Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116699 - 116699
Published: Dec. 1, 2024
Language: Английский
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 5, 2024
Targeting non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long (lncRNAs), has recently emerged as a promising strategy for treating malignancies other diseases. In recent years, the development of ncRNA-based therapeutics targeting protein-coding genes also gained momentum. This review systematically examines ongoing completed clinical trials to provide comprehensive overview emerging landscape therapeutics. Significant efforts have been made advance ncRNA early studies. The most advanced conducted with small interfering (siRNAs), miRNA replacement using nanovector-entrapped mimics, or silencing by antisense oligonucleotides. While siRNA-based already received FDA approval, inhibitors, lncRNA-based are still under evaluation in preclinical We critically discuss rationale methodologies strategies illustrate this rapidly evolving field.
Language: Английский
Citations
26
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 17, 2025
As cancer incidence and mortality rates rise, there is an urgent need to develop effective immunotherapy strategies. Circular RNA (circRNA), a newly identified type of non-coding RNA, abundant within cells can be released via exosomes, facilitating communication between cells. Studies have demonstrated that exosomal circRNAs alter the tumor microenvironment modulate immune responses by influencing functions T cells, natural killer (NK) macrophages, thereby enabling tumors evade system. Moreover, show potential as diagnostic biomarkers therapeutic targets for cancer. This review summarizes regulatory roles in their applications progression treatment, highlighting promise improving immunotherapy. Future research should concentrate on understanding mechanisms key developing targeted methods.
Language: Английский
Citations
2
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Sept. 30, 2024
Language: Английский
Citations
15
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155259 - 155259
Published: March 11, 2024
Language: Английский
Citations
12
iScience, Journal Year: 2024, Volume and Issue: 27(4), P. 109350 - 109350
Published: Feb. 27, 2024
Colorectal cancer (CRC) ranks as the second leading cause of cancer-related mortality, with metastasis being primary determinant poor prognosis in patients. Investigating molecular mechanisms underlying CRC is currently a prominent and challenging area research. Exosomes, crucial intercellular communication mediators, facilitate transfer metabolic genetic information from cells origin to recipient cells. Their roles mediating exchange between immune cells, fibroblasts, other cell types are pivotal reshaping tumor microenvironment, regulating key biological processes such invasion, migration, formation pre-metastatic niche. This article comprehensively examines function mechanism exosomes derived different metastasis, while also presenting an outlook on current research advancements future application prospects. The aim offer distinctive perspective that contributes accurate diagnosis rational treatment strategies for CRC.
Language: Английский
Citations
9
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 169, P. 115853 - 115853
Published: Nov. 9, 2023
Exosomes are nano-scale extracellular vesicles that found widely in various biological fluids. As messengers, exosomes deliver characteristic information from donor cells, facilitating their accumulation and subsequent transfer of to tumor immune cells. Immunotherapy is a cutting-edge strategy for cancer therapy, but it has not yet reached its full potential owing severe side effects limited efficacy. possess antigens immunostimulatory molecules can serve as cell-free vaccines induce antitumor immunity. In addition, given stability, low immunogenicity, targeting ability, represent ideal drug delivery systems immunotherapy by delivering cargoes, including non-coding ribonucleic acids (RNAs), membrane proteins, chemotherapeutic agents, cell death inducers. also be engineered precisely target However, rising star immunotherapy, impeded some challenges, the lack uniform technical standards isolation purification, need improve exosomal cargo loading efficient exosome delivery, expansion clinical trials, which currently infancy. Long-term, multi-center, large-scale trials needed evaluate performance future. Nonetheless, have demonstrated encouraging immunotherapy. this review, we summarize challenges with aim shed light on new-era tools.
Language: Английский
Citations
15
Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(3), P. 970 - 994
Published: May 5, 2024
Cancer cells exhibit altered metabolic pathways, prominently featuring enhanced glycolytic activity to sustain their rapid growth and proliferation. Dysregulation of glycolysis is a well-established hallmark cancer contributes tumor progression resistance therapy. Increased supplies the energy necessary for increased proliferation creates an acidic milieu, which in turn encourages cells' infiltration, metastasis, chemoresistance. Circular RNAs (circRNAs) have emerged as pivotal players diverse biological processes, including development reprogramming. The interplay between circRNAs explored, illuminating how regulate key glycolysis-associated genes enzymes, thereby influencing profiles. In this overview, we highlight mechanisms by enzymes modulate glycolysis. addition, discuss clinical implications dysregulated glycolysis, potential use diagnostic prognostic biomarkers. All all, provide most recent findings on operate at molecular level control various types cancer, hepatocellular carcinoma (HCC), prostate (PCa), colorectal (CRC), cervical (CC), glioma, non-small cell lung (NSCLC), breast gastric (GC). conclusion, review provides comprehensive overview significance shedding light intricate roles presenting innovative therapeutic avenues.
Language: Английский
Citations
6
MedComm, Journal Year: 2024, Volume and Issue: 5(12)
Published: Nov. 24, 2024
Exosomes can regulate the malignant progression of tumors by carrying a variety genetic information and transmitting it to target cells. Recent studies indicate that exosomal circular RNAs (circRNAs) multiple biological processes in carcinogenesis, such as tumor growth, metastasis, epithelial-mesenchymal transition, drug resistance, autophagy, metabolism, angiogenesis, immune escape. In microenvironment (TME), circRNAs be transferred among cells, endothelial cancer-associated fibroblasts, microbiota, affecting initiation progression. Due high stability widespread presence circRNAs, they hold promise biomarkers for diagnosis prognosis prediction blood urine. addition, designing nanoparticles targeting utilizing derived from cells or stem provide new strategies cancer therapy. this review, we examined crucial role regulating tumor-related signaling pathways summarized transmission between various types their impact on TME. Finally, our review highlights potential diagnostic prognostic biomarkers, well suggesting clinical
Language: Английский
Citations
6
Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11
Published: May 6, 2024
Gastrointestinal (GI) cancers account for one-fourth of the global cancer incidence and are incriminated to cause one-third cancer-related deaths. GI includes esophageal, gastric, liver, pancreatic, colorectal cancers, mostly diagnosed at advanced stages due a lack accurate markers early stages. The invasiveness diagnostic methods like colonoscopy solid biopsy reduces patient compliance as it cannot be frequently used screen patients. Therefore, minimally invasive approaches liquid may explored screening identification gastrointestinal cancers. Liquid involves qualitative quantitative determination certain cancer-specific biomarkers in body fluids such blood, serum, saliva, urine predict disease progression, therapeutic tolerance, toxicities, recurrence by evaluating minimal residual its correlation with other clinical features. In this review, we deliberate upon various tumor-specific cellular molecular entities circulating tumor cells (CTCs), tumor-educated platelets (TEPs), DNA (ctDNA), cell-free (cfDNA), exosomes, exosome-derived biomolecules cite recent advances pertaining their use predicting therapy response, or risk relapse. We also discuss technical challenges associated translating into settings applications
Language: Английский
Citations
4
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 17, 2025
Osteoarthritis (OA) is the most common degenerative joint disease worldwide, characterized by synovial inflammation, cartilage loss, and reactive hyperplasia of subchondral bone, affecting quality life hundreds millions people. However, molecular mechanisms underlying occurrence progression OA remain unclear, there no therapy can substantially interrupt or reverse destructive process OA. More insight into pathogenesis may result in innovative therapeutics. The microenvironment plays a pivotal role development OA, which encompasses chondrocytes, adipocytes, fibroblasts, endothelial cells, immune cells. Extracellular vesicles (EVs) have emerged as novel form intercellular communication, mediating transfer range bioactive molecules to create specific microenvironment. Recent studies reported that cargos EVs play crucial including noncoding RNAs (ncRNAs), proteins, lipids. This review systematically analyzes summarizes biological characteristics functionalities derived from diverse cellular sources, especially how mediate communication between different cells microenvironment, with view providing new insights
Language: Английский
Citations
0