Synthesis and Regulation of miRNA, Its Role in Oncogenesis, and Its Association with Colorectal Cancer Progression, Diagnosis, and Prognosis DOI Creative Commons
Monika Rać

Diagnostics, Journal Year: 2024, Volume and Issue: 14(13), P. 1450 - 1450

Published: July 7, 2024

The dysfunction of several types regulators, including miRNAs, has recently attracted scientific attention for their role in cancer-associated changes gene expression. MiRNAs are small RNAs ~22 nt length that do not encode protein information but play an important post-transcriptional mRNA regulation. Studies have shown miRNAs involved tumour progression, cell proliferation, cycle, apoptosis, and angiogenesis invasion, a complex the regulation tumourigenesis. detection selected may help early cancer cells, monitoring expression profile serve as prognostic factor course disease or its treatment. diagnostic biomarkers, well potential therapeutic targets colorectal cancer. In recent years, there been increasing evidence epigenetic interaction between DNA methylation miRNA tumours. This article provides overview which more frequently expressed suggesting oncogenic nature.

Language: Английский

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition DOI Creative Commons
Antonino Glaviano,

Hannah Lau,

Lukas M. Carter

et al.

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 13, 2025

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.

Language: Английский

Citations

16
Mesenchymal Stem Cell-Derived Exosomes as Drug Delivery Vehicles in Disease Therapy DOI Open Access

Wenzhe Zhao,

Kaixuan Li,

Liangbo Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7715 - 7715

Published: July 14, 2024

Exosomes are small vesicles containing proteins, nucleic acids, and biological lipids, which responsible for intercellular communication. Studies have shown that exosomes can be utilized as effective drug delivery vehicles to accurately deliver therapeutic substances target tissues, enhancing effects reducing side effects. Mesenchymal stem cells (MSCs) a class of widely used tissue engineering, regenerative medicine, immunotherapy. derived from MSCs special immunomodulatory functions, low immunogenicity, the ability penetrate tumor high yield, expected engineered into efficient systems. Despite promising promise MSC-derived exosomes, exploring their optimal preparation methods, drug-loading modalities, potential remains challenging. Therefore, this article reviews related characteristics, application, risks systems in order find breakthroughs.

Language: Английский

Citations

15
Novel Carbohydrate Polymer‐Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials DOI

Nikita Udaipuria,

Sankha Bhattacharya

Biopolymers, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

ABSTRACT Due to their biocompatibility, biodegradability, and controlled release, carbohydrates polymers are crucial targeted drug delivery systems, notably for colon cancer treatment. This article examines how carbohydrate like chitosan, pectin, guar gum, alginate, hyaluronic acid, dextran, chondroitin sulfate used in improved delivery. Modifying these improves loading, stability, release patterns, enhancing chemotherapeutic drugs' therapeutic index. Chitosan nanoparticles pH‐responsive, making them perfect Pectin's resistance gastric enzymes colonic bacteria makes it a promising colon‐specific medication agent. The combination of with nanotechnology, 3D printing, AI allows the creation stimuli‐responsive systems that drugs precisely response environmental signals pH, redox potential, or enzymatic activity. review highlights intelligent system design advances reduce systemic toxicity, improve treatment efficacy, patient adherence. Carbohydrate will revolutionize personalized accurate alternatives.

Language: Английский

Citations

8
Innovative Strategies to Combat 5-Fluorouracil Resistance in Colorectal Cancer: The Role of Phytochemicals and Extracellular Vesicles DOI Open Access
Muttiah Barathan, Ahmad Khusairy Zulpa, Sook Luan Ng

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7470 - 7470

Published: July 8, 2024

Colorectal cancer (CRC) is a significant public health challenge, with 5-fluorouracil (5-FU) resistance being major obstacle to effective treatment. Despite advancements, 5-FU remains formidable due complex mechanisms such as alterations in drug transport, evasion of apoptosis, dysregulation cell cycle dynamics, tumor microenvironment (TME) interactions, and extracellular vesicle (EV)-mediated pathways. Traditional chemotherapy often results high toxicity, highlighting the need for alternative approaches better efficacy safety. Phytochemicals (PCs) EVs offer promising CRC therapeutic strategies. PCs, derived from natural sources, exhibit lower toxicity can target multiple pathways involved progression resistance. facilitate targeted delivery, modulate immune response, interact TME sensitize cells However, potential PCs engineered overcoming reshaping immunosuppressive underexplored. Addressing this gap crucial identifying innovative therapies enhanced reduced toxicities. This review explores multifaceted evaluates synergistic effects combining improve treatment while minimizing adverse effects. Additionally, it investigates by serving delivery vehicles modulating TME. By synthesizing current knowledge addressing research gaps, enhances academic understanding CRC, interdisciplinary involving revolutionizing therapy. Further clinical validation are essential translating these findings into improved patient outcomes.

