Shared molecular, cellular, and environmental hallmarks in cardiovascular disease and cancer: any place for drug repurposing? DOI Creative Commons
Elisa Avolio, Barbara Bassani, Marzia Campanile

et al.

Pharmacological Reviews, Journal Year: 2024, Volume and Issue: 77(2), P. 100033 - 100033

Published: Dec. 24, 2024

Cancer and cardiovascular disease (CVD) are the 2 biggest killers worldwide. Specific treatments have been developed for diseases. However, mutual therapeutic targets should be considered because of overlap cellular molecular mechanisms. research has grown at a fast pace, leading to an increasing number new mechanistic treatments. Some these drugs could prove useful treating CVD, which realizes concept cancer drug repurposing. This review provides comprehensive outline shared hallmarks primarily ischemic heart failure. We focus on chronic inflammation, altered immune response, stromal vascular cell activation, underlying signaling pathways causing pathological tissue remodeling. There is obvious scope targeting those mechanisms, thereby achieving reciprocal preventive benefits. Major attention devoted illustrating logic, advantages, challenges, viable examples repurposing discussing potential influence sex, gender, age, ethnicity in realizing this approach. Artificial intelligence will help refine personalized application patients with CVD. SIGNIFICANCE STATEMENT: (CVD), worldwide, share several So far, specific therapies tackle development slow compared drugs. Understanding intersection between mechanisms diseases basis therapeutics CVD treatment. approach allow rapid CVDs.

Language: Английский

Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology DOI
Tommaso Angelone, Carmine Rocca, Vincenzo Lionetti

et al.

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 40(7-9), P. 369 - 432

Published: Feb. 1, 2024

Physiological levels of reactive oxygen and nitrogen species (ROS/RNS) function as fundamental messengers for many cellular developmental processes in the cardiovascular system. ROS/RNS involved cardiac redox-signaling originate from diverse sources, their are tightly controlled by key endogenous antioxidant systems that counteract accumulation. However, dysregulated redox-stress resulting inefficient removal leads to inflammation, mitochondrial dysfunction, cell death, contributing development progression disease (CVD).

Language: Английский

Citations

18
Elucidating emerging signaling pathways driving endothelial dysfunction in cardiovascular aging DOI

Anna De Bartolo,

Tommaso Angelone, Carmine Rocca

et al.

Vascular Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 107462 - 107462

Published: Jan. 1, 2025

Language: Английский

Citations

1
Mitochondrial quality control: Biochemical mechanism of cardiovascular disease DOI Creative Commons

Francesca Inferrera,

Ylenia Marino,

Tiziana Genovese

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: 1872(3), P. 119906 - 119906

Published: Jan. 19, 2025

Language: Английский

Citations

1
Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction DOI Creative Commons
Michael W. Rudokas,

Margaret McKay,

Zeren Toksoy

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 18, 2024

Abstract Mitochondria play a central role in cellular energy metabolism, and their dysfunction is increasingly recognized as critical factor the pathogenesis of diabetes-related cardiac pathophysiology, including vulnerability to ischemic events that culminate myocardial infarction on one hand ventricular arrhythmias other. In diabetes, hyperglycemia altered metabolic substrates lead excessive production reactive oxygen species (ROS) by mitochondria, initiating cascade oxidative stress damages mitochondrial DNA, proteins, lipids. This injury compromises efficiency phosphorylation, leading impaired ATP production. The resulting deficit damage contribute functional abnormalities cells, placing heart at an increased risk electromechanical irreversible cell death response insults. While mitochondria are often considered be relatively autonomous entities capacity produce ROS, highly dynamic nature within elaborate network closely-coupled organelles occupies 30–40% cardiomyocyte volume fundamental ability exert intricate regulation over global function. this article, we review evidence linking properties overall function its injury. We then highlight select studies ultrastructural alterations driven changes fission, fusion mitophagy promoting diabetic heart.

