Can Genetic Markers Predict the Sporadic Form of Alzheimer’s Disease? An Updated Review on Genetic Peripheral Markers DOI Open Access
D. Theron,

Lloyd N. Hopkins,

Heidi G. Sutherland

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13480 - 13480

Published: Aug. 30, 2023

Alzheimer’s disease (AD) is the most common form of dementia that affects millions individuals worldwide. Although research over last decades has provided new insight into AD pathophysiology, there currently no cure for disease. often only diagnosed once symptoms have become prominent, particularly in late-onset (sporadic) AD. Consequently, it essential to further avenues early diagnosis. With recent advances genomic analysis and a lower cost use, exploration genetic markers alongside RNA molecules can offer key avenue We here brief overview potential differentially expressed peripheral tissues cases compared controls, as well considering changes dynamics molecules. By integrating both genotype reported AD, biomarker profiling be developing reliable diagnostic tools.

Language: Английский

A systematic review of non-coding RNA therapeutics in early clinical trials: a new perspective against cancer DOI Creative Commons
Katia Grillone, Giulio Caridà, Francesco Luciano

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 5, 2024

Targeting non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long (lncRNAs), has recently emerged as a promising strategy for treating malignancies other diseases. In recent years, the development of ncRNA-based therapeutics targeting protein-coding genes also gained momentum. This review systematically examines ongoing completed clinical trials to provide comprehensive overview emerging landscape therapeutics. Significant efforts have been made advance ncRNA early studies. The most advanced conducted with small interfering (siRNAs), miRNA replacement using nanovector-entrapped mimics, or silencing by antisense oligonucleotides. While siRNA-based already received FDA approval, inhibitors, lncRNA-based are still under evaluation in preclinical We critically discuss rationale methodologies strategies illustrate this rapidly evolving field.

Language: Английский

Citations

30
CircRNA and lncRNA-encoded peptide in diseases, an update review DOI Creative Commons
Qian Yi,

Jianguo Feng,

Weiwu Lan

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 30, 2024

Language: Английский

Citations

20
Circular RNAs in the KRAS pathway: Emerging players in cancer progression DOI
Md Sadique Hussain, Ehssan Moglad, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155259 - 155259

Published: March 11, 2024

Language: Английский

Citations

12
Immunoregulatory role of exosomal circRNAs in the tumor microenvironment DOI Creative Commons
Changsheng Lv,

Jinhao Chen,

Yuxiang Wang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 17, 2025

As cancer incidence and mortality rates rise, there is an urgent need to develop effective immunotherapy strategies. Circular RNA (circRNA), a newly identified type of non-coding RNA, abundant within cells can be released via exosomes, facilitating communication between cells. Studies have demonstrated that exosomal circRNAs alter the tumor microenvironment modulate immune responses by influencing functions T cells, natural killer (NK) macrophages, thereby enabling tumors evade system. Moreover, show potential as diagnostic biomarkers therapeutic targets for cancer. This review summarizes regulatory roles in their applications progression treatment, highlighting promise improving immunotherapy. Future research should concentrate on understanding mechanisms key developing targeted methods.

Language: Английский

Citations

2
Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis DOI Creative Commons

E Yimin,

Chen Lü,

Kuixuan Zhu

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(4), P. 109350 - 109350

Published: Feb. 27, 2024

Colorectal cancer (CRC) ranks as the second leading cause of cancer-related mortality, with metastasis being primary determinant poor prognosis in patients. Investigating molecular mechanisms underlying CRC is currently a prominent and challenging area research. Exosomes, crucial intercellular communication mediators, facilitate transfer metabolic genetic information from cells origin to recipient cells. Their roles mediating exchange between immune cells, fibroblasts, other cell types are pivotal reshaping tumor microenvironment, regulating key biological processes such invasion, migration, formation pre-metastatic niche. This article comprehensively examines function mechanism exosomes derived different metastasis, while also presenting an outlook on current research advancements future application prospects. The aim offer distinctive perspective that contributes accurate diagnosis rational treatment strategies for CRC.

Language: Английский

Citations

9
A Novel Circ_0004104/MiR‐493‐5p/SYPL1 Cascade Contributes to Colorectal Cancer Progression DOI Open Access
Bin Zhang, Bin Shao, Zhixian Liu

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(4)

Published: March 21, 2025

Circular RNAs (circRNAs) play critical roles in human tumorigenesis. Circ_0004104 is abnormally expressed the tumors of colorectal cancer (CRC). However, its specific function CRC remains unknown. In this report, we explored biological action and mechanism circ_0004104 development. Quantitative real-time PCR was used to detect circ_0004104, microRNA (miR)-493-5p, synaptophysin-like 1 (SYPL1) mRNA levels. Fluorescence situ hybridization (FISH) assay visualize circ_0004104. The impact on cell phenotypes assessed by measuring proliferation, migration, invasion, apoptosis. Animal experiments were performed analyze effect xenograft growth vivo. potential interacting miRNAs predicted using RNA Interactome database, binding sites for miR-493-5p SYPL1 Starbase3.0 database. circ_0004104/miR-493-5p miR-493-5p/SYPL1 relationships validated dual-luciferase reporter assay. tissues lines, levels upregulated expression decreased. mainly located cytoplasm cells exhibited resistance RNase R digestion. High a poor prognosis patients. Functionally, knockdown suppressed invasiveness accelerated apoptosis vitro, as well diminished tumor depletion also decreased N-cadherin Vimentin increased E-cadherin cells. Mechanistically, could act sponge, direct target miR-493-5p. Moreover, targeted regulate expression. effects behavior alterations reversed inhibitor. Additionally, overexpression phenotypes. Our findings suggest that enhances malignant progression through cascade, providing treatment.