Language: Английский

Citations

6
Cell Membrane-Integrated Neuroligin-1 Regulates the Anti-Inflammatory Effects of CRC Cell-Derived Exosomes DOI Open Access
Mohammad Mahmoudian, Francesco Trotta, Stefania Raimondo

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 503 - 503

Published: Jan. 9, 2025

Tumor-associated macrophages (TAMs) are one of the most abundant cell types in colorectal cancer (CRC) tumor microenvironment (TME). CRC cell-derived exosomes support macrophage polarization toward an M2-like phenotype, which leads to growth and metastasis. Neuroligin 1 (NLG1) is a transmembrane protein critical synaptic function. We reported that NLG1 via autocrine manner promotes progression by modulating APC/β-catenin pathway. This study aimed answer whether involved exosome-mediated intercellular cross-talk between TAMs. Our results showed NLG1-expressing cells induce (CD206high CD80low) macrophages. On other hand, we found knocked-down reinforce expression CD80 pro-inflammatory genes, including IL8, IL1β, TNFα, macrophages, indicating M1-like phenotype polarization. In conclusion, NLG1, as cell-membrane-integrated protein, could be therapeutic target on surface for developing clinical treatments inhibit exosome-induced anti-inflammatory immune responses TME.

Language: Английский

Citations

0
Ribosomal Proteins as Exosomal Cargo: Random Passengers or Crucial Players in Carcinogenesis? DOI Open Access
D. M. Graifer, Alexey A. Malygin, Aleksei Shefer

et al.

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Many ribosomal proteins (RPs) have functions beyond their canonical role as constituents of the ribosome. They often relate to human pathologies, primarily, carcinogenesis, and expression specific RPs is considerably changed in malignant cells. On other hand, extracellular vesicles (including exosomes), which provide intercellular communication by transporting molecular cargo from donor recipient cells, contain sets RPs. Thus, one can assume that oncogenic properties be transferred cell another exosomes. Such kind transfer has been already documented with RPS3 gastric cancer However, it remains largely unclear how widespread above effect extent contributes tumor progression metastasis. To shed light on this issue, a comparative analysis found exosomes available data these conducted.

Language: Английский

Citations

0
Exploring the influence of anemia and inflammation indices on colorectal cancer: analysis of the national health and nutrition examination survey From 2011 to 2018 DOI Creative Commons
Chao Qu, Shuting Yang, Tianli Shen

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 3, 2024

Purpose Patients with colorectal cancer (CRC) frequently present anemia and signs of infection. However, the relationships between these factors remain unclear. This study investigated potential association anemia, inflammatory indices, CRC. Methods We analyzed data from 2011–2018 National Health Nutrition Examination Survey to investigate links inflammation, Inflammatory including neutrophil-percentage-to-albumin ratio, neutrophil-to-lymphocyte eosinophil-to-lymphocyte were analyzed. Following rigorous inclusion criteria, 14,114 participants included. Statistical methods such as logistic regression subgroup analyses employed. Moreover, survival analysis was performed. Results Among participants, 0.6% had CRC 11.0% diagnosed anemia. Anemia indices associated CRC, suggesting an increased risk (OR range: 2.03-2.50, P<0.05). lower red blood cell counts, reduced hemoglobin levels, higher indices. is accompanied by increase in which also a factor for 1.12-7.00, Survival indicated that rates, impacting all-cause, cancer, mortality. Conclusion Our results indicate are correlated tend exhibit decreased count albumin potentially survival.

Language: Английский

Citations

2
Sex Differences in Cardiovascular Diseases: Exploring the Role of Microbiota and Immunity DOI Creative Commons
Laura Franza, Mario Caldarelli, Emanuele Rocco Villani

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1645 - 1645

Published: July 24, 2024

Cardiovascular diseases (CVDs) are the most common cause of mortality and morbidity in Western countries, thus representing a global health concern. CVDs show different patterns terms prevalence presentation men women. The role sex hormones has been extensively implicated these sex-specific differences, due to presence menstrual cycle menopause Moreover, gut microbiota (GM) cardiovascular health, considering growing evidence that it is involved determining development specific diseases. In particular, gut-derived metabolites have linked kidney disorders, which can turn promote progression CVDs. Considering differences composition GM between women, possible act as mediator regard disparities This narrative review aims comprehensively interplay sex, GM, CVDs, discussing potential mechanisms therapeutic options.

Language: Английский

Citations

1
Synthesis and Regulation of miRNA, Its Role in Oncogenesis, and Its Association with Colorectal Cancer Progression, Diagnosis, and Prognosis DOI Creative Commons
Monika Rać

Diagnostics, Journal Year: 2024, Volume and Issue: 14(13), P. 1450 - 1450

Published: July 7, 2024

The dysfunction of several types regulators, including miRNAs, has recently attracted scientific attention for their role in cancer-associated changes gene expression. MiRNAs are small RNAs ~22 nt length that do not encode protein information but play an important post-transcriptional mRNA regulation. Studies have shown miRNAs involved tumour progression, cell proliferation, cycle, apoptosis, and angiogenesis invasion, a complex the regulation tumourigenesis. detection selected may help early cancer cells, monitoring expression profile serve as prognostic factor course disease or its treatment. diagnostic biomarkers, well potential therapeutic targets colorectal cancer. In recent years, there been increasing evidence epigenetic interaction between DNA methylation miRNA tumours. This article provides overview which more frequently expressed suggesting oncogenic nature.

Language: Английский

Citations

1