Language: Английский

Citations

7
Design, Synthesis, and In Vivo Evaluation of Isosteviol Derivatives as New SIRT3 Activators with Highly Potent Cardioprotective Effects DOI
Zhen‐Yu Chen, Zhiyin Li, Ruilong Xu

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(8), P. 6749 - 6768

Published: April 4, 2024

Cardiovascular diseases (CVDs) persist as the predominant cause of mortality, urging exploration innovative pharmaceuticals. Mitochondrial dysfunction stands a pivotal contributor to CVDs development. Sirtuin 3 (SIRT3), prominent mitochondrial deacetylase known for its crucial role in protecting mitochondria against damage and dysfunction, has emerged promising therapeutic target treatment. Utilizing isosteviol, natural

Language: Английский

Citations

6
Obesity and Cancer Rehabilitation for Functional Recovery and Quality of Life in Breast Cancer Survivors: A Comprehensive Review DOI Open Access
Lorenzo Lippi, Alessandro de Sire, Arianna Folli

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 521 - 521

Published: Jan. 25, 2024

Obesity is a global health challenge with increasing prevalence, and its intricate relationship cancer has become critical concern in care. As result, understanding the multifactorial connections between obesity breast imperative for risk stratification, tailored screening, rehabilitation treatment planning to address long-term survivorship issues. The review follows SANRA quality criteria includes an extensive literature search conducted PubMed/Medline, Web of Science, Scopus. biological basis linking involves complex interactions adipose tissue tumor microenvironment. Various mechanisms, such as hormonal alterations, chronic inflammation, immune system modulation, mitochondrial dysfunction, contribute development. underlines importance comprehensive oncologic rehabilitation, including physical, psychological, nutritional aspects. Cancer plays crucial role managing obesity-related symptoms, offering interventions physical impairments, pain management, lymphatic disorders, improving both psychological well-being. Personalized technology-driven approaches hold promise optimizing effectiveness outcomes obese patients. insights provided this evolving landscape care, emphasizing well-being

Language: Английский

Citations

5
Targeting of mitochondrial fission through natural flavanones elicits anti-myeloma activity DOI Creative Commons

Roberta Torcasio,

Maria Eugenia Gallo Cantafio,

Claudia Veneziano

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 27, 2024

Abstract Background Mitochondrial alterations, often dependent on unbalanced mitochondrial dynamics, feature in the pathobiology of human cancers, including multiple myeloma (MM). Flavanones are natural flavonoids endowed with targeting activities. Herein, we investigated capability Hesperetin (Hes) and Naringenin (Nar), two aglycones Hesperidin Naringin flavanone glycosides, to selectively target Drp1, a pivotal regulator prompting anti-MM activity. Methods Molecular docking analyses were performed crystallographic structure Dynamin-1-like protein (Drp1), using Hes Nar molecular structures. Cell viability apoptosis assessed MM cell lines, or co-culture systems primary bone marrow stromal cells, Titer Glo Annexin V-7AAD staining, respectively; clonogenicity was determined methylcellulose colony assays. Transcriptomic carried out Ion AmpliSeq™ platform; mRNA expression levels by quantitative RT-PCR western blotting, respectively. architecture transmission electron microscopy. Real time measurement oxygen consumption high resolution respirometry living cells. In vivo anti-tumor activity evaluated NOD-SCID mice subcutaneously engrafted Results found accommodate within GTPase binding site inhibit Drp1 activity, leading hyperfused mitochondria reduced OXPHOS. vitro, viability, even presence patient-derived triggering ER stress apoptosis. Interestingly, rewired metabolism through down-regulation master transcriptional activators (SREBF-1, c-MYC) lipogenesis genes. An extract Tacle, Citrus variety rich Naringin, capable recapitulate phenotypic perturbations each flavanone, vivo. Conclusion proliferation, rewire induce cells via antagonism fission driver Drp1. These results provide framework for development therapeutics aberrant dependencies.

Language: Английский

Citations

4
Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma DOI
Honghao Zhang, Hao Wang,

Yuxing Hu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216802 - 216802

Published: March 11, 2024

Language: Английский

Citations

4
Investigating the temporal link between PM2.5 exposure and acceleration of myocardial ischemia reperfusion injury: Emphasizing the hazardous presence of metals in inhaled air DOI
Bhavana Sivakumar,

Gino A. Kurian

Environmental Pollution, Journal Year: 2024, Volume and Issue: 355, P. 124113 - 124113

Published: May 9, 2024

Language: Английский

Citations

4
Integrative analysis of genes provides insights into the molecular and immune characteristics of mitochondria-related genes in atherosclerosis DOI Creative Commons
Zhipeng Zheng,

Huimin Lu,

Xiaowen Wang

et al.

Genomics, Journal Year: 2025, Volume and Issue: 117(2), P. 111013 - 111013

Published: Feb. 4, 2025

Language: Английский

Citations

0