Language: Английский

Citations

1
Biology and function of exosomes in tumor immunotherapy DOI Creative Commons
Can Liu, Cong Xia, Chenglai Xia

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 169, P. 115853 - 115853

Published: Nov. 9, 2023

Exosomes are nano-scale extracellular vesicles that found widely in various biological fluids. As messengers, exosomes deliver characteristic information from donor cells, facilitating their accumulation and subsequent transfer of to tumor immune cells. Immunotherapy is a cutting-edge strategy for cancer therapy, but it has not yet reached its full potential owing severe side effects limited efficacy. possess antigens immunostimulatory molecules can serve as cell-free vaccines induce antitumor immunity. In addition, given stability, low immunogenicity, targeting ability, represent ideal drug delivery systems immunotherapy by delivering cargoes, including non-coding ribonucleic acids (RNAs), membrane proteins, chemotherapeutic agents, cell death inducers. also be engineered precisely target However, rising star immunotherapy, impeded some challenges, the lack uniform technical standards isolation purification, need improve exosomal cargo loading efficient exosome delivery, expansion clinical trials, which currently infancy. Long-term, multi-center, large-scale trials needed evaluate performance future. Nonetheless, have demonstrated encouraging immunotherapy. this review, we summarize challenges with aim shed light on new-era tools.

Language: Английский

Citations

16
Exploring the impact of circRNAs on cancer glycolysis: Insights into tumor progression and therapeutic strategies DOI Creative Commons
Chou‐Yi Hsu, Ahmed Faisal,

Sally Salih Jumaa

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(3), P. 970 - 994

Published: May 5, 2024

Cancer cells exhibit altered metabolic pathways, prominently featuring enhanced glycolytic activity to sustain their rapid growth and proliferation. Dysregulation of glycolysis is a well-established hallmark cancer contributes tumor progression resistance therapy. Increased supplies the energy necessary for increased proliferation creates an acidic milieu, which in turn encourages cells' infiltration, metastasis, chemoresistance. Circular RNAs (circRNAs) have emerged as pivotal players diverse biological processes, including development reprogramming. The interplay between circRNAs explored, illuminating how regulate key glycolysis-associated genes enzymes, thereby influencing profiles. In this overview, we highlight mechanisms by enzymes modulate glycolysis. addition, discuss clinical implications dysregulated glycolysis, potential use diagnostic prognostic biomarkers. All all, provide most recent findings on operate at molecular level control various types cancer, hepatocellular carcinoma (HCC), prostate (PCa), colorectal (CRC), cervical (CC), glioma, non-small cell lung (NSCLC), breast gastric (GC). conclusion, review provides comprehensive overview significance shedding light intricate roles presenting innovative therapeutic avenues.

Language: Английский

Citations

6
Exosomal circular RNAs in tumor microenvironment: An emphasis on signaling pathways and clinical opportunities DOI Creative Commons
Junshu Li, Wencheng Zhou, Huiling Wang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 24, 2024

Exosomes can regulate the malignant progression of tumors by carrying a variety genetic information and transmitting it to target cells. Recent studies indicate that exosomal circular RNAs (circRNAs) multiple biological processes in carcinogenesis, such as tumor growth, metastasis, epithelial-mesenchymal transition, drug resistance, autophagy, metabolism, angiogenesis, immune escape. In microenvironment (TME), circRNAs be transferred among cells, endothelial cancer-associated fibroblasts, microbiota, affecting initiation progression. Due high stability widespread presence circRNAs, they hold promise biomarkers for diagnosis prognosis prediction blood urine. addition, designing nanoparticles targeting utilizing derived from cells or stem provide new strategies cancer therapy. this review, we examined crucial role regulating tumor-related signaling pathways summarized transmission between various types their impact on TME. Finally, our review highlights potential diagnostic prognostic biomarkers, well suggesting clinical

Language: Английский

Citations

6
Prospects of liquid biopsy in the prognosis and clinical management of gastrointestinal cancers DOI Creative Commons

Deepankar Mondal,

Sapnita Shinde,

Vibha Sinha

et al.

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: May 6, 2024

Gastrointestinal (GI) cancers account for one-fourth of the global cancer incidence and are incriminated to cause one-third cancer-related deaths. GI includes esophageal, gastric, liver, pancreatic, colorectal cancers, mostly diagnosed at advanced stages due a lack accurate markers early stages. The invasiveness diagnostic methods like colonoscopy solid biopsy reduces patient compliance as it cannot be frequently used screen patients. Therefore, minimally invasive approaches liquid may explored screening identification gastrointestinal cancers. Liquid involves qualitative quantitative determination certain cancer-specific biomarkers in body fluids such blood, serum, saliva, urine predict disease progression, therapeutic tolerance, toxicities, recurrence by evaluating minimal residual its correlation with other clinical features. In this review, we deliberate upon various tumor-specific cellular molecular entities circulating tumor cells (CTCs), tumor-educated platelets (TEPs), DNA (ctDNA), cell-free (cfDNA), exosomes, exosome-derived biomolecules cite recent advances pertaining their use predicting therapy response, or risk relapse. We also discuss technical challenges associated translating into settings applications

Language: Английский

Citations

5