aging is a risk factor for numerous diseases, and diet has been identified as an especially effective anti-aging method. Currently, research on the relationship between dietary nutrient intake accelerated remains limited, with existing studies focusing small number individual nutrients. Comprehensive single mixed effects nutrients not conducted. This study aimed to comprehensively explore intakes, both singly in combination, aging. Data this were extracted from 2015–2018 National Health Nutrition Examination Surveys (NHANES). was measured by phenotypic age acceleration. Linear regression (linear), restricted cubic spline (RCS) (nonlinear), weighted quantile sum (WQS) (mixed effect) models used association A total 4692 participants aged ≥ 20 included study. In fully adjusted models, intakes 16 negatively associated (protein, vitamin E, A, beta-carotene, B1, B2, B6, K, phosphorus, magnesium, iron, zinc, copper, potassium, fiber, alcohol). Intakes sugars, C, caffeine, alcohol showed significant nonlinear associations Additionally, Single well may mitigate Moderately increasing specific maintaining balance be key strategies prevent

Language: Английский

Citations

6
The relationship of dietary flavonoids and periodontitis in US population: a cross-sectional NHANES analysis DOI
Yundong Liu, Tao Yin,

He Mi

et al.

Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 28(3)

Published: Feb. 24, 2024

Language: Английский

Citations

6
A narrative review on the mechanism of natural flavonoids in improving glucolipid metabolism disorders DOI
Wen-jing Niu,

Yongshi Feng,

Minwen Peng

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 4202 - 4229

Published: June 26, 2024

Abstract Glucolipid metabolism disorder (GLMD) is a complex chronic disease characterized by glucose and lipid disorders with diverse etiology rapidly increasing incidence. Many studies have identified the role of flavonoids in ameliorating GLMD, mechanisms related to peroxisome proliferator‐activated receptors, nuclear factor kappa‐B, AMP‐activated protein kinase, (erythroid‐derived 2)‐like 2, transporter type 4, phosphatidylinositol‐3‐kinase/protein kinase B pathway. However, comprehensive summary flavonoid effects on GLMD lacking. This study reviewed roles natural different structures treatment reported globally past 5 years provides reference for developing as drugs treating GLMD.

Language: Английский

Citations

5
Accelerated biological aging, inflammatory bowel disease, genetic susceptibility and life expectancy: Evidence from UK Biobank and All of Us Cohorts DOI Creative Commons
Hao Chen, Lingyi Li, Han Zhang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Background: Inflammatory bowel disease (IBD) is a chronic condition affecting individuals across all age groups. However, the association between IBD and biological aging remains unclear. Methods: We utilized data from UK Biobank diverse cohort of All Us (AoU) Research Programme to investigate role in development its subtypes. Biological was assessed using Klemera-Doubal method (KDMAge) phenotypic (PhenoAge), with KDMAgeAccel PhenoAgeAccel defined as residuals chronological minus KDMAge PhenoAge, respectively. impact accelerated on life expectancy patients through survival analysis. Additionally, we examined genetic susceptibility potential mediating effects IBD. Findings: In Biobank, associated an increased risk (KDMAgeAccel: HR 1.22, 95% CI 1.13-1.32; PhenoAgeAccel: 1.57, 1.46-1.69). This further validated AoU cohort, where also linked elevated (HR 1.18-2.09). An additive interaction observed for Individuals both high exhibited highest developing 1.36, 1.20-1.53; 1.59, 1.41-1.79). Life analysis indicated that experienced significant reduction expectancy, average decrease 1.36 years (KDMAgeAccel) 1.95 (PhenoAgeAccel). Mediation analyses suggested partially mediated protective dried fruit cooked vegetables Results multistate modelling showed significantly occurrence mortality 1.44 [95% 1.17-1.77]). Interpretation: subtypes, especially susceptibility, it reduces these patients. Identifying can serve marker effective prevention management

Language: Английский

Citations

0
The effect of healthy eating index-2015 in the associations of biological aging and non-alcoholic fatty liver disease: an interaction and mediation analysis DOI Creative Commons

Xiang Zhang,

Zhijie Ding, Yong Yan

et al.

Journal of Health Population and Nutrition, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 24, 2025

The present study explored the association between biological aging (BA), healthy eating index-2015 (HEI-2015) and non-alcoholic fatty liver disease (NAFLD) in general population of United States. We used data from NHANES database 2017-2018 years to conduct study. Weighted multivariable logistic regression analysis, restricted cubic spline (RCS), subgroup analysis were performed analyze BA HEI-2015 with prevalence NAFLD mediation effect was also discussed. Additionally, generalized additive model conducted investigate ZJU index, BARD score, fibrosis score. There a total 2,421 individuals. RCS shown that positively correlated NAFLD, while negative risk. After adjusting for interfering factors, compared lowest quartiles HEI-2015, odds ratios 95% confidence intervals across (1.24 (0.84, 1.84), 2.07 (1.15, 3.73) 2.49 (1.16, 5.38)) (0.89 (0.66, 1.18), 0.87 (0.65, 1.16) 0.64 (0.46, 0.87)), respectively. linear positive score However, correlation existed Mediation showed could be mediated weakened by HEI-2015. gradually increases BA, but this can diet.

Language: Английский

Citations

0
Association between serum albumin levels and erectile dysfunction in American Adults: A cross-sectional study from NHANES 2001–2004 DOI Creative Commons

Haibin Wen,

Zhenyu Lan,

X Liang

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0318147 - e0318147

Published: Feb. 6, 2025

Background The aim of this study is to investigate the association between Serum Albumin Levels (ALB) and erectile dysfunction (ED) within U.S. general population. Methods We conducted a cross-sectional analysis using data from National Health Nutrition Examination Survey (NHANES) 2001–2004 cycles. albumin was analyzed both as continuous variable categorized into quartiles. Erectile assessed via self-reported questionnaires. serum evaluated weighted logistic regression models across four models: (1) Crude model (unadjusted); (2) Model 1: Adjusted for age, race, poverty-to-income ratio (PIR), marital status, education level, body mass index (BMI); (3) 2: factors in 1 plus physical activity, smoking drinking Healthy Eating Index (HEI-2015); (4) 3: 2 remaining potential covariates. A generalized additive (GAM) employed examine non-linear associations, followed by subgroup analyses interaction tests. Results total 2925 participants were included study, which 747 diagnosed with ED. After adjusting all covariates, significant negative found ALB ED (OR: 0.53, 95% CI: 0.29–0.97, P = 0.04). Higher quartiles significantly correlated decreased risk [Q4 vs. Q1: OR: 0.56 (0.35–0.90), 0.02; trend 0.03]. GAM smoothed curve fit indicated linear relationship Stratified tests further substantiated inverse prevalence. Conclusions This revealed an Therefore, it important clinicians recognize assessment patients.

Language: Английский

Citations

0
Associations between flavonoid-rich food and flavonoid intakes and incident unhealthy aging outcomes in older U.S. males and females DOI Creative Commons
Nicola P. Bondonno,

Yan Lydia Liu,

Francine Grodstein

et al.

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Flavonoids serve as a promising therapeutic agent for ischemic stroke DOI
Hongxin Shu,

Qiuye Liao,

Zhihao Chen

et al.

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149528 - 149528

Published: Feb. 1, 2025

Language: Английский

Citations